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Parthenolide increases the sensitivity of gastric cancer cells to chemotherapy

Journal of Traditional Chinese Medicine 2020年第6期40卷 908-916页

作者： Liu Minghua Yang Ying Liu Dajun Cao Ye Li Yan Department of Gastroenterology China Medical University Affiliated Shengjing HospitalShenyang 110002China Department of Renal Medicine China Medical University Affiliated Shengjing HospitalShenyang 110002China

OBJECTIVE:To investigate the effect of parthenolide(PTL),a sesquiterpene lactone medicinal compound,on the sensitivity of the gastric cancer cell line SGC7901 and the DPP-and ADR-resistant sublines SGC7901/DDP and SGC7901/ADR to cisplatin[diamminedichloroplatinum(Ⅱ),DDP]and adriamycin(ADR)in ***:SGC7901,SGC7901/DDP,and SGC7901/ADR were treated with various concentrations of PTL alone or in combination with DDP or *** effects on cell proliferation,apoptosis,and expression/activity of several proliferation/apoptosis-related proteins[B-cell lymphoma-2(Bcl-2),cyclin D1,nuclear factor-kappa B(NF-κB),and Caspase-8]and drug transporters(P-glycoprotein and multidrug resistance protein-1)were measured using flow cytometry,Western blotting,and in vitro activity ***:Treatment of SGC7901 cells with PTL inhibited cell growth,increased apoptosis,and sensitized the cells to ***,PTL treatment resulted in downregulation of NF-κB activity and Bcl-2 expression,and upregulation of Caspase-8 ***,PTL co-treatment of SGC7901/DDP and SGC7901/ADR overcame their resistance to DDP and ADR,respectively,with concomitant inhibition of NF-κB,Bcl-2,Cyclin D1,P-glycoprotein,and multidrug resistance protein-1 expression and/or ***:PTL treatment decreases drug resistance in SGC7901,SGC7901/DDP,and SGC7901/ADR cells,as reflected by induction of apoptosis,inhibition of proliferation,downregulation of pro-survival and drug resistance pathways,and upregulation of pro-apoptotic *** results suggest that co-treatment with PTL may thus complement existing therapies for gastric cancer.

关键词： Parthenolide Cisplatin Adriamycin Gastric cancer Chemotherapy Sensitivity

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Anticonvulsant potential of rosuvastatin in combination with carbamazepine and valproate in animal models of epilepsy

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World Journal of Methodology 2025年第2期15卷 137-144页

作者： Vandana Tayal Akash Mandal Ijasul Haque M Akhilesh Mishra Bhupinder S Kalra Vandana Roy Department of Pharmacology Maulana Azad Medical CollegeNew Delhi 110002India Department of Pharmacology MES Medical CollegePerintalmanna 679338KeralaIndia Department of Central Animal Facility Maulana Azad Medical CollegeNew Delhi 110002India

BACKGROUND Epilepsy impacts millions of people,with many not responding to existing *** evidence links neuroinflammatory processes to *** exhibit anti-inflammatory and neuroprotective properties,potentially offering antiepileptic *** To evaluate the anticonvulsant effects of rosuvastatin in animal models of *** Ninety-six albino mice were divided into 16 *** the maximal electroshock seizure(MES)model,eight groups received intraperitoneal vehicle,carbama-zepine,rosuvastatin,or a *** measured included seizure protection[tonic hind limb extension(THLE)],duration of THLE,seizure duration,and *** the pentylenetetrazol(PTZ)model,eight groups were pretreated with vehicle,valproate,rosuvastatin,or a combination,with outcomes measured as seizure latency,seizure duration,and *** In the MES model,rosuvastatin exhibited protection against THLE in a small percentage of *** shortens the duration of THLE in a dose-dependent ***,none of these were statistically significant com-pared to the control *** combination of rosuvastatin 10 mg/kg with carbamazepine 4 mg/kg resulted in a significant reduction in seizure duration compared to the control group,better than carbamazepine alone at 4 mg/kg and 6 mg/*** the PTZ model,rosuvastatin alone showed no significant effects on latency,duration of seizure,or ***,rosuvastatin 10 mg/kg combined with valproate 100 mg/kg significantly delayed the onset of seizures,seizure duration and mortality percentage,better than valproate alone at 100 mg/*** Rosuvastatin enhanced the anticonvulsant effects of carbamazepine and *** studies are required to explore the antiepileptic potential of rosuvastatin at various doses,durations,dosage forms,routes and models.

关键词： Antiepileptic Anticonvulsant Statins Rosuvastatin Maximal electroshock seizure Pentylenetetrazol

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Cytocompatibility of High Nitrogen Nickel-Free Stainless Steel for Orthopedic Implants

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Journal of Materials Science & Technology 2012年第7期28卷 647-653页

作者： Tianchi Ma Peng Wan Yuyan Cui Guirong Zhang Jiqiang Li Jihui Liu Yibin Ren Ke Yangg Li Lu School of Stomatology China Medical University Shenyang 110002 China Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China Shenyang the Fourth Hospital of People Shenyang 110032 China Shenyang Stomatoiogy Hospital Shenyang 110002 China

Cytocompatibility of high nitrogen nickel-free stainless steel （HNS） with different nitrogen content was evalu- ated and compared with a conventional austenitic stainless steel 317L. The MTT assay （3-（4,5-dimethylthiazol- 2-yl）-2,5-diphenyltetrazolium bromide） was performed on MG63 osteoblasts to assess the cytotoxicity. The expression of selected marker typical of differentiated osteoblasts, such as alkaline phosphatase activity （AKP）, was also monitored in MG63 cells cultured on the tested materials. As a result, HNS had higher cell growth than 317L; meanwhile the cytocompatibility was increased with increasing nitrogen content. Furthermore, HNS enhanced osteoblasts differentiation, as confirmed by AKP activity. Overall these facts indicated that HNS had higher cytocompatibility than 317L and the nitrogen content contributed to the higher cytocompatibility of HNS. The influence of nitrogen on surface energy further explained the cytocompatibility of HNS.

关键词： High nitrogen stainless steel Cytoxicity evaluation Osteoblasts Bone Surfaceenergy

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Effect of modified Sanhuang Xiexin Tang plus additional herbs combined with ＂standard triple therapy＂ on Helicobacter pylori eradication

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Journal of Traditional Chinese Medicine 2018年第1期38卷 101-106页

作者： Yao Xinjie Li Yan Department of Gastroenterology Shengjing Hospital Affiliated to China Medical University Shenyang 110002 China

OBJECTIVE： To determine the effectiveness of modified Sanhuang Xiexin Tang （SHXXT） plus additional herbs （MSAH） combined with ＂standard tri- ple therapy＂ for eradication of Helicobacter pylori （H. pylori） and amelioration of related symptoms in comparison with standard triple and standard quadruple therapies. METHODS： From October 2015 to May 2016, we recruited patients with dyspepsia symptoms con- firmed to have H. pylori infection by the ^13C urea breath test in our outpatient clinic. Patients were randomly divided into three treatment groups： Nexium standard triple therapy （group A, EAC）, Nexium standard quadruple therapy （group B, EBAC）, or Nexium standard triple therapy combined with MSAH （group C; EAC＋MSAH）. Comparisons of H. pylori eradication and symptom amelioration rates were made among the three groups at 2 or 6 weeks after group assignment. RESULTS： There was no difference in H. pylori eradication rates between groups B （EBAC） and C （EAC＋ MSAH）（P = 0.486）, and eradication rates in groups B and C were significantly higher than that in group A （EAC）（P Av, e = 0.001; P AvsC= 0.003）. There was no difference in the total symptom score among the groups before treatment. In all groups, the total symptom scores after treatment （2 or 6 weeks after group assignment） were significantly lower than those before treatment （P 〈 0.001 for all）. However, group C （EAC ＋ MSAH） demonstrated superior total symptom scores and symptom amelioration rates than groups A （EAC） and B （EBAC）. Group B also demonstrated better scores and rates than group A. There was no difference in symptom amelioration rates at 2 and 6 weeks within each group. CONCLUSION： There is no difference between MSAH combined with standard triple therapy and standard quadruple therapy containing bismuth with regard to H. pylori eradication rate. However, MSAH combined with standard triple therapy has a higher symptom amelioration rate and therefore appears to be an ideal treatment scheme for H. pyIori eradi

关键词： Helicobacter pylori Disease eradica-tion Symptom assessment Sanhuang Xiexin Tang

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Composite pheochromocytoma masquerading as solidpseudopapillary neoplasm of pancreas

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World Journal of Clinical Cases 2015年第5期3卷 474-478页

作者： Geetanjali Gupta Ravindra Kumar Saran Satyajit Godhi Siddharth Srivastava Sundeep Singh Saluja Pramod Kumar Mishra Department of Pathology Academic Block GB Pant Hospital New Delhi 110002 India Department of Gastroenterology Academic Block GB Pant Hospital New Delhi 110002 India Department of Gastrointestinal Surgery Academic Block GB Pant Hospital New Delhi 110002 India

Pheochromocytoma and ganglioneuroma form rare composite tumours of the adrenal medulla comprising less than 3% of all sympathoadrenal tumours. We present a case of intraoperatively detected adrenal medullary tumour of composite pheochromocytoma and ganglioneuroma diagnosed on histopathology, in a normotensive patient. A 50-year-old male with a past history of chronic obstructive pulmonary disease presented with abdominal pain and significant weight loss since one month. Ultrasound and contrast-enhanced computed tomography abdomen revealed a large lobulated lesion in the distal body and tail of pancreas suggestive of solid and papillary neoplasm of body and tail of pancreas. Intra-operatively, a 15 cm × 10 cm solid lesion with cystic areas was seen arising from the left lower pole of the adrenal gland pushing the pancreas which appeared unremarkable. In our case, exploratory laparotomy with tumour excision was done. Extensive sectioning and microscopic examination of this adrenal tumour confirmed a diagnosis of composite Pheochromocytoma with Ganglioneuroma on histopathology. Immunophenotyping with S-100 further supported the diagnosis. The goal of this report is to increase the awareness of this rare disease and to further identify its variable presentation.

关键词： Ganglioneuroma Pheochromocytoma Adrenal

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Pancreatic ductal adenocarcinoma associated with pancreatic ductal intraepithelial neoplasia:report of a case

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Hepatobiliary & Pancreatic Diseases International 2007年第5期6卷 553-556页

作者： Rajkumar Krishnasamy Shaleen Agarwal Shivendra Singh Sunil Puri Puja Sakhuja Anil K Agarwal Department of Gastrointestinal Surgery Govind Ballabh Pant Hospital and Maulana Azad Medical College(Delhi University)New Delhi 110002India Department of Radiology Govind Ballabh Pant Hospital and Maulana Azad Medical College(Delhi University)New Delhi 110002 Department of Pathology Govind Ballabh Pant Hospital and Maulana Azad Medical College(Delhi University)New Delhi 110002

BACKGROUND:The presence of pancreatic ductal intraepithelial neoplasia in patients with chronic pancreatitis is a risk factor for development of pancreatic adenocarcinoma. METHOD:A case of pancreatic ductal adenocarcinoma associated with pancreatic ductal intraepithelial neoplasia was diagnosed in the setting of chronic pancreatitis. RESULTS:Distal pancreatectomy combined with splenec- tomy was performed with a diagnosis of pancreatic body *** examination suggested adenocarcinoma associated with pancreatic ductal intraepithelial *** tumor was detected in the remaining head of the pancreas,for which a total pancreatectomy was done. CONCLUSIONS:When a patient with pancreatic ductal intraepithelial neoplasia associated with adenocarcinoma of the pancreas in the setting of chronic pancreatitis is at an increased risk of recurrence in the remaining pancreatic parenchyma,total pancreatectomy may be feasible.

关键词： pancreatectomy pancreatic ductal carcinoma chronic pancreatitis

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A randomized trial of a 4- vs 12-week daily interferon dose regimen combined with ribavirin in treatment of patients with chronic hepatitis C

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Hepatobiliary & Pancreatic Diseases International 2004年第1期3卷 42-48页

作者： Shiv K. Sarin Ankur Goyal Sudheer Kumar Rajkumar C. Guptan Abid Zaffar Hashmi Pooja Sakhuja Veena Malhotra Departments of Gastroenterology G. 13. Pant Hospital New Delhi 110002 India Departments of Pathology G. 13. Pant Hospital New Delhi 110002 India

BACKGROUND: Standard combination-therapy of ribavi- rin with alternate day interferon (IFN) in patients with chronic hepatitis C ( CHC) has been reported to achieve 30%-55% sustained viral response. Early reduction of viral load by daily dosage of IFN could enhance viral clearance. However, the duration of daily dosage protocol and the likely side-effects have not been well studied. We compared the efficacy and safety of a 4- vs 12-week daily IFN dosage in patients with CHC. METHODS: Fifty-nine, histologically proven CHC patients having ALT levels >1.5 ×ULN were divided randomly into 2 groups, group I was given IFN 3 MIU daily for 4 weeks, followed by tiw up to 12 months and group was given IFN 3 MIU daily for 12 weeks, followed by tiw up to 12 months. Ribavirin was given in a dose of 800-1200 mg/d for 12 months. RESULTS: Fifty-two of the 59 patients (group group completed the study. The pretreatment vari- ables and the prevalence of HCV genotype 1 were compara- ble between the groups. Nine patients (29%) in group and 6 (25%) in group had stage 3, 4 fibrosis. At the end of 4, 12, 24 and 52 weeks, HCV RNA negativity was ob- served in 27%, 54%, 65% and 71% in group I and 38%, 54%, 71% and 75% in group respectively (P =ns). Four of the eight (50%) patients with genotype 1 and 30 (69.8%) of 43 patients with genotype non-1 responded to therapy (P =ns). Sustained viral response was achieved in 61% and 71% in groups respectively. None of the variables predicted non-response precisely. No serious adverse effects were observed and they were comparable between the two groups. CONCLUSION: Daily IFN dosage with ribavirin is safe and can achieve response in up to 65% patients. Since the effica- cy of a 4-week daily dosage of IFN is comparable to a 12- week schedule, we recommend the former regimen.

关键词： hepatitis C virus hepatitis C interferon ribavirin induction dosage sustained viral response chronic hepatitis combination therapy

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Comparison of conventional and Hang-back methods of inferior oblique recession in V-pattern strabismus with inferior oblique overaction

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International Journal of Ophthalmology(English edition) 2020年第6期13卷 985-990页

作者： Kamlesh AnAND Ankita Bharadwaj Shweta Dhiman Yashpal Goel Anju Rastogi Richa Agarwal Manisha Misthra Prateek Kumar Department of Ophthalmology Guru Nanak Eye CentreMaulana Azad Medical CollegeNew Delhi 110002India

AIM:To compare outcomes of conventional and Hangback methods of inferior oblique(IO)recession in V-pattern strabismus with inferior oblique overaction(IOOA).METHODS:Comparative randomized study was conducted consisting of 50 patients,age 6 to 35 y having V-pattern strabismus[>15 prism diopter(PD)]with *** were divided equally in two groups and underwent IO recession,group A by conventional method and group B by Hang-back *** evaluated were reduction in V-pattern and IOOA,shift in torsion,improvement in binocular *** was a residual V-pattern of less than 10 PD at 1 y of follow ***:The mean V-pattern preoperatively and postoperatively at 1 y was 24±5.4 PD and 4.2±3.51 PD in group A and 23.44±6.44 PD and 5.76±3.8 PD in group B *** mean reduction in V-pattern was 20±6.78 PD in group A and 18.2±5.48 PD in group *** mean correction of IOOA was 18.48±3.13 PD in group A and 16±2.93 PD in group *** shift in extorsion was 3.08±1.8 degree in group A and 3.72±2.14 degree in group ***:Both the procedures achieve a significant and comparable reduction in V-pattern and ***-back recession being a landmark free surgery eliminates the need for intrascleral suturing thereby reducing the risk of scleral perforation with possible postoperative adjustment of *** may be considered as a good alternative for IO recession in patients of V-pattern strabismus with mild to moderate amount of IOOA.

关键词： V-pattern inferior oblique overaction Hang-back recession conventional recession

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Combination of pegylated interferon and lamivudine for patients with chronic hepatitis B who have failed treatment

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Hepatobiliary & Pancreatic Diseases International 2006年第3期5卷 374-380页

作者： Shiv K.Sarin Manoj Kumar Syed Hissar Barjesh C.Sharma Department of Gastroenterology G.B.Pant Hospital New Delhi-110002India

BACKGROUND: Treatment of chronic hepatitis B (CHB) alone with interferon or lamivudine alone or in combination is effective in only a small proportion of patients. Treatment of patients in whom antiviral therapy fails is challenging. This study was made to determine the efficacy of combined pegylated interferon alpha (peg-IFN) and lamivudine in patients with CHB who had failed to respond to antiviral treatment. METHODS: Twenty patients with CHB proven by liver biopsy, with ALT levels >1.5×ULN,HBV DNA levels>141 500 copies/ml, and previous treatment failure with an adequate regimen were treated with a combination of peg-IFN 1.5μg/kg and lamivudine 100 mg/day for 52 weeks and followed up for a further 24 weeks. Biochemical response was defined as normalization of ALT and DNA response as HBV DNA<141 500 copies/ml. Secondary efficacy measures included HBsAg loss, HBeAg loss and appearance of anti-HBe (in cases of HBeAg-positive patients). RESULTS: Twenty patients were treated, of whom 16 were HBeAg positive. At 52 weeks, normal ALT was seen in 10 (50%) (8 of 16 HBeAg+ and 2 of 4 HBeAg), HBV DNA response in 5 (25%) (5 of 16 in HBeAg+ and none in HBeAg-), and HBeAg loss with appearance of anti-HBe in 5 (31.3%) of the 16 HBeAg positive patients. At 76 weeks, 8 (80%) of the 10 patients with normal ALT at 52 weeks relapsed, with normal ALT only in 2 (10%) (1 of 16 HBeAg+ and 1 of 4 HBeAg-), and all 5 patients who had a DNA response at 52 weeks relapsed at 76 weeks and had no DNA response. HBeAg loss with appearance of anti-HBe was seen in 1 (6.3%) of 16 HBeAg-positive patients. None of the patients lost HBsAg. CONCLUSIONS: The combination of peg-IFN and lamivudine for 52 weeks is not effective for treatment of CHB patients with a failed treatment. New treatment strategies need to be developed.

关键词： chronic hepatitis B pegylated interferon lamivudine non-responder

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心肌局部缺血的预适应(英文)

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Acta Pharmacologica Sinica 2002年第10期23卷 3-8页

作者： Priya TYAGI,Girish TAYAL Department of Pharmacology Maulana Azad Medical College New Delehi 110002 India Department of Pharmacology Maulana Azad Medical College New Delehi 110002 India

Preconditioning of the myocardium with short episodes of sublethal ischemia will delay the onset of necrosis during a subsequent lethal ischemic insult. Ischemic preconditioning seems to involve a variety of stress signals which include activation of membrane receptors and signaling molecules such as protein kinase C, mitogen-acti-vated protein kinases, opening of ATP-sensitive potassium channel, and expression of many protective proteins. The purpose of this review is to assess the current position in this field and to facilitate future research.

关键词：局部缺血预处理腺苷线粒体一氧化氮心肌

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