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A SPE-HPLC-MS/MS method for the simultaneous determination of pr ior itised pharmaceuticals and EDCs with high environmental risk potential in freshwater

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Journal of Environmental Sciences 2021年第2期33卷 18-27页

作者： Yuan Li MarkATaggart Craig McKenzie Zulin Zhang Yonglong Lu Sabolc Pap Stuart WGibb Environmental Research Institute North Highland CollegeUniversity of the Highlands and IslandsCastle StreetThursoCaithnessScotlandKW147JDUK Forensic Drug Research Group Centre for Anatomy and Human IdentificationSchool of Science and EngineeringUK Environm ental and Biochem ical Sciences Group Ja m es Hutton InstituteCraigiebucklerA berdeen AB158QHUK Research Centre for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China University of Novi Sad Faculty of Technical SciencesDepartment of Environmental Engineering and Occupational Safety and H ealthUniversity of Novi Sad21000 NoviSadSerbia 不详

This work describes the development,optimisation and validation of an analytical method for the rapid determination of 17 priority pharmaceutical compounds and endocrine disrupting chemicals(EDCs).Rather than studying compounds from the same therapeutic class,the analyses aimed to determine target compounds with the highest risk potential(with particular regard to Scotland),providing a tool for further monitoring in different water *** was based on a systematic environmental risk assessment approach,using consumption data;wastewater treatment removal efficiency;environmental occurrence;toxicological effects;and pre-existing regulatory *** process highlighted 17 compounds across various therapeutic classes,which were then quantified,at environmentally relevant concentrations,by a single analytical *** determination was achieved using a single-step solid phase extraction(SPE)procedure followed by high-performance liquid chromatography with tandem mass spectrometry(HPLC-MS/MS).The fully optimised method performed well for the majority of target compounds,with recoveries>71%for 15 of 17 *** limits of quantification for most target analytes(14 of 17)ranged from 0.07 ng/L to 1.88 ng/L in river *** utility of this method was then demonstrated using real water samples associated with a rural hospital/*** compounds were targeted and detected,with the highest levels found for the analgesic,paracetamol(at up to 105,910 ng/L in the hospital discharge).This method offers a robust tool to monitor high priority pharmaceutical and EDC levels in various aqueous sample matrices.

关键词： Pharmaceuticals prioritisation Risk assessment trace level determination Water quality

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Radial artery access site complications during cardiac procedures,clinical implications and potential solutions: The role of nitric oxide

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World Journal of Cardiology 2020年第1期12卷 26-34页

作者： Emma M Coghill Timothy Johnson Russell E Morris Ian L Megson Stephen J Leslie Free Radical Research Facility Division of Biomedical SciencesUniversity of the Highlands and IslandsInverness IV23JHUnited Kingdom Johnson Matthey Technology Centre Blount’s CourtSonning CommonReading RG49NHUnited Kingdom School of Chemistry University of St.AndrewsSt Andrews KY169STUnited Kingdom Department of Cardiology NHS HighlandInverness IV23UJUnited Kingdom

Percutaneous coronary intervention for the treatment of coronary artery disease is most commonly performed in the UK through the radial artery,as this is considered to be safer than the femoral ***,despite improvements in technology and techniques,complications can *** most common complication,arterial spasm,can cause intense pain and,in some cases,procedural *** incidence of spasm is dependent on several variables,including operator experience,artery size,and equipment *** antispasmolytic cocktail can be applied to reduce spasm,which usually includes an exogenous nitric oxide(NO)donor(glyceryl trinitrate).NO is an endogenous local vasodilator and therefore is a potential target for anti-spasm ***,systemic administration can result in unwanted side-effects,such as hypotension.A method that adopts local delivery of NO might be *** review article describes the mechanisms involved in radial artery spasm,discusses the advantages and disadvantages of current strategies to reduce spasm,and highlight the potential of NO-loaded nanoporous materials for use in this setting.

关键词： Radial artery Cannulation Spasm Nitric oxide Vasodilation Nanoporous material

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Effects on the quality of frozen-thawed alpaca(Lama pacos)semen using two different cryoprotectants and extenders

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Asian Journal of Andrology 2005年第3期7卷 303-309,页

作者： AlexeiSantiani WilfredoHuanca RómuloSapana TeodosioHuanca NéstorSepúlveda RaúlSánchez VeterinaryInstitute for Tropical and highland Research Faculty of Veterinary MedicineUniversidad Nacional Mayor de San MarcosP.O.Box 03-5034Lima 41Perú OuimsachataExperimental Station National Institute of Agrarian ResearchPunoPerú Reproductive Biotechnology Center Universidad de La FronteraP.O.Box 54-DTemucoChile

Aim： To evaluate two extenders and two cryoprotectant agents （CPA） for alpaca semen cryopreservation. Methods： Semen samples were obtained from four adult alpacas （Lama pacos） and frozen using extender Ⅰ （TRIS, citrate, egg yolk and glucose） or extender Ⅱ （skim milk, egg yolk and fructose）, each containing either glycerol （G） or ethylene glycol （EG） as CPA. Consequently, four groups were formed： 1） extender Ⅰ-G; 2） extender Ⅰ-EG; 3） extender Ⅱ-G; and 4） extender Ⅱ-EG. Semen was diluted in a two-step process： for cooling to 5 ℃ （extenders without CPA）, and for freezing （extenders with CPA）. Viability and acrosome integrity were assessed using trypan blue and Giemsa stains. Results： When compared, the motility after thawing was higher （P 〈 0.05） in groups Ⅱ-EG （20.0 %±6.7 %） and Ⅱ-G （15.3 %±4.1%） than that in groups Ⅰ-G （4.0 %±1.1%） and Ⅰ-EG （1.0 %±1.4 %）. Viable spermatozoa with intact acrosomes in groups Ⅱ-EG （18.7 %±2.9 %） and Ⅱ-G （12.7 %±5.9 %） were higher than that in groups Ⅰ-G （5.7 %±1.5 %） and Ⅰ-EG （4.0 %±1.0 %）. Conclusion： The skim milk- and egg yolk-based extenders containing ethylene glycol or glycerol to freeze alpaca semen seems to promote the survival of more sperm cells with intact acrosomes than the other extenders. （Asian J Androl 2005 Sep; 7： 303-309）

关键词： cryopreservation glycerol ethylene glycol extenders alpaca spermatozoa

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黏液绿脓杆菌感染随年龄纵向恶化对囊性纤维化患儿慢性肺病病程的影响

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世界核心医学期刊文摘（儿科学分册） 2005年第6期1卷 2-3页

作者： Kosorok M. R. Farrell P. M. 李开 Farrell Univ. of Wisconsin Medical School HSLC 750 Highland Ave Madison WI 53705-2221 United States

Context: Although Pseudomonas aeruginosa is the most common virulent respiratory pathogen in cystic fibrosis (CF), the longitudinal development of P aeruginosa in fection and its effect on antibody responses and lung disease progression in children with CF remain unclear. Objective: To prospectively examine the epidemiology of P aeruginosa infection and its impact on CF pulmonary morbidity. Design, Setting, and Patients: We prospectively evaluated 56 CF patients at 2 CF centers in Madison and Milwaukee, Wis, from birth up to age 16 years between April 15, 1985, and April 15, 2004, with diagnoses made through the Wisconsin CF Neonatal Screening Project. Main Outcome Measures: Timing of nonmucoid P aeruginosa and mucoid P aeruginosa acquisition was assessed by first positive result. Longitudinal development from no P aeruginosa to nonmucoid P aeruginosa and from nonmucoid P aeruginosa to mucoid P aeruginosa was examined. Outcome measurements included antibody titers, respiratory symptoms, quantitative chest radiography, and pulmonary function tests. Results: Sixteen patients (29%) acquired nonmucoid P aeruginosa in the first 6 months of life. The age-specific prevalence of mucoid P aeruginosa increased markedly from age 4 to 16 years. Nonmucoid and mucoid P aeruginosa were acquired at median ages of 1.0 and 13.0 years, respectively. In contrast with the short transition time from no P aeruginosa to nonmucoid P aeruginosa, the transition time from nonmucoid to mucoid P aeruginosa was relatively long (median, 10.9 years) and could be slightly extended by brief/low anti-P aeruginosa antibiotic treatment. Antibody titers increased with both transitions, but the deterioration in cough scores, chest radiograph scores, and pulmonary function correlated best with transition from nonmucoid to mucoid P aeruginosa. Conclusions: Early prevention and detection of nonmucoid and mucoid P aeruginosa are critical because of early acquisition and prevalence. There is a window of opport

关键词：绿脓杆菌感染慢性肺病囊性纤维化黏液性肺功能测定评估研究抗体反应抗体滴度年龄组感染过程

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排出固体料螺杆:用于挤出的一个新观点

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塑料 1980年第4期 13-18页

作者： ImrichKIein ReubenKIein 王建伟新译西州highland Park科学方法和研究公司北京塑料研究所

历来的资料表明挤出机熔融固体塑料所消耗的能量大大高于实际需要的能量。根据最近进行的一项研究,目前使用的挤出机熔融并成型塑料所消耗的能量至少为理论上所需能量的2倍,大多数为200%至1,200以上。挤出机中的熔融速率由螺杆转速和机... 详细信息

历来的资料表明挤出机熔融固体塑料所消耗的能量大大高于实际需要的能量。根据最近进行的一项研究,目前使用的挤出机熔融并成型塑料所消耗的能量至少为理论上所需能量的2倍,大多数为200%至1,200以上。挤出机中的熔融速率由螺杆转速和机筒温度所决定。提高螺杆转速并冷却机筒一般可获得高熔融粘度。在一较短挤出机中,这样做能较快实现熔融,但是也能带走通过驱动而进入到塑料中的大部分能量,造成热量浪费。此外,用于避免这种热量浪费的方法本身效率也不高。

关键词：螺杆机筒螺槽挤出机压出机橡胶机械排料孔

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瑞木项目生产运营情况介绍

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有色设备 2018年第6期32卷 1-5页

作者：高永学 Peter Jolly 瑞木镍钴管理(中冶)有限公司北京100028 highland Pacific Pty.Ltd

瑞木项目是中国在海外投资矿业并成功生产运营的项目,经过几年的生产实践,积累了丰富的生产和管理经验;文章介绍了项目的发展历史、生产进展、工艺技术和设备运行情况,以及项目对巴新当地的贡献,从而为国内外同行提供借鉴。

关键词：瑞木项目红土矿生产运营

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Prehospital identification of sepsis patients and alerting of receiving hospitals:impact on early goal-directed therapy

Prehospital identification of sepsis patients and alerting o...

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国际全身性感染论坛-2011北京

作者： K Halimi J Freeman-Garrick C Agcaoili K Choy F Claridge M Jacobs M Taigman Department of Emergency Medicine and Intensive Care Washington HospitalFremontCAUSA highland Hospital OaklandCAUSA Alameda County Emergency Medical Services San LeandroCAUSA American Medical Response Alameda CountyCAUSA

＜正＞Introduction Over the past several years,the early identification and aggressive treatment of sepsis patients has become a standard of care in the hospital setting.A relatively small number of emergency medical service（EMS） systems have started programs to screen for sepsis;an even smaller number provide treatment based on that screening process in the prehospital setting.

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关于布比卡因刀口内持续注入系统在妇科肿瘤中应用的随机试验

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世界核心医学期刊文摘（妇产科学分册） 2005年第11期1卷 54-55页

作者： Kushner D.M. LaGalbo R. Connor J.P. 张巧利 Department of Gynecologic Oncology University of Wisconsin Hospital and Clinics 600 Highland Avenue Madison WI 53792 United States Dr.

Objective: The aim of the current study was to evaluate the safety and efficacy of a widely available bupivacaine continuous wound infusion system in gynecologic oncology patients undergoing laparotomy. Methods: A prospective, randomized, double-blind, placebo-controlled trial was performed. After closure of the fascia, flexible soaker catheters were placed in the deep subcutaneous space. The infusion pump was filled with 290 mL of either 0.5% bupivacaine or normal saline, to infuse over 72 hours. Daily assessments of pain scores utilized the Wisconsin Brief Pain Inventory. All patients received intravenous narcotics via patient-controlled devices. Results: Eighty surgeries were evaluated in a total of 79 women (40 per arm). Mean age was 56 years, with 79% having invasive gynecologic pathology. The two groups were not significantly different in terms of type of surgery, length of incision, estimated blood loss, operative time, or medical history. Postoperative outcomes, including wound toxicity, time to flatus, and hospital stay, did not differ. Study patients averaged 75 mg intravenously and 107 mg total narcotic use (morphine equivalent), whereas controls averaged 60 mg intravenously and 86 mg total (P = .40 intravenously; P = .25 total). Acetaminophen and intravenous ketorolac consumption were equal between groups. The Brief Pain Inventory score for “ current pain” was 2.84 for bupivacaine patients and 3.14 for controls (P = .46; least = 0, most = 10). There was no individual postoperative day when “ current pain” BPI scores differed. “ Worst pain” and “ least pain” Brief Pain Inventory scores showed similar results. Conclusion: The results suggest that although the continuous infusion system seems safe, it is not efficacious in this patient population.

关键词：妇科肿瘤注入系统随机试验药物用量输注系统手术时间留置导管随机双盲乙酰氨基酚失血量

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黏液型铜绿假单胞菌感染的纵向发展与囊性纤维化患儿肺疾病进展

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世界核心医学期刊文摘（胃肠病学分册） 2005年第6期1卷 6-7页

作者： Kosorok M.R. Farrell P.M. 姜志茹 Univ. of Wisconsin Medical School HSLC 750 Highland Ave Madison WI 53705-2221 United States Dr.

Context: Although Pseudomonas aeruginosa is the most common virulent respiratory pathogen in cystic fibrosis (CF), the longitudinal development of P aeruginosa infection and its effect on antibody responses and lung disease progression in children with CF remain unclear. Objective: To prospectively examine the epidemiology of P aeruginosa infection and its impact on CF pulmonary morbidity. Design, Setting, and Patients: We prospectively evaluated 56 CF patients at 2 CF centers in Madison and Milwaukee, Wis, from birth up to age 16 years between April 15, 1985, and April 15, 2004, with diagnoses made through the Wisconsin CF Neonatal Screening Project. Main Outcome Measures: Timing of nonmucoid P aeruginosa and mucoid P aeruginosa acquisition was assessed by first positive result. Longitudinal development from no P aeruginosa to nonmucoid P aeruginosa and from nonmucoid P aeruginosa to mucoid P aeruginosa was examined. Outcome measurements included antibody titers, respiratory symptoms, quantitative chest radiography, and pulmonary function tests. Results: Sixteen patients (29%) acquired nonmucoid P aeruginosa in the first 6 months of life. The age-specific prevalence of mucoid P aeruginosa increased markedly from age 4 to 16 years. Nonmucoid and mucoid P aeruginosa were acquired at median ages of 1.0 and 13.0 years, respectively. In contrast with the short transition time from no P aeruginosa to nonmucoid P aeruginosa, the transition time from nonmucoid to mucoid P aeruginosa was relatively long (median, 10.9 years) and could be slightly extended by brief/low anti-P aeruginosa antibiotic treatment. Antibody titers increased with both transitions, but the deterioration in cough scores, chest radiograph scores, and pulmonary function correlated best with transition from nonmucoid to mucoid P aeruginosa. Conclusions: Early prevention and detection of nonmucoid andmucoid P aeruginosa are critical because of early acquisition and prevalence. There is a window of opportun

关键词：黏液型铜绿假单胞菌纵向发展囊性纤维化新生儿筛查呼吸系统症状铜绿假单胞杆菌检查和抗体应答呼吸道病原体

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Genome-Wide Association Study of Nitrogen Use Efficiency and Agronomic Traits in Upland Rice

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Rice science 2021年第4期28卷 379-390,I0027-I0034页

作者： Tatiana Rakotoson Julie Dusserre Philippe Letourmy Julien Frouin Isabelle Ramonta Ratsimiala Noronirina Victorine Rakotoarisoa Tuong-Vi CAO Kirsten Vom Brocke Alain Ramanantsoanirina Nourollah Ahmadi Louis-Marie Raboin National Center for Applied Research on Rural Development Regional Research Station AntsirabeAntsirabe 110Madagascar Faculty of Sciences University of AntananarivoAntananarivo 101Madagascar Higher Education Institute of Antsirabe Vakinankaratra University of AntananarivoAntsirabe 110Madagascar Agroecology and Sustainable Intensification of Annual Crops Research Unit French Agricultural Research Centre for International Development(CIRAD)Avenue AgropolisMontpellier 34398France Genetic Improvement and Adaptation of Mediterranean and Tropical Plants Research Unit(UMR AGAP) CIRADAvenue AgropolisMontpellier 34398France UMR AGAP Highland Production Systems and Sustainability in Madagascar Platform in PartnershipCIRADAntsirabe 110Madagascar University of Montpellier/CIRAD Montpellier 34398France

Genome-wide association study(GWAS)was performed for 16 agronomic traits including nitrogen use efficiency(NUE)and yield-related components using a panel of 190 mainly japonica rice varieties and a set of 38390 single nucleotide polymorphism(SNP)*** panel was evaluated under rainfed upland conditions in Madagascar in two consecutive cropping seasons with two contrasted nitrogen input *** another set of five grain traits,we identified previously known genes(GW5,GS3,Awn1 and Glabrous1),thus validating the pertinence and accuracy of our datasets for GWAS.A total of 369 significant associations were detected between SNPs and agronomic traits,gathered into 46 distinct haplotype groups and 28 isolated *** association signals were identified for the complex quantitative trait NUE,however,larger number of quantitative trait loci(QTLs)were detected for its component traits,with 10 and 2 association signals for nitrogen utilization efficiency and nitrogen uptake efficiency,*** detected association signals co-localized with genes involved in nitrogen transport or nitrogen remobilization within 100 *** present study thus confirmed the potential of GWAS to identify candidate genes and new loci associated with agronomic ***,because of the quantitative and complex nature of NUE-related traits,GWAS might have not captured a large number of QTLs with limited effects.

关键词： genome-wide association study nitrogen use efficiency agronomic trait upland rice

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