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microsystems & {1.engineering 2024年第2期10卷 91-99页

作者： Zhixian Zhu Hui Ren Dan Wu Zhonghua Ni Nan Xiang School of Mechanical Engineering and Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical InstrumentsSoutheast University211189NanjingChina School of Mechanical Technology Wuxi Institute of TechnologyNo.1600 Gaolang West Road214129WuxiChina Department of Oncology Jiangyin People’s Hospital214400JiangyinChina

Tumor cell clusters are regarded as critical factors in cancer pathophysiology,and increasing evidence of their higher treatment resistance and metastasis compared to single tumor cells has been ***,existing cell separation methods that are designed for single tumor cells cannot be used to simultaneously purify tumor cell *** address this problem,we demonstrated a {1.fluidic approach for the high-throughput,continuous-flow ternary separation of single tumor cells,tumor cell clusters,and WBCs from clinical pleural or abdominal effusions by coupling slanted spiral channels and periodic contraction-expansion *** first systematically explored the influence of particle size and flow rate on particle *** separation performance indicated that 94.0%of WBCs were removed and more than 97%of MDA-MB-231.tumor cells were recovered at a high flow rate of 3500µL/***,more than 90%of tumor cell clusters were effectively preserved after ***,we successfully applied our device for the ternary separation of single tumor cells,tumor cell clusters,and WBCs from different malignant effusions collected from patients with metastatic ***,our spiral-contraction-expansion device has potential as a sample pretreatment tool for the cytological diagnosis of malignant effusions.

关键词： separation contraction removed

Implantable probe with integrated reference electrode for in situ neural signal and calcium ion monitoring

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Bio-design and Manufacturing 2024年第4期7卷 591-595页

作者： Junyu Xiao Mengfei Xu Longchun Wang Bin Yang Jingquan Liu National key {1. of Advanced micro and nano manufacture Technology Shanghai Jiao Tong UniversityShanghai 200240China Department of micro/{1. Electronics Shanghai Jiao Tong UniversityShanghai 200240China

Monitoring the electrophysiology activity of neurons and blood calcium signals can enable a better understanding of disease-related neural system ***,currently,in situ calcium ion monitoring tools are scarce and exhibit low integration and limited *** this letter,we propose an implantable probe with an integrated in situ Ag/AgCl reference electrode(ISA/ARE)that can monitor action potential(AP)and Ca^(2+) concentrations.

关键词： neural electrode enable

Delivering microrobots in the Musculoskeletal System

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nano-{1. Letters 2024年第11期16卷 585-617页

作者： Mumin Cao Renwang Sheng Yimin Sun Ying Cao Hao Wang Ming Zhang Yunmeng Pu Yucheng Gao Yuanwei Zhang Panpan Lu Gaojun Teng Qianqian Wang Yunfeng Rui Department of Orthopaedics Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsuPeople’s Republic of China School of Medicine Southeast UniversityNanjing 210009People’s Republic of China Orthopaedic Trauma Institute(OTI) Southeast UniversityNanjing 210009People’s Republic of China jiangsu {1. laboratory for design and manufacture of micro‑nano biomedical instruments School of Mechanical EngineeringSoutheast UniversityNanjing 210009People’s Republic of China Center of Interventional Radiology and Vascular Surgery Department of RadiologyZhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009People’s Republic of China

Disorders of the musculoskeletal system are the major contributors to the global burden of disease and current treatments show limited *** often suffer chronic pain and might eventually have to undergo end-stage ***,future treatments should focus on early detection and intervention of regional *** have been gradually used in organisms due to their advantages of intelligent,precise and minimally invasive targeted *** the combination of control and imaging systems,microrobots with good biosafety can be delivered to the desired area for *** the musculoskeletal system,microrobots are mainly utilized to transport stem cells/drugs or to remove hazardous substances from the *** to traditional biomaterial and tissue engineering strategies,active motion improves the efficiency and penetration of local targeting of cells/*** review discusses the frontier applications of microrobotic systems in different tissues of the musculoskeletal *** summarize the challenges and barriers that hinder clinical translation by evaluating the characteristics of different microrobots and finally point out the future direction of microrobots in the musculoskeletal system.

关键词： microrobot Musculoskeletal system Targeted delivery microrobotic systems Magnetic actuation

Knowledge-reused transfer learning for molecular and materials science

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Journal of Energy Chemistry 2024年第11期 149-168页

作者： An Chen Zhilong Wang Karl Luigi Loza Vidaurre Yanqiang Han Simin Ye Kehao Tao Shiwei Wang Jing Gao Jinjin Li National key {1. of Advanced micro and nano manufacture Technology Shanghai Jiao Tong University Department of micro/{1. Electronics School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University

Leveraging big data analytics and advanced algorithms to accelerate and optimize the process of molecular and materials design, synthesis, and application has revolutionized the field of molecular and materials science, allowing researchers to gain a deeper understanding of material properties and behaviors,leading to the development of new materials that are more efficient and reliable. However, the difficulty in constructing large-scale datasets of new molecules/materials due to the high cost of data acquisition and annotation limits the development of conventional machine learning(ML) approaches. Knowledgereused transfer learning(TL) methods are expected to break this dilemma. The application of TL lowers the data requirements for model training, which makes TL stand out in researches addressing data quality issues. In this review, we summarize recent progress in TL related to molecular and materials. We focus on the application of TL methods for the discovery of advanced molecules/materials, particularly, the construction of TL frameworks for different systems, and how TL can enhance the performance of models. In addition, the challenges of TL are also discussed.

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General theory for designing phonon transport in alloyed/doped materials

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Science China(Physics,Mechanics & Astronomy) 2024年

作者： Chenhan Liu Chao Wu Wei Liu Yunshan Zhao Gang Zhang Hongmin Yang Yunfei Chen micro-and {1.-scale Thermal Measurement and Thermal Management laboratory Key Laboratory of Numerical Simulation for Large Complex Systems Ministry of Education School of Energy and Mechanical Engineering Nanjing Normal University School of Electrical and Automation Engineering Nanjing Normal University Phonon Engineering Research Center of jiangsu Province Center for Quantum Transport and Thermal Energy Science Institute of Physics Frontiers and Interdisciplinary Sciences School of Physics and Technology Nanjing Normal University Institute of High-Performance Computing Agency for Science Technology and ResearchSingapore jiangsu {1. laboratory for design and manufacture of micro-nano biomedical instruments School of Mechanical Engineering Southeast University

Alloying/doping is a widely used technique for improving the electrical, mechanical, and optical properties of ***, this technology induces significant distortions in the lattice structure, mass distribution, and potential field, greatly enhancing phonon scattering. Here, we introduce the concept of alloying/doping path and employ crystal symmetry, lattice deformation, and electron distribution to characterize it. Based on this new concept, the phonon thermal transport behavior in alloyed/doped materials can be well designed, and along different alloying/doping paths, the difference in thermal conductivity can be up to 45 times. On one hand, strategic alloying/doping that combines high crystal symmetry, large lattice contraction, and the same electron distribution suppresses phonon-phonon scattering phase space, induces phonon stiffening, and bolsters electronic structure symmetry, respectively. These synergistic effects significantly improve thermal conductivity. On the other hand, random alloying/doping has a low symmetry, leading to the typical “U” shape of alloying/doping level-dependent thermal conductivity. Our theory is corroborated in three-dimensional（3D） Si, 2D MoS2, and quasi-1. TiS3, affirming its efficacy and broad applicability in controlling phonon transport.

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Untethered micro/{1.robots for Remote Sensing:Toward Intelligent Platform

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nano-{1. Letters 2024年第2期16卷 450-483页

作者： Qianqian Wang Shihao Yang Li Zhang jiangsu {1. laboratory for design and manufacture of micro‑nano biomedical instruments School of Mechanical EngineeringSoutheast UniversityNanjing 211189People’s Republic of China Department of Mechanical and Automation Engineering The Chinese University of Hong KongShatinHong Kong 999077People’s Republic of China Chow Yuk Ho Technology Centre for Innovative Medicine The Chinese University of Hong KongShatinHong Kong 999077People’s Republic of China T Stone Robotics Institute The Chinese University of Hong KongShatinHong Kong 999077People’s Republic of China Department of Surgery The Chinese University of Hong KongShatinHong Kong 999077People’s Republic of China

Untethered micro/{1.robots that can wirelessly control their motion and deformation state have gained enormous interest in remote sensing applications due to their unique motion characteristics in various media and diverse *** are developing micro/{1.robots as innovative tools to improve sensing performance and miniaturize sensing systems,enabling in situ detection of substances that traditional sensing methods struggle to *** the past decade of development,significant research progress has been made in designing sensing strategies based on micro/{1.robots,employing various coordinated control and sensing *** review summarizes the latest developments on micro/{1.robots for remote sensing applications by utilizing the self-generated signals of the robots,robot behavior,microrobotic manipulation,and robot-environment *** recent studies and relevant applications in remote sensing,we also discuss the challenges and future perspectives facing micro/{1.robots-based intelligent sensing platforms to achieve sensing in complex environments,translating lab research achievements into widespread real applications.

关键词： micro/{1.robot Remote sensing Wireless control Self-propulsion Actuation at small scales

Manipulating the Phase Transition Behavior of Dual Temperature-Responsive Block Copolymers by Adjusting Composition and Sequence

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Chinese Journal of Polymer Science 2024年第2期42卷 176-187,I0006页

作者： Zhi Zou Xiang Xu Hai-Tao Zhao Jian-Nan Cheng Wei-Wei He Li-Fen Zhang Zhen-Ping Cheng Suzhou key {1. of Macromolecular design and Precision Synthesis Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationState and Local Joint Engineering Laboratory for Novel Functional Polymeric MaterialsCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou215123China State key {1. of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of JiangsuSoochow UniversitySuzhou215123China

Temperature-responsive polymers have garnered significant attention due to their ability to respond to external *** this work,dual temperature-responsive block copolymers are synthesized via reversible addition-fragmentation chain transfer polymerization(RAFT)polymerization utilizing zwitterionic monomer methacryloyl ethyl sulfobetaine(SBMA) and N-isopropyl acrylamide(NIPAAm) as *** thermal responsive behaviors can be easily modulated by incorporating additional hydrophobic monomer benzyl acrylate(BN) or hydrophilic monomer acrylic acid(AA),adjusting concentration or pH,or varying the degree of polymerization of the block chain *** cloud points of the copolymers are determined by UV-Vis spectrophotometry,and these copolymers exhibit both controlled upper and lower critical solu bility temperatures(LCST and UCST) in aqueous *** study analyzes and summarizes the influencing factors of dual temperature responsive block copolymers by exploring the effects of various conditions on the phase transition temperature of temperature-sensitive polymers to explore the relationship between their properties and environment and structure to make them more selective in terms of temperature application range and regulation *** is very interesting that the introduction of poly-acrylic acid(PAA) segments in the middle of di-block copolymer PSBMA_(55)-b-PNIPAAm_(80) to form PSBMA_(55)-b-PAA_(x)-b-PNIPAAm_(80) results in a reversal of temperature-responsive behaviors from 'U'(LCST UCST) type,while the copolymer PSBMA_(55)-b-P(NIPAAm_(80)-co-AA_(x)) *** work provides a clue for tuning the phase transition behavior of polymers for manufacture of extreme smart materials.

关键词： Temperature responsive polymers High critical solubility temperature(UCST) Low critical solubility temperature(LCST) Block copolymers

Dissolvable temporary barrier:a novel paradigm for flexible hydrogel patterning in organ-on-a-chip models

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Bio-design and Manufacturing 2024年第2期7卷 153-166页

作者： Ding Wang Qinyu Li Chenyang Zhou Zhangjie Li Kangyi Lu Yijun Liu Lian Xuan Xiaolin Wang Department of micro/{1. Electronics School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Ophthalmology LKS Faculty of MedicineThe University of Hong KongHong Kong 999077China Institute of Medical Robotics Shanghai Jiao Tong UniversityShanghai 200240China National key {1. of Advanced micro and nano manufacture Technology Shanghai Jiao Tong UniversityShanghai 200240China National Center for Translational Medicine(Shanghai)SHU Branch Shanghai UniversityShanghai 200444China

A combination of hydrogels and microfluidics allows the construction of biomimetic three-dimensional(3D)tissue models in vitro,which are also known as *** hydrogel patterningwith awell-controlled spatial distribution is typically achieved by embedding sophisticated microstructures to act as a ***,these physical barriers inevitably expose cells/tissues to a less physiologically relevant microenvironment than in vivo ***,we present a novel dissolvable temporary barrier(DTB)strategy that allows robust and flexible hydrogel patterning with great freedom of design and desirable flow stimuli for cellular *** key aspect of this approach is the patterning of a water-soluble rigid barrier as a guiding path for the hydrogel using stencil printing technology,followed by a barrier-free medium perfusion after the dissolution of the *** and multiple tissue compartments with different geometries can be established using either straight or curved DTB *** effectiveness of this strategy is further validated by generating a 3D vascular network through vasculogenesis and angiogenesis using a vascularized microtumor *** a new proof-of-concept in vasculature-on-a-chip,DTB enables seamless contact between the hydrogel and the culture medium in closed microdevices,which is an improved protocol for the fabrication ofmultiorgan ***,we expect it to serve as a promising paradigm for organ-on-a-chip devices for the development of tumor vascularization and drug evaluation in the future preclinical studies.

关键词： Dissolvable temporary barrier Hydrogel patterning microfluidics Organ-on-a-chip Vascularization

Tumor-targeted metabolic inhibitor prodrug labelled with cyanine dyes enhances immunoprevention of lung cancer

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Acta Pharmaceutica Sinica B 2024年第2期14卷 751-764页

作者： Wen Li Jiali Huang Chen Shen Weiye Jiang Xi Yang Jingxuan Huang Yueqing Gu Zhiyu Li Yi Ma Jinlei Bian State key {1. of Natural Medicines China Pharmaceutical UniversityNanjing 210009China Department of biomedical Engineering School of EngineeringChina Pharmaceutical UniversityNanjing 210009China jiangsu {1. laboratory of Drug design and Optimization Department of Medicinal ChemistrySchool of PharmacyChina Pharmaceutical UniversityNanjing 210009China

Recent progress in targeted metabolic therapy of cancer has been limited by the considerable toxicity associated with such *** address this challenge,we developed a smart theranostic prodrug system that combines a fluorophore and an anticancer drug,specifically 6-diazo-5-oxo-L-norleucine(DON),using a thioketal linkage(TK).This system enables imaging,chemotherapy,photodynamic therapy,and on-demand drug release upon radiation *** optimized prodrug,DON-TK-BM3,incorporating cyanine dyes as the fluorophore,displayed potent reactive oxygen species release and efficient tumor cell *** the parent drug DON,DON-TK-BM3 exhibited no toxicity toward normal ***,DON-TK-BM3 demonstrated high tumor accumulation and reduced side effects,including gastrointestinal toxicity,in *** study provides a practical strategy for designing prodrugs of metabolic inhibitors with significant toxicity stemming from their lack of tissue selectivity.

关键词： Smart prodrug system Glutamineantagonists Immunotherapy Photodynamictherapy Reactive oxygen species Metabolicinhibitor Cyaninedye Non-small-cell lung cancer(NSCLC)

Optimizing Electrocatalytic Hydrogen Evolution Stability via Minimal Bubble Adhesion at Electrodeposited Crack-Structured NiPx Catalysts

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Energy & Environmental Materials 2024年第5期7卷 248-258页

作者： Qian Sun Xiaoyu Hao Dina Zhang Tianyi Zhang Yuanfang Zhao Xiaolei Huang Xuqing Liu State key {1. of Solidification Processing Center of Advanced Lubrication and Seal Materials Northwestern Polytechnical University College of Art and design Shenzhen University Institute of Material and Chemistry Ganjiang Innovation Academy Chinese Academy of Sciences Shandong laboratory of Yantai Advanced Materials and Green {1.

In response to the ongoing energy crisis, advancing the field of electrocatalytic water splitting is of utmost significance, necessitating the urgent development of high-performance, cost-effective, and durable hydrogen evolution reaction catalysts. But the generated gas bubble adherence to the electrode surface and sluggish separation contribute to significant energy loss, primarily due to the insufficient exposure of active sites, thus substantially hindering electrochemical performance. Here, we successfully developed a superaerophobic catalytic electrode by loading phosphorus-doped nickel metal （NiPx） onto various conductive substrates via an electrodeposition method. The electrode exhibits a unique surface structure, characterized by prominent surface fissures, which not only exposes additional active sites but also endows the electrode with superaerophobic properties. The NiPx/Ti electrode demonstrates superior electrocatalytic activity for hydrogen evolution reaction, significantly outperforming a platinum plate, displaying an overpotential of mere 21. mV to achieve a current density of-500 mA cm-2in 1.M KOH. Furthermore,the NiPx/Ti electrode manifests outstanding durability and robustness during continuous electrolysis, maintaining stability at a current density of-1. mA cm-2over a duration of 2000 h. Owing to the straightforward and scalable preparation methods, this highly efficient and stable NiPx/Ti electrocatalyst offers a novel strategy for the development of industrial water electrolysis.

关键词： electrocatalyst gas bubble adhesion hydrogen evolution reaction long-term durability superaerophobic surface