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Open Journal of obstetrics and {1. 2018年第14期8卷 1501-1509页

作者： Dantola Paul Kain Issa Ouédraogo Yobi Alexis Sawadogo Evelyne Komboigo Sibraogo Kiemtoré Adama Ouattara Hyacinthe Zamané Blandine Thiéba department of {1. and gynecology Yalgado Ouedraogo Teaching Hospital in Ouagadougou Ouagadougou Burkina Faso department of {1. and gynecology Teaching Hospital in Ouahigouya Ouahigouya Burkina Faso

Objective: The objective of our study was to study the surgical activities carried out in the gynecology-{1. department of the CHU-YO (Teaching Hospital Yalgado Ouédraogo) from January 1.t 201. to December 31.t, 201.. Patients and Methods: This dealt with a cross-cutting descriptive and analytic study with retrospective data collection. Our study has included the female patients who underwent surgery in the operating room and whose medical records were usable. Results: 45% of female patients admitted in the concerned department underwent a surgery. The average age of patients was estimated at 28.02 years ±7 years with extremes of 1. years and 80 years. Obstetrical surgery has involved 89.9% of cases. Female patients have received a loco-regional anesthesia in 92.7% of cases. Emergency surgical operations accounted for 88.8% and caesarean section was the main surgical operation carried out in 87.1. of cases. The mortality rate of the overall surgical operations was 1.04%. Conclusion: A better availability of labile blood products is more likely to reduce the mortality rate of surgical operations under the threshold of 1..

关键词： Surgery Caesarean Section Prognosis Mortality Rate

Epidemiological and Prognostic Aspects of Obesity and Pregnancy in the gynecology-{1. department at the Sylvanus Olympio University Hospital Center (CHU SO) in Lomé

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Open Journal of obstetrics and {1. 2023年第1期13卷 88-96页

作者： Komlan Alessi Andele Ameyo Ayoko Ketevi Baguilane Douaguibe Akila Bassowa Dédé Régine Diane Ajavon Kodjo Fiagnon Abdoul Samadou Aboubakari Koffi Akpadza department of {1. and obstetrics Sylvanus Olympio University Hospital Center Lome Togo department of {1. and obstetrics Campus University Hospital Center Lome Togo department of {1. and obstetrics Regional Hospital Center Kara Togo department of {1. and obstetrics Kara University Hospital Center Kara Togo

Introduction: Obesity and pregnancy is a major public health problem worldwide, both maternal and fetal. Objective: This is to describe the epidemiological and prognostic aspects of obesity and pregnancy in the gynecology-{1. department at the Sylvanus Olympio University Hospital Center (CHU SO) in Lomé. Methodology: This was a descriptive cross-sectional study concerning obesed pregnant women. The survey was conducted from the 1.sup>st to the 30th of June 2022 at the CHU SO. Results: We enrolled 55 obese pregnant women. The frequency of obesity and pregnancy was 5.1.%. Resellers were represented at 41.8%. The average age was 31.years old. As risk factors, 85.5% claimed to have a fatty diet and 76% did not practice sports. The gestational pathologies found during pregnancy were hypertension in 47.4% of cases, preeclampsia in 24.6% and gestational diabetes in 7%. Caesarean section was the way of delivery in 63.6% of cases and those who gave birth vaginally presented a tear of the soft tissues in 85% of cases. Birth weight was abnormal (low weight and excess weight) in 61.8% of cases. Conclusion: The association between obesity and pregnancy constitutes an important risk factor for the mother and the fetus.

关键词： Obesity Pregnancy CHU SO Togo

Stage IV malignant transformation of mature cystic teratoma palliatively treated with concurrent chemoradiotherapy:A case report

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World Journal of Clinical Cases 2025年第1期13卷 56-61页

作者： Saori Kondo Takashi Suzuki Kanato Yoshiike Sakura Yamanaka Kenta Sonehara Hiroshi Nabeshima Osamu Oguchi department of {1. and gynecology Saku Central Hospital Advanced Care CenterSaku City 385-0051NaganoJapan

BACKGROUND Malignant transformation(MT)of mature cystic teratoma(MCT)has a poor prognosis,especially in advanced *** chemoradiotherapy(CCRT)has an inhibitory effect on *** SUMMARY Herein,we present a case in which CCRT had a reduction effect preoperatively.A 73-year-old woman with pyelonephritis was referred to our *** tomography revealed right hydronephrosis and a 6-cm pelvic *** ultrasound-guided fine-needle biopsy(EUS-FNB)revealed squamous cell *** patient was diagnosed with MT of *** to her poor general con-dition and renal malfunction,we selected CCRT,expecting fewer adverse *** CCRT,her performance status improved,and the tumor size was reduced;surgery was *** months postoperatively,the patient developed dis-semination and lymph node *** chemotherapy was *** died 1. months after treatment *** EUS-FNB was useful in the diagnosis of MT of MCT;CCRT suppressed the disea-se and improved quality of life.

关键词： Mature cystic teratoma Malignant transformation Squamous cell carcinoma Concurrent chemoradiotherapy Endoscopic ultrasound-guided fine-needle biopsy Case report

Bacteriology of Healthcare-Associated Infections in the gynecology and {1. department of CHU Gabriel Touré

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Open Journal of obstetrics and {1. 2019年第10期9卷 1336-1346页

作者： Amadou Bocoum Seydou Fané Youssouf Traoré Siaka Amara Sanogo Ibrahim Kanté Aminata Kouma Mamadou Sima Abdoulaye Sissoko Ibrahima Ongoiba Soumana Oumar Traore Ibrahima Tegueté Maténé Sacko Daouda Camara Alassane Traoré Assitan Wane Niani Mounkoro Amadou Dolo gynecology-{1. department of CHU G. Touré Bamako Mali gynecology-{1. Service of CHU of Point G Bamako Mali gynecology-{1. department of CHU of Kati Bamako Mali gynecology-{1. Service of Referral Health Center of Kati Kati Mali gynecology-{1. Service of Referral Health Center of Commune V Bamako Mali Gynécology-Obstétrics department of CHU of Mali Bamako Mali

Introduction: Healthcare-associated infections (HAIs) are a public health issue. An infection is said to be associated with the care if it occurs during or after the care of a patient, and if it was neither present nor incubation at the beginning of the care. Objective: The purpose of this work was to study the bacteriology of infections associated with obstetric care in the gynecology-{1. department of CHU Gabriel Touré. Patients and Methods: This is an epidemiological, descriptive, analytical study conducted in the gynecology-{1. department of the CHU Gabriel Touré, from April 1.th, 201. to August 29th, 201. (5 months). Data collection focused on the clinical and laboratory characteristics of healthcare-associated infections in patients during their hospitalization. Included in the study were any patients hospitalized in the gynecology and {1. department who agreed to participate in the study. The criteria used to diagnose the associated infection were those of the Atlanta CDC. Operative wound monitoring was done up to the 30th postoperative day. Results: We have recorded 200 patients, out of whom 1.8 were operated on and 23 cases of bacterial infection associated with care (1..50%). The average age of the patients was 32.52 years ± 1..36 years against 29.36 years ± 1..28 years for the patients who did not present the infection. Seven point five percent of the evacuated patients had an infection associated with care. The most common types of infection were surgical site infection (60.86%), urinary tract infection (26.08%), endometritis and sepsis with 1..04% each. The isolated organisms were all resistant to Amoxicillin, to Amoxicillin + Clavulanic acid (88.88%) and to Ciprofloxacin (77.77%). The average duration of hospitalization for patients who developed the infection was 1..70 days. The lethality was 1.50%. The average cost of management of patients who developed the surgical site infection was 1.9,837 FCFA. Conclusion: The bacterial infe

关键词： Bacterial Infection Resistances Gabriel Touré University Hospital Antibiotics obstetrics

Tubal Ligation under Local Anesthesia in a Country with Limited Resources: 56 Cases of Wife and Husband’s Experience in the gynecology-{1. department of Ignace Deen National Teaching Hospital, Conakry, Guinea

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Open Journal of obstetrics and {1. 2020年第3期10卷 348-356页

作者： I.Sylla M.H.Diallo O.Baldé F.B.Diallo I.S.Baldé A.D.Diallo Telly Sy department of {1.-obstetrics at Ignace Deen National Hospital ConakryGuinea department of {1.-obstetrics at Donka National Hospital ConakryGuinea Visceral Surgery department Donka National HospitalConakryGuinea

Tubal ligation is a surgical sterilization procedure that provides permanent and reliable contraception to women.?Tubal obstruction is a method of permanent birth control that can be performed after mini-laparotomy under local anesthesia. Objective:?To determine the outcome of tubal sterilizations by mini-laparotomy under local anesthesia performed in clients who underwent the surgical operation in the Maternity Ward of Ignace Deen National Hospital. Patients and Methods:?The gynecology and {1. department of Ignace Deen National Hospital was used as the place for the study. The study involved all the women seeking voluntary surgical contraception. This was a retrospective study of a descriptive type carried out from January 1. 201. to December 31. 201.. A consent form was filled out and signed by spouses after an interview and a systematically carried out pre-operative clinical and para-clinical assessment. Results:?During the study period, 56 tubal ligations were performed i.e. 4.72 percent of all family planning methods. The recruiting for the surgical contraception involved clients whose typical profile is that of women with an average age of 35, mostly housewives (35.71.), major multiparous (69.63%) with 6 living children on average. Married women made up the bulk of the recruiting i.e. 96.44%. Unmarried women made much more use of other methods. Indications of personal convenience were the most frequently encountered common reason. Among medical causes, high blood?pressure concerned the majority of cases: 38% of the indications. Surgical contraception in between was more practiced than the post-partum one. The recorded complication was the parietal hematoma due to a lack of hemostasis and it accounted for 1.79% of cases. The progress was uncomplicated in?98.68% of cases. Forty couples (71.42%) expressed their feelings of satisfaction against only 6 cases of regret (1..71.). Conclusion:?The surgical contraception has become a requirement for modern couple

关键词： Tubal Ligation Local Anesthesia Conakry Ignace Deen

Pan-TRK positive uterine sarcoma in immunohistochemistry without neurotrophic tyrosine receptor kinase gene fusions:A case report

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World Journal of Clinical Cases 2025年第2期13卷 39-49页

作者： Seungmee Lee Yu-Ra Jeon Changmin Shin Sun-Young Kwon Sojin Shin department of {1. and gynecology Keimyung University School of MedicineDaegu 42601South Korea department of Pathology and Institute for Cancer Research Keimyung University School of MedicineDaegu 42601South Korea

BACKGROUND The classification of uterine sarcomas is based on distinctive morphological and immunophenotypic characteristics,increasingly supported by molecular genetic *** on neurotrophic tyrosine receptor kinase(NTRK)gene fusionpositive uterine sarcoma,potentially aggressive and morphologically similar to fibrosarcoma,are limited due to its recent ***-TRK immunohistochemistry(IHC)analysis serves as an effective screening tool with high sensitivity and specificity for NTRK-fusion *** SUMMARY We report a case of a malignant mesenchymal tumor originating from the uterine cervix,which was pan-TRK IHC-positive but lacked NTRK gene fusions,accompanied by a brief literature review.A 55-year-old woman presented to the emergency department with abdominal pain and distension,exhibiting significant ascites and multiple solid pelvic *** examination revealed a tumor encompassing the uterine cervix,extending to the vagina and uterine corpus.A punch biopsy of the cervix indicated NTRK sarcoma with positive immunochemical pan-TRK ***,subsequent next generation sequencing revealed no NTRK gene fusion,leading to a diagnosis of poorly differentiated,advanced-stage *** The clinical significance of NTRK gene fusion lies in potential treatment with TRK inhibitors for positive *** such rare tumors is crucial due to the potential applicability of tropomyosin receptor kinase inhibitor treatment.

关键词： Uterine sarcoma Cervical sarcoma Neurotrophic tyrosine receptor kinase gene fusion Next generation sequencing Case report

Sexual Experience of Women after Gynecological Hysterectomy in the department of {1. and gynecology of Yalgado Ouedraogo Teaching Hospital, Burkina Faso

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Open Journal of obstetrics and {1. 2019年第9期9卷 1273-1283页

作者： Der Adolphe Somé Rélwendé Barnabé Yaméogo Souleymane Ouattara Dantola Paul Kain Béwendin Evélyne Komboigo Blandine Thiéba Bonané department of {1. Obstetrics and Reproductive Medicine Souro Sanou University Teaching Hospital Bo-bo-Dioulasso Burkina Faso department of {1. and gynecology Yalgado Ouedraogo University Teaching Hospital Ouagadougou Burkina Faso

Objective: To study the sexual experience of women after gynecological hysterectomy in the obstetrics and {1. department of Yalgado Ouedraogo University Teaching Hospital in Burkina Faso. Patient and Method: We conducted a cross-sectional study from October 1. 201. to March 30, 201.. It included any patient who had a gynecological indication for a hysterectomy in the department of obstetrics and {1. of Yalgado Ouedraogo University Teaching Hospital (CHU-YO) during the study period. A total of 85 patients were included. We collected information from the consultation records, clinical records, and operating room registries and by surveying the patients themselves. Result: The frequency of hysterectomy in the gynecological period was 3.9%. The mean age of the patients was 51.71.(extremes: 35 and 66 years) and the mean parity was 4.8. Married women were the majority. Fibromyoma and genital prolapse accounted for 56.47% and 23.53% respectively of operative indications. Regarding postintervention sexuality, 29.41. of women declared no longer having sexual desire. Also, they complained of vaginal dryness (31.8%), decreased frequency of orgasm (42.3%), dyspareunia (37.65). Sexual dysfunction was present in 82.35% of women. There was a statistically significant difference between global sexual functioning and geographic origin, educational attainment, socio-economic level, surgical approach, preintervention sexual counseling, women’s psychological profile and their emotional relationship with their spouses. Conclusion: The psychosexual soundness of hysterectomy is important. A diagnosis of sexual disorders prior to the intervention and psychological follow-up throughout the therapeutic process of the pathology indicative of a hysterectomy is necessary for successful postoperative sexuality.

关键词： Sexual Experience Gynecological Hysterectomy Satisfaction Ouagadougou Burkina Faso

Obstetrical Fistula: Clinical, Therapeutic and Prognostic Aspects at the gynecology and {1. department of Borgou University Hospital Center in Benin

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Open Journal of obstetrics and {1. 2018年第11期8卷 1052-1062页

作者： Kabibou Salifou Adrien Dayi Fanny Hounkponou Sambo Tamou Imorou Rachidi Sidi Eusèbe Alihonou UFR of gynecology and {1. Faculty of Medicine University of Parakou Parakou Benin UFR of gynecology and {1. Faculty of Health Sciences University of Abomey-Calavi Cotonou Benin

Introduction: Obstetric Fistula (OF) is a tragedy and a public health problem (physical, social, moral and psychological). Objective: To determine the clinical, therapeutic and prognostic aspects of obstetric fistula at CHUD/B-A maternity ward in 201.. Study Method: This is a descriptive, analytic study with prospective data collection from March 07 to December 31. 201.. Patients with obstetric fistula were the study population. Results: A total of 37 patients were treated including 35 operated, the other two not operated for pyuria and bladder calculus after examination under spinal anesthesia. The average age was 36.6 ± 1..5 years with the extremes of 21.years and 65 years. The mean age of onset of Obstetric Fistula (OF) was 28.9 ± 6.5 years. Patients came from southern Benin (51.4%), were married (67.6%), peasant (35.1.) and out of school (81.1.). The types of OF were vesico-vaginal fistula (VVF) (62.2%), urethro-vaginal fistula (24.3%), vesico-uterine fistula (VUF) (5.4%), and uretero-vaginal fistula (2.7%). The fistula site was supra trigonal (54.1.), urethral (1..9%), trigonal (1..8%), vesico-uterine (1..8%), cervical urethral (2.7%), ureteroid vaginal (2.7%). Fistulas were complex (70.3%), complicated (24.3%) and simple (5.4%). The vaginal route was one of the first routes (64.9%). The operative techniques used were CHASSAR MOIR hysterorrhaphy (74.3%). The cure with continence was 68.6%. Conclusion: OF is observed in young women of childbearing age. VVF is the most common. The management is surgical with several operating techniques. Healing is possible. Hence the importance of paying special attention to these patients for their care.

关键词： Obstetric Fistula Continence Hysterorrhaphy Vesico-Uterine Fistula Benin

Epidemiological, Diagnostic and Therapeutic Aspects of Breast Cancer in the gynecology and {1. department of the CHU Gabriel Touré from 2020 to 2022

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Advances in Breast Cancer Research 2023年第3期12卷 97-113页

作者： Sirama Diarra Moussa Samake Amaguiré Saye Brehima Dembélé Birama Traoré Souleymane B. Dembélé Déssé Diarra Yely Dianéssy Abdou Guiré Bakarou Kamate gynecology and {1. department of the District Hospital of Commune IV Bamako Mali General Surgery department of the Commune IV District Hospital Bamako Mali obstetrics {1. Service of the CSREF of San Bamako Mali Anatomo-Pathology and Cytology department of the Point G University Hospital Bamako Mali

In Mali, breast cancer remains a real health problem in the absence of an adequate and adapted health policy for their early diagnosis and their often late or even non-existent treatment. Objectives: This study aimed to study the epidemiological, diagnostic, and therapeutic aspects of breast cancer to write the clinical aspects of breast cancer in the gynecology-{1. department of the CHU Gabriel Touré from 2020 to 2022. Methodology: This was a retrospective and descriptive study of 21. cases of breast cancer that were diagnosed in the gynecology and {1. department of the CHU Gabriel Touré in Bamako, from 2020 to 2022. Results: The annual frequency was 77.2 cases per year, the average age 45.55 years with extremes of 1. to 85 years;housewives represented 92.7%;multiparas were reported at 57%. Considering the history, the personal history of benign breast pathology was 55.6%. Regarding the localization, the left breast was the most affected with 53.9%, and the tumor was found in the supero-external quadrant in 53.9%. The cancer was metastatic in 81.28%. The diagnosis biopsy + histology contributed to 98.6%. The histological type was invasive carcinoma of non-specific type in 95%. As for the histoprognostic grade of SBR studied, grade II was predominant at 46%, grade III at 34.95%. The therapeutic strategy was chemotherapy in 83.1.. Neoadjuvant chemotherapy followed by surgery in 1.%, primary surgery in 6.4%, radiotherapy in 0.5%. Conclusion: The major challenges in the fight against breast cancer in Mali remain a better organization of the system for early diagnosis, the establishment of a screening program, early diagnosis in women from the age of 40 and also adequate care.

关键词： Epidemiology Diagnosis Therapeutics Breast Cancer Bamako (Mali)

Systematical identification of regulatory GPCRs by single-cell trajectory inference reveals the role of ADGRD1.and GPR39 in adipogenesis

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Science China Life Sciences 2025年

作者： Chuan Ye Xuemei Wang Jun Lin Chenyang Wu Yuhua Gao Chenghao Guo Yunxi Liao Ziyan Rao Shaodong Huang Weixuan Chen Ying Huang Jinpeng Sun Dongyu Zhao Changtao Jiang Center of Basic Medical Research Institute of Medical Innovation and ResearchPeking University Third Hospital department of Physiology and Pathophysiology School of Basic Medical SciencesPeking University department of Biomedical Informatics School of Basic Medical SciencesPeking University State Key Laboratory of Vascular Homeostasis and Remodeling Peking University Center for Obesity and Metabolic Disease Research School of Basic Medical SciencesPeking University State Key Laboratory of Female Fertility Promotion Center for Reproductive MedicineDepartment of Obstetrics and GynecologyPeking University Third Hospital National Clinical Research Center for obstetrics and {1. Peking University Third Hospital department of Endocrinology and Metabolism Peking University Third Hospital Key Laboratory Experimental Teratology of the Ministry of Education Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesCheeloo College of MedicineShandong University department of Immunology School of Basic Medical SciencesPeking University

Adipogenesis is the healthy expansion of white adipose tissue (WAT),serving as a compensatory response to maintain metabolic homeostasis in the presence of excess energy in the ***,the identification of novel regulatory molecules in adipogenesis,specifically membrane receptors such as G protein-coupled receptors (GPCRs),holds significant clinical *** receptors can serve as viable targets for pharmaceuticals,offering potential for restoring metabolic homeostasis in individuals with *** utilized trajectory inference methods to analyze three distinct single-nucleus sequencing (sNuc-seq) datasets of adipose tissue and systematically identified GPCRs with the potential to regulate *** verification in primary adipose progenitor cells (APCs) of mice,we discovered that ADGRD1.promoted the differentiation of APCs,while GPR39 inhibits this *** the obese mouse model induced by a high-fat diet(HFD),both gain-of-function and loss-of-function studies validated that ADGRD1.promoted adipogenesis,thereby improving metabolic homeostasis,while GPR39 inhibited adipogenesis,leading to metabolic ***,through the analysis of 2,400 ChIP-seq data and 1.204 bulk RNA-seq data,we found that the transcription factors (TFs) MEF2D and TCF1. regulated the expression of ADGRD1.nd GPR39,*** study revealed the regulatory role of GPCRs in adipogenesis,providing novel targets for clinical intervention of metabolic dysfunction in obese patients.

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