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Evaluation of genetic response of mesenchymal stem cells to nanosecond pulsed electric fields by whole transcriptome sequencing

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World Journal of Stem Cells 2024年第3期16卷 305-323页

作者： Jian-Jing Lin Tong Ning Shi-Cheng Jia Ke-Jia Li Yong-Can Huang Qiang Liu Jian-Hao Lin Xin-Tao Zhang Department of Sports Medicine and Rehabilitation Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina Institute of Medical Science The Second HospitalCheeloo College of MedicineShandong UniversityJinan 250033Shandong ProvinceChina Department of biomedical {1. Institute of Future TechnologyPeking UniversityBeijing 100871China Shenzhen engineering Laboratory of Orthopaedic Regenerative Technologies Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina Arthritis Clinical and Research center Peking University People’s HospitalBeijing 100044China

BACKGROUND Mesenchymal stem cells(MSCs)modulated by various exogenous signals have been applied extensively in regenerative medicine ***,nanosecond pulsed electric fields(nsPEFs),characterized by short duration and high strength,significantly influence cell phenotypes and regulate MSCs differentiation via multiple ***,we used transcriptomics to study changes in messenger RNA(mRNA),long noncoding RNA(lncRNA),microRNA(miRNA),and circular RNA expression during nsPEFs *** To explore gene expression profiles and potential transcriptional regulatory mechanisms in MSCs pretreated with *** The impact of nsPEFs on the MSCs transcriptome was investigated through whole transcriptome *** were pretreated with 5-pulse nsPEFs(1.0 ns at 1. kV/cm,1.Hz),followed by total RNA *** transcript was normalized by fragments per kilobase per *** change and difference significance were applied to screen the differentially expressed genes(DEGs).Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were performed to elucidate gene functions,complemented by quantitative polymerase chain reaction *** In total,263 DEGs were discovered,with 92 upregulated and 1.1.*** were predominantly enriched in epithelial cell proliferation,osteoblast differentiation,mesenchymal cell differentiation,nuclear division,and wound *** cellular components,DEGs are primarily involved in condensed chromosome,chromosomal region,actin cytoskeleton,and *** aspect of molecular functions,DEGs are mainly involved in glycosaminoglycan binding,integrin binding,nuclear steroid receptor activity,cytoskeletal motor activity,and steroid *** real-time polymerase chain reaction confirmed targeted transcript *** Our systematic investigation of the wide-ranging transcriptional pattern modulated by nsPEFs revealed the differential expression of 26

关键词： Nanosecond pulsed electric fields Whole transcriptome sequencing Mesenchymal stem cells Genetic response Stem cell engineering

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氧化石墨烯包埋普鲁士蓝复合物的高效电容去离子和水消毒研究

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Science China Materials 2024年第1期67卷 143-152页

作者：李南任攀宇田苗王科 Atif Saleem 刘念余骆峰李鹏 Frontiers Science center for Flexible Electronics(FSCFE) Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&Engineering(IBME)Northwestern Polytechnical University(NPU)Xi’an 710072China School of Ecology and Environment Northwestern Polytechnical University(NPU)Xi’an 710072China

具有除菌性能的电容去离子材料对于制备高效节能同时具备脱盐和抗微生物污染功能的电极材料至关重要,然而由于双电层电吸附机制的影响,多数碳基材料的吸附容量受到限制.同时,近年来部分研究学者通过对电极材料进行抗菌化合物的修饰并用... 详细信息

具有除菌性能的电容去离子材料对于制备高效节能同时具备脱盐和抗微生物污染功能的电极材料至关重要,然而由于双电层电吸附机制的影响,多数碳基材料的吸附容量受到限制.同时,近年来部分研究学者通过对电极材料进行抗菌化合物的修饰并用于电容法水除菌已得到证明.因此为了实现高效、低成本的同时实现电容脱盐和除菌,本研究提出了一种简便的方法制备氧化石墨烯/聚苯胺/普鲁士蓝纳米复合材料作为类法拉第电极用于电容去离子和水消毒应用.所合成的电极材料具有较高的BET表面积(1.8.08m^(2)g^(-1.)、介孔体积(34.02cm^(3)g^(-1.)和孔体积(0.66cm^(3)g^(-1.),在1.g^(-1.下的脱盐容量为91.6mgg^(-1.,脱盐率为3.05mgg^(-1.min^(-1..此外,在未添加额外消毒剂的情况下,该复合材料所制备的电极能有效去除和灭活94.0%±3.1.的大肠杆菌,其杀菌效率是活性炭电极的7倍.本研究对未来将普鲁士蓝基复合材料的法拉第电极用于高效环保海水淡化和消毒材料的应用奠定了研究基础.

关键词：氧化石墨烯电容去离子普鲁士蓝水消毒法拉第碳基材料微生物污染海水淡化

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AZD1.75 synergizes with SLC7A1. inhibition to promote ferroptosis

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Science China Life Sciences 2024年

作者： Chen Xiong Hong Ling Yingdan Huang Hanzhi Dong Bangxiang Xie Qian Hao Xiang Zhou Fudan University Shanghai Cancer center and Institutes of {1. Sciences Fudan University Department of Oncology Shanghai Medical College Fudan University Department of Breast Surgery Fudan University Shanghai Cancer Center Fudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan Hospital Capital Medical University Beijing engineering Research {1. for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer Center Fudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology) Institutes of Biomedical Sciences Fudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1.inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1.inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1.inhibitor AZD1.75-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1.75 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1.by the WEE1.inhibitors or siRNAs induced compensatory upregulation of SLC7A1., which conferred resistance to ferroptosis. Mechanistically, AZD1.75 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A1. promoter by repressing the expression of the histone methyltransferase SETDB1. thereby enhancing NRF2-mediated SLC7A1. transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A1. expression by activating p53, thus augmenting AZD1.75-induced ferroptosis. Moreover, the combination of AZD1.75 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1.75promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A1. through the WEE1.SETDB1.cascade and NRF2-induced transcription, and inhibition of SLC7A1. by Act. D boosts the anti-tumor efficacy of AZD1.75 by enhancing ferroptosis in cancers with wild-type p53.

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Disruption of PABPN1.phase separation by SNRPD2 drives colorectal cancer cell proliferation and migration through promoting alternative polyadenylation of CTNNBIP1

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Science China(Life Sciences) 2024年第6期67卷 1212-1225页

作者： Zhijie Hu Mengxia Li Yufeng Chen Liutao Chen Yuting Han Chengyong Chen Xin Lu Nan You Yawen Lou Yingye Huang Zhanfeng Huo Chao Liu Cheng Liang Susu Liu Ke Deng Liangfu Chen Shangwu Chen Guohui Wan Xiaojian Wu Yonggui Fu Anlong Xu State Key Laboratory of Biocontrol Guangdong Province Key Laboratory of Pharmaceutical Functional GenesDepartment of BiochemistrySchool of Life SciencesSun Yat-sen UniversityGuangzhou 510275China Department of General Surgery(Colorectal Surgery)&Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases&biomedical Innovation {1. The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China National-Local Joint engineering Laboratory of Druggability and New Drug Evaluation National Engineering Research Center for New Drug and Druggability(cultivation)Guangdong Province Key Laboratory of New Drug Design and EvaluationSchool of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006China School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China

Generally shortened 3′UTR due to alternative polyadenylation(APA)is widely observed in cancer,but its regulation mechanisms for cancer are not well ***,with profiling of APA in colorectal cancer tissues and poly(A)signal editing,we firstly identified that the shortened 3′UTR of CTNNIBP1.in colorectal cancer promotes cell proliferation and *** found that liquid-liquid phase separation(LLPS)of PABPN1.is reduced albeit with higher expression in cancer,and the reduction of LLPS leads to the shortened 3′UTR of CTNNBIP1.nd promotes cell proliferation and ***,the splicing factor SNRPD2 upregulated in colorectal cancer,can interact with glutamic-proline(EP)domain of PABPN1.and then disrupt LLPS of PABPN1.which attenuates the repression effect of PABPN1.on the proximal poly(A)*** results firstly reveal a new regulation mechanism of APA by disruption of LLPS of PABPN1.suggesting that regulation of APA by interfering LLPS of 3′end processing factor may have the potential as a new way for the treatment of cancer.

关键词： alternative polyadenylation colorectal cancer CTNNBIP1 PABPN1 liquid-liquid phase separation SNRPD2

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Using Linear and Non-Linear Techniques to Characterize Gait Coordination Patterns of Two Individuals with NGLY1.Deficiency

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Case Reports in Clinical Medicine 2024年第9期13卷 391-409页

作者： Charles S. Layne Dacia Martinez Diaz Christopher A. Malaya Brock Futrell Christian Alfaro Hannah E. Gustafson Bernhard Suter Department of Health and Human Performance University of Houston Houston TX USA center for Neuromotor and {1. Research University of Houston Houston TX USA center for Neuro {1. and Cognitive Science University of Houston Houston TX USA Research center Parker University Dallas TX USA Blue Bird Circle Rett center Texas Childrens Hospital Houston TX USA Baylor College of Medicine Houston TX USA

Individuals with NGLY1.Deficiency, an inherited autosomal recessive disorder, exhibit hyperkinetic movements including athetoid, myoclonic, dysmetric, and dystonic movements impacting both upper and lower limb motion. This report provides the first set of laboratory-based measures characterizing the gait patterns of two individuals with NGLY1.Deficiency, using both linear and non-linear measures, during treadmill walking, and compares them to neurotypical controls. Lower limb kinematics were obtained with a camera-based motion analysis system and bilateral time normalized lower limb joint time series waveforms were developed. Linear measures of joint range of motion, stride times and peak angular velocity were obtained, and confidence intervals were used to determine if there were differences between the patients and control. Correlations between participant and control mean joint waveforms were calculated and used to evaluate the similarities between patients and controls. Non-linear measures included: joint angle-angle diagrams, phase-portrait areas, and continuous relative phase (CRP) measures. These measures were used to assess joint coordination and control features of the lower limb motion. Participants displayed high correlations with their control counterparts for the hip and knee joint waveforms, but joint motion was restricted. Peak angular velocities were also significantly less than those of the controls. Both angle-angle and phase-portrait areas were less than the controls although the general shapes of those diagrams were similar to those of the controls. The NGLY1.Deficient participants’ CRP measures displayed disrupted coordination patterns with the knee-ankle patterns displaying more disruption than the hip-knee measures. Overall, the participants displayed a functional walking pattern that differed in many quantitative ways from those of the neurotypical controls. Using both linear and non-linear measures to characterize gait provides a more compre

关键词： NGLY1 Gait Disability Kinematics Angle-Angle Diagrams Phase Portraits

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General theory for designing phonon transport in alloyed/doped materials

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Science China(Physics,Mechanics & Astronomy) 2024年

作者： Chenhan Liu Chao Wu Wei Liu Yunshan Zhao Gang Zhang Hongmin Yang Yunfei Chen Micro-and Nano-scale Thermal Measurement and Thermal Management Laboratory Key Laboratory of Numerical Simulation for Large Complex Systems Ministry of Education School of Energy and Mechanical Engineering Nanjing Normal University School of Electrical and Automation engineering Nanjing Normal University Phonon engineering Research {1. of Jiangsu Province Center for Quantum Transport and Thermal Energy Science Institute of Physics Frontiers and Interdisciplinary Sciences School of Physics and Technology Nanjing Normal University Institute of High-Performance Computing Agency for Science Technology and ResearchSingapore Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano biomedical Instruments School of Mechanical Engineering Southeast University

Alloying/doping is a widely used technique for improving the electrical, mechanical, and optical properties of ***, this technology induces significant distortions in the lattice structure, mass distribution, and potential field, greatly enhancing phonon scattering. Here, we introduce the concept of alloying/doping path and employ crystal symmetry, lattice deformation, and electron distribution to characterize it. Based on this new concept, the phonon thermal transport behavior in alloyed/doped materials can be well designed, and along different alloying/doping paths, the difference in thermal conductivity can be up to 45 times. On one hand, strategic alloying/doping that combines high crystal symmetry, large lattice contraction, and the same electron distribution suppresses phonon-phonon scattering phase space, induces phonon stiffening, and bolsters electronic structure symmetry, respectively. These synergistic effects significantly improve thermal conductivity. On the other hand, random alloying/doping has a low symmetry, leading to the typical “U” shape of alloying/doping level-dependent thermal conductivity. Our theory is corroborated in three-dimensional（3D） Si, 2D MoS2, and quasi-1. TiS3, affirming its efficacy and broad applicability in controlling phonon transport.

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Organic-inorganic hybrid piezotronic bipolar junction transistor for pressure sensing

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Microsystems & Nanoengineering 2024年第3期10卷 229-244页

作者： Emad Iranmanesh Zihao Liang Weiwei Li Congwei Liao Shunyu Jin Chuan Liu Kai Wang Shengdong Zhang Charalampos Doumanidis Gehan A.J.Amaratunga Hang Zhou Guangdong Provincial Key Laboratory of In-Memory Computing Chips School of Electronic and Computer EngineeringPeking University Shenzhen Graduate SchoolShenzhen 518055P.R.China School of Mechanical engineering Guangdong Technion-Israel Institute of TechnologyShantou 515063P.R.China State Key Laboratory of Microelectronics Device and Integrated Technology Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029P.R.China Hefei National Research center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 23000PR China School of Electronics and Information Technology Sun Yat-sen UniversityNo.132 East Waihuan RoadGuangzhou 510006P.R.China Department of Mechanical Aerospaceand Biomedical EngineeringUniversity of South AlabamaShelby Hall3128MobileAL 36688USA Electrical engineering Division Department of EngineeringUniversity of Cambridge9 JJ Thomson AvenueCambridge CB30FAUnited Kingdom Zhejiang University International CampusHainingChina

With the rapid development of the Internet of Things(IoTs),wearable sensors are playing an increasingly important role in daily monitoring of personal health and *** signal-to-noise-ratio has become the most critical performance factor to *** enhance it,on the one hand,good sensing materials/devices have been employed;on the other hand,signal amplification and noise reduction circuits have been ***,most of these devices and circuits work in an active sampling mode,requiring frequent data acquisition and hence,entailing high-power *** this scenario,a flexible and wearable event-triggered sensor with embedded signal amplification without an external power supply is of great ***,we report a flexible two-terminal piezotronic n-p-n bipolar junction transistor(PBJT)that acts as an autonomous and highly sensitive,current-and/or voltage-mediated pressure *** PBJT is formed by two back-to-back piezotronic diodes which are defined as emitter-base and collectorbase *** force exertion on the emitter side,as a result of the piezoelectric effect,the emitter-base diode is forward biased while the collector-base diode is reverse *** to the inherent BJT amplification effect,the PBJT achieves record-high sensitivities of 1.9.7 kPa^(-1.(current-based)and 88.66 kPa^(-1.(voltage-based)in sensing *** PBJT also has a fast response time of1.0 ms under exertion of dynamic stimuli ranging from a flying butterfly to a gentle finger ***,the PBJT advances the state of the art not only in terms of sensitivity but also in regard to being self-driven and autonomous,making it promising for pressure sensing and other IoT applications.

关键词： bipolar transistor IoT

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Correction:Anti-lymphangiogenesis for boosting drug accumulation in tumors

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3141-3142页

作者： Chunling Wang Junchao Xu Xiaoyu Cheng Ge Sun Fenfen Li Guangjun Nie Yinlong Zhang CAS Key Laboratory for biomedical Effects of Nanomaterials & Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China Sino-Danish College University of Chinese Academy of Sciences Beijing 100190 China Sino-Danish center for Education and Research Beijing 100190 China Department of Bioengineering University of Pennsylvania Philadelphia PA 19104 USA School of Nanoscience and engineering University of Chinese Academy of Sciences Beijing 100049 China

Correction to:Signal Transduction and Targeted Therapy https://***/1..1.38/s41.92-024-01.94-4,published online 1. April 2024 After the article was published online,1.the authors noticed one inadvertent mistake in Supplementary *** image of lung H&E in the Lip-Dox group was repeatedly inserted as the image of Dox group by mistake during the preparation of the *** correct figure was provided as *** correction did not affect any of our results or discussion presented in the original *** apologize for this inadvertent *** original article has been corrected.

关键词： lung boosting repeatedly

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Nonlinear dynamics of self-oscillating polymer gels

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Science China(Technological Sciences) 2010年第7期53卷 1862-1868页

作者： WANG PengFei1. ZHOU JinXiong1. LI MeiE2, XU Feng1.3 & LU TianJian1.1.biomedical {1. and biomechanics center, SV Laboratory, Xi’an Jiaotong University, Xi’an 71.049, China 2 School of Materials Science and {1., Xi’an Jiaotong University, Xi’an 71.049, China 3 HST center for biomedical {1., Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, 51.660, USA 1. biomedical engineering and biomechanics center SV Laboratory Xi’an Jiaotong University Xi’an 710049 China2. School of Materials Science and Engineering Xi’an Jiaotong University Xi’an 710049 China3. HST Center for Biomedical Engineering Department of Medicine Brigham and Women’s Hospital Harvard Medical School Boston 510660 USA

Self-oscillating polymer gels driven by Belousov-Zhabotinsky (BZ) chemical reaction are a new class of functional gels that have a wide range of potential applications (e.g., autonomously functioning membranes, actuate artificial muscles). However, the precise control of these gels has been an issue due to limited investigations of the influences of key system parameters on the characteristics of BZ gels. To address this deficiency, we studied the self-oscillating behavior of BZ gels using the nonline-ar dynamics theory and an Oregonator-like model, with focus placed upon the influences of various system parameters. The analysis of the oscillation phase indicated that the dynamic response of BZ gels represents the classical limit cycle oscillation. We then investigated the characteristics of the limit cycle oscillation and quantified the influences of key parameters (i.e., ini-tial reactant concentration, oxidation and reduction rate of catalyst, and response coefficient) on the self-oscillating behavior of BZ gels. The results demonstrated that sustained limit cycle oscillation of BZ gels can be achieved only when these key pa-rameters meet certain requirements, and that the pattern, period and amplitude of the oscillation are significantly influenced by these parameters. The results obtained in this study could enable the controlled self-oscillation of BZ gels system. This has several potential applications such as controlled drug delivery, miniature peristaltic pumps and microactuators.

关键词： Belousov-Zhabotinsky reaction self-oscillating gels numerical simulation limit cycle parameter analysis

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3-Dimensional Kinematic Comparison of Arm Movements between an Individual with NGLY1.Deficiency and a Neurotypical Individual

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Case Reports in Clinical Medicine 2024年第4期13卷 122-146页

作者： Charles S. Layne Christopher A. Malaya Brock Futrell Dacia Martinez Diaz Christian Alfaro Hannah E. Gustafson Subhalakshmi Chandrasekaran Rhea M. Phatak Bernhard Suter Department of Health and Human Performance University of Houston Houston TX USA center for Neuromotor and {1. Research University of Houston Houston TX USA center for Neuro {1. and Cognitive Science University of Houston Houston TX USA Department of Computer Science and engineering Texas A&M University College Station TX USA Blue Bird Circle Rett center Texas Children&#8217s Hospital Houston TX USA Baylor College of Medicine Houston TX USA

NGLY1.Deficiency is an ultra-rare autosomal recessively inherited disorder. Characteristic symptoms include among others, developmental delays, movement disorders, liver function abnormalities, seizures, and problems with tear formation. Movements are hyperkinetic and may include dysmetric, choreo-athetoid, myoclonic and dystonic movement elements. To date, there have been no quantitative reports describing arm movements of individuals with NGLY1.Deficiency. This report provides quantitative information about a series of arm movements performed by an individual with NGLY1.Deficiency and an aged-matched neurotypical participant. Three categories of arm movements were tested: 1. open ended reaches without specific end point targets;2) goal-directed reaches that included grasping an object;3) picking up small objects from a table placed in front of the participants. Arm movement kinematics were obtained with a camera-based motion analysis system and “initiation” and “maintenance” phases were identified for each movement. The combination of the two phases was labeled as a “complete” movement. Three-dimensional analysis techniques were used to quantify the movements and included hand trajectory pathlength, joint motion area, as well as hand trajectory and joint jerk cost. These techniques were required to fully characterize the movements because the NGLY1.individual was unable to perform movements only in the primary plane of progression instead producing motion across all three planes of movement. The individual with NGLY1.Deficiency was unable to pick up objects from a table or effectively complete movements requiring crossing the midline. The successfully completed movements were analyzed using the above techniques and the results of the two participants were compared statistically. Almost all comparisons revealed significant differences between the two participants, with a notable exception of the 3D initiation area as a percentage of the complete movement. The stati

关键词： NGLY1.Deficiency Developmental Disorders Kinematics 3 Dimensional Analyses

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