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Comparative assessment of liver tissue:from microstructural and mesoscale vascular architecture to macroscopic mechanics

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Acta Mechanica Sinica 2024年第7期40卷 195-205页

作者： Wei Kang Kaixin Sun Lizhen Wang Yubo Fan Key Laboratory for biomechanics and Mechanobiology of Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China School of engineering Medicine Beihang UniversityBeijing 100083China

Accurately characterizing the liver's mechanical properties is of paramount importance for disease diagnosis,treatment,surgical prosthetic modeling,and impact injury ***,due to its inherent biological soft tissue nature,the characterization of mechanical behavior varies across testing methods and sample *** this study,we employed transmission electron microscope and Micro CT to observe the morphology of the marginal and center of rat livers and conducted macroscopic mechanical tests to characterize their elasticity and *** results revealed that the central region displayed higher metabolic levels,elongated mitochondria,and an abundance of rough endoplasmic reticulum at the *** the mesoscale,larger diameter portal veins were mainly distributed in the central region,while smaller diameter arteries were predominantly located at the *** the macroscale,under a strain rate of 0.01.7 s^(-1.,no significant differences were observed in the elastic properties between the two ***,as the strain rate increased up to 0.1.7 s^(-1.,the central region displayed higher porosity,resulting in reduced liquid loss,increased hardness,and higher viscosity compared to the ***,the liver demonstrated overall heterogeneity,with isotropic models suitable for the peripheral region,while more intricate models may be required to capture the complexity of the central region with its intricate vasculature.

关键词： Liver Mechanical properties Micro and macro tests

Responses of osteoblasts under varied tensile stress types induced by stretching basement materials

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International Journal of Smart and Nano Materials 2024年第2期15卷 279-295页

作者： Xuezheng Geng Qiao Li Yan Yao Lizhen Wang Yubo Fan Beijing Advanced Innovation center for {1. engineering School of Biological Science and Medical EngineeringKey Laboratory of Biomechanics and Mechanobiology(Beihang University)Ministry of EducationBeijingChina School of engineering Medicine Beihang UniversityBeijingChina

Osteoblasts are mechanosensitive *** stress with different conditions,including loading time,frequency,magnitude,*** cause varied responses in ***,it was not clarified that the effect of the loading types on the *** this study,we focused on the effect of varied tensile stress types on osteoblasts,including isotropic stretch,biaxial stretch,and uniaxial stretch with the negative ratio of transverse strain to axial strain(NR)-1.0,and 0.2 *** proliferation was determined to be most efficient when stimulated by 6%strain at a frequency of 1.Hz and a negative value of 0 for 1.h/*** varied strain resulted in a thickening of the F-actin cytoskeleton and a thinning of the *** flattening caused Yes-associated protein(YAP)to be transported to the *** was suggested that the influence of loading types on the mechanobiology responses must be *** mechanism of cell mechanical sensitivity under varied loading types was explored,which would provide good sugges-tions for designing microstructures to control deformation patterns in bone tissue engineering.

关键词： MC3T3-E1 tensile stress negative poisson’s ratio cell proliferation YAP

The research of collagen for tissue repair in China from 201. to 2023 based on bibliometrics and visualization analysis

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Medicine in Novel Technology and Devices 2024年第3期23卷 59-69页

作者： Hanzhen Zhang Yixu Zhao Dandan Hou Key Laboratory for biomechanics and Mechanobiology of Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Engineering MedicineBeihang UniversityBeijing100083China Key Laboratory for biomechanics and Mechanobiology of Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China

Due to its unique structure,collagen has exceptional biocompatibility,hemostasis,degradability and other biological properties,and is widely used for tissue repair in bone,cartilage,skin,teeth,neurons,cornea,urinary and various other ***,collagen has garnered in significant attention in the field of tissue repair in recent *** can objectively reflect the hot spots of research and predict the research frontier through quantitative analysis of the quality and quantity of published papers,authors and institutions,and *** paper uses bibliometrics to summarize the number and composition structure of published papers,the quality of published journals,authors/institutions and countries,and keywords in the past five years,aiming to objectively provide an objective overview of the domestic research landscape of collagen for tissue repair research from 201. to 2023,and hope to offer valuable insights for future related research.

关键词： Collagen Tissue repair Bibliometrics Visualization analysis

Biophysical cues involved in the stem cell niche for stemness maintenance

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Medicine in Novel Technology and Devices 2024年第2期22卷 80-89页

作者： Chiyu Li Lisha Zheng Yubo Fan Key Laboratory of biomechanics and Mechanobiology(Beihang University) Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China

The characteristics of stem cells are self-renewal ability and differentiation *** properties are defined as stemness,offering them application in tissue repair and regeneration based on stem cells with great ***,stem cells undergo functional deterioration and gradually lose stemness with long-term *** evidence implies that the regulation of stemness is primarily orchestrated by the niche,which comprises the connection between stem cells and niche cells,extracellular matrix(ECM)proteins,and secreted ***,physical signals are being acknowledged as paramount regulators of cellular behavior,governing stem cell stemness,tissue development,and *** review outlines current approaches for stemness maintenance and the important biophysical cues involved in the stem *** first encompass the latest discoveries regarding the sources and transduction pathways of these biophysical ***,the specific biophysical factors for regulating stemness have been ***,we summarize existing challenges and prospect future research in this field.

关键词： Stemness Stem cell Biophysical Niche

Current research progress on cell membrane decorated macroscopic biomaterials

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Medicine in Novel Technology and Devices 2024年第1期21卷 23-30页

作者： Lingbing Yang Linhao Li Yubo Fan Key Laboratory of biomechanics and Mechanobiology(Beihang University) Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China

The cell membranes,derived from natural sources,possesses unique physicochemical properties of phospholipid bilayers and biological functionalities of membrane *** makes it an ideal biomimetic coating to enhance the in vivo circulation and retention time of micro/nanodrug carriers,provide targeted drug delivery effects,and neutralize bacterial ***,recent studies have successfully coated various types of cell membranes onto the surfaces of macroscopic materials,such as electrospun fiber scaffolds and decellularized matrices,to promote tissue repair,modulate host responses to foreign materials,and alleviate *** review comprehensively summarizes the latest research progress in the modification of macroscopic biomaterials with cell *** insights provided aim to serve as a valuable reference for the preparation of cell membrane biomimetic coatings and their applications in the field of tissue repair.

关键词： Cell membrane coating Macroscopic biomaterials Tissue repair Foreign body reactions

The utilization of chitosan/Bletilla striata hydrogels to elevate anti-adhesion,anti-inflammatory and pro-angiogenesis properties of polypropylene mesh in abdominal wall repair

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Regenerative Biomaterials 2024年第4期3卷 111-124页

作者： Yuntao Di Lu Wang Wei He Shuyan Liu Yuqi He Jie Liao Ruihong Zhang Lan Yin Zhiwei Xu Xiaoming Li Department of Neurosurgery The Fourth Central Hospital of Baoding CityBaoding 072350China Research center for {1. engineering Medical Innovation&Research DivisionChinese PLA General HospitalKey Laboratory of Biomedical Engineering and Translational MedicineMinistry of Industry and Information TechnologyBeijing 100853China Key Laboratory for biomechanics and Mechanobiology of Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China College of Lab Medicine Hebei North UniversityZhangjiakou 075000China Key Laboratory of Advanced Materials of Ministry of Education Tsinghua UniversityBeijing 100084China

Polypropylene(PP)mesh is commonly used in abdominal wall repair due to its ability to reduce the risk of organ damage,infections and other ***,the PP mesh often leads to adhesion formation and does not promote functional tissue *** this study,we synthesized one kind of aldehyde Bletilla striata polysaccharide(BSPA)modified chitosan(CS)hydrogel based on Schiff base *** hydrogel exhibited a porous network structure,a highly hydrophilic surface and good *** wrapped the PP mesh inside the hydrogel and evaluated the performance of the resulting composites in a bilateral 1.1.5cm abdominal wall defect model in *** results of gross observation,histological staining and immunohistochemical staining demonstrated the positive impact of the CS hydrogel on anti-adhesion and wound healing ***,the addition of BSPA to the CS hydrogel further improved the performance of the composites in vivo,promoting wound healing by enhancing collagen deposition and capillary *** study suggested that the BSPA-modified CS hydrogel significantly promoted the anti-adhesion,anti-inflammatory and pro-angiogenesis properties of PP meshes during the healing ***,this work offers a novel approach to the design of abdominal wall repair patches.

关键词： abdominal wall wound healing hydrogel Bletilla striata anti-adhesion

Multi-objective structural optimization and degradation model of magnesium alloy ureteral stent

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Medicine in Novel Technology and Devices 2024年第2期22卷 19-28页

作者： Lin Zhu Qiao Li Yuanming Gao Lizhen Wang Yubo Fan Key Laboratory for biomechanics and Mechanobiology of Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China School of engineering Medicine Beihang UniversityBeijing100191China

Background:Mg alloys have attractive properties,including biocompatibility,biodegradability,and ideal mechanical ***,Mg alloys are regarded as one of the promising candidates for manufacturing ureteral *** study proposed a multi-objective optimization method based on the Kriging surrogate model,NSGA-III,and finite element analysis to improve the degradation performance of Mg alloy ureteral ***:The finite element model for the degradation of Mg alloy ureteral stents has been established to compare the degradation performance of the stents under different *** hypercube sampling was adopted to generate train sample points in the design ***,the Kriging surrogate model was constructed between strut parameters and stent degradation *** NSGA-III was utilized to determine the optimal solution in the global design ***:The optimized stent achieved 5.52degradation uniformity(M),1.degradation time(DT),and 4work time(FT).The errors between the Kriging surrogate model and the finite element calculation results were less than 6%.Conclusion:The optimized stent achieved better degradation *** degradation behavior of stents was dependent on the design *** multi-objective optimization method based on the Kriging surrogate model and finite element analysis was effective in stent design optimization problems.

关键词： Mg alloys ureteral stent Kriging surrogate model NSGA-III Multi-objective optimization Degradation model

Traceable Lactate-Fueled Self-Acting Photodynamic Therapy against Triple-Negative Breast Cancer

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Research 2024年第3期2024卷 723-733页

作者： Yifan Zhang Guangle Feng Ting He Min Yang Jing Lin Peng Huang Marshall Laboratory of biomedical {1. International Cancer CenterShenzhen Key Laboratory of Tumor Visualization Molecular MedicineLaboratory of Evolutionary Theranostics(LET)School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen UniversityShenzhen518055China.

The depth of light penetration and tumor hypoxia restrict the efficacy of photodynamic therapy(PDT)in triple-negative breast cancer(TNBC),while the overproduction of lactate(LA)facilitates the development,aggressiveness,and therapy resistance of *** address these issues,a self-acting PDT nanosystem(HL@hMnO_(2)-LO_(x)@HA)is fabricated by loading 2-(1.hexyloxyethyl)-2-devinyl pyropheophorbide-alpha(HPPH),luminol,and LA oxidase(LO_(x))in a hyaluronic acid(HA)-coated hollow manganese dioxide(hMnO_(2))***_(x) catalyzes the oxidation of LA into pyruvate and hydrogen peroxide(H_(2)O_(2)),thus depleting the overproduced intratumoral *** the acidic tumor microenvironment,H_(2)O_(2) reacts with luminol and hMnO_(2) to yield blue luminescence as well as O_(2) and Mn^(2+),***^(2+)could further enhance this *** is then excited by the chemiluminescence through chemiluminescence resonance energy transfer for self-illuminated *** generated O_(2) alleviates the hypoxia state of the TNBC tumor to produce sufficient 1._(2) for self-oxygenation *** Mn^(2+)performs T1.magnetic resonance imaging to trace the self-acting PDT *** work provides a biocompatible strategy to conquer the limits of light penetration and tumor hypoxia on PDT against TNBC as well as LA overproduction.

关键词： Breast Therapy manganese

In vivo measurement of NADH fluorescence lifetime in skeletal muscle via -ber-coupled time-correlated single photon counting

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Journal of Innovative Optical Health Sciences 2024年第1期17卷 121-134页

作者： Kathryn M.Priest Jacob V.Schluns Nathania Nischal Colton L.Gattis Jeffrey C.Wolchok Timothy J.Muldoon Department of biomedical {1. University of Arkansas FayettevilleARUSA

Nicotinamide adenine dinucleotide(NADH)is a cofactor that serves to shuttle electrons during metabolic processes such as glycolysis,the tricarboxylic acid cycle,and oxidative phosphorylation(OXPHOS).NADH is autofluorescent,and itsfluorescence lifetime can be used to infer metabolic dynamics in living ***-coupled time-correlated single photon counting(TCSPC)equipped with an implantable needle probe can be used to measure NADH lifetime in vivo,enabling investigation of changing metabolic demand during muscle contraction or tissue *** study illustrates a proof of concept for point-based,minimally-invasive NADHfluorescence lifetime measurement in *** muscle loss(VML)injuries were created in the left tibialis anterior(TA)muscle of male Sprague Dawley *** lifetime measurements were collected before,during,and after a 30 s tetanic contraction in the injured and uninjured TA muscles,which was subsequently-t to a biexponential decay model to yield a metric of NADH utilization(cytoplasmic vs protein-bound NADH,the A1.1.A22 ratio).On average,this ratio was higher during and after contraction in uninjured muscle compared to muscle at rest,suggesting higher levels of free NADH in contracting and recovering muscle,indicating increased rates of *** injured muscle,this ratio was higher than uninjured muscle overall but decreased over time,which is consistent with current knowledge of inflammatory response to injury,suggesting tissue regeneration has *** data suggest that-ber-coupled TCSPC has the potential to measure changes in NADH binding in vivo in a minimally invasive manner that requires further investigation.

关键词： Glycolysis oxidative phosphorylation energy metabolism volumetric muscle loss