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Low-volume plus ascorbic acid vs high-volume plus simethicone bowel preparation before colonoscopy

World Journal of Gastroenterology 2011年第42期17卷 4689-4695页

作者： Stefano Pontone Rita Angelini Monica Standoli Gregorio Patrizi Franco Culasso Paolo Pontone Adriano Redler Department of Surgical Sciences "Sapienza" University of Rome Department of Medical Statistics "Sapienza"University of Rome

AIM： To investigate the effectiveness of low-volume plus ascorbic acid [polyethylene glycol plus ascorbic acid （PEG ＋ Asc）] and high-volume plus simethicone [polyethylene glycol plus simethicone （PEG ＋ Sim）] bowel preparations. METHODS： A total of one hundred and forty-four outpatients （76 males）, aged from 20 to 84 years （median age 59.5 years）, who attended our Department, were divided into two groups, age and sex matched, and underwent colonoscopy. Two questionnaires, one for patients reporting acceptability and the other for endoscopists evaluating bowel cleansing effectiveness according to validated scales, were completed. Indications, timing of examination and endoscopical findings were recorded. Biopsy forceps were used as a measuring tool in order to determine polyp endoscopic sizeestimation. Difficulty in completing the preparation was rated in a 5-point Likert scale （1 = easy to 5 = unable）. Adverse experiences （fullness, cramps, nausea, vomiting, abdominal pain, headache and insomnia）, number of evacuations and types of activities performed during preparation （walking or resting in bed） were also investigated. RESULTS： Seventy-two patients were selected for each group. The two groups were age and sex matched as well as being comparable in terms of medical history and drug therapies taken. Fourteen patients dropped out from the trial because they did not complete the preparation procedure. Ratings of global bowel cleansing examinations were considered to be adequate in 91% of PEG ＋ Asc and 88% of PEG ＋ Sim patients. Residual Stool Score indicated similar levels of amount and consistency of residual stool; there was a significant difference in the percentage of bowel wall visualization in favour of PEG ＋ Sim patients. In the PEG ＋ Sire group, 12 adenomas≤ 10 mm diameter （5/left colon ＋ 7/right colon） vs 9 （8/left colon ＋ 1/right colon） in the PEG ＋ Asc group were diagnosed. Visualization of small lesions seems to be one of the primary advantages of the PEG

关键词： Bowel preparation Polyethylene glycol Ascorbic acid Colonoscopy Simethicone

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Efficacy of current guidelines for the treatment of spontaneous bacterial peritonitis in the clinical practice

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World Journal of Gastroenterology 2008年第17期14卷 2757-2762页

作者： Stefania Angeloni Cinzia Leboffe Antonella Parente Mario Venditti Alessandra Giordano Manuela Merli Oliviero Riggio Department of Clinical Medicine "Sapienza" University of Rome Department of Public Health "Sapienza" University of Rome

AIM： To verify the validity of the International Ascites Club guidelines for treatment of spontaneous bacterial peritonitis （SBP） in clinical practice. METHODS： All SBP episodes occurring in a group of consecutive cirrhotics were managed accordingly and included in the study. SBP was diagnosed when the ascitic fluid polymorphonuclear （PIN） cell count was 〉 250 cells/mm^3, and empirically treated with cefotaxime. RESULTS： Thirty-eight SBP episodes occurred in 32 cirrhotics （22 men/20 women; mean age： 58.6 ＋ 22.2 years）. Prevalence of SBP, in our population, was 27%. Ascitic fluid culture was positive in nine （24%） cases only. Eleven episodes were nosocomial and 71% community-acquired. Treatment with cefotaxime was successful in 59% of cases, while 41% of episodes required a modification of the initial antibiotic therapy because of a less-than 25% decrease in ascitic PMN count at 48 h. Change of antibiotic therapy led to the resolution of infection in 87% of episodes. Among the cases with positive culture, the initial antibiotic therapy with cefotaxime failed at a percentage （44%） similar to that of the whole series. In these cases, the isolated organisms were either resistant or with an inherent insufficient susceptibility to cefotaxime. CONCLUSION： In clinical practice, ascitic PMN count is a valid tool for starting a prompt antibiotic treatment andevaluating its efficacy. The initial treatment with cefotaxime failed more frequently than expected. An increase in healthcare-related infections with antibiotic-resistant pathogens may explain this finding. A different first-line antibiotic treatment should be investigated.

关键词： Spontaneous bacterial peritonitis Cefotaxi-me Antibiotic-resistant pathogens Ascitic polymorpho-nuclear count Cirrhosis

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Hazelnut mapping detection system using optical and radar remote sensing:Benchmarking machine learning algorithms

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Artificial Intelligence in Agriculture 2024年第2期12卷 97-108页

作者： Daniele Sasso Francesco Lodato Anna Sabatini Giorgio Pennazza Luca Vollero Marco Santonico Mario Merone Department of Engineering Research Unit of Computer Systems and BioinformaticsUniversitàCampus Bio-Medico di RomaviaÁlvaro del PortilloRome 00128Italy Department of Science and Technology for Sustainable Development and One Health Research Unit of Electronics for Sensor SystemsUniversitàCampus Bio-Medico di RomaviaÁlvaro del PortilloRome 00128Italy Department of Engineering Research Unit of Electronics for Sensor SystemsUniversitàCampus Bio-Medico di RomaviaÁlvaro del PortilloRome 00128Italy Department of Biology University of Naples FedericoⅡNaples 80138Italy

Mapping hazelnut orchards can facilitate land planning and utilization policies,supporting the development of cooperative precision farming *** present work faces the detection of hazelnut crops using optical and radar remote sensing data.A comparative study of Machine Learning techniques is *** system proposed utilizes multi-temporal data from the Sentinel-1 and Sentinel-2 datasets extracted over several years and processed with cloud *** provide a dataset of 62,982 labeled samples,with 16,561 samples belonging to the‘hazelnut’class and 46,421 samples belonging to the‘other’class,collected in 8 heterogeneous geograph-ical areas of the Viterbo *** different comparative tests are conducted:firstly,we use a Nested 5-Fold Cross-Validation methodology to train,optimize,and compare different Machine Learning algorithms on a single *** a second experiment,the algorithms were trained on one area and tested on the remaining seven geo-graphical *** developed study demonstrates how AI analysis applied to Sentinel-1 and Sentinel-2 data is a valid technology for hazelnut *** the results,it emerges that Random Forest is the classifier with the highest generalizability,achieving the best performance in the second test with an accuracy of 96%and an F1 score of 91%for the‘hazelnut’class.

关键词： Remote sensing Crop detection Hazelnut Machine learning Classification

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Characterization of the molecular dysfunctions occurring in Aicardi-Goutieres syndrome patients with mutations in ADAR1

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Genes & Diseases 2024年第3期11卷 116-119页

作者： Sofan Al wardat Loredana Frasinlli Elisa Orecchini Federica Rey Silvia Anna Ciafre Silvia Galardi Jessica Garau Stella Gagliardi Simona Orcesi Davide Tonduti Stephana Carelli Cristina Cereda Ernesto Picardi Alessandro Michienzi Department of Biomedicine and Prevention University of Rome Tor VergataRome 00133Italy Pediatric Clinical Research Center"romeo ed Enrica Invernizzi" Department of Biomedical and Clinical SciencesUniversity of MilanoMilano 20157Italy Center of Functional Genomics and Rare Diseases Department of PediatricsBuzzi Children's HospitalMilano20154Italy Department of Child Neurology and Psychiatry IRccs Mondino FoundationPavia 27100Italy Unit of Pediatric Neurology C.O.A.L.A(Center for Diagnosis and Treatment of Leukodystrophies)Buzzi Children's HospitalMilano 20154Italy Department of Biosciences Biotechnologies and EnvironmentUniversityof Bari"AldoMoro"Bari 70125Italy Institute of Biomembranes Bioenergetics and Molecular Biotechnologies(IBIOM)National Research Council(CNR)Bari 70126Italy Biostructures and Biosystems National Institute(INBB) Rome00136Italy Institute of Biochemistry and Cell Biology IBBC-CNRCampus Adriano Buzzati TraversoRome 00015Italy

Aicardi-Goutieres syndrome(AGS)is a systemic inflammatory disorder caused by mutations in any one of the nine different genes,whose deficiency provokes a type I(interferon)IFN response probably central to pathogenesis.^(1) ADAR1,one of the genes mutated in AGS(AGS6),encodes for an enzyme that belongs to the ADAR family(ADAR1,ADAR2,and ADAR3)that catalyzes the conversion of adenosine to inosine within double-stranded RNAs(dsRNAs)(RNA editing A-to-1).

关键词： ADAR1 interferon res

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Key challenges of post-liver transplant weight management

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World Journal of Transplantation 2024年第4期14卷 29-37页

作者： Maja Cigrovski Berkovic ViborŠeša Ivan Balen Quirino Lai Hrvoje Silovski Anna Mrzljak Department for Sport and Exercise Medicine University of ZagrebFaculty of KinesiologyZagreb 10000Croatia Department of Gastroenterology and Hepatology University Hospital Centre ZagrebZagreb 10000Croatia Department of Gastroenterology and Endocrinology General Hospital“Dr.Josip Bencevic”Slavonski Brod 35000Croatia General Surgery and Organ Transplantation Unit Department of SurgerySapienza University of RomeRome 00018Italy Department of Hepatobiliary Surgery and Transplantation University Hospital Center ZagrebZagreb 10000Croatia Department of Medicine University of ZagrebSchool of MedicineZagreb 10000Croatia

Liver transplantation serves as a life-saving intervention for patients with endstage liver disease,yet long-term survival remains a ***-liver transplant obesity seems to have a significant contribution to this challenge and it emerges as a significant risk factor for graft steatosis,metabolic syndrome and denovo malignancy *** review synthesizes current literature on prevalence,risk factors and management strategies for post-liver transplant obesity,emphasizing its impact on graft and patient *** review consultation was conducted in Medline/PubMed,SciELO and EMBASE,with the combination of the following keywords:Weight management,liver transplantation,immunosuppressive therapy,lifestyle interventions,bariatric *** therapy has a significant influence on long-term survival of liver transplant patients,yet it seems to have lesser effect on post-transplant obesity development than previously ***,it significantly contributes to the development of other components of metabolic *** predisposing factors for post-transplant obesity development encompass elevated recipient and donor body mass index,a history of alcoholic liver disease,hepatocellular carcinoma,male gender,the absence of cellular rejection and the marital status of the *** immunosuppressive regimens,pharmacotherapy,lifestyle interventions and bariatric surgery represent key components in mitigating post-transplant obesity and improving long-term survival and quality of life in this group of *** identification and intervention thus hold paramount *** research is warranted to refine optimal management strategies and enhance outcomes in this patient population.

关键词： Weight management Liver transplantation Immunosuppressive therapy Lifestyle interventions Bariatric surgery

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A General Approach to L(h,k)-Label Interconnection Networks

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Journal of Computer Science & Technology 2008年第4期23卷 652-659页

作者： Tiziana Calamoneri Saverio Caminiti Rossella Petreschi Department of Computer Science Sapienza University of Rome

Given two non-negative integers h and k, an L（h, k）-labeling of a graph G = （V, E） is a function from the set V to a set of colors, such that adjacent nodes take colors at distance at least h, and nodes at distance 2 take colors at distance at least k. The aim of the L（h, k）-labeling problem is to minimize the greatest used color. Since the decisional version of this problem is NP-complete, it is important to investigate particular classes of graphs for which the problem can be efficiently solved. It is well known that the most common interconnection topologies, such as Butterfly-like, Beneg, CCC, Trivalent Cayley networks, are all characterized by a similar structure： they have nodes organized as a matrix and connections are divided into layers. So we naturally introduce a new class of graphs, called （l × n）-multistage graphs, containing the most common interconnection topologies, on which we study the L（h, k）-labeling. A general algorithm for L（h, k）-labeling these graphs is presented, and from this method an efficient L（2, 1）-labeling for Butterfly and CCC networks is derived. Finally we describe a possible generalization of our approach.

关键词： multistage interconnection network L(h k)-labeling channel assignment problem

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Human semen hyperviscosity： prevalence, pathogenesis and therapeutic aspects

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Asian Journal of Andrology 2009年第5期11卷 609-615,I0004页

作者： Jlenia Elia[意大利] Michele Delfino[意大利] Norina Imbrogno[意大利] Francesca Capogreco[意大利] Marco Lucarelli[意大利] Tiziana Rossi[意大利] Fernando Mazzilli[意大利] Department of Medical Physiopathology University of Rome Sapienza Rome 00189 Italy Department of Cellular Biotechnologies and Hematology University of Rome Sapienza Rome 00189 Italy

The aims of this study were （a） to determine the prevalence of subjects with semen hyperviscosity （SHV） in a large population of male partners of subfertile couples; （b） to identify any correlation between SHV and infections or inflammation of the genital tract; （c） to assess the effects of therapeutic approaches for treating SHV; and （d） to assess sperm kinetic parameters after successful treatment of SHV. A retrospective study of 1 833 male partners of subfertile couples was conducted. Next, clinical, seminal, bacteriological and ultrasound studies involving 52 subjects suffering from SHV were performed, and the SHV was classified as being mild （length of thread 〉 2 cm and ≤4 cm）, moderate （〉 4 cm and ≤ 6 cm） or severe （〉 6 cm）. The prevalence of SHV was observed in 26.2% （480） of the subjects, with 13.2% suffering from mild, 6.6% from moderate and 6.4% from severe SHV. Treatment was completely successful in only 27 subjects （52.0%）, primarily in those who had mild basal SHV with a positive semen culture. In these subjects, progressive motility percentage, straight line velocity and linearity were significantly higher than pre-treatment levels. SHV is often found in subjects with subfertility. Pathogenesis was strictly related to infective/inflammatory factors in only 48.0% of cases; therefore, it is possible that biochemical, enzymatic or genetic factors have a role in this condition.

关键词： genital tract infection genital tract inflammation genital tract ultrasound semen culture semen hyperviscosity (SHV) sperm motility

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Calcium-sensitive protein MLC1 as a possible modulator of the astrocyte functional state

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Neural Regeneration Research 2025年第7期20卷 2008-2010页

作者： Elena Ambrosini Angela Lanciotti Maria Stefania Brignone Department of Neuroscience Istituto Superiore di SanitàRomeItaly

Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental stage to adult *** maintain the optimal functionality of the brain,astroglial cells are particularly committed to reacting to every change in tissue homeostatic conditions,from mild modifications of the physiological environment,a process called astrocyte activation,to the more severe alterations occurring in pathological situations causing astrocyte reactivity or reactive astrogliosis(Escartin et al.,2021).During these reactive states,astrocytes mount an active,progressive response encompassing morphological,molecular,and interactional remodeling,leading to the acquisition of new functions and the loss of others,whose intensity,duration,and reversibility are dependent on the nature of the stimulus and regulated in a context-specific manner.

关键词： alterations modulator maintain

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Human bocavirus in children hospitalized for acute respiratory tract infection in rome

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World Journal of Pediatrics 2020年第3期16卷 293-298页

作者： Laura Petrarca Raffaella Nenna Antonella Frassanito Alessandra Pierangeli Greta Di Mattia Carolina Scagnolari Fabio Midulla Maternal-Infantile and Urological Science Department "Sapienza"University of RomeRomeItaly Virology Laboratory Department of Molecular Medicine"Sapienza"University of RomeRomeItaly

Background The role of human bocavirus (HBoV) as a respiratory pathogen has not been fulfilled *** aimed to describe clinical and serological characteristics of children with HBoV hospitalized for acute respiratory tract infection and to evaluate whether differences occur between HBoV alone and in *** We retrospectively reviewed data from 60 children (median age of 6.2 months,range 0.6-70.9) hospitalized for acute respiratory symptoms,with HBoV detected from a respiratory sample,using a reverse transcriptase-PCR for 14 respiratory viruses (including respiratory syncytial virus (RSV),influenza virus A and B,human coronavirus OC43,229E,NL-63 and HUK1,adenovirus,rhinovirus,parainfluenza virus 1-3,and human metapneumovirus).Results HBoV was detected alone in 29 (48.3%) patients,while in co-infection with other viruses in 31 patients (51.7%),with a peak between December and *** the 60 patients,34 were bronchiolitis,19 wheezing,3 pneumonia,2 upper respiratory tract infection,and 2 whooping *** children (11.6%) required admission to the paediatric intensive care unit (PICU) for respiratory *** differences was observed in age,family history for atopy and/or asthma,clinical presentations,chest X-ray,or laboratory findings in children with HBoV alone *** viral *** was the most frequently co-detected virus (61.3%).When compared with HBoV detection alone,the co-detection of RSV and HBoV was associated with male sex (P=0.013),younger age (P=0.01),and lower blood neutrophil count (P=0.032).Conclusions HBoV can be detected alone and in co-infection respiratory samples of children with an acute respiratory tract infection.A cause-effect relationship between HBoV and respiratory infection is not clear,so further studies are needed to clarify this point.

关键词： Human bocavirus Pediatrics Respiratory tract infection Viral infection

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ABCB1 and ABCB19 auxin transporters have synergistic effects on early and late Arabidopsis anther development

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Journal of Integrative Plant Biology 2015年第12期57卷 1089-1098页

作者： Valentina Cecchetti Patrizia Brunetti Nadia Napoli Laura Fattorini Maria Maddalena Altamura Paolo Costantino Maura Cardarelli IBPM-CNR Institute of Molecular Biology and Pathology National Research Council Sapienza University of Rome Department of Biology and Biotechnology Sapienza University of Rome Department of Environmental Biology Sapienza University of Rome

Arabidopsis abcbl abcb19 double mutants defective in the auxin transporters ABCB1/PGP1 and ABCB19/PGP19 are altered in stamen elongation, anther dehiscence and pollen maturation. To assess the contribution of these transporters to stamen development we performed phenotypic, histological analyses, and in situ hybridizations on abcbl and abcbl9 single mutant flowers. We found that pollen maturation and anther dehiscence are precocious in the abcbl but not in the abcb19 mutant. Accordingly, endothecium ligniflcation is altered only in abcbl anthers. Both abcbl and abcb1 abcb19 stamens also show altered early development, with asynchronous anther Iocules and a multilayer tapetum. DAPI staining showed that the timing of meiosis is asynchronous in abcbl abcb19 anther Iocules, while only a small percentage of pollen grains are non- viable according to Alexander＇s staining. In agreement, TAM （TARDY ASYNCHRONOUS MEIOSIS）, as well as BAM2 （BARELY ANY MERISTEM）involved in tapetal cell development--areoverexpressed in abcbl abcb19 young flower buds. Corre- spondingly, ABCB1 and ABCB19 mRNA localization supports the observed phenotypes of abcbl and abcbl abcb19 mutant anthers. In conclusion, we provide evidence that auxin transport plays a significant role both in early and late stamen development： ABCB1 plays a major role during anther development, while ABCB19 has a synergistic role.

关键词： Anther development Arabidopsis auxin transport endothecium lignification tapetum differentiation

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