Key challenges of post-liver transplant weight management
作者机构：Department for Sport and Exercise MedicineUniversity of ZagrebFaculty of KinesiologyZagreb 10000Croatia Department of Gastroenterology and HepatologyUniversity Hospital Centre ZagrebZagreb 10000Croatia Department of Gastroenterology and EndocrinologyGeneral Hospital“Dr.Josip Bencevic”Slavonski Brod 35000Croatia General Surgery and Organ Transplantation UnitDepartment of SurgerySapienza University of RomeRome 00018Italy Department of Hepatobiliary Surgery and TransplantationUniversity Hospital Center ZagrebZagreb 10000Croatia Department of MedicineUniversity of ZagrebSchool of MedicineZagreb 10000Croatia
出 版 物：《World Journal of Transplantation》 (世界移植杂志)
年 卷 期：2024年第14卷第4期
页 面：29-37页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Weight management Liver transplantation Immunosuppressive therapy Lifestyle interventions Bariatric surgery
摘 要：Liver transplantation serves as a life-saving intervention for patients with endstage liver disease,yet long-term survival remains a ***-liver transplant obesity seems to have a significant contribution to this challenge and it emerges as a significant risk factor for graft steatosis,metabolic syndrome and denovo malignancy *** review synthesizes current literature on prevalence,risk factors and management strategies for post-liver transplant obesity,emphasizing its impact on graft and patient *** review consultation was conducted in Medline/PubMed,SciELO and EMBASE,with the combination of the following keywords:Weight management,liver transplantation,immunosuppressive therapy,lifestyle interventions,bariatric *** therapy has a significant influence on long-term survival of liver transplant patients,yet it seems to have lesser effect on post-transplant obesity development than previously ***,it significantly contributes to the development of other components of metabolic *** predisposing factors for post-transplant obesity development encompass elevated recipient and donor body mass index,a history of alcoholic liver disease,hepatocellular carcinoma,male gender,the absence of cellular rejection and the marital status of the *** immunosuppressive regimens,pharmacotherapy,lifestyle interventions and bariatric surgery represent key components in mitigating post-transplant obesity and improving long-term survival and quality of life in this group of *** identification and intervention thus hold paramount *** research is warranted to refine optimal management strategies and enhance outcomes in this patient population.
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