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New frontiers in retinal transplantation

World Journal of Transplantation 2024年第4期14卷 67-77页

作者： Francesco Saverio Sorrentino Patrick Di Terlizzi Francesco De Rosa Carlo Salati Leopoldo Spadea Caterina Gagliano Mutali Musa Marco Zeppieri Department of Surgical Sciences Unit of OphthalmologyOspedale MaggioreBologna 40100Italy Department of Oncology IRCCS Istituto Romagnolo per lo Studio dei Tumori“Dino Amadori”Meldola 47014Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I"Sapienza"University of RomeRome 00142Italy Department of Medicine and Surgery University of Enna"Kore"Enna 94100Italy Eye Clinic Catania University San Marco HospitalCatania 95121Italy Department of Optometry University of BeninBenin 300283Nigeria Department of Ophthalmology Centre for Sight AfricaNkporOnitsha 434112Nigeria

New frontiers about retinal cell transplantation for retinal degenerative diseases start from the idea that acting on stem cells can help regenerate retinal layers and establish new synapses among retinal *** or alterations of synaptic input and neurotrophic factors result in trans-neuronal degeneration of the inner retinal ***,the disruption of photoreceptors takes ***,even in advanced forms of retinal degeneration,a good percentage of the ganglion cells and the inner nuclear layer neurons remain *** phenomenon provides evidence for obtaining retinal circuitry through the transplantation of photoreceptors into the subretinal *** eye is regarded as an optimal organ for cell transplantation because of its immunological privilege and the relatively small number of cells collaborating to carry out visual *** eyeball's immunological privilege,characterized by the suppression of delayed-type hypersensitivity responses in ocular tissues,is responsible for the low rate of graft rejection in transplant *** main discoveries highlight the capacity of embryonic stem cells(ESCs)and induced pluripotent stem cells to regenerate damaged retinal *** progress has shown significant enhancements in transplant procedures and *** research also explores the ethical ramifications linked to the utilization of stem cells,emphasizing the ongoing issue surrounding *** analysis centers on recent breakthroughs,including the fabrication of three-dimensional retinal organoids and the innovation of scaffolding for cell ***,researchers are currently assessing the possibility of CRISPR and other advanced gene editing technologies to enhance the outcomes of retinal *** widespread use of universally recognized safe surgical and imaging methods enables retinal transplantation and monitoring of transplanted cell growth toward the correct ***,most therapy approaches

关键词： Retinal transplantation Retinal stem cell Human embryonic stem cells Pluripotent stem cells Retinal tissue transplant

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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1506-1517页

作者： Nicola Pescosolido Andrea Barbato Rossella Giannotti Chiara Komaiha Fiammetta Lenarduzzi Department of Cardiovascular RespiratoryNephrologicAnesthesiologic and Geriatric SciencesSapienza University of Rome Department of Sense Organs Sapienza University of Rome

The crystalline lens is a transparent,biconvex structure in the eye that,along with the cornea,helps to refract light to be focused on the retina and,by changing shape,it adjusts focal distance（accommodation）.The three classes of structural proteins found in the lens areα,β,and γ *** proteins make up more than 90% of the total dry mass of the eye *** components which can be found are sugars,lipids,water,several antioxidants and low weight *** ageing changes occur in the lens,it causes a gradual reduction in transparency,presbyopia and an increase in the scattering and aberration of light waves as well as a degradation of the optical quality of the *** main changes that occur with aging are： 1） reduced diffusion of water from the outside to the inside of the lens and from its cortical to its nuclear zone; 2）crystalline change due to the accumulation of high molecular weight aggregates and insoluble proteins; 3）production of advanced glycation end products（AGEs）,lipid accumulation,reduction of reduced glutathione content and destruction of ascorbic *** if effective strategies in preventing cataract onset are not already known,good results have been reached in some cases with oral administration of antioxidant substances such as caffeine,pyruvic acid,epigallocatechin gallate（EGCG）,α-lipoic acid and ascorbic ***,methionine sulfoxide reductase A（MSRA） over expression could protect lens cells both in presence and in absence of oxidative stress-induced ***,promising results have been obtained by reducing ultraviolet-induced oxidative damage.

关键词： antioxidants cataract crystalline eye lens kynurenines ultraviolet radiations

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Numerical Model for the Characterization of Retro-reflective Materials Behavior in an Urban Street Canyon

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Journal of Thermal Science 2018年第5期27卷 456-462页

作者： VALLATI Andrea MAURI Luca COLUCCI Chiara DE LIETO VOLLARO Roberto Department of DIAEE Sapienza University of Rome Department of Mechanical Engineering University of Roma Tre

In this work, a preliminary numerical model of the behavior of retro-reflective materials used as envelope coatings on street canyon buildings facades has been tested. Retro-reflective materials have a surface finish that allows to reflect the solar radiation back in the same direction of the incident radiation. In the last years this kind of materials has been studied as buildings envelope coating for their potentials in the reduction of the UHI effect. As a matter of fact, the angular dependence of their optical-radiative response would help to mitigate the phenomenon of radiative entrapment due to the urban fabric environment. For this reason, an urban canyon was selected as the most common urban architecture to perform the analysis. A virtual retroreflective material has been simulated considering its response as almost diffusive but in the same direction of the incident radiation. The assessment of the energy advantages of the adoption of a virtual retro-reflective material as envelope coating is investigated by means of a numerical model developed in MATLAB and based on the Gebhart factors theory. The final purpose of the numerical model is the evaluation of the surfaces solar loads by a comparison between perfectly diffusive materials and RR materials used as fa？ades coating.

关键词： retro-reflective materials numerical model Gebhart factors radiative trapping urban street canyon

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Full recycling of spent lithium ion batteries with production of core-shell nanowires//exfoliated graphite asymmetric supercapacitor

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Journal of Energy Chemistry 2021年第7期30卷 336-344页

作者： Pier Giorgio Schiavi Pietro Altimari Robertino Zanoni Francesca Pagnanelli Department of Chemistry Sapienza University of RomePiazzale Aldo Moro n.500185 RomeItaly

A novel process is reported which produces an asymmetric supercapacitor through the complete recycling of end-of-life lithium ion *** electrodic powder recovered by industrial scale mechanical treatment of spent batteries was leached and the dissolved metals were precipitated as mixed metals *** battery-type positive electrodes were produced by electrodeposition into nanoporous alumina templates from the electrolytic baths prepared by dissolution of the precipitated *** impact of the different metals contained in the electrodic powder was evaluated by benchmarking the electrochemical performances of the recovered nanowires-based electrodes against electrodes produced by using high-purity *** of inactive Cu in the nanowires lowered the final capacitance of the electrodes while Ni showed a synergistic effect with cobalt providing a higher capacitance with respect to synthetic Co *** carbonaceous solid recovered after leaching was indepth characterized and tested as negative *** the chemical and electrochemical characterization indicate that the recovered graphite is characterized by the presence of oxygen functionalities introduced by the leaching *** has led to the obtainment of a recovered graphite characterized by an XPS C/O ratio,Raman spectrum and morphology close to literature reports for reduced graphene *** asymmetric supercapacitor assembled using the recovered nanowires-based positive electrodes and graphite as negative electrodes has shown a specific capacitance of 42 F g^(-1), computed including the whole weight of the positive electrode and recovered graphite,providing a maximum energy density of ~9 Wh kg^(-1) and a power density of 416 W kg^(-1) at 2.5 mA cm^(-2).

关键词： Lithium ion battery recyling Core-shell nanowires Supercapacitors Closed-loop recycling process

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Evaluating Pharmacological and Rehabilitation Strategies for Effective Management of Bipolar Disorder: A Comprehensive Clinical Study

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Advances in Bioscience and Biotechnology 2024年第7期15卷 406-431页

作者： Rocco de Filippis Abdullah Al Foysal Department of Neuroscience Institute of Psychopathology Rome Italy Department of Computer Engineering (AI) University of Genova Genova Italy

Bipolar disorder presents significant challenges in clinical management, characterized by recurrent episodes of depression and mania often accompanied by impairment in functioning. This study investigates the efficacy of pharmacological interventions and rehabilitation strategies to improve patient outcomes and quality of life. Utilizing a randomized controlled trial with multiple treatment arms, participants will receive pharmacotherapy, polypharmacotherapy, rehabilitation interventions, or combination treatments. Outcome measures will be assessed using standardized scales, including the Hamilton Depression Scale, Yale-Brown Obsessive Compulsive Scale (Y-BOCS), and Mania Scale. Preliminary data suggest improvements in symptom severity and functional outcomes with combination treatments. This research aims to inform clinical practice, guide treatment decisions, and ultimately enhance the quality of care for individuals living with bipolar disorder. Findings will be disseminated through peer-reviewed journals and scientific conferences to advance knowledge in this field.

关键词： Bipolar Disorder (BD) Pharmacotherapy (PT) Rehabilitation Interventions (RI) Hamilton Depression Scale (HAM-D) Yale-Brown Obsessive Compulsive Scale (Y-BOCS) Mania Scale (MS) Machine learning (ML) and Artificial Intelligence (AI).

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Paleontology and evolution-part II

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Integrative Zoology 2014年第4期9卷 379-382页

作者： Maria Rita PALOMBO Department of Earth Sciences sapienza university of rome rome Italy

Explaining the history of life through geological deep time is undoubtedly a fascinating and challenging task that intrigued scientists even before the inception of Darwin’s *** fossil record,bearing witness to the changing of life and the continuous origination of new organisms in the course of time,on one hand represents the primary evidence for evolution,and on the other provides hints for deciphering dynamic processes and factors shaping the long,multifaceted evolutionary history of the *** at the past,therefore,is of crucial importance in the never-ending cognitive process of deciphering the way we came to be here.

关键词： doubt plain Biosphere

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Consequences of Helicobacter pylori infection in children

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World Journal of Gastroenterology 2010年第41期16卷 5181-5194页

作者： Lucia Pacifico Caterina Anania John F Osborn Flavia Ferraro Claudio Chiesa Department of Pediatrics Sapienza University of Rome 324 I-00161 Rome Italy Department of Public Health Sciences Sapienza University of Rome I-00185 Rome Italy Department of Molecular Medicine National Research Council I-00133 Rome Italy

Although evidence is emerging that the prevalence of Helicobacter pylori (H. pylori) is declining in all age groups, the understanding of its disease spectrum continues to evolve. If untreated, H. pylori infection is lifelong. Although H. pylori typically colonizes the hu-man stomach for many decades without adverse con-sequences, children infected with H. pylori can manifest gastrointestinal diseases. Controversy persists regarding testing (and treating) for H. pylori infection in children with recurrent abdominal pain, chronic idiopathic thrombocytopenia, and poor growth. There is evidence of the role of H. pylori in childhood iron deficiency anemia, but the results are not conclusive. The possibility of an inverse relationship between H. pylori and gastroesophageal reflux disease, as well as childhood asthma, remains a controversial question. A better understanding of the H. pylori disease spectrum in childhood should lead to clearer recommendations about testing for and treating H. pylori infection in children who are more likely to develop clinical sequelae.

关键词： Helicobacter pylori Children Gastrointestinal diseases Epigastric pain Anemia Growth retardation Chronic idiopathic thrombocytopenic pupura

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Insights from human sleep research on neural mechanisms of Alzheimer’s disease

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Neural Regeneration Research 2020年第7期15卷 1251-1252页

作者： Susanna Cordone Luigi De Gennaro Department of Psychology University of Rome"Sapienza"RomeItaly IRCCS Fondazione Santa Lucia RomeItaly

Alzheimer's disease(AD)is considered as the major cause of dementia and affects about 50 million people in world population,with an expected increase of 27%in the coming decades,as reported by the most recent AD *** fast-growing empirical evidence is highlighting the close relationship between sleep and AD since the preclinical stage of the disease,pointing to an important role of sleep in the occurrence and progression of AD.

关键词： sleep Alzheimer clinical

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Is colonoscopy sufficient for colorectal cancer surveillance in all HNPCC patients?

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World Journal of Gastroenterology 2005年第47期11卷 7541-7544页

作者： Vito D Corleto Ermira Zykaj Paolo Mercantini Emanuela Pilozzi Michele Rossi Antonella Carnuccio Emilio Di Giulio Vincenzo Ziparo Gianfranco Delle Fave Department of Digestive and Liver Diseases Ⅱ School of MedicineUniversity "La Sapienza"RomeItaly Department of Digestive and Liver Diseases Ⅱ School of MedicineUniversity "La Sapienza"Centro Ricerche S.Pietro FBFRomeItaly Department of Surgery Ⅱ School of MedicineUniversity "La Sapienza"RomeItaly Department of Pathology Ⅱ School of MedicineUniversity "La Sapienza"RomeItaly Department of Radiology Ⅱ School of MedicineUniversity "La Sapienza"RomeItaly

A 34-year-old male with hereditary non-polyposis colon cancer with a mutation in hMSH2 line is reported. Despite regular colonoscopic follow-up, he developed cecal cancer involving the extraluminal area. Due to sub-occlusive symptoms, the patient was submitted to further colonoscopy, however with no clear evidence of neoplasia. Thin slice multiplanar reconstruction computed tomography CT scan performed thereafter revealed a transmural mass 2.5 cm in size localized near the cecal valve. Discussion is made on the reliability of colonoscopic examinations as well as the need for further investigations in the follow-up of patients at very high risk of right-sided colon cancer, such as male hMSH2 carrier affected by hereditary non-polyposis colon cancer.

关键词： Hereditary non-polyposis colon cancer Spiral CT scan Colonoscopy hMSH2 carrier

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How useful are biomarkers for the diagnosis of Alzheimer’s disease and especially for its therapy?

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Neural Regeneration Research 2022年第10期17卷 2205-2207页

作者： Marta Valenza Caterina Scuderi Department of Physiology and Pharmacology“V.Erspamer” SAPIENZA University of RomeRomeItaly

Alzheimer’s disease key facts:Alzheimer’s disease(AD)is a slowly progressive neurodegenerative disease with no available effective *** is possible to distinguish an early-onset AD that affects a limited number of subjects of young age,and a sporadic or late-onset form of the disease that affects the vast majority of subjects who are diagnosed with *** life expectancy has increased considerably over the past century,the number of people diagnosed with AD has grown ***,AD and AD-related pathologies represent a huge social and economic *** number of individuals waiting for effective disease-modifying therapy is *** is estimated that 50 million people worldwide live with dementia,the majority of these cases are caused by AD(World Health Organization,2021).In the US about 6 million individuals are living with AD,and more than 9 million people are in EU member states(OECD and European Union,2020).The costs of health care and long-term care are *** this massive societal impact,enormous efforts have been made to understand the pathogenetic mechanisms of the disease with the hope of identifying new targets and,therefore,developing effective drugs.

关键词： Alzheimer diagnosis slowly

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