Is colonoscopy sufficient for colorectal cancer surveillance in all HNPCC patients?

作     者：Vito D Corleto Ermira Zykaj Paolo Mercantini Emanuela Pilozzi Michele Rossi Antonella Carnuccio Emilio Di Giulio Vincenzo Ziparo Gianfranco Delle Fave 

作者机构：Department of Digestive and Liver DiseasesⅡ School of MedicineUniversity "La Sapienza"RomeItaly Department of Digestive and Liver DiseasesⅡ School of MedicineUniversity "La Sapienza"Centro Ricerche S.Pietro FBFRomeItaly Department of SurgeryⅡ School of MedicineUniversity "La Sapienza"RomeItaly Department of PathologyⅡ School of MedicineUniversity "La Sapienza"RomeItaly Department of RadiologyⅡ School of MedicineUniversity "La Sapienza"RomeItaly 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2005年第11卷第47期

页      面：7541-7544页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by Ricerche Ateneo 2004 n.C26A044873 University "La Sapienza" Rome and PRIN 2003 n.2003063877_002 

主　　题：Hereditary non-polyposis colon cancer Spiral CT scan Colonoscopy hMSH2 carrier 

摘      要：A 34-year-old male with hereditary non-polyposis colon cancer with a mutation in hMSH2 line is reported. Despite regular colonoscopic follow-up, he developed cecal cancer involving the extraluminal area. Due to sub-occlusive symptoms, the patient was submitted to further colonoscopy, however with no clear evidence of neoplasia. Thin slice multiplanar reconstruction computed tomography CT scan performed thereafter revealed a transmural mass 2.5 cm in size localized near the cecal valve. Discussion is made on the reliability of colonoscopic examinations as well as the need for further investigations in the follow-up of patients at very high risk of right-sided colon cancer, such as male hMSH2 carrier affected by hereditary non-polyposis colon cancer.