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Effect of Low-Dose Vitamin D Supplementation on Serum 25(OH)D in School Children and white-collar workers

Effect of Low-Dose Vitamin D Supplementation on Serum 25(OH)...

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2017浙江省营养学会年会暨西湖营养学术论坛

作者： Ronghua Zhang Xiamusiye Muyiduli Danting Su Biao Zhou Yueqiang Fang Shuying Jiang Shuojia Wang Lichun Huang Minjia Mo Minchao Li Bule Shao Yunxian Yu Zhejiang Provincial Center for Disease Control and Prevention Department of Epidemiology & Health Statistics School of Public HealthSchool of MedicineZhejiang University

Objective:Our study aimed to investigate the nutritional vitamin D status of school children aged 9-15 years and white-collar workers in Zhejiang province,and evaluate the efficacy of low-dose-oral vitamin D supplementation in both ***:We conducted a prospective controlled trial during March 2014 to November 2015,comparing the efficacy of vitamin D supplements(400 IU/day)with non-intervention for 18 months in school children aged 9-15 ***,a before-after study was conducted among white-collar workers for 1 *** 25(OH)D concentration was measured at baseline and after vitamin D supplementation,***:At the baseline,95%of school children and 84%of adult participants had vitamin D deficiency(white-collar workers were 12.77 ± 3.01 ng/mL,14.17 ± 3.59 ng/mL and 16.58 ± 3.66 ng/mL at baseline and increased to 17.34 ± 3.78 ng/mL,18.04 ± 4.01 ng/mL and 17.75 ± 5.36 ng/mL after vitamin D supplementation,***,after adjusting for potential confounders,the 400 IU oral vitamin D supplementation increased serum 25(OH)D concentration in school children(β = 0.81,p = 0.0426) as well as in white-collar workers(p = 0.0839),the prevalence of vitamin D deficiency was still very high among school children(79.23%in intervention group and 72.38%in control group) and white-collar workers(76.00%).Conclusions:High prevalence of vitamin D deficiency was common in these two study *** doses of 400 IU oral vitamin D supplementation was not able to adequately increase serum 25(OH)D concentrations.A suitable recommendation regarding the level of vitamin D supplementation is required for this Chinese population.

关键词： serum 25(OH)D vitamin D supplementation school children white-collar workers

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