Effect of Low-Dose Vitamin D Supplementation on Serum 25(OH)D in School Children and White-Collar Workers
作者单位：Zhejiang Provincial Center for Disease Control and Prevention Department of Epidemiology & Health StatisticsSchool of Public HealthSchool of MedicineZhejiang University
会议名称：《2017浙江省营养学会年会暨西湖营养学术论坛》
会议日期：2017年
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100403[医学-营养与食品卫生学] 10[医学]
关 键 词：serum 25(OH)D vitamin D supplementation school children white-collar workers
摘 要：Objective:Our study aimed to investigate the nutritional vitamin D status of school children aged 9-15 years and white-collar workers in Zhejiang province,and evaluate the efficacy of low-dose-oral vitamin D supplementation in both ***:We conducted a prospective controlled trial during March 2014 to November 2015,comparing the efficacy of vitamin D supplements(400 IU/day)with non-intervention for 18 months in school children aged 9-15 ***,a before-after study was conducted among white-collar workers for 1 *** 25(OH)D concentration was measured at baseline and after vitamin D supplementation,***:At the baseline,95%of school children and 84%of adult participants had vitamin D deficiency(20 ng/mL).In school children,no difference was observed between the intervention and control groups with regard to anthropometric *** 25(OH)D concentrations of the school children intervention group,school children control group and white-collar workers were 12.77 ± 3.01 ng/mL,14.17 ± 3.59 ng/mL and 16.58 ± 3.66 ng/mL at baseline and increased to 17.34 ± 3.78 ng/mL,18.04 ± 4.01 ng/mL and 17.75 ± 5.36 ng/mL after vitamin D supplementation,***,after adjusting for potential confounders,the 400 IU oral vitamin D supplementation increased serum 25(OH)D concentration in school children(β = 0.81,p = 0.0426) as well as in white-collar workers(p = 0.0839),the prevalence of vitamin D deficiency was still very high among school children(79.23%in intervention group and 72.38%in control group) and white-collar workers(76.00%).Conclusions:High prevalence of vitamin D deficiency was common in these two study *** doses of 400 IU oral vitamin D supplementation was not able to adequately increase serum 25(OH)D concentrations.A suitable recommendation regarding the level of vitamin D supplementation is required for this Chinese population.