检索结果-南通市图书馆

Efficacy and safety of local candida immunotherapy in recalcitrant warts in pediatric kidney transplantation:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Transplantation 2023年第4期13卷 201-207页

作者： Ratna Acharya Rachel Bush Felicia Johns Kiran Upadhyay Department of Pediatrics University of FloridaGainesvilleFL 32610United States Department of Pediatric Nephrology University of FloridaGainesvilleFL 32610United States

BACKGROUND warts are common in recipients of kidney transplantation(KT).Resistant warts which are not amenable to conventional therapies may lead to significant *** data exists on safety and efficacy of local immunotherapy among immunocompromised KT *** SUMMARY We report a seven-year-old child who presented with recalcitrant plantar periungual warts in the early KT *** consisted of tacrolimus,mycophenolate and *** to failure of conventional anti-wart therapies,he was treated with two sessions of intralesional(IL)candida immunotherapy along with liquid nitrogen cryotherapy leading to complete resolution of the ***,de novo BK viremia was seen about three weeks following the last candida *** required reduction of immunosuppression and other anti-BK viral *** function remained stable but there were donor specific antibodies *** also was elevated level of plasma donor derived cell-free DNA.A pneumocystis jirovecii pneumonia occurred ten months following completion of immunotherapy that was successfully treated with *** this ten-month follow-up period,there have been no recurrence of warts,and transplant kidney function has remained *** Stimulation of cell-mediated immunity against the human papilloma virus induced by the IL candida immunotherapy is thought to be a cause for wart *** this therapy,whether it is necessary to augment the immunosuppression to prevent rejection is unclear as that may come with a risk of infectious ***,prospective studies in pediatric KT recipients are needed to explore these important issues.

关键词： warts Kidney transplantation Candida Immunotherapy Pediatric Case report

Managing Recalcitrant warts: Facts about Bacillus Calmette-Guerin (BCG), Mycobacterium Indicus Pranii (Mw Vaccine), and Purified Protein Derivative (PPD) as Immunotherapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cosmetics, Dermatological Sciences and Applications 2018年第4期8卷 218-235页

作者： Nabeel K. Al Hamzawi Mais H. Abdallah Department of Dermatology Diwaniyah Teaching Hospital Diwaniyah Iraq

Recalcitrant warts can accurately be defined as warts that persist after six months of conventional therapy. Up to one-third of non-genital warts, especially periungual and plantar warts, become recalcitrant. Traditional treatment options for warts include topical salicylic acid, cryotherapy, and electrocautery;however, patients with recalcitrant warts remain a major therapeutic challenge. There is evidence that immunotherapy can clear recalcitrant warts if traditional treatment fails. Given this, clinical studies published in PubMed and Google Scholar that used Bacillus Calmette-Guerin (BCG), Mycobacterium Indicus Pranii (Mw vaccine), and purified protein derivative (PPD) as immunotherapy for wart, were reviewed in this study. Neither of these treatments has been subjected to a randomized controlled trial, thus to date, there are no standardized protocols to use them. Our review highlights the scientific facts in the clinical applications of the previous options to treat recalcitrant warts and investigate the differences among them, concerning efficacy, adverse effects, dosage, and route of administration.

关键词： Recalcitrant warts BCG Vaccine Mycobacterium W Vaccine PPD (Purified Protein Derivative)

Genital warts in Infants and Children <br>—Re-Evaluation of Podophylline 15% as an Effective Topical Therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cosmetics, Dermatological Sciences and Applications 2014年第4期4卷 259-267页

作者： Khalifa E. Sharquie Adil A. Noaimi Mohammed N. Almallah Department of Dermatology and Venereology Baghdad Teaching Hospital Baghdad Iraq Department of Dermatology College of Medicine University of Baghdad Baghdad Iraq

Background: Condylomataacuminata is an infection caused by Human Papilloma Virus, rarely reported in infants and children. Podophylline as a treatment for this condition has been used cautiously in this age group. Objective: To report the cases of anogenital warts including condy lomataacuminata in infants and children and to evaluate the effectiveness and side effects of 15% podophyllin in treatment of genital warts. Patient and Methods: Thirty infants and young children were seen in Department of Dermatology and Venereology—Baghdad Teaching Hospital in this case descriptive and therapeutic trial, in the period from January 2011 to August 2012. Their ages ranged from 8 - 72 (30.43 ± 15.85) months, 20 females and 10 males with a female:male ratio of 2:1. The duration of the disease ranged from 1 - 12 (5.26 ± 4.00) months. All demographics data were recorded in this study. History and examination were carried out to all patients. Family members including mothers were assessed about the presence of any type of viral warts in other location of body. Podophyllin (15%) in tincture benzoin was applied once weekly to all viral warts and the parents advised to wash out after 2 hours of application. The number of applications was repeated until full recovery. Follow-up after recovery was carried out for 6 months to watch for any relapse and to record local or systemic side effects. Results: The clinical pictures were mostly acondylomata acuminata in a form of cauliflower like warts in 20 (73.33%) patients, while in 10 (26.77%) patients there were ordinary verruca vulgaris like warts. The location of warts was perianal in 23 (76.66%) patients, genital only in 2 (6.66%) patients, and mixed in 5 (16.66%) patients. Topical applications of podophyllin 15% gave a full recovery in 27 (90%) patients, while in 3 (10%) patients there was partial response. The number of applications ranged from 1 - 4 (2.7 ± 1.42) applications. Follow up for 6 months after recovery showed relapse in onl

关键词： Genital warts in Infants and Children Podophylline Topical Therapy

Local hyperthermia cleared multiple cutaneous warts on a nephrotic syndrome patient

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Dermatology 2016年第3期5卷 125-128页

作者： Yu-Jing Zhang Rui-Qun Qi Xing-Hua Gao Department of Dermatology No. 1 Hospital of China Medical University

Cutaneous warts are caused by human papillomavirus infection. Immunosuppressive state is one of the risk factors of human papillomavirus infection. A girl diagnosed of nephrotic syndrome and on immunosuppressive therapy developed multiple common warts. We treated her on a single lesion by local hyperthermia therapy at 44 ℃ for 3 consecutive days, each therapy lasted for 30 min. Ten days later, the patient received another 2 consecutive therapy. All lesions are completely resolved at the 9th week after the treatment. No recurrent sign was observed in a 3-mo follow-up. Side effects included burning sensation, stabbing pain at the target site during treatment.

关键词： Hyperthermia warts Nephrotic syndrome Immunosuppression

Tuberculosis of the Spine (L5, S1) Secondary to Scrofuloderma with Viral warts in a 15-Year-Old Male

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Case Reports in Clinical Medicine 2018年第1期7卷 70-83页

作者： Akunnaya Chioma Ohanenye Nneka Chioma Okoronkwo Department of Paediatrics Abia State University Teaching Hospital Aba Nigeria

We report this case of a 15-year-old male who presented to the children outpatient clinic (CHOP) of Abia State University Teaching Hospital (ABSUTH), Aba on the 5th of November 2015. He had tuberculosis (TB) of the skin (scrofuloderma) which was not diagnosed and had received treatment other than anti-TB medication. He now presented 9 years after with multiple body discharging sinuses, cicatricial skin lesions, tuberculosis of the spine (L5, S1) with contracture of the Achilles Tendon and genital warts. Subsequent treatment with full anti-TB drugs led to resolution of his illness. A higher index of suspicion is required for early diagnosis of extrapulmonary TB. Prompt and adequate treatment with anti-TB medication ensures cure in such cases. Appropriate control program is also known to improve the outcome and reduce sequelae.

关键词： Tuberculosis Spine Scrofuloderma Viral warts Anti-TB Drugs ABSUTH

Treatment of Recalcitrant Viral warts with Photodynamic Therapy with Mal and Red Light

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cosmetics, Dermatological Sciences and Applications 2013年第1期3卷 117-120页

作者： Montserrat Fernández Guarino Antonio Harto Pedro Jaén Dermatology Departament Hospital Universitario Ramón y Cajal Madrid Spain

Background: Photodynamic therapy (PDT) is a treatment for non-melanoma skin cancer. In recent years, its use has expanded to new indications. Viral warts (VW) are some of the most promising. Methods: A retrospective, descriptive, observational study was carried out. Patients who did not respond to cryotherapy were selected and were occluded with methyl aminolevulinate (MAL) for three hours and they were illuminated with red light. Tolerance to treatment was evaluated using a visual analog scale for pain (from 0 to 10). Results: A total of 15 patients with 134 VW were treated. A complete response was obtained in 13 of 15 patients (87%) and in 127 of 134 lesions (95%). The mean number of sessions was 3.1 (range 1 to 6) and the average pain score was 3.1 (range 0 to 8). Conclusions: PDT is a treatment that offers good results in the treatment of VW that are resistant to routine treatment. The treatment was well tolerated in our patient group.

关键词： Photodynamic Therapy Viral warts Red Light

Perianal verrucous epidermal nevus masquerading as warts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Dermatology 2014年第1期3卷 1-3页

作者： Anupam Das Tirthankar Gayen Nilay Kanti Das Kaushik Shome Medical College and Hospital Kolkata

Verrucous epidermal naevus(VEN) is a rare form of epidermal naevus. We present a case of VEN occurring over the perianal region of a 7-year-old boy. The lesion was initially thought to be an area of chronic dermatitis; however it was refractory to treatment. Histopathology confirmed the diagnosis of VEN. VEN in the inguinogenital region may be misdiagnosed as flexural psoriasis, genital warts or sexual abuse. This is what precisely happened to our patient for a duration of more than 1 year.

关键词： Perianal Verrucous epidermal nevus warts

Huge Recalcitrant warts Treated with Pulse Dye Laser after Conventional Therapies and Others Destructive Physical Modalities Failed

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cosmetics, Dermatological Sciences and Applications 2011年第3期1卷 47-49页

作者： Nuno Menezes Paulo Varela Rita Guedes Inês Leite Armando Baptista 不详

Cutaneous infections with the human papilloma virus, despite being almost always asymptomatic, can induce slow-growing lesions knowed as warts that can remain subclinical for long periods of time. There are several therapeutical options namely keratolytics, retinoids, imiquimod, cryotherapy, electrosurgery, lasers and classic surgery, but none has antiviral effects. We describe the case of a patient with large warts located on the dorsal surface of the right hand, treated with cryotherapy, CO2 laser and topical imiquimod having either no clinical response or quick relapse. Treatment with PDL was started and after 13 sessions, the patient was without lesions, with a good cosmetic result and so far without relapse. This case report is relevant to us and deserves to be published because of the size of the lesions and the great response to PDL despite all the failures with the other treatments.

关键词： Pulse Dye laser Recalcitrant warts

Effects of a Carbonated Soft Drink on Epitheial Tumor Incidence in Drosophila melanogaster

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmacy and Pharmacology 2018年第3期6卷 240-247页

作者： Paula Marynella Alves Pereira Lima Priscila Capelari Orsoli Thaise Gongalves Araujo Douglas Brandao Cardoso Julio Cesar Nepomuceno Laboratory of Genetics and Biotechnology Institute of Biotechnology Federal University of Uberlandia Patos de Minas 38700-000 Brazil Laboratory of Cytogenetic and Mutagenesis University Center of Patos de Minas Patos de Minas 38700-000 Brazil

Diet represents an important risk factor for tumor development and numerous food dyes have been tested for their carcinogenic potential. Caramel IV colorant and its byproduct, the 4-methylimidazole （4-MI）, are part of the composition of cola soft drinks, although in undefined concentration. Considering that this concentration depends on the manufacturing place, we aimed to evaluate the potential carcinogenic activity of cola soft drinks from Brazil, Canada, Egypt and Netherlands, through the test for detection of epithelial tumor clones （warts） in somatic cells of Drosophila melanogaster. We used 72-hour larvae resulting from the crossing of wts/TM3, Sb^1 virgin females and mwh/mwh males. Larvae were exposed to the media containing the cola soft drinks for 48 hours and the analysis was performed in adults after transformation. Cola soft drinks from Brazil significantly induced epithelial tumor in D. melanogaster, while those from Canada, Egypt and Netherlands did not. In fact, the concentration of 4-MI is higher in cola soft drink commercialized in Brazil. Our results highlight the importance of investigating the toxic potential of current drinks, which may correlate with the rising incidence of malignant diseases.

关键词： Carcinogenic effect Drosophila melanogaster caramel IV warts