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vitamin b3 inhibits apoptosis and promotes autophagy of isletβcells under high glucose stress

bIOCELL 2023年第4期47卷 859-868页

作者： YU ZHANG XI’AN ZHOU CHUNYAN ZHANG DENGNI LAI DONGbO LIU YANYANG WU Key Laboratory for Food Science and biotechnology of Hunan Province College of Food Science and TechnologyHunan Agricultural UniversityChangsha410128China Horticulture and Landscape College Hunan Agricultural UniversityChangsha410128China Hunan Co-Innovation Center for Utilization of botanical Functional Ingredients Changsha410128China State Key Laboratory of Subhealth Intervention Technology Changsha410128China Hunan Agricultural Products Processing Institute Hunan Food Test and Analysis CenterChangsha410004China

background:Hyperglycemia is a typical symptom of *** glucose induces apoptosis of isletβ*** autophagy functions in cytoprotection and autophagic cell *** interaction between autophagy and apoptosis is important in the modulation of the function of isletβ*** b3 can induce autophagy and inhibit isletβ***:The mechanism of vitamin b3-mediated protective effect on the function of isletβcells was explored by the method of western blot,immunofluorescence and flow ***:In the present study,high glucose stress increased the apoptosis rate,while vitamin b3 reduced the apoptosis *** effect of vitamin b3 on autophagy flux under normal and high glucose stress was also *** b3 increased the number of autophagosomes and increased the light chain(LC)3-II/LC3-I *** contrast,vitamin b3 decreased sequestosome 1(SQSTM1)/p62 protein expression and inhibited the phosphorylation of mammalian ribosomal protein S6 kinaseβ-1(p70S6K/S6K1),which was a substrate of mammalian target of rapamycin(mTOR)under normal and high glucose *** further verify the protective effect of vitamin b3 on apoptosis,we treated isletβcell RIN-m5F with autophagy inhibitor 3-methyladenine(3-MA).vitamin b3 decreased the apoptosis rate under high glucose stress,while the inhibition of apoptosis by vitamin b3 was blocked after adding ***:Our data suggested that vitamin b3 reduced the apoptosis rate ofβcells,possibly through inducing autophagy under high glucose stress.

关键词： vitamin b3 High glucose Autophagy Apoptosis

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Impact of increasing one-carbon metabolites on traumatic brain injury outcome using pre-clinical models

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Neural Regeneration Research 2024年第8期19卷 1728-1733页

作者： Sanika M.Joshi Theresa Currier Thomas Nafisa M.Jadavji College of Osteopathic Medicine Midwestern UniversityGlendaleCAUSA Department of biomedical Sciences Midwestern UniversityGlendaleCAUSA Department of Child Health College of Medicine–PhoenixUniversity of ArizonaPhoenixAZUSA College of Veterinary Medicine Midwestern UniversityGlendaleCAUSA Department of Neuroscience Carleton UniversityOttawaCanada

Traumatic brain injury is a major cause of death and disability worldwide,affecting over 69 million individuals ***-carbon metabolism has been shown to have beneficial effects after brain damage,such as ischemic ***,whether increasing one-carbon metabolite vitamins impacts traumatic brain injury outcomes in patients requires more *** aim of this review is to evaluate how one-carbon metabolites impact outcomes after the onset of traumatic brain ***,Web of Science,and Google Scholar databases were searched for studies that examined the impact of b-vitamin supplementation on traumatic brain injury *** search terms included combinations of the following words:traumatic brain injury,dietary supplementation,one-carbon metabolism,and *** focus of each literature search was basic science *** year of publication in the literature searches was not *** analysis of the literature has shown that dietary supplementation of b-vitamins has significantly improved the functional and behavioral recove ry of animals with traumatic brain injury compared to *** r,this improvement is dosage-dependent and is contingent upon the onset of supplementation and whether there is a sustained or continuous delive ry of vitamin supplementation post-traumatic brain *** details of supplementation post-traumatic brain injury need to be further ***,we conclude that b-vitamin supplementation improves behavioral outcomes and reduces cognitive impairment post-traumatic brain injury in animal model *** investigation in a clinical setting should be stro ngly considered in co njunction with current medical treatments for traumatic brain injury-affected individuals.

关键词： folic acid nicotinamide one-carbon metabolism riboflavin traumatic brain injury vitamin b12 vitamin b2 vitamin b3

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