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Prevalence of vitamin d deficiency in exclusively breastfed infants at Charoenkrung Pracharak Hospital

World Journal of Clinical Pediatrics 2024年第1期13卷 84-92页

作者： Supawut Suksantilerd Rotchanart Thawatchai Nattapol Rungrojjananon department of Pediatrics Charoenkrung Pracharak HospitalBangkok 10120Krung Thep Maha Nakhon BangkokThailand

BACKGROUNd vitamin d deficiency is a common problem in exclusively breastfed infants,with supplementation recommended by various international medical ***,in Thailand,no advice for routine vitamin d supplementation is ***,this study investigated the prevalence of vitamin d deficiency and its associated factors in exclusively breastfed infants in Bangkok,*** To investigated the prevalence of vitamin d deficiency and its associated factors in exclusively breastfed infants in Bangkok,*** This descriptive observational cross-sectional study assessed 1094-month-old infants at Charoenkrung Pracharak Hospital from May 2020 to April *** 25-OH vitamin d level of the infants was measured using an electrochemiluminescence binding *** d deficiency was defined as 25-OH levelvitamin d insufficiency 20-30 ng/*** sun index and maternal vitamin d supplementation data were collected and analyzed using the independent t-test,univariate logistic regression,and multivariate logistic regression to identify the associated *** The prevalences of vitamin d deficiency and vitamin d insufficiency were 35.78%and 33.03%,respectively with mean serum 25-OH vitamin d levels in these two groups 14.37±3.36 and 24.44±3.29 ng/*** logistic regression showed that the main factors associated with vitamin d status were maternal vitamin d supplementation and birth weight,with crude odds ratios 0.26(0.08–0.82)and 0.08(0.01–0.45),*** sun index showed no correlation with the 25-OH vitamin d level in exclusively breastfed infants(r=−0.002,P=0.984).CONCLUSION Two-thirds of healthy exclusively breastfed infants had hypovitaminosis *** d supplementation prevented this condition and was recommended for both lactating women and their babies.

关键词： Breastfeeding Sunlight vitamin d deficiency Thailand

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vitamin d deficiency and Its Relationship with Child-Pugh Class in Patients with Chronic Liver disease

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Journal of Clinical and Translational Hepatology 2018年第2期6卷 135-140页

作者： Zubia Jamil Sharmin Arif Anum Khan Asghar Aurangzeb durrani Nayyar Yaqoob department of Medicine Foundation University Medical CollegeIslamabadPakistan department of Medicine Fauji Foundation HospitalRawalpindiPakistan

Background and Aims:Skeletal manifestation in liver dis-eases represents the minimally scrutinized part of the disease *** d deficiency has a central role in developing hepatic osteodystrophy in patients with chronic liver *** study aimed to investigate vitamin d levels and their relationship with disease advancement in these ***:vitamin d levels were checked in 125 chronic liver disease *** patients were classified in three stages according to Child-Pugh score:A,B and *** relationship of vitamin d levels with Child-Pugh score and other variables in the study was assessed by the contingency *** and logistic regression analyses were also carried out to find additional predictors of low vitamin d ***:Among the patients,88%had either insufficient or deficient stores of vitamin d,while only 12%had sufficient vitamin d levels(p>0.05).vitamin d levels were notably related to Child-Pugh class(contingency coefficient=0.5,pd multinomial regression analyses,age,female sex,MELd and Child-Pugh class were predictors of low vitamin d ***,model of end-stage liver disease score and Child-Pugh score were negatively correlated to vitamin d levels(pvitamin d deficiency is notably re-lated to age,female sex and model of end-stage liver disease score,in addition to Child-Pugh class of liver ***-min d levels should be routinely checked in patients with ad-vanced liver cirrhosis(Child-Pugh class B and C)and this deficiency must be addressed in a timely manner to improve general well-being of cirrhotic patients.

关键词： vitamin d deficiency Liver cirrhosis Osteodystrophy Liver disease Skeletal manifestations

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Fatigue is not associated with vitamin d deficiency in inflammatory bowel disease patients

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World Journal of Gastroenterology 2018年第29期24卷 3293-3301页

作者： Svein Oskar Frigstad Marte Lie Hoivik Jorgen Jahnsen Milada Cvancarova Tore Grimstad Ingrid Prytz Berset Gert Huppertz-Hauss Oistein Hovde Tomm Bernklev Bjorn Moum Lars-Petter Jelsness-Jorgensen department of Medicine Vestre Viken Baeum HospitalGjettum 1346Norway department of Gastroenterology Ostfold Hospital KalnesGralum 1714Norway department of Health Sciences Ostfold University CollegeHalden 1757Norway department of Gastroenterology Stavanger University HospitalStavanger 4068Norway department of Research Otfold Hospital KalnesGralum 1714Norway department of Gastroenterology Oslo University HospitalOslo 0424Norway department of Gastroenterology Akershus University HospitalLorenskog 1478Norway Faculty of Health Sciences Oslo Metropolitan UniversityOslo 0130Norway department of Medicine Alesund Hospital TrustAlesund 6026Norway department of Gastroenterology Telemark Hospital TrustSkien 3710Norway department of Medicine Innlandet Hospital TrustGjovik 2819Norway department of Research and development Vestfold Hospital TrustTonsberg 3103Norway

AIM To investigate if vitamin d deficiency is associated with fatigue in patients with inflammatory bowel disease(IBd).METHOdS IBd patients were recruited from nine hospitals in the southeastern and western regions of Norway to participate in a multicenter cross-sectional study lasting from March 2013 to April 2014. data were collected by interviews, from medical records and laboratory tests. The Fatigue Questionnaire(FQ) was used to measure fatigue. Linear and logistic regression models were applied to explore the possible association between vitamin d deficiency and total fatigue scores and chronic fatigue, respectively. The analyses were adjusted for age, gender, disease activity, depressive symptoms and sleep *** In total, 405 patients were included in the analyses, of which 227(56%) had Crohn's disease(Cd) and 178(44%) had ulcerative colitis(UC). vitamin d deficiency(d by 116(29%) of all included patients with substantial fatigue reported by 194(48%). vitamin d levels were neither associated with total fatigue nor with chronic fatigue. Higher total fatigue scores and chronic fatigue were both associated with increased disease activity scores in patients with UC and Cd, but not with increased CRP or fecal calprotectin. In UC patients, female gender was associated with fatigue in the univariate analysis, but no such difference was found when adjusted for elevated disease activity scores. Sleep disturbance and more depressive symptoms were associated with total fatigue scores in both UC and Cd patients, but with chronic fatigue only in Cd *** In this study, no significant association between fatigue and vitamin d deficiency in IBd patients was revealed.

关键词： Inflammatory bowel disease Crohn's disease Ulcerative colitis Fatigue Chronic fatigue vitamin d deficiency

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Association of vitamin d receptor gene polymorphism(VdR)with vitamin d deficiency,metabolic and inflammatory markers in Egyptian obese women

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Genes & diseases 2017年第3期4卷 176-182页

作者： Moushira Zaki Sanaa Kamal Walaa ABasha Eman Youness Wafaa Ezzat Hala El-Bassyouni Khalda Amr Biological Anthropology department National Research CentreGizaEgypt Medical Biochemistry department National Research CentreGizaEgypt Internal Medicine department National Research CentreGizaEgypt Clinical Genetics department National Research CentreCairoEgypt Medical Molecular Genetics department National Research CentreEgypt

vitamin d deficiency might contribute to the pathogenesis of metabolic syndrome and could cause immune *** aim of this study is to analyze the associations between vitamin d receptor(VdR)gene polymorphism,serum 25-hydroxy vitamin d,metabolic and inflammatory biomarkers in Egyptian obese *** study included 201 obese women with vitamin d deficiency and 249 obese matched age healthy controls with sufficient vitamin d *** age ranged between 25 and 35 *** biomarkers(interleukin-6 and C-reactive protein)and serum 25(OH)d were measured by enzyme-linked immunosorbent *** resistance(IR)was determined by the homeostasis model assessment of insulin resistance(HOMA-IR).vitamin d receptor(VdR)gene polymorphisms of FokI,ApaI,and TaqI were studied by PCR using the restriction fragment length polymorphism(RFLP)*** women with vitamin d deficiency had significant higher values of inflammatory and metabolic parameters compared to ***-logistic regression showed associations between 25(OH)d deficiency and metabolic components when comparing cases with ***,cases carrying polymorphic alleles showed significant lower levels of serum 25(OH)d and higher HOMA-IR,blood pressure levels and lipid parameters compared to those with the wild type homozygote in obese cases with vitamin d *** d deficiency in Egyptian obese women with vitamin d deficiency is associated with abnormal metabolic components and abnormal inflammatory ***,VdR polymorphisms play important role in immune and inflammation status.

关键词： Inflammatory biomarkers Obese women vitamin d deficiency vitamin d receptor(VdR)gene polymorphism Egyptian

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Predictors of vitamin d deficiency in inflammatory bowel disease and health: A Mississippi perspective

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World Journal of Gastroenterology 2017年第4期23卷 638-645页

作者： Kumar Pallav daniel Riche Warren L May Patrick Sanchez Nitin K Gupta division of digestive diseases University of Mississippi Medical Center department of Pharmacy Practice University of Mississippi Medical Center

AIMTo identify the predictors of vitamin d deficiency in patients with and without inflammatory bowel disease (IBd).METHOdSPatients with ulcerative colitis (UC) or Crohn’s disease (Cd) related diagnostic codes who received medical care at University of Mississippi Medical Center between July 2012 and 2015 were identified. After thorough chart review, we identified patients with biopsy proven IBd who had also been tested for serum 25-hydroxyvitamin d [25(OH)d] concentration. We compared these patients to a previously studied cohort of healthy controls who also had vitamin d concentration checked. Logistic regression analysis was performed to determine the association between vitamin d deficiency and UC, Cd, race, age, gender and body mass index (BMI).RESULTSWe identified 237 patients with confirmed IBd. Of these, only 211 had a serum 25(OH)d concentrations available in the medical record. The group of healthy controls consisted of 98 individuals with available serum 25(OH)d concentration. 43% of IBd patients were African American (AA). Patients with Cd were more likely to have vitamin d concentration checked. Bivariate analysis showed that AA (51% vs 21%, P = 0.00001), subjects with BMI >30 kg/m2 (39% vs 23% P = 0.01) and Cd (40% vs 26%, P = 0.04) were more likely to be vitamin d deficient than vitamin d sufficient. Those with Age > 65 were more likely to be vitamin d sufficient (46% vs 15%, P = 0.04). Multiple regression showed that only BMI > 30 kg/m2 and AA race are associated with vitamin d *** > 30 kg/m2 and AA race are predictive of vitamin d deficiency. Gender, age and diagnosis of IBd are not predictive of vitamin d deficiency.

关键词： vitamin d deficiency Inflammatory bowel disease Body mass index Ulcerative colitis Crohn’ s disease African American

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The presence of primary sclerosing cholangitis in patients with ileal pouch anal-anastomosis is associated with an additional risk for vitamin d deficiency

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Gastroenterology Report 2016年第4期4卷 320-324,I0003页

作者： Andre Fialho Andrea Fialho Gursimran Kochhar Bo Shen department of Internal Medicine Cleveland Clinic FoundationClevelandOHUSA department of Gastroenterology and Hepatology Cleveland Clinic FoundationClevelandOHUSA

Objective:vitamin d deficiency is common in patients with ileal pouch-anal anastomosis(IPAA)for ulcerative colitis(UC).Whether vitamin d levels are further lowered in patients with concomitant IPAA and primary sclerosing cholangitis(PSC)is not *** aim of this study was to evaluate the presence of PSC as a risk factor for vitamin d deficiency in patients with UC and ***:In this case control study,74 patients with concurrent IPAA and PSC were included in the study group,and 79 patients with IPAA,but without PSC,served as ***-four variables were *** analysis and multivariate analysis with stepwise logistic regression were ***:A total 153 eligible patients were included,with 74(48.4%)in the study group and 79(51.6%)in the control *** d level in the study group was 18.961.4 ng/dL compared with 30.361.7 ng/d in the control group(P=0.011).vitamin d deficiency(≤20 ng/dL)was present in 65(42.5%)*** occurred in 49(75.4%)of the 65 patients with vitamin d *** the multivariate analysis,only the presence of PSC(odds ratio[OR]:7.56;95% confidence interval[CI]:2.39–24.08;P=0.001)and vitamin d supplementation(OR:2.58;95% CI:1.57–9.19;P=0.018)remained associated with vitamin d ***:The presence of PSC was found to be an independent risk factor for vitamin d deficiency in UC patients with *** patients should be routinely screened and closely monitored for vitamin d deficiency.

关键词： inflammatory bowel disease primary sclerosing cholangitis ileal pouch-anal anastomosis vitamin d deficiency

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vitamin d deficiency in cirrhosis relates to liver dysfunction rather than aetiology

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World Journal of Gastroenterology 2011年第7期17卷 922-925页

作者： Mikkel Malham SΦren Peter JΦrgensen Peter Ott JΦrgen Agnholt Hendrik Vilstrup Mette Borre Jens F dahlerup department of Medicine V (Hepatology and Gastroenterology) Aarhus University Hospital

AIM: To examine the vitamin d status in patients with alcoholic cirrhosis compared to those with primary biliary cirrhosis. METHOdS: Our retrospective case series comprised 89 patients with alcoholic cirrhosis and 34 patients with primary biliary cirrhosis who visited our outpatient clinic in 2005 and underwent a serum vitamin d status assessment. RESULTS: Among the patients with alcoholic cirrhosis, 85% had serum vitamin d levels below 50 nmol/L and 55% had levels below 25 nmol/L, as compared to 60% and 16% of the patients with primary biliary cirrhosis, respectively (P vitamin d levels decreased with increasing liver disease severity, as determined by the Child-Pugh score. CONCLUSION: vitamin d deficiency in cirrhosis relates to liver dysfunction rather than aetiology, with lower levels of vitamin d in alcoholic cirrhosis than in primary biliary cirrhosis.

关键词： Alcoholic liver cirrhosis Child-Pugh score Primary biliary cirrhosis vitamin d deficiency

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vitamin d deficiency and Insufficiency in Northeast Tennessee

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Health 2020年第9期12卷 1085-1094页

作者： Arun Joseph Kattakayam donovan Reed Sajin M. Karakattu Beth Bailey Millard Ray Lamb Paul O. Lewis dima Youssef department of Internal Medicine Norwalk Hospital Norwalk CT USA Texas Oculoplastics Consultants TOC Eye & Face Austin TX USA department of Internal Medicine Division of Pulmonary and Critical Care East Tennessee State University Johnson City TN USA department of Family Medicine East Tennessee State University Johnson City TN USA Recovery Associates Johnson City TN USA department of Pharmacy Johnson City Medical Center Johnson City TN USA department of Internal Medicine Division of Infectious Diseases East Tennessee State University Johnson City TN USA

Background: The role of vitamin d in population subgroups throughout the world continues to be a topic of interest among researchers. Current evidence demonstrates that treating vitamin d deficiency plays a significant role in improving mortality in hospitalized patients, reducing hospital length of stay, and boosting innate immune system. vitamin d levels vary with age, gender, body mass index (BMI) and geographical area. The purpose of this study is to evaluate vitamin d levels in a cohort of patients in Northeast Tennessee. Study: This institutional review board-approved, retrospective study evaluated vitamin d levels of patients obtained from Mcleod Cancer and Blood Center. vitamin d levels were collected over a 2-year period and classified as deficient (30 ng/mL). data were then stratified based on patient characteristics (age, gender, body mass index (BMI), race, seasons, and place of residence) and compounds of vitamin d (d2 and d3). Results: There were 2011 individuals included, with only 44.3% having replete levels and 21.4% with levels less than 20 ng/mL. Females with vitamin d deficiency are more likely to have levels below 20 ng/ml compared to males (18.6% vs. 23%, respectively, p = 0.003). Regarding BMI, the highest levels were reported in normal weight and overweight. With regards to age, advanced age (≥70) was associated with the highest levels and most replete patients. Winter months were associated with the lowest levels of vitamin d. Higher vitamin d levels were found in individuals over 70 years, normal weight and overweight category. Conclusion: Testing vitamin d levels in high-risk groups becomes of utmost importance in areas with longer winter months, obese and underweight patients. vitamin d levels should be routinely tested and treated in vulnerable populations.

关键词： vitamin d vitamin d deficiency vitamin d Insufficiency Northeast Tennessee

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Fitting logistic regression models to assess vitamin d deficiency with clinical parameters in chronic hepatitis B patients

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Infectious disease Modelling 2021年第1期6卷 612-617页

作者： Freshteh Osmani Ghodsiyeh Azarkar department of Biostatistics and Epidemiology Faculty of HealthBirjand University of Medical SciencesBirjandIran Infectious disease Research Center Birjand University of Medical SciencesBirjandIran

Statistical models provide a quantitative structure with which clinicians can evaluate their hypotheses to explain patterns in observed data and generate *** contrast,vitamin d is an important immune modulator that plays an emerging role in liver diseases such as chronic hepatitis B(CHB).Therefore,we quantified 25(OH)d_(3) serum levels in 292 CHB patients tested for their association with clinical *** 292 patients,69(63%),95(47%),and 39(19%)had severe vitamin d deficiency(25(OH)d_(3)vitamin d insufficiency(25(OH)d_(3)10 anddequate vitamin d serum levels(25(OH)d_(3)20 ng/mL),*** both univariate and multivariate analyses,zinc serum level was a strong predictor of low 25(OH)d_(3) serum levels(Pd models showed that lower vitamin d levels were significantly associated with:younger age,lower uric acid levels,HBeAg-positive status,lower calcium levels(pvitamin d deficiency(deficiency(d more frequently among HBV patients(52%).vitamin d deficiency was observed in most CHB ***,our results recommend that substitution of vitamin d can be a substitution method in the treatment of patients with HBV-associated disorders.

关键词： vitamin d deficiency data-mining Chronic HBV infection

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vitamin d deficiency promotes prostatic hyperplasia in middle-age mice through exacerbating local inflammation

Vitamin D deficiency promotes prostatic hyperplasia in middl...

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2018环境与健康学术会议--精准环境健康：跨学科合作的挑战

作者： Zhihui Zhang Biao Luo Shen Xu dexiang Xu department of Toxicology Anhui Medical University

Objectives This study investigated the effects of vitamin d persistent deficiency from early life on prostatic hyperplasia in middle-aged ICR *** Pregnant mice were divided randomly into two *** the control group,dams were fed with standard diets(with 1000 IU vitamin d/kg) throughout pregnancy and *** weaning,male pups were fed with standard diets for 37 *** the Vdd group,dams were fed with Vdd diets(with 0 IU vitamin d/kg)throughout pregnancy and *** weaning,male pups were divided randomly into two *** the Vdd group,male pups were fed with Vdd diets for 37 *** the VdS group,male pups were fed with Vdd diets for 17 weeks and then replaced with standard diets for 20 *** weeks after birth,mice were *** Prostate weight was elevated and prostatic hyperplasia was observed in Vdd-fed *** number of prostatic Ki67-positive epithelial cells was increased in Vdd-fed *** analysis found that vitamin d deficiency promoted inflammatory infiltration and stromal fibrosis in prostate of middle-aged ***,vitamin d deficiency activated NF-kB and up-regulated I1-6 mRNA in prostate of middle-aged *** addition,vitamin d deficiency activated prostatic STAT3,a proliferation pathway in middle-aged *** interest,Vdd-induced prostatic inflammation and hyperplasia were partially reversed when Vdd diets was replaced with standard *** These results provide evidence that vitamin d persistent deficiency from early life promotes prostatic hyperplasia in middle-aged mice through exacerbating local inflammation.

关键词： vitamin d deficiency Prostatic hyperplasia Inflammation

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