The presence of primary sclerosing cholangitis in patients with ileal pouch anal-anastomosis is associated with an additional risk for vitamin D deficiency
原发性硬化性胆管炎会进一步导致回肠储袋肛管吻合患者维生素D缺乏作者机构：Department of Internal MedicineCleveland Clinic FoundationClevelandOHUSA Department of Gastroenterology and HepatologyCleveland Clinic FoundationClevelandOHUSA
出 版 物：《Gastroenterology Report》 (胃肠病学报道（英文）)
年 卷 期：2016年第4卷第4期
页 面：320-324,I0003页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：inflammatory bowel disease primary sclerosing cholangitis ileal pouch-anal anastomosis vitamin D deficiency
摘 要：Objective:Vitamin D deficiency is common in patients with ileal pouch-anal anastomosis(IPAA)for ulcerative colitis(UC).Whether vitamin D levels are further lowered in patients with concomitant IPAA and primary sclerosing cholangitis(PSC)is not *** aim of this study was to evaluate the presence of PSC as a risk factor for vitamin D deficiency in patients with UC and ***:In this case control study,74 patients with concurrent IPAA and PSC were included in the study group,and 79 patients with IPAA,but without PSC,served as ***-four variables were *** analysis and multivariate analysis with stepwise logistic regression were ***:A total 153 eligible patients were included,with 74(48.4%)in the study group and 79(51.6%)in the control *** D level in the study group was 18.961.4 ng/dL compared with 30.361.7 ng/d in the control group(P=0.011).Vitamin D deficiency(≤20 ng/dL)was present in 65(42.5%)*** occurred in 49(75.4%)of the 65 patients with vitamin D *** the multivariate analysis,only the presence of PSC(odds ratio[OR]:7.56;95% confidence interval[CI]:2.39–24.08;P=0.001)and vitamin D supplementation(OR:2.58;95% CI:1.57–9.19;P=0.018)remained associated with vitamin D ***:The presence of PSC was found to be an independent risk factor for vitamin D deficiency in UC patients with *** patients should be routinely screened and closely monitored for vitamin D deficiency.
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