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Proximate and mineral components of viscum album var. coloratum grown on eight different host tree species

Journal of Forestry Research 2019年第4期30卷 1245-1253页

作者： Chul-Woo Kim Chan-Hoon An Hyun-Seok Lee Jae-Seon Yi Eun Ju Cheong Sang-Hyun Lim Hee-Yeon Kim Forest Bioresources Department National Institute of Forest Science39 OnjeongroGwonseon-guSuwon 16631Republic of Korea Forest Medicinal Resources Research Center National Institute of Forest ScienceSobaek-ro 2009PunggiYoungjuGyungsangbuk-do 36040Republic of Korea Program of Forest Resources Division of Forest ScienceCollege of Forest and Environmental SciencesKangwon National UniversityChuncheon 24341Republic of Korea Agriproduct Processing Experiment Station Gangwon-do Agicultural Research and Experiment ServicesChuncheon 24203Republic of Korea

Mistletoes are parasite plants growing on various tree species,taking nutrients from the *** compounds of mistletoe were used in medicine and these mistletoes were commonly collected from oak species that were not well *** analyzed the nutritional value by measuring proximate and mineral components of Korean mistletoe(viscum album ***)from various host *** was the most proximate component in both leaves and twigs followed crude protein,crude fiber,crude ash and crude *** the contents of the proximate components and minerals varied among hosts and between plant parts,leaves contained higher crude protein and ash,and more minerals except for magnesium than twigs,although no significant difference was found inmistletoe grown on Prunus *** were significant differences of proximate and mineral contents depending on the host *** grown on Chaenomeles sinensis contained higher levels of carbohydrates,crude fat,crude ash,magnesium,calcium,sodium,iron,and zinc than mistletoe grown on other *** grown on *** contained high mineral levels of potassium,copper and *** nutritional value of mistletoes were greatly influenced by the host species but among the hosts,specific nutrients accumulated in leaves more than in twigs,and vice *** on the analysis,Korean mistletoe contains relatively good quality of nutrients and has high potential for dietary supplements as well as for medicinal compounds.

关键词： Mistletoe viscum album var coloratum Proximate compositions Mineral contents Nutritional value Host species

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Three new bioactive flavonoid glycosides from viscum album

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Chinese Journal of Natural Medicines 2019年第7期17卷 545-550页

作者： DAI Jia-Kun CAO Duo LI Cui-Hua GAO Jing LI Meng-Qing FAN Na WEI Ya-Hui SUN Zheng-Liang HOU Meng-Yang The College of Life Science Northwest University Xi 'an 710069 China State Key Laboratory of New Drug and Pharmaceutical Process Shanghai Institute of Pharmaceutical Industry China State Institute of Pharmaceutical Industry Shanghai 201203 China The College of Life Science Yan 'an University Yan 'an 710000 China Shanghai University of Medicine & Health Sciences Affiliated Sixth People s Hospital South Campus Shanghai 201499 China Bio-Agriculture Institute of Shaanxi Xi 'an 710043 China School of Life Science and Biotechnology Dalian University of Technology Dalian 116024 China College of Healthy Management Shangluo University Shangluo 726000 China

Two new flavonoid glycosides, named viscumneoside XⅡ(1), and viscumneoside XⅢ(2);a new dihydrogen flavonoid glycoside product named viscumneoside XⅣ(3), were isolated from the aerial part of viscum album, along with seven known compounds(4-10). Their structures were identified by analysis of spectroscopic data. In addition, cytotoxicity assay showed that 1, 2 and 3 possessed significant inhibitory activities against C6, A549 and MDA-MB-231(the inhibition rate arrived about 50%, 70% and74% respectively with IC50 ≤ 60.00 μmol·L^-1), while the inhibition of TF-1 and Hela was not significant.

关键词： viscum album Flavonoid glycosides Cytotoxic activities

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Two symmetrical unsaturated acids isolated from viscum album

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Chinese Journal of Natural Medicines 2019年第2期17卷 145-148页

作者： CAO Duo WANG Li-Qing HAN Xiao-Min GUAN Hui-Rui LEI Meng WEI Ya-Hui CHENG Liang YANG Pei-Ming SUN Zheng-Liang GAO Wen DAI Jia-Kun College of Life Science Northwest University State Key Laboratory of New Drug and Pharmaceutical Process Shanghai Institute of Pharmaceutical IndustryChina State Institute of Pharmaceutical Industry Shanghai University of Medicine&Health Sciences Affiliated Sixth People's Hospital South Campus Shineway Pharmaceutical Group Co. Ltd. Bio-Agricultue Institute of Shaanxi

In the present study,two new acetylene conjugate compounds,dibutyl(2Z,6Z)-octa-2,6-dien-4-yne dioate(1),and dibutyl(2E,6E)-octa-2,6-dien-4-yne dioate(2),were isolated from the dry stem leaves of viscum album,along with nine known compounds(3–11).Their structures were confirmed on the basis of spectroscopic *** 1 and 8 showed antioxidant activity against xanthine oxidase(XOD)and 1,1-diphenyl-2-picrylhydrazyl radical 2,2-diphenyl-1-(2,4,6-trinitrophenyl)hydroxyl(DPPH),with the IC_(50) of 1.22 and 1.33μmol·L^(–1),and the SC_(50 )of 4.34 and 8.22μmol·L^(–1),respectively.

关键词： viscum album Symmetrical unsaturated acid Antioxidant activity

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Efficacy and safety of viscum fraxini-2 in advanced hepatocellular carcinoma:a phase Ⅱ study

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The Chinese-German Journal of Clinical Oncology 2010年第8期9卷 452-458页

作者： Mohamed A.Ebrahim Hend A.El-Hadaad Omyma A.Alemam Salah A Keshta Lecturer of Medical Oncology Oncology Center-Mansoura University Lecturer of Clinical Oncology and Nuclear Medicine Faculty of MedicineMansoura University Consultant Oncology and Nuclear Medicine Faculty of MedicineMansoura University

Objective： New systemic therapies are needed to improve the prognosis of patients with advanced-stage hepatocellular carcinoma. The study was conducted to determine the efficacy and safety of viscum fraxini-2 in advanced Hepatocellular carcinoma. Methods： A phase II study with a two-stage design that enrolled a total of 120 patients with chemotherapy nai＇ve advanced hepatocellular carcinoma. The mistletoe preparation for the study is an aqueous injectable solution that contains one milliliter of viscum fraxini. Two ampoules of viscum fraxini were administered subcutaneously once weekly. Re- suits： Chronic hepatitis C virus infection was the predominant cause of liver disease （60%） in studied cases. According to the response evaluation criteria in solid tumors 24 patients （20%） achieved objective response （including 2 complete responses） and 40 patients （33.3%） achieved stable disease. The median progression free survival for all patients was 4 months （range 1-28 months; 95% CI 3.3：4.7 months）. The median overall survival for all patients was 8 months （range 1-28 months; 95% CI 6.3：9.7 months）. The median survival for patients who achieved responsive or stable disease was 16 months. The toxicity was generally mild and well tolerated, mainly in the form of local reaction and fever. There were no drug related discontinu- ation or toxic deaths. Conclusion： viscum fraxini-2 is an effective, safe treatment for patients with advanced hepatocellular carcinoma. Further randomized controlled trials are recommended.

关键词： viscum fraxini-2 HCC phase II

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Mild Steel Corrosion Mitigation in Sulphuric Acid via Benign Isolated Phytochemicals from <I>viscum album</I>

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Journal of Materials Science and Chemical Engineering 2018年第4期6卷 132-146页

作者： N. E. Nya A. I. Ikeuba P. C. Okafor B. U. Ugi V. M. Bassey A. I. Obike Corrosion and Electrochemistry Research Group Department of Pure and Applied Chemistry University of Calabar Calabar Nigeria Department of Chemistry Abia State University Uturu Nigeria

We present the evaluation of four Eco-friendly corrosion inhibitors for the corrosion mitigation of mild steel in acid media. The corrosion inhibition of mild steel by ethanol extracts from viscum album (EEVA) and some of its isolated phytochemical components;phytates extract (PEVA), saponins extract (SEVA), and flavonoids extracts (FEVA) have been studied using gravi-metric and gasometric techniques. The results of the study reveal that these ecofriendly and benign extracts function as good inhibitors for mild steel corrosion in sulphuric acid. Inhibition efficiency of the extracts increases with inhibitor concentration and temperature rise. The trend of inhibition efficiency in lower inhibitor concentration is EEVA > PEVA > SEVA > FEVA and at higher concentration, the order was SEVA > PEVA > EEVA > FEVA. The presence of the plant extracts decreases the corrosion activation energy in the solution which indicates chemical adsorption mechanism. The adsorption of the components of the extracts is consistent with Temkin isotherm. The interaction between the isolated extracts is synergistic at lower inhibitor concentration and antagonistic at higher concentrations. The Kads values for PEVA and SEVA are higher than those of EEVA and FEVA. This implies that PEVA and SEVA are more efficiently adsorbed on the mild steel surface.

关键词： Acid Corrosion Mild Steel viscum album Corrosion Inhibition Phytochemicals

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Renoprotective and Blood Pressure Lowering Impact of Equisetum arvense and viscum album Therapy in Experimental Model of Chronic Kidney Disease

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World Journal of Cardiovascular Diseases 2018年第12期8卷 545-556页

作者： ülle Pechter Ingrid Kalev Mai Ots-Rosenberg Department of Internal Medicine University of Tartu Tartu Estonia Institute of General and Molecular Pathology University of Tartu Tartu Estonia

Background: Chronic kidney disease (CKD) is an irreversible decline in the glomerular filtration due to nephrosclerosis and glomerular loss. Rat remnant kidney model enables to assess the benefits of different treatment possibilities. Aim: The aim of our study was to investigate renal morphology and functioning after 12 weeks of treatment with Equisetum arvense and viscum album. Methods: Male Wistar rats with 5/6 nephrectomy received herbal drug preparation Equisetum/viscum in a dosage of 0.007 g/kg/die (herbal group) or losartan (180 mg/l, ARB group) or remained untreated. Systolic blood pressure (SBP) and proteinuria were measured. Renal cortex tissue samples examined for focal-segmental glomerulosclerosis (FSGS) and interstitial fibrosis (IF). mRNA was isolated to estimate CCL2/MCP-1 gene transcription. Results: SBP was significantly lower both in herbal group and ARB group compared with untreated animals (p between ARB group and untreated NPX (p = 0.001). Quantitative RT-PCR analysis revealed statistically significant differences of mRNA transcription for MCP-1 between herbal group and untreated group (p Conclusions: We report about beneficial impact of horsetail Equisetum arvense and mistletoe viscum album treatment on kidney functioning and morphology.

关键词： Equisetum arvense Experimental Chronic Kidney Disease MCP-1 Relative Transcription viscum album

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