Three new bioactive flavonoid glycosides from Viscum album
Three new bioactive flavonoid glycosides from Viscum album作者机构:The College of Life Science Northwest University Xi 'an 710069 China State Key Laboratory of New Drug and Pharmaceutical Process Shanghai Institute of Pharmaceutical Industry China State Institute of Pharmaceutical Industry Shanghai 201203 China The College of Life Science Yan 'an University Yan 'an 710000 China Shanghai University of Medicine & Health Sciences Affiliated Sixth People s Hospital South Campus Shanghai 201499 China Bio-Agriculture Institute of Shaanxi Xi 'an 710043 China School of Life Science and Biotechnology Dalian University of Technology Dalian 116024 China College of Healthy Management Shangluo University Shangluo 726000 China
出 版 物:《Chinese Journal of Natural Medicines》 (中国天然药物(英文版))
年 卷 期:2019年第17卷第7期
页 面:545-550页
核心收录:
学科分类:1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
基 金:supported by the National Science and Technology Development Fund(No.2009ZX09301-007) the Scientific Research Projects of Shannxi Academy of Sciences(No.2016K-17) the Projects of Shaanxi Provincial Science and Technology Department(No.2016SF-264) Special Fund for Agro-scientific Research in The Public Interest(Grant 389,No.201203062) Support Plan for Young 392 Talents of Science and Technology Association of Colleges and Universities in Shaanxi Province 393(No.20150105) Key Research and Development Plan Project of Shaanxi Province(No.2018SF-034) Scientific Research from Shaanxi Provincial Department of Education(Nos.14JS100 and 17JK0243)
主 题:Viscum album Flavonoid glycosides Cytotoxic activities
摘 要:Two new flavonoid glycosides, named viscumneoside XⅡ(1), and viscumneoside XⅢ(2);a new dihydrogen flavonoid glycoside product named viscumneoside XⅣ(3), were isolated from the aerial part of Viscum album, along with seven known compounds(4-10). Their structures were identified by analysis of spectroscopic data. In addition, cytotoxicity assay showed that 1, 2 and 3 possessed significant inhibitory activities against C6, A549 and MDA-MB-231(the inhibition rate arrived about 50%, 70% and74% respectively with IC50 ≤ 60.00 μmol·L^-1), while the inhibition of TF-1 and Hela was not significant.