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Fluorescence Nanobiosensor for Simultaneous Detection of Multiple veterinary drugs in Chicken Samples

Journal of Analysis and Testing 2022年第2期6卷 77-88页

作者： Ya-Ping Peng Ya-Wen He Ya-Fang Shen Ao-Ming Liang Xi-Bin Zhang Yuan-Jie Liu Jian-Han Lin Jian-Ping Wang Yan-Bin Li Ying-Chun Fu College of Biosystems Engineering and Food Science Zhejiang UniversityHangzhou 310058China Quality Control for Feed and Products of Livestock and Poultry Key Laboratory of Sichuan Province New Hope Liuhe Co.Ltd.Chengdu 610023China Weifang Heshengyuan Food Co. Ltd.Weifang 262100China College of Information and Electrical Engineering China Agricultural UniversityBeijing 100083China Department of Biological and Agricultural Engineering University of ArkansasFayettevilleAR 72701USA

Some veterinary drug residues in food products and environment have been widely regarded as severe threats to human *** and simultaneous detection methods are crucial to monitor and control veterinary drug ***,we propose a fluorescence biosensor utilizing immunomagnetic beads(IMBs)and quantum dots(QDs)for the rapid and simultaneous detection of 1-adamantylamine(ADA),enrofloxacin(ENR)and tilmicosin(TIL)in raw chicken meat.A pretreatment method using sodium phosphotungstate–magnesium as extraction reagent was developed to simultaneously extract ADA,ENR and TIL from chicken meat with minor interference in background or *** adding the IMBs modified with three types of antibodies and the QD-antigens modified with three types of BSA-antigens to sample,IMBs competitively conjugated to target antigens in a sample or *** magnetic separation,the residual QD-antigens were adopted to collect signals using fluorescence *** QDs with well separated emission peaks,the detection of one type of targets was minorly interfered by the *** the optimum conditions,the biosensor exhibited the limit of detection of 0.96,3.32,and 3.17 ng/mL for ADA,ENR and TIL in chicken samples,respectively,as well as good *** to the way of direct collection of signals in extracts,the tedious and complicated multiple magnetic separation and signal amplification procedures in conventional methods were avoided,thus the procedures were significantly simplified,and the reduction of the operation time of 30 min for sample pretreatment and 40 min for detection part was *** biosensor might be promising in the rapid,in-field and sensitive screening of multiple veterinary drugs to ensure agriculture and food safety.

关键词： Simultaneous detection veterinary drugs Magnetic separation Quantum dots Poultry

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A multiclass multiresidue veterinary drugs analysis by dispersive pipette extraction and LC-MS/MS

A multiclass multiresidue veterinary drugs analysis by dispe...

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2018年中国质谱学术大会（CMSC2018）

作者： KAMOLRAT Metavarayuth LI Min WANG Zhi-Ying FEI Jing YAN Lu YANG Jia Delisi Group Co. Ltd. Wuxi MicroSep Biotechnology Co. Ltd.

Sample preparation is often the most challenging step of multi-residue veterinary drug analysis, especially in complex matrix as meat. Solid phase extraction(SPE) is a widely used sample preparation method for clean extracts with consistent, high quality data that ensures long term robustness of mass spectrometry analysis. However, the conventional SPE is time-consuming and expensive. Dispersive Pipette Extraction(DPX) tip technology addresses the drawbacks of traditional SPE methods. In this study, a novel ultra-high performance liquid chromatography–tandem mass spectrometry(UHPLC-MS/MS) based protocol has been developed and validated for the analysis of multi-class, multi-residue(a group of 33) veterinary drugs in pork. The included analytes belong to β-agonists, sulfonamides, quinolones and chloramphenicol veterinary drug classes. The sample preparation procedure involves protein precipitation by acetonitrile followed by bind-elute extraction using DPX Tips(Microsep-105). The analyte detection, identification, and quantitation are performed by UHPLC-MS/MS using positive electrospray ionization mode. The method was validated in pork, typically achieving limits of quantitation(meeting acceptable recovery and precision validation criteria) at the government regulation standard.

关键词： Dispersive pipette extraction(DPX) Ultra-high performance liquid chromatography-tandem mass spectrometry(UHPLC-MS/MS) veterinary drugs residue animal-derived food

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Dairy manure as a potential source of crop nutrients and environmental contaminants

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Journal of Environmental Sciences 2021年第2期33卷 117-130页

作者： Danika Hill Matthew J.Morra Thibault Stalder Sven Jechalke Eva Top Anne T.Pollard Inna Popova Department of Soil&water Systems University of IdahoID 83844-2340USA Department of Biology University of IdahoID 83844-3051USA Justus Liebig University Giessen Institute for Phytopathology35392 GieJenGermany

Although animal manure is applied to agricultural fields for its nutrient value,it may also contain potential *** determine the variability in such contaminants as well as in valuable nutrients,nine uncomposted manure samples from Idaho dairies collected during 2.5 years were analyzed for macro-and micro-nutrients,hormones,phytoestrogens,antibiotics,veterinary drugs,antibiotic resistance genes,and genetic elements involved in the spread of antibiotic *** N ranged from 6.8 to 30.7(C:N of 10 to 21),P from 2.4 to 9.0,and K from 10.2 to 47.7 g/kg ***(103-348 mg/kg)was more abundant than Cu(56-127 mg/kg)in all *** were the most prevalent contaminants detected,with concentrations fluctuating over time,reflecting animal *** is the first study to document the presence of flunixin,a non-steroidal anti-inflammatory drug,in solid stacked manure from regular dairy *** was the most frequently detected *** and sulfonamides were regularly *** also investigated the relative abundance of several types of plasmids involved in the spread of antibiotic resistance in clinical *** belonging to the Inc I,Inc P,and Inc Q1 incompatibility groups were found in almost all manure *** Q1 plasmids,class 1 integrons,and sulfonamide resistance genes were the most widespread and abundant genetic element surveyed,emphasizing their potential role in the spread of antibiotic *** benefits associated with amending agricultural soils with dairy manure must be carefully weighed against the potential negative consequences of any manure contaminants.

关键词： Manure Antibiotics Hormones veterinary drugs Emerging contaminants

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Rapid testing methods for food contaminants and toxicants

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Journal of Integrative Agriculture 2015年第11期14卷 2243-2264页

作者： Jiachi Chiou Arthur Ho Hon Leung Hang Wai Lee Wing-tak Wong Department of Applied Biology and Chemical Technology Food Safety and Technology Research CenterThe Hong Kong Polytechnic University Shenzhen Key Laboratory for Food Biological Safety Control Food Safety and Technology Research CentreThe Hong Kong Polytechnic University Shenzhen Research Institute

Food safety is one of the major concerns in every country regardless of the economic and social development. The frequent occurrence of food scandals in the world has led the Chinese government to implement several strategies to fortify the food supply system to a high food safety standard. This relies heavily on laboratory testing services but conventional methods for detection of food contaminants and toxicants are limited by sophisticated sample preparation procedures, long analysis time, large instruments and professional personnel to meet the increasing demands. In this review, we have incorporated most of the current and potential rapid detection methods for many notorious food contaminants and toxicants including microbial agents, toxic ions, pesticides, veterinary drugs and preservatives, as well as detection of genetically modified food genes and adulterated edible oil. Development of rapid, accurate, easy-to-use and affordable testing methods could urge food handlers and the public to actively screen for food contaminants and toxicants instead of passively relying on monitoring by the government examination facility. This review also provides several recommendations including how to encourage the public to engage in the food safety management system and provide optimal education and financial assistance that may improve the current Chinese food safety control system.

关键词： rapid testing food contaminants and toxins microbial agents pesticides veterinary drugs preservatives formaldehyde nitrite nitrate test strips

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British pharmacopoeia (veterinary) 2002

British pharmacopoeia (Veterinary) 2002

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2002年

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Advance in Effect of veterinary Drug Residues on Ecological Environment

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Animal Husbandry and Feed Science 2015年第3期7卷 148-151页

作者： Zhang Zhimei Fu Shijun Guo Shijin Zhang Ying Ma Li Yang Limei Wang Jianjun Shen Zhiqiang Shandong Binzhou Animal Science & veterinary Medicine Institute Shandong Lvdu Ante veterinary Drug Industry Shandong Binzhou Research Development and Promotion Center for Livestock and Poultry Propolis Vaccine

Thousands of tons of pharmaceutically active substances are used in veterinary medicines in intensive livestock and poultry production, but most of the drugs are poorly absorbed by animals and excreted with the animal feces. The veterinary medicines can cause various kinds of harmful impact to the environment. Now the relevant research has been a hot all over the world. With the feces excreted to the environment, the veterinary medicines can be accumulated in the soil and water, and produce all sorts of reaction. Some medicines can cause toxic effect to animals, plants and microorganisms. The article summarized the residue, the environmental impact, the transformation and the development direction of the veterinary medicine in the environment to supply frame of reference for further research.

关键词： veterinary drugs Residue Environment Impact Advance

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UPLC-QTOF/MS Method for Screening and Determination of 59 Non-labeled Components in veterinary Drug Preparations

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Agricultural Biotechnology 2022年第1期11卷 86-89,96页

作者： Xueliang PANG Lei WANG Biao QI Sining TANG Yanhua YAN Xuesong WANG Lixue DONG Yi ZHANG Aijun LI Tangshan Food and Drug Comprehensive Inspection and Testing Center/Tangshan Agricultural Products Quality and Safety Inspection and Testing Center Tangshan 063000China Food Inspection Full Lab Automation Hebei Engineering Research CenterTangshan 063000China

[Objectives]This study was conducted to provide an accurate and reliable method for rapid high-throughput screening of veterinary drug preparations.[Methods]For the matrixes of veterinary drug preparations,high-performance liquid chromatography-high resolution quadrupole time-of-flight mass spectrometry(UPLC-QTOF/MS)was used to establish a fast screening method for 59 non-standard components in five categories of antiviral agents,aminoglycosides,quinolones,sulfonamides,and tetracyclines in veterinary *** target drugs were separated by a Waters ACQUITY UPLC HSS T3 chromatographic column(50 mm×2.1 mm,1.8μm),and data were collected in the positive ion *** separation of the 59 drugs was achieved within 7 min.[Results]In the concentration range of 0-100 ng/ml,each drug showed a good linear relationship,and the correlation coefficients were all greater than *** detection limits of the 59 drugs were in the range of 0.1-0.5 mg/ml,and the recovery under the addition concentration of 5 mg/ml was in the range of 85.2%-103.8%.[Conclusions]The method is fast,simple,accurate,and highly sensitive,and is suitable for high-throughput screening and qualitative identification of non-standard components in veterinary drug preparations.

关键词： High performance liquid chromatography-tandem time-of-flight mass spectrometry veterinary drugs Non-standard component

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British pharmacopoeia (veterinary) 2003

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2003年

作者：匿名

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British pharmacopoeia 2000: Amendments, No.1 Complete ed. CD

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2000年

作者：匿名

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Research Progress of Transdermal Patches in veterinary Drug Preparations

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Agricultural Science & Technology 2017年第8期18卷 1470-1473页

作者：曹允北京农业职业学院畜牧兽医系北京102442

With the development of pharmaceutics and other disciplines theories and advanced technologies, the application of many new drug delivery systems has gradually increased in clinical veterinary. Among the many drug delivery systems, transdermal patch can maintain stable and effective plasma concentration and therapeutic effect in vivo for a long time after skin dressing delivery, which provides a safe and effective drug-delivery way for the therapy and prevention of some chronic diseases and partial analgesia in a simple and convenient way. veterinary drug transdermal preparations have been developed both at home and abroad, and satisfactory results have been achieved in the experimental application. Based on the study of veterinary transdermal patches at home and abroad, this paper systematically describes the development and characteristics of transdermal patches, the factors affecting skin permeation and the evaluation this type of preparations in veterinary drugs.

关键词： veterinary drugs Transdermal patches Formulation development New formulation Clinical veterinary

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