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Biomedical and Environmental Sciences 2018年第9期31卷 667-676页

作者： ZHANG Jia Yan XIAO Xiang DONG Ying ZHOU Xing Hua School of Food and Biological Engineering Jiangsu University

Objective To investigate the effect of fermented barley extracts with Lactobacillus plantarum dy-1（LFBE） for modulating glucose consumption in HepG2 cells via miR-212 regulation. Methods Hepatocellular carcinoma（HepG2） cells were treated with palmitate. After 12 h, palmitate-induced HepG2 cells were treated with LFBE and its main components. Changes in glucose consumption, proinflammatory cytokine secretion, and miRNA-212 expression in HepG2 cells was observed. Results Treatment with LFBE rich in vanillic acid（VA） increased glucose consumption and reduced proinflammatory cytokine secretion in HepG2 cells. LFBE and VA normalized the upregulation of miR-212, which led to the upregulation of dual-specificity phosphatase-9（DUSP9）, a direct target of miR-212, at both protein and mR NA levels. Downregulation of miR-212 markedly increased glucose consumption and reduced proinflammatory cytokine secretion by enhancing DUSP9 expression. Conclusion The results showed the benefit of LFBE and miR-212 downregulation in modulating glucose consumption and reducing proinflammatory cytokine secretion by targeting DUSP9. VA in LFBE was a strong regulator of palmitate-induced abnormal glucose consumption in HepG2 cells and can be a primary mediator.

关键词： Fermented barley extract vanillic acid Glucose consumption HepG2 Dual-specificity phosphatase-9

Dietary ferulic acid and vanillic acid on inflammation,gut barrier function and growth performance in lipopolysaccharide-challenged piglets

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Animal Nutrition 2022年第1期8卷 144-152页

作者： Ruizhi Hu Shusong Wu Baizhen Li Jijun Tan Jiahao Yan Ying Wang Zhiyi Tang Ming Liu Chenxing Fu Hongfu Zhang Jianhua He Hunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients College of Animal Science and TechnologyHunan Agricultural UniversityChangsha410128China Beijing China-Agri HongKe Bio-Technology Co. Ltd.Beijing102206China State Key Laboratory of Animal Nutrition Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing100193China

Ferulic acid(FA)and vanillic acid(VA)are considered as major phenolic metabolites of cyanidin 3-glucoside,a polyphenol that widely exists in plants that possess a protective effect against oxidative stress and inflammation in our previous *** study aimed to investigate the effect of FA and VA on inflammation,gut barrier function,and growth performance in a weaned piglet model challenged with lipopolysaccharide(LPS).Thirty-six piglets(PIC 337×C48,28 d of age)were randomly allocated into 3 treatments with 6 replicate pens(2 piglets per pen).They were fed with a basal diet or a diet containing 4,000 mg/kg of FA or *** supplementation of VA significantly increased average daily gain(ADG)(Pacid reactive substances(TBARS),interlukin(IL)-1β,IL-2,IL-6,and tumor necrosis factor(TNF)-α(P<0.05),and enhanced the expression of tight junction protein oclaudin(P<0.05).Analysis of gut microbiota indicated that both FA and VA increased the Firmicutes/Bacteroidetes ratio alongside reducing the relative abundance of the Prevotellaceae family including Prevotella 9 and Prevotella 2 genera,but enriched the Lachoiraceaea family including the Lachnospiraceae FCS020 group(P<0.05).Moreover,VA reduced the relative abundance of Prevotella 7 and Prevotella 1 but enriched Lachnospira,Eubacterium eligens group,and Eubacterium xylanophilum group(P<0.05),while FA showed a limited effect on these *** results demonstrated that both VA and FA could alleviate inflammation and oxidative stress,but only VA has a significant positive effect on the growth performance of LPS-challenged piglets potentially through modulating gut microbiota.

关键词： Ferulic acid vanillic acid Inflammation Gut barrier function Growth performance Piglet

Biobased vanillic acid and Ricinoleic acid: Building Blocks for Fully Renewable Copolyesters

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Journal of Renewable Materials 2018年第1期6卷 126-135页

作者： Claudio Gioia Maria Barbara Banella Grazia Totaro Micaela Vannini Paola Marchese Martino Colonna Laura Sisti Annamaria Celli University of Bologna Department of CivilChemicalEnvironmental and Materials EngineeringVia Terracini 28Bologna40131Italy

New fully biobased polyether/esters have been synthesized by a one-pot polymerization reaction of ricinoleic acid(RA),vanillic acid(VA)and ethylene carbonate(EC).In particular,EC selectively reacts with the phenolic group of VA to obtain in-situ 4-(2-hydroxyethoxy)-3-methoxybenzoate(EV),suitable for subsequent copolymerization with *** procedure was carried out in a single step,without any *** structure and thermal properties of the new materials were studied in order to explore relationships between composition and final *** combination of EV,bearing a rigid aromatic structure,with RA,characterized by high flexibility and potential biocidal activity,allows the production of a novel class of fully biobased aliphatic-aromatic polymers presenting tuneable thermal properties and suitable for a range of applications,for example,in active packaging and biomedical fields.

关键词： Biobased building blocks vanillic acid ricinoleic acid copolyesters

THERMAL DEGRADATION OF THERMOTROPIC LIQUID CRYSTALLINE TERPOLYESTERS BASED ON vanillic acid, p-HYDROXYBENZOIC acid AND POLY(ETHYLENE TEREPHTHALATE )

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Chinese Journal of Polymer Science 1993年第3期11卷 230-235页

作者：李新贵黄美荣关桂荷孙桐 Institute of Membrane Separation Engineering Tianjin Institute of Textile Science and Technology Tianjin 300160 Department of Chemical Fiber Technology China Textile University Shanghai 200051

Nine thermotropic liquid crystalline terpolyesters based on vaniUic acid(V), p-hydroxybenzoic acid(H) and poly(ethylene terephthalate)(E) were investigated by thermogravimetry to ascertain their thermostability and the kinetic parameters for thermal degradation. Overall activation energy data of the degradation had been calculated over the range 5 ～ 70% weight loss. The temperatures and the activation energy of the degradation lie in the ranges of 384 ～ 394 ℃ at a heating rate of 1℃/min and 176 ～ 205 KJ/mol at the weight loss of 5%, respectively, which suggests that the terpolyesters have good thermostability.

关键词： Thermotropic liquid crystal vanillic acid Terpolyester Thermogravimetry Thermal degradation Thermostability Kinetic analysis.

Effects of phenolic acids on soil nitrogen mineralization over successive rotations in Chinese fir plantations

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Journal of Forestry Research 2020年第1期31卷 303-311页

作者： Long-Chi Chen Xin Guan Qing-Kui Wang Qing-Peng Yang Wei-Dong Zhang Si-Long Wang Huitong Experimental Station of Forest Ecology Institute of Applied EcologyChinese Academy of SciencesShenyang 110016People’s Republic of China Hunan Key Laboratory for Structure and Ecosystem Service of Subtropical Forest Huitong National Research Station of Forest EcosystemHuitong 418307People’s Republic of China

Phenolic acids are secondary metabolites of plants that significantly affect nutrient cycling *** investigate such effects,the soil available nitrogen(N)content,phenolic acid content,and net N mineralization rate in three successive rotations of Chinese fir plantations in subtropical China were *** N mineralization and nitrification rates in soils treated with phenolic acids were measured in an ex situ *** with first-rotation plantations(FCP),the contents of total soil nitrogen and nitrate in second(SCP)-and third-rotation plantations(TCP)decreased,and that of soil ammonium *** net N mineralization rates in the second-and third-rotation plantations also increased by 17.8%and 39.9%,*** contrast,soil net nitrification rates decreased by 18.0%and 25.0%,*** concentrations of total phenolic acids in the FCP soils(123.22±6.02 nmol g^-1)were 3.0%and 17.9%higher than in the SCP(119.68±11.69 nmol g^-1)and TCP(104.51±8.57 nmol g^-1,respectively).The total content of phenolic acids was significantly correlated with the rates of net soil N mineralization and net *** ex situ experiment showed that the net N mineralization rates in soils treated with high(HCPA,0.07 mg N kg^-1 day^-1)and low(LCPA,0.18 mg N kg^-1 day^-1)concentrations of phenolic acids significantly decreased by 78.6%and 42.6%,respectively,comparing with that in control(0.32 mg N kg^-1 day^-1).Soil net nitrification rates under HCPA and LCPA were significantly higher than that of the *** results suggested that low contents of phenolic acids in soil over successive rotations increased soil net N mineralization rates and decreased net nitrification rates,leading to consequent reductions in the nitrate content and enhancement of the ammonium content,then resulting in enhancing the conservation of soil N of successive rotations in Chinese fir plantation.

关键词： Secondary metabolics Nitrogen cycle Chinese fir Vanillin vanillic acid p-Hydroxybenzoic acid

“Cachacas”(Sugarcane Spirit)Aged Quantitation of Phenolic Compounds,Antibacterial and Antioxidant Activity

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American Journal of Plant Sciences 2014年第20期5卷 2935-3942页

作者： Leonardo Milani Avelar Rodrigues Maria das Gracas Cardoso Luís Roberto Batista Wilder Douglas Santiago Juliana Maria Valério Resende Juliana de Andrade Santiago Marcos de Souza Gomes Milene Aparecida Andrade Maria Luisa Teixeira Fabiana Reinis Franca Passamani Department of Food Science Federal University of LavrasLavrasBrazil Department of Chemistry Federal University of LavrasLavrasBrazil

The “cachaça” is currently one of the fastest growing agro-industrial industries in the country as the drink considered as a symbol of Brazilian nationality. This study aimed to quantify the phenolic compounds, evaluate the antioxidant and antibacterial activity of different samples of aged “cachaça”. The physic-chemical analysis was performed at the Brandy Quality Laboratory of the Federal University of Lavras, and the determination of phenolic compounds was performed by High Performance Liquid Chromatography (HPLC). The antimicrobial activity evaluation was held at the Food Mycology Laboratory through the cavity agar diffusion technique and by steam using the micro-organisms Escherichia coli, Staphylococcus aureus, Salmonella choleraesuis, Listeria monocytogenes and Pseudomonas aeruginosa. The antioxidant activity was evaluated using the DPPH radical sequestering method. The values obtained for the phenolic compounds ranged from 0.41 to 9.69 mg/L, observing the predominance of syringaldehyde, gallic acid and vanillic acid. The phenolic extracts showed a satisfactory antibacterial activity for both Gram-negative and Gram-positive but did not show inhibition against the bacteria Pseudomonas aeruginosa. The antioxidant activity was evidenced by the DPPH test for cachaças tested and the “cachaça” aged in oak barrel showed the highest activity, followed by “cachaça” aged in jequitibá, amburana and balm barrels.

关键词： Syringaldehyde Gallic acid vanillic acid Bacteria DPPH Test

A New Phenylated Flavone from Melicope pteleifolia

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Chinese Herbal Medicines 2011年第2期3卷 81-83页

作者： ZHU Sheng-hua1,2,GAO You-heng1,WEI Zhi-xiong1,XU Rui1 1.Guangzhou University of Chinese Medicine,Guangzhou 510405,China 2.Guangdong Food and Drug Vocational College,Guangzhou 510520,China Guangzhou University of Chinese Medicine Guangzhou 510405 China Guangdong Food and Drug Vocational College Guangzhou 510520 China Guangzhou University of Chinese Medicine Guangzhou 510405 China

Objective To study the constituents in Melicope *** Plant material was isolated with 80% *** were separated with chromatographic methods and their structures were elucidated on the basis of spectral analysis(EI-MS,1H-NMR,and 13C-NMR) and chemical *** Five compounds were isolated from petrol ether or ethyl acetate soluble *** structures were identified as 3,5,3’-trihydroxy-4’-methoxy-7-(3-methylbut-2-enyloxy) flavone(pteleifolosin C,1),3,7-dimethoxyl kaempferol(kamatakenin,2),vanillic acid(3),tricosanoic acid tetradecyl ester(4),and β-sitosterol(5),*** Compound 1 is a new structure named pteleifolosin *** 2-4 are isolated from this plant for the first time.

关键词： kamatakenin Melicope pteleifolia tricosanoic acid tetradecyl ester 3,5,3'-trihydroxy-4'-methoxy-7-(3-methylbut-2-enyloxy) flavone vanillic acid

Simultaneous Determination of eight constituents in Qin-Lian-Si-Wu Decoction by High-Performance Liquid Chromatography-DAD

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Simultaneous Determination of eight constituents in Qin-Lian...

Constituents of Chinese Drug Fangfeng, the Root of Saposhnikovia divaricata

中华中医药学会中药分析分会第三届学术交流会

作者：刘春梅 Jiangsu Key laboratory for TCM formulae Research Nanjing University of Chinese Medicine

A high-performance liquid chromatography-DAD method was applied to the determination of vanillic acid,caffeic acid,ferulic acid,protocatechuic acid,paeoniflorin, baicalin and scutellarin in Qin-Lian-Si-Wu decoction and other 5 crude *** eight compounds were analysed simultaneously with a Diamonsil C-18 column by gradient elution using 0.5%(v/v) acetic acid-acetonitrile as the mobile *** follow rate was 0.8mL/min, the temperate was 30℃,and detection was set at 230,260,280,310,323 *** linearity (r≥0.9995) of the 8 compounds was good in a relatively wide concertration rage,and the average recovery was 96.1～101.3%.The result indicated that the content of these eight compounds changed after decocting *** the compounds decreased significantly.

关键词： HPLC Qin-Lian-Si-Wu Decoction vanillic acid caffeic acid ferulic acid protocatechuic acid paeoniflorin baicalin scutellarin Chuanxiongzine

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Journal of Chinese Pharmaceutical Sciences 1992年第2期1卷 81-83页

作者：果德安刘治安楼之岑北京医科大学药学院北京100083

从防风根的乙醇浸出物中分离鉴定出8个化合物。通过理化数据及光谱分析,分别鉴定为香柑内酯(Ⅰ),花椒毒内酯(Ⅱ),亥茅酚(Ⅲ),异紫花前胡内酯(Ⅳ),东茛菪内酯(Ⅴ),香草酸(Ⅵ),D-甘露醇(Ⅶ)和蔗糖(Ⅷ),其中Ⅳ与Ⅵ为首次自此植物中提得。

关键词： Saposhnikovia divaricata Coumarins Marmesin vanillic acid