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Potential effect of Silybum marianum L. and Cistus ladaniferus *** on urine volume, creatinine clearance and renal function

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Asian Pacific Journal of Tropical Medicine 2018年第6期11卷 393-398页

作者： Nawal El Menyiy Noori Al-Waili Redouan El-Haskoury Meryem Bakour Soumia Zizi Thia Al-Waili Badiaa Lyoussi Physiology-Pharmacology and Environmental Health Laboratory Faculty of Sciences Dhar MahrazUniversity Sidi Mohamed Ben AbdallahFez 30000Morocco New York Medical Care for Nephrology Richmond HillNew York 11418USA

Objective:To investigate the diuretic and renal effects of Silybum marianum *** Cistus ladaniferus *** normal ***:Four groups of rats were used in each *** first group received water,the second group received Cistus ladaniferus ***(100 mg/kg ***),the third group received Silybum marianum ***(100 mg/kg ***),and the fourth group received furosemide(10 mg/kg ***).Variables including urine volume,plasma and urine sodium,potassium and creatinine,and creatinine clearance were *** experiments were conducted.A single dose of each intervention was used and the variables were measured during 24 h,and the interventions were given daily for a total of 8 d and the variables were measured during various ***:The single dose of each plant extract increased urine volume at all-time intervals and increased urine sodium and potassium excretion without affecting plasma sodium and potassium(P<0.05).On the day 8 after daily administration,the plant extracts induced a significant diuresis and natriuresis without affecting serum electrolytes(P<0.05),while furosemide caused *** plant extracts significantly increased creatinine clearance(P<0.05).Conclusions:Silybum marianum *** Cistus ladaniferus L Increase creatinine clearance and have a significant diuretic effect without affecting serum *** marianum *** more potent than furosemide or Cistus ladaniferus L.

关键词： Silybum marianum L. Cistus ladaniferus L. Diuresis urine volume Sodium Potassium Creatinine clearance

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San-Ao Decoction (三拗汤) Regulates urine volume on Bronchial Asthma Model Mice

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Chinese Journal of Integrative Medicine 2021年第3期27卷 212-219页

作者： WANG Min SUN Yan ZHANG Shu-jing GAO Yu-shan WEI Ya-nan ZHAO Peng-na LIU Miao YANG Jia-min ZHENG Feng-jie XU Hong LI Yu-hang School of Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China

Objective To observe the effect of San-Ao Decoction(三拗汤,SAD)on water metabolism of bronchial asthra model *** Forty-five female BALB/c mice were randomly divided into control,model and SAD groups by a random number table,15 mice in each group.A composite method with ovalbumin(OVA)sensitization and challenge was developed to establish bronchial asthma *** in the control group were intraperitoneally injected with distilled water without aerosol inhalation *** day 15–22,0.3 mL SAD was administered via gastric route in SAD group,one time per day,while an equivalent volume of normal saline was used for gastric administration in the control and model *** in airway resistance in the inspiratory phase(RI-R-Area)were detected using an AniRes2005 system,and 5-h urine output was collected by metabolic *** changes in lung and kidney were observed by hematoxylin-eosin *** expressions of aquaporin(AQP)1 and AQP2 in kidney were detected by reverse transcription-polymerase chain reaction,and the protein expressions of AQP1 and AQP2 in kidney were detected by ***-linked immune sorbent assay was used to detect the OVA-specific endothelium-1(ET-1),antidiuretic hormone(ADH),atrial natriuretic peptide(ANP),prostaglandin E_(2)(PGE_(2)),and angiotensin II(Ang II)levels in serum,lung and kidney tissues,*** nitric oxide(NO)contents in serum,lung,and kidney tissues were tested by chemical method,*** Compared with the control group,the serum IgE level in model group increased(P<0.01).Following the pathologic changes in lung tissue,no significant change in kidney tissue was observed among 3 *** with the control group,the mice in the model group showed elevated airway resistance during inhalation phase,higher mRNA and protein expression levels on AQP1 and AQP2 in kidney tissue and higher ET-1 levels in serum,lung and kidney tissues,ADH and ANP in lung and serum,PGE

关键词： regulation of fluid passage urine volume aquaporin San-Ao Decoction bronchial asthma

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Evaluation of the diuretic effects of crude stem bark extraction of Zanthoxylum heitzii(Rutaceae) in Wistar rats

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Journal of Integrative Medicine 2015年第5期13卷 326-335页

作者： Fidèle Ntchapda Maguirgue Kakesse Michel Archange Tagne Fokam Olivier Mbouemboue Pancha Djedouboum Abakar Théophile Dimo Department of Biological Sciences Faculty of Science University of Ngaoundéré Cameroon Department of Biomedical Sciences Faculty of Science University of Ngaoundéré Cameroon Department of Animal Biology and Physiology Faculty of Science University of Yaoundé I

OBJECTIVE： Zanthoxylum heitzii is a medicinal plant widely used in central Africa for the treatment of many diseases, especially cardiovascular diseases and hypertension. The diuretic effects of crude stern bark extraction were determined and its safety in rats was evaluated. METHODS： The diuretic effects of crude stem bark extraction of Z. heitzii were investigated in Wistar rats （250 g ＋ 10 g） of both sexes. The crude stem bark extraction of Z. heitzii at the doses of 225, 300 and 375 mg/kg was administered to rats at 5 mL/kg body weight. urine volume was determined 1, 2, 3, 4, 5, 6 and 24 h after administration of the extract. Kinetics of electrolyte elimination in response to a single oral administration dose of acute treatment was measured. The experiments were performed under the same conditions with two synthetic pharmacological diuretics considered as reference （furosemide and hydrochlorothiazide）. Urinary and plasma concentrations of sodium and potassium ions were determined using flame photometry. Concentrations of creatinine, urea, glucose, albumin and electrolytes in the plasma and urine samples were evaluated using a two-way digital bidirectional spectrophotometer. The osmolarity of plasma and urine samples was measured by cytometry using an osmometer. Aldosterone was measured by radioimmunoassay. RESULTS： The plant extract accelerated the elimination of overloaded fluid and increased urine volume and the excretion of Na＋, K＋ and CI 24 h after administration （P〈0.05）. The increase in elimination of Na＋, K＋, and Cl- induced by the extract caused alkalinization of the urine, and showed a strong inhibitory effect on carbonic anhydrase and saluretic. These effects were mainly observed at the dose of 375 mg/kg. At the maximum diuretic response, urinary osmolarity decreased significantly （P 〈 0.05） when compared to controls. The stability of aldosterone level, the absence of correlation with the plasma levels of Na＋, and increased clearance of free water in t

关键词： Zanthoxylum heitzii diuretic urine volume urine pH electrolytes temperature rectal

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Activation of mammalian target of rapamycin complex 1（m TORC1） impairs urine concentration in mice

Activation of mammalian target of rapamycin complex 1（m TOR...

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中国生理学会第24届全国会员代表大会暨生理学学术大会

作者：黄世铮 Qifei Han Liwei Ding Hu Xu Yuxiang Qiu Jialin Fu Yunfeng Zhou Xiaoyan Zhang Youfei Guan 北京大学 Department of Physiology and Pathophysiology Peking University Health Science CenterKey Laboratory of Cardiovascular Science of the Ministry of Education Department of Nephrology Nantong School of MedicineNantong University Department of Physiology Shenzhen University Health Science Center

The mammalian target of rapamycin（mTOR）signaling pathway is a master regulator of cell ***,inhibition of m TOR complex 1（m TORC1）with rapamycin has also been shown in both clinical and experimental studies to have beneficial effects in diabetic nephropathy and other kidney diseases including autosomal dominant polycystic kidney disease and renal cell ***,the activity and the physiological function of m TORC1 in the kidney remain largely *** determined the intrarenal localization of phosphorlation-ribosomal protein S6（p S6）,which is the major activated target of m TORC1 signal cascade,in mouse *** study demonstrated that the kidney exhibited constitutively high expression of p S6 with a ubiquitous expression pattern along renal *** further investigate the distribution of p S6 in renal tubules,we used several tubule-specific makers to determine intrarenal localization of p S6 in renal *** found that p S6 was specifically expressed in the thick ascending limbs,distal tubules,and collecting ducts,suggesting that m TOR may play an important role in renal physiology and *** C57BL/6 mice were treated with rapamycin by intraperitoneal injection for either 7 days or 21 *** urine osmolality was increased dramatically,while urine excretion significantly declined compared to the control untreated *** suggests that inactivation of m TORC1 promotes urine concentration in *** the four major types of aquaporins（AQPs）expressed in the kidney,expression of AQP2 was significantly increased,while AQP3 and AQP4was significantly decreased in rapamycin treated *** unbalanced changes of these AQPs in the collecting duct cells may contribute to the increased water absorption in rapamycin treated *** sclerosis complex 1（TSC1）is a negative regulator of m *** crossed AQP2-Cre mice with TSC1flox/flox mice to generate AQP2-Cre+TSC1flox/flox（AQP2-TSC1-/-）mice in which m TORC1

关键词： mTORC1 urine volume rapamycin aquaporin

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