检索结果-南通市图书馆

One Stone Four Birds:A Novel Liposomal Delivery System Multi-functionalized with Ginsenoside Rh2 for tumor targeting Therapy

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2020年第10期12卷 69-86页

作者： Chao Hong Jianming Liang Jiaxuan Xia Ying Zhu Yizhen Guo Anni Wang Chunyi Lu Hongwei Ren Chen Chen Shiyi Li Dan Wang Huaxing Zhan Jianxin Wang Department of Pharmaceutics School of PharmacyFudan University&Key Laboratory of Smart Drug DeliveryMinistry of EducationShanghai 201203People’s Republic of China Institute of Tropical Medicine Guangzhou University of Chinese MedicineGuangzhou 510006People’s Republic of China Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhou 510006People’s Republic of China School of Pharmacy Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Shanghai Ginposome Pharmatech Co. LtdShanghai 201600People’s Republic of China Institute of Integrated Chinese and Western Medicine Fudan UniversityShanghai 200040People’s Republic of China

Liposomes hold great potential in anti-cancer drug delivery and the targeting treatment of ***,the clinical therapeutic efficacy of liposomes is still limited by the complexity of tumor microenvironment(TME)and the insufficient accumulation in tumor ***,the application of cholesterol and polyethylene glycol(PEG),which are usually used to prolong the blood circulation and stabilize the structure of liposomes respectively,has been questioned due to various ***,we developed a ginsenoside Rh2-based multifunctional liposome system(Rh2-lipo)to effectively address these challenges once for *** with the conventional’wooden’liposomes,Rh2-lipo is a much more brilliant carrier with multiple *** Rh2-lipo,both cholesterol and PEG were substituted by Rh2,which works as membrane stabilizer,long-circulating stealther,active targeting ligand,and chemotherapy adjuvant at the same ***,Rh2 could keep the stability of liposomes and avoid the shortcomings caused by ***,Rh2-lipo showed a specifically prolonged circulation behavior in the ***,the accumulation of the liposomes in the tumor was significantly enhanced by the interaction of glucose transporter of tumor cells with ***,Rh2-lipo could remodel the structure and reverse the immunosuppressive environment in *** tested in a 4T1 breast carcinoma xenograft model,the paclitaxel-loaded Rh2-lipo realized high efficient tumor growth ***,Rh2-lipo not only innovatively challenges the position of cholesterol as a liposome component,but also provides another innovative potential system with multiple functions for anti-cancer drug delivery.

关键词： Ginsenoside Rh2 Liposomes Cholesterol Multifunction tumor targeting

A detachable coating of cholesterol-anchored PEG improves tumor targeting of cell-penetrating peptide-modified liposomes

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2014年第1期4卷 67-73页

作者： Jie Tang Li Zhang Han Fu Qifang Kuang Huile Gao Zhirong Zhang Qin Hen Key Laboratory of Drug targeting and Drug Delivery Systems Ministry of EducationWest China School of PharmacySichuan UniversityChengdu 610041China

Cell-penetrating peptides(CPPs)have been widely used to enhance the membrane transloca-tion of various carriers for many years,but the non-specificity of CPPs seriously limits their utility in *** this study,cholesterol-anchored,reduction-sensitive PEG(first synthesized by our laboratory)was applied to develop a co-modified liposome with improved tumor *** optimization of the formulation,the in vitro and in vivo properties of the co-modified liposome were *** co-modified liposome had a much lower cellular uptake and tumor spheroid uptake,but a much higher tumor accumulation compared to CPP-modified liposome,indicating the non-specific penetration of CPPs could be attenuated by the outer PEG *** the addition of exogenous reducing agent,both the in vitro and in vivo cellular uptake was markedly increased,demonstrating that the reduction-sensitive PEG coating achieved a controllable detachment from the surface of liposomes and did not affect the penetrating abilities of *** present results demonstrate that the combination of cholestervsitive PEG and CPPs is an ideal alternative for the application of CPP-modified carriers in vivo.

关键词： Cell penetrating peptide Reduction-sensitive PEG tumor targeting Cholesterol Liposome

A novel tumor-targeting treatment strategy uses energy restriction via co-delivery of albendazole and nanosilver

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2018年第9期11卷 4507-4523页

作者： Jianming Liang Ruixiang Li Yuwei He Chengli Ling Qi Wang Yongzhuo Huang Jing Qin Weigen Lu Jianxin Wang Department of Pharmaceutics School of Pharmacy Fudan University & Key Laboratory of Smart Drug Delivery Ministry of Education Shanghai 201203 China Institute of Clinical Pharmacology Guangzhou University of Traditional Chinese Medicine Guangzhou 510006 China Shanghai Institute of Materia Medica Chinese Academy of Sciences 501 Haike Rd. Shanghai201203 China Shanghailnstitute of Pharmaceuticallndustry China State Institute of Pharmaceutical Industry 285 Gebaini Rd. Shanghai201203 China School of Pharmacy Chengdu University of Traditional Chinese Medicine No 1166 Liu TaiAvenue Wenjiang District Chengdu 610072 China

Although nanotechnology has been rapidly developed and applied in tumor targeting, the outcome of chemotherapy remains greatly restricted by the toxicity of cytotoxic drugs in normal tissues and cells. Therefore, the development of alternative delivery systems, with few side effects in normal cells, has attracted increasing attention. Energy restriction is a novel and promising approach to cancer treatment, which can restrict tumor growth via inhibition of cellular energy metabolism. In this study, a novel tumor targeting system, based on folate-conjugated bovine serum albumin （BSA）, was developed to co-deliver albendazole and nanosilver simultaneously, to restrain the energy metabolism of tumor cells. This nanosystem showed stronger anti-tumor efficacy than those using nanoparticles without folic acid modification, nanosilver, or albendazole, both in vitro and in vivo. This nanosystem depleted cellular ATP via direct inhibition of glycolytic enzymes and mitochondrial damage, resulting in inhibition of proliferation, cell-cycle arrest, and apoptosis of tumor cells. The enhanced anti-tumor activity contributed to the tumor-targeting ability of this system, resulting in specific energy inhibition in tumor cells. Toxicity evaluation was performed to confirm the safety of this system. This nanosystem provides an efficient and safe strate~ for tumor therapy.

关键词： albendazole nano silver co-delivery tumor targeting energy metabolism

Harnessing bacteria for tumor therapy:Current advances and challenges

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第2期35卷 97-106页

作者： Lina Guo Jinsong Ding Wenhu Zhou Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Changsha Medical University Academician WorkstationChangsha 410219China Key Laboratory of Biological Nanotechnology of National Health Commission Changsha 410008China

After a century of standstill,bacteria-based tumor therapy has resurged recently benefiting from the revolution of tumor immunotherapy,which provides unique solutions to tackle the obstacles of traditional tumor *** and facultative anaerobes with active tropism can selectively colonize at tumor sites and suppress tumor growth via different mechanisms,serving as attractive tools for tumor treatment either as a monotherapy or combining with other therapies for synergistic anti-tumor *** this critical review,we introduce the recent advances of bacteria-based tumor therapy from the following ***,the general properties of bacteria are reviewed emphasizing on their structural components related to tumor immunotherapy,and the main bacteria that have been used in tumor therapy are ***,the benefits of bacteria for tumor therapy are illustrated,such as tumor targetability,deep penetration,and facile genetic engineering for attenuation,enhanced efficacy,as well as ***,anti-tumor mechanisms of bacteria are summarized,which refer to intrinsic tumoricidal activities,immune activation,bacteria metabolism,and their capability to regulate gut microbiota ***,bacteria could act as carriers to deliver various types of therapeutics to achieve combination therapy with improved *** addition,several challenges for anti-tumor applications of bacteria are discussed regarding the delivery,efficacy and safety issues,and potential solutions are also ***,the possible improvements and perspectives are discussed in the end,which provide a guideline for the design of advanced bacteria-based tumor therapeutics in the future.

关键词： Bacteria tumor targeting Immunotherapy Combination therapy Genetic engineering Surface decoration

Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第7期14卷 3009-3026页

作者： Saini Setua Shabia Shabir Poornima Shaji Ana Martinez Bulnes Anupam Dhasmana Swathi Holla Nivesh K.Mittal Nirakar Sahoo Tripti Saini Francesco Giorgianni Mohammad Sikander Andrew E.Massey Bilal B.Hafeez Manish K.Tripathi Vincent P.Diego Meena Jaggi Junming Yue Nadeem Zafar Murali M.Yallapu Stephen W.Behrman Sheema Khan Subhash C.Chauhan Department of Pharmaceutical Sciences College of Pharmacyand College of MedicineUniversity of Tennessee Health Science Center(UTHSC)MemphisTN 36163USA Department of Computer Science Islamic University of Science and TechnologyAwantiporaJ&K 192122India Department of Immunology and Microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX 78504USA South Texas Center of Excellence in Cancer Research School of Medicinethe University of Texas Rio Grande ValleyMcAllenTX 78504USA Himalayan School of Biosciences and Cancer Research Institute Himalayan Institute of Medical SciencesSwami Rama Himalayan UniversityDehradun 248016India Plough Center for Sterile Drug Delivery Solutions UTHSCMemphisTN 38104USA Department of Biology College of SciencesUTRGVMcAllenTX 78539USA National Institute of Biomedical Imaging and Bioengineering(NIBIB) National Institutes of HealthBethesdaMD 20892USA South Texas Diabetes and Obesity Institute UTRGVMcAllenTX 78504USA Dept.of Laboratory Medicine&Pathology University of WashingtonSeattleWA 98195USA Department of Surgery Baptist Memorial Medical EducationBaptist Memorial HospitalMemphisTN 38120USA Baptist Health Sciences University MemphisTN 38104USA

The application of extracellular vesicles,particularly exosomes(EXs),is rapidly expanding in the field of medicine,owing to their remarkable properties as natural carriers of biological *** study investigates utilization of exosomes derived from stromal cells of tumor adjacent normal tissues(NAF-EXs)for personalized medicine,which can be derived at the time of diagnosis by endoscopic ***,we show that exosomes(EXs)derived from NAFs demonstrate differential bio-physical characteristics,efficient cellular internalization,drug loading efficiency,pancreatic tumor targeting and delivery of ***-derived EXs(NAF-EXs)were used for loading ormeloxifene(ORM),a potent anti-cancer and desmoplasia inhibitor as a model *** found that ORM maintains normal fibroblast cell phenotype and renders them incompatible to be triggered for a CAF-like phenotype,which may be due to regulation of Ca^(2+) influx in fibroblast ***-EXs-ORM effectively blocked oncogenic signaling pathways involved in desmoplasia and epithelial mesenchymal transition(EMT)and repressed tumor growth in xenograft mouse *** conclusion,our data suggests preferential tropism of NAF-EXs for PDAC tumors,thus imply feasibility of developing a novel personalized medicine for PDAC patients using autologous NAF-EXs for improved therapeutic outcome of anti-cancer ***,it provides the opportunity of utilizing this biological scaffold for effective therapeutics in combination with standard therapeutic regimen.

关键词： Pancreatic cancer tumor adjacent normal tissue fibroblasts(NAF) Desmoplasia Extracellular vesicles Exosomes tumor targeting Ormeloxifene Personalized medicine

Far-Red and Near-IR AIE-Active Fluorescent Organic Nanoprobes with Enhanced tumor-targeting Efficacy: Shape-Specific Effects

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Far-Red and Near-IR AIE-Active Fluorescent Organic Nanoprobe...

targeting neuropilin-1 interactions is a promising anti-tumor strategy

中国化学会第十三届全国分析化学年会

作者： Jie Zhang ong Shao Zhiqian Guo HeTian Wei-Hong Zhu Key Laboratory for Advanced Materials and Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science ＆ Technology

The rational design of high-performance fluorescent materials for cancer targeting in vivo is still challenging. A unique molecular design strategy is presented that involves tailoring aggregation-induced emission（AIE）-active organic molecules to realize preferable far-red and NIR fluorescence, well-controlled morphology（from rod-like to spherical）, and also tumor-targeted bioimaging. The shape-tailored organic quinoline–malononitrile（QM） nanoprobes are biocompatible and highly desirable for cell-tracking applications. Impressively, the spherical shape of QM-5 nanoaggregates exhibits excellent tumor-targeted bioimaging performance after intravenously injection into mice, but not the rod-like aggregates of QM-2.

关键词： Aggregation-induced emission fluorescent probes morphology effects near infrared tumor targeting

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Chinese Medical Journal 2021年第5期134卷 508-517页

作者： Shao-Dan Liu Li-Ping Zhong Jian He Yong-Xiang Zhao National Center for International Research of Bio-targeting Theranostics Guangxi Key Laboratory of Bio-targeting TheranosticsCollaborative Innovation Center for Targeting Tumor Diagnosis and TherapyGuangxi Medical UniversityNanningGuangxi 530021China

Neuropilins(NRP1 and NRP2)are multifunctional receptor proteins that are involved in nerve,blood vessel,and tumor ***1 was first found to be expressed in neurons,but subsequent studies have demonstrated its surface expression in cells from the endothelium and lymph ***1 has been demonstrated to be involved in the occurrence and development of a variety of ***1 interacts with various cytokines,such as vascular endothelial growth factor family and its receptor and transforming growth factor p i and its receptor,to affect tumor angiogenesis,tumor proliferation,and *** addition,NRP1+regulatory T cells(Tregs)play an inhibitory role in tumor *** numbers of NRP1+Tregs were associated with cancer *** NRP1 has shown promise,and antagonists against NRP1 have had therapeutic efficacy in preliminary clinical ***1 treatment modalities using nanomaterials,targeted drugs,oncolytic viruses,and radio-chemotherapy have gradually been ***,we reviewed the use of NRP1 in the context of tumorigenesis,progression,and treatment.

关键词： Neuropilin-1 Anti-tumor Immunotherapy tumor targeting

Construction of Magnetic Resonance Imaging Visible Polymeric Vector for Efficient tumor Targeted siRNA Delivery

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2022年第9期40卷 1071-1079页

作者： Rong-Ze Wang Si Huang Qiao-Yun Zhang Xing-Su Yu Ke-Ze Hong Jian-Rong Cao Hong Xiao Yong Wang Xin-Tao Shuai College of Chemistry and Materials Science Jinan UniversityGuangzhou 510632China Nanomedicine Research Center The Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China Department of Reproductive Medical Center Guangdong Women and Children HospitalGuangzhou 511400China

RNA interference(RNAi),known for the highly efficient targeted gene silencing,has been demonstrated to be a promising means for cancer ***,an effective approach for siRNA delivery is urgently needed to meet the needs for its clinical ***,we constructed a polymeric vector labeled with superparamagnetic iron oxide(SPIO)for magnetic resonance imaging(MRI)visible siRNA *** antibody was also modified to the surface of nanodrug to enhance the delivery *** results showed that the vector exhibited great siRNA complexation ability and mediated an increased endocytosis of siRNA without obvious ***,both in vitro and in vivo studies evidenced the vector could effectively deliver siRNA into tumor cells,exert highly interfering effect,and show potent MR imaging *** study provides a promising MRI-visible and EGFR targeting delivery system to improve RNAi efficacy for cancer therapy.

关键词： Polymeric vector siRNA delivery Magnetic resonance imaging visible tumor targeting

Preparation and functional study of pH-sensitive amorphous calcium phosphate nanocarriers

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2022年第8期35卷 244-252页

作者： Baolong Niu Min Li Jianhong Jia Lixuan Ren Xin Gang Bin Nie Yanying Fan Xiaojie Lian Wenfeng Li College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Interface Science and Engineering in Advanced Materials Taiyuan University of TechnologyTaiyuan 030024China Department of Biomedical Engineering Research Center for Nano-biomaterials&Regenerative MedicineCollege of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China Shanxi Key Laboratory of Material Strength&Structural Impact Institute of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China School of Basic Medical Sciences Shanxi Medical UniversityTaiyuan 030001China

Recently,multifunctional nanoparticles have shown great prospects in cancer treatment,which have the ability to simultaneously deliver the drug,image and target tumor *** this paper,we designed a luminescent nanoparticles platform based on hydrothermal hyaluronic acid/amorphous calcium phosphate(HA-FCNs/ACP)with multifunctional properties for drug delivery,bio-imaging,and targeting ***-FCNs/ACP shows an ability to load curcumin(Cur)with pH-sensitive responsive drug release behavior and excellent ***-FCNs/ACP dispersed in the cytoplasm through the overexpressed CD44 receptor that is actively targeted into human lung cancer cells(A549 cells).Meanwhile,the viability of A549 cells was significantly inhibited in *** prepared HA-FCNs and HA-FCNs/ACP both exhibit excellent targeted bioimaging performance on cancer ***,the as-prepared nanoparticles have promising applications in treating tumor disease.

关键词： Hyaluronic acid Amorphous calcium phosphate Fluorescent carbon nanoparticles pH-sensitive tumor targeting