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Effect of iron supplementation on glucose transporter 4 expression in adipose tissue and skeletal muscle of pregnant rats

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Open Journal of Obstetrics and Gynecology 2013年第6期3卷 500-507页

作者： Mulan He Jing Jiang Shuangping Liu Haidong Cheng Department of Obstetrics Obstetrics and Gynecology Hospital Fudan University Shanghai China

Objective: The main goal of the present study was to investigate the effect of iron supplementation on glucose transporter 4 expressions in adipose tissue and skeletal muscle in female rats during pregnancy. Methods: Twenty-four pregnant Sprague-Dawley rats were randomly divided into 2 groups: a control group with a standard diet (containing iron 150 mg/kg) and an iron-supplementation group with a high-iron diet (containing iron 700 mg/kg) from day 0 to day 21 of pregnancy. Intraperitoneal glucose tolerance test was performed on gestational day 19. On gestational day 21, all of the pregnant rats from each group were sacrificed. The mean neonatal weights were measured and samples of maternal intraabdominal adipose tissue and skeletal muscle were taken to measure the expression of Glucose transporter 4 (GLUT4) mRNA and protein. Results: Glucose tolerance decreased significantly in the iron supplementation group compared to the control group. The mean neonatal weights in the iron supplementation group were higher than that in the control group. Levels of GLUT4 mRNA in the adipose tissue were reduced by the administrations of high-iron diet. The skeletal muscle GLUT4 mRNA levels were not changed significantly by iron supplementation. Expression of GLUT4 protein both in the adipose tissue and skeletal muscle reduced significantly. Conclusion: These results suggest that iron supplementation during pregnancy would increase neonatal weights and could decrease maternal glucose tolerance by interfering GLUT4 expression in adipose tissue and skeletal muscle of rats.

关键词： Iron Diabetes Gestational Insulin Resistance Glucose transporter Type 4 (GLUT4) Rats

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Genetic Polymorphisms of Hepatic ABC-transporter in Patients with Hepatocellular Carcinoma

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Journal of Cancer Therapy 2010年第3期1卷 114-123页

作者： Minoru Fukuda Yasutsugu Kawahara Takeshi Hirota Setsuko Akizuki Shigeto Shigeto Hisato Nakajima Ichiro Ieiri Akihiro Ohnishi 不详

We examined whether genetic polymorphisms of efflux transporters in hepatocytes are associated with susceptibility to develop hepatocellular carcinoma (HCC). Genetic polymorphisms of drug transporters expressed in hepatocytes were analyzed using DNA samples from hepatitis C virus (HCV)-seropositive cirrhotic patients with HCC (n = 58), and allele and haplotype frequencies were compared with those in healthy subjects (n = 61). To search for single nucleotide polymorphisms (SNPs) in HCC susceptibility genes, 34 SNPs in 6 efflux transporters [MDR1 (ABCB1), ABCC1, ABCC2, ABCC3, ABCG2 and ABCB11] were determined. No significant association was observed for any single SNP;however, some haplotypes in ABCC1 and ABCB11 were associated with HCC. Furthermore, three combinations of SNPs (3435C > T in ABCB1 and 825T > C in ABCC1), (3435C > T in ABCB1 and -15281_-15278CTCT > delete in ABCB11), and (825T > C in ABCC1 and -15281_-15278CTCT > delete in ABCB11) were significantly associated with HCC. The present study suggests that genetic variations of ABC transporters such as ABCB1, ABCB11, and ABCC1 are associated with susceptibility to develop HCC, implying that aberrant hepatic clearance of toxic substances may increase the risk of hepatocarcinogenesis. Further studies of how these polymor-phisms are associated with phenotypic differences are warranted.

关键词： Genetic Polymorphism Drug transporter Hepatitis C Virus Hepatocellular Carcinoma

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EFFECT OF ELECTRO-ACUPUNCTURE ON GLUTAMATE transporter mRNA EXPRESSION FOLLOWING FOCAL CEREBRAL ISCHEMIA IN RATS

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World Journal of Acupuncture-Moxibustion 1998年第3期8卷 31-34页

作者：晏义平孙风艳

In this study, in situ hybridization histochemistry technique was used to observe the effect of electro-acupuncture (EA) on glutamate transporter mRNA expression following focal cerebral ischemia. We observed that glutamate transporter mRNA expression decreased significantly in the area penumbra of cerebral cortex at 12h following focal cerebral ischemia. EA did not change glutamate transporter mRNA expression in normal rat brain but prevented the decrease of glutamate transporter mRNA expression in the area penumbra of cerebral cortex following focal cerebral ischemia. The results suggest that the protective effect of EA on ischemic neuronal death may bhe related to the increase of uptake of glutamate by its transporter.

关键词： Electro-acupuncture Glutamate transporter Cerebral ischemia Neurotoxicity

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Immunohistochemical localization of glutamate transporter EAAC1in the brainstem of adult rat

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Journal of Medical Colleges of PLA(China) 2001年第4期16卷 247-251页

作者：张富兴刘涛赵经纬李金莲董玉琳李继硕 Department of A natomy and K. K. Leung Brain Research Center Fourth Military Medical University Xi'an 710032China Institute of Neurobiology Fudan University Shanghai 200433 China

Objective:To observethedistributionof EAAC1, a subtypeof glutamatetransporters,inthebrainstemof adultrat.Methods:Immunocytochemicalstainingwithavidin-biotincomplex(ABC)methodwas employed.Results:EAAC1waswidely distributedthroughoutthebrainstem.In manyregions,theEAAC1-likeimmunoreactivitywaspri-marilydistributedin theneuropil.Cellbodystainingwas observedin theprepositushypoglossalnucleus,externalcortex of theinferiorcolliculus,rednucleus,substantianigra,mesencephalicraphenuclei,ventraltegmentalnucleus,superior olivarycomplex,nucleus of thetrapezoidbody,cochlearnucleus,sensorytrigeminalcomplex,Barrington’snucleus,trigeminalmotornucleus,parabrachialnuclei,dorsalnucleus of vagus,hypoglossalnucleus,locuscoeruleus,lateraland superiorvestibularnuclei,lateralparagigantocellularnucleusanddorsalparagigantocellularnucleus.Conclusion:Gluta-matetransporterEAAC1iswidelydistributedthroughoutthebrainstemof adultrat,whichmayplayan importantrolein excitatoryactivitiesof theneuronsinducedby glutamate.

关键词： glutamate transporter EAAC 1 immunocytochemistry brainstem, rat

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Molecular basis for optimizing sugar metabolism and transport during fruit development

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aBIOTECH 2021年第3期2卷 330-340页

作者： Tong Chen Zhanquan Zhang Boqiang Li Guozheng Qin Shiping Tian Key Laboratory of Plant Resources Institute of BotanyChinese Academy of SciencesBeijing 100093China University of Chinese Academy of Sciences Beijing 100049China

Sugars are fundamental metabolites synthesized in leaves and further delivered to fruit in fruit crops.They not only provide"sweetness"as fruit quality traits,but also function as signaling molecules to modulate the responses of fruit to environmental stimuli.Therefore,the understanding to the molec-ular basis for sugar metabolism and transport is crucial for improving fruit quality and dissecting responses to abiotic/biotic factors.Here,we provide a review for mol ecular components involved in sugar metabolism and transport,crostalk with hormone signaling and the roles of sugars in responses to abiotic and biotic stresses.Moreover,we also envisage the strategies for optimizing sugar metabolism during fruit quality maintenance.

关键词： Abiotic and biotic stress Fruit quality maintenance Postharvest diseases Sugar metabolism transporter

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Epigenetic regulation of drug metabolism and transport

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Acta Pharmaceutica Sinica B 2015年第2期5卷 106-112页

作者： Lai Peng Xiaobo Zhong Department of Pharmaceutical Sciences School of Pharmacy University of Connecticut Key Laboratory of System Biomedicine Center for Comparative Biomedicine Institute of Systems BiomedicineShanghai Jiao Tong University

The drug metabolism is a biochemical process on modification of pharmaceutical substances through specialized enzymatic systems. Changes in the expression of drug-metabolizing enzyme genes can affect drug metabolism. Recently, epigenetic regulation of drug-metabolizing enzyme genes has emerged as an important mechanism. Epigenetic regulation refers to heritable factors of genomic modifications that do not involve changes in DNA sequence. Examples of such modifications include DNA methylation, histone modifications, and non-coding RNAs. This review examines the widespread effect of epigenetic regulations on genes involved in drug metabolism, and also suggests a network perspective of epigenetic regulation. The epigenetic mechanisms have important clinical implications and may provide insights into effective drug development and improve safety of drug therapy.

关键词： Drug metabolism DNA methylation Epigenetics Histone modification Non-coding RNA transporter

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Design and Analysis of a Self-Adaptive Monorail transporter without Power Supply

Design and Analysis of a Self-Adaptive Monorail Transporter ...

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作者： Bao Zhou Rui Hu Miao He Yujin Wang Hui Jin College of Mechanical Engineering Chongqing University of Technology

An unpowered monorail transporter with self-adaptive function is proposed, which can convey crops downward at a relatively stable speed in mountainous regions. The monorail transporter is composed of the body, guiding mechanism, damping mechanism, braking mechanism, etc. Through the combination of compression spring, torsion spring and linear bearing, the transporter can adapt itself to the track passively and adjust its speed self-adaptively. The mechanical structure is designed in the paper firstly, and then the functional relationship between the speed and the stiffness of springs and the track parameters is obtained through the analysis of the kinematics and turning performance. Furthermore, a virtual simulation model is established to verify the reasonableness of the mechanical structure design and the analysis process.

关键词： transporter no power supply adaptive function

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Serotonin transporter gene polymorphisms in irritable bowel syndrome and their impact on tegaserod treatment

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China Medical Abstracts(Internal Medicine) 2006年第4期23卷 216-217页

作者：李瑜元 Dept Gastroenterol 1st People's Hosp Guangzhou 510180

Objective To investigate the serotonin reuptake transporter (SERT) genetic polymorphisms in the 5 -hydroxytryptamine (5-HT) transporter gene-linked polymorphic region (5-HTTLPR) and the variable number tandem repeats (VNTRs) in intron 2 among Chinese people, and their relationship to the pathogenesis of irritable bowel syndrome (IBS);and to investigate the im-

关键词： irritable transporter pathogenesis polymorphic serotonin tandem severity intron predominant repeats

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Manganese methionine hydroxy analog chelated affects growth performance,trace element deposition and expression of related transporters of broilers

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Animal Nutrition 2021年第2期7卷 481-487页

作者： Tiantian Meng Lumin Gao Chunyan Xie Yangkui Xiang Yiqiang Huang Yawei Zhang Xin Wu CAS Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical Agriculture National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry ProductionChangsha410125China Hunan Co-Innovation Center of Safety Animal Production College of Animal Science and Technology College of Resources and EnvironmentHunan Agricultural UniversityChangsha410128China Tianjin Institute of Industrial Biotechnology Chinese Academy of SciencesTianjin300308China Hunan Provincial Research Center of Mineral Element Nutrition Engineering Technology Xing-Jia Bio-engineering Co.Ltd.410300ChangshaChina

The present study aimed to evaluate the effects of manganese methionine hydroxyl analog chelated(Mn-MHAC)as a manganese(Mn)source on growth performance and trace element deposition in broilers.A total of 432 Arbor Acres commercial female broilers were fed a basal corn-soybean diet containing Mn at 25.64 mg/kg diet for 10 d.They were then randomly assigned to 6 groups,including a control group(the basal diet),a Mn sulfate group(the basal diet supplemented with Mn at 100 mg/kg diet),and 4 Mn-MHAC groups(the basal diet supplemented with Mn-MHAC at 25,50,75 and 100 mg Mn/kg diet,respectively).The results showed that compared with the control group,groups supplemented with Mn-MHAC had a positive effect on BW(quadratic,P=0.017)and ADG(quadratic,P=0.017).Moreover,the Mn-MHAC(50 mg Mn/kg diet)group had significantly greater BW and ADG(Ptransporter 1(DMT1)(P=0.024),ferro-portin 1(FPN1)(P=0.049),and Cu transporter-1(CTR1)(P<0.001)in the duodenum,as well as CTR1 in the jejunum and ileum(P=0.040 and 0.011,respectively)were higher in the Mn-supplemented group than in the control group.Furthermore,the relative mRNA level of DMT1 in the jejunum and ileum of broilers in the Mn-MHAC group(50 mg Mn/kg diet)did not differ from those in the control group,but was lower than those in the Mn sulfate group(P<0.05).In conclusion,Mn-MHAC dietary supplementation improved the growth performance and trace element deposition in broilers.From this study,we recommend the opti-mum Mn-MHAC level to meet the Mn requirement of broilers is 50 to 75 mg Mn/kg diet.

关键词： Manganese methionine hydroxy analog chelated Trace element Deposition transporter Broiler

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Plant Nutrition for Human Nutrition:Hints from Rice Research and Future Perspectives

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Molecular Plant 2020年第6期13卷 825-835页

作者： Sheng Huang Peitong Wang Naoki Yamaji Jian Feng Ma Institute of Plant Science and Resources Okayama UniversityChuo 2-20-1Kurashiki 710-0046Japan

Both plants and humans require mineral elements for their healthy growth and development.Mineral elements in the soil are taken up by the plant roots and transported to the edible parts for human consumption through various different transporters.An ideal future crop for human health should be rich in essential mineral elements but with less toxic elements in the edible parts.However,due to the great difference in the numbers and amounts of mineral elements required between plants and humans,it is a challenge to balance plant growth and nutrient requirement for humans.In this article,we mainly focus on the transport system of mineral elements from soil to grain in rice,a staple food for half of the world's population,and discuss recent progress on the underlying genetic and physiological mechanisms.Examples are given for silicon,zinc,and iron essential/beneficial for both plants and humans,selenium and iodine only essential for humans,and toxic cadmium and arsenic for all organisms.Manipulation of some transporters for these elements,especially those localized in the node for allocation of mineral elements to the grain,has been successful in generating rice with higher density and bioavailability of essential elements but with less accumulation of toxic elements.We provide our perspectives toward breeding future crops for human health.

关键词： plant nutrition human health mineral elements transporter rice biofortification

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