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Serum estradiol levels decrease after oophorectomy in transmasculine individuals on testosterone therapy

Asian Journal of Andrology 2023年第3期25卷 309-313页

作者： Sahil Kumar Elise Bertin Cormac O' Dwyer Amir Khorrami Richard Wassersug Smita Mukherjee Neeraj Mehra Marshall Dahl Krista Genoway Alexander G Kavanagh Faculty of Medicine University of British ColumbiaVancouver V6T 1Z4British ColumbiaCanada Gender Surgery Program Vancouver Coastal HealthVancouver V5Z 1M9British ColumbiaCanada Department of Obstetrics and Gynecology University of British ColumbiaVancouver V6T 1Z4British ColumbiaCanada Division of Endocrinology Department of MedicineUniversity of British ColumbiaVancouver V6T 1Z2British ColumbiaCanada Division of Plastic and Reconstructive Surgery University of British ColumbiaVancouver V5Z 1M9British ColumbiaCanada Department of Urologic Sciences University of British ColumbiaVancouver V5Z 1M9British ColumbiaCanada

transmasculine individuals,considering whether to undergo total hysterectomy with bilateral salpingectomy,have the option to have a concomitant *** studies have evaluated hormone changes following testosterone therapy initiation,most of those patients have not undergone *** are currently limited to support health outcomes regarding the decision to retain or remove the *** performed a retrospective chart review of transmasculine patients maintained on high-dose testosterone therapy at a single endocrine clinic in Vancouver,British Columbia,*** transmasculine individuals who underwent bilateral oophorectomy and had presurgical and postsurgical serum data were *** identified 12 transmasculine subjects as controls,who were on testosterone therapy and did not undergo oophorectomy,but additionally matched to the first group by age,testosterone dosing regimen,and body mass *** was a statistically significant decrease in the estradiol levels of case subjects postoophorectomy,when compared to presurgical estradiol levels(P=0.02).There was no significant difference between baseline estradiol levels between control and case subjects;however,the difference in estradiol levels at follow-up measurements was significant(P=0.03).Total testosterone levels did not differ between control and case subjects at baseline and follow-up(both P>0.05).Our results demonstrate that oophorectomy further attenuates estradiol levels below what is achieved by high-dose exogenous testosterone *** clinical outcomes,such as impacts on bone health,were not *** clinical implications of oophorectomy versus ovarian retention on endocrinological and overall health outcomes are currently limited.

关键词： estradiol gender-affirming surgery hysterectomy oophorectomy testosterone therapy transmasculine

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Established and experimental techniques to improve phalloplasty outcomes/optimization of a hypercomplex surgery

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Plastic and Aesthetic Research 2020年第6期7卷 50-64页

作者： Erin E.Carter Curtis N.Crane Richard A.Santucci Department of Urology Boston University School of MedicineBostonMA 02119USA The Crane Center for Transgender Surgery AustinTX 78746USA

An increasing number of transgender and gender non-conforming patients are seeking genital gender affirming surgeries in order to better align their physical characteristics with their innate gender identity and treat gender *** is the most complex of these surgeries,and this complexity creates a wide range of potential *** of the most common complications and therefore,targets for improvement in outcomes,concern neourethral fistula/stricture,efficacy of reinnervation of the phalloplasty flap,postoperative flap monitoring,and donor site *** the setting of no established"gold standard",this review seeks to describe the components and staging of phalloplasty,with an emphasis on established and experimental solutions to the most common and vexing problems.

关键词： Phalloplasty transgender female to male transmasculine surgical complications radial forearm flap anterolateral thigh flap genital gender confirmation

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