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Enhancing the stability and ecological safety of mass-reared transgenic strains for field release by redundant conditional lethality systems

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Insect Science 2016年第2期23卷 225-234页

作者： Alfred M. Handler USDA Agricultural Research Service Center for Medical Agricultural and Veterinary Entomology Gainesville FL 32608 USA

The genetic manipulation of agriculturally important insects now allows the development of genetic sexing and male sterility systems for more highly efficient biologically-based population control programs, most notably the Sterile Insect Technique （SIT）, for both plant and animal insect pests. Tetracycline-suppressible （Tet-off） conditional lethal systems may function together so that transgenic strains will be viable and fertile on a tetracycline-containing diet, but female-lethal and male sterile in tetracycline-free condi- tions. This would allow their most efficacious use in a unified system for sterile male-only production for SIT. A critical consideration for the field release of such transgenic insect strains, however, is a determination of the frequency and genetic basis of lethality revertant survival. This will provide knowledge essential to evaluating the genetic stability of the lethality system, its environmental safety, and provide the basis for modifications ensur- ing optimal efficacy. For Tet-off lethal survival determinations, development of large-scale screening protocols should also allow the testing of these modifications, and test the ability of other conditional lethal systems to fully suppress propagation of rare Tet-off survivors. If a dominant temperature sensitive （DTS） pupal lethality system proves efficient for sec- ondary lethality in Drosophila, it may provide the safeguard needed to support the release of sexing/sterility strains, and potentially, the release of unisex lethality strains as a form of genetic male sterility. Should the DTS Prosβ21 mutation prove effective for redundant lethality, its high level of structural and functional conservation should allow host-specific cognates to be created for a wide range of insect species.

关键词： conditional lethality ecological safety redundant lethality Sterile InsectTechnique transgenic insects

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