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Current scenario of traditional medicines in management of diabetic foot ulcers:A review

World Journal of Diabetes 2023年第1期14卷 1-16页

作者： Abhijit S Rayate Basavraj S Nagoba Sachin S Mumbre Hardi B Mavani Ajay M Gavkare Advait S Deshpande Department of Surgery Maharashtra Institute of Medical Sciences&Research(Medical College)Latur 413531India Department of Microbiology Maharashtra Institute of Medical Sciences&Research(Medical College)Latur 413531India Department of Community Medicine Ashwini Rural Medical CollegeSolapur 413006India Department of Physiology Maharashtra Institute of Medical Sciences&Research(Medical College)Latur 413531India

Diabetic foot infections and diabetic foot ulcers(DFU)cause significant suffering and are often *** have three important pathogenic factors,namely,microangiopathy causing local tissue anoxia,neuropathy making the foot prone to injuries from trivial trauma,and local tissue hyperglycaemia favouring infection and delaying the wound *** have been the leading cause for non-traumatic amputations of part or whole of the *** medicines focus mainly on euglycaemia,antimicrobials,debridement and wound cover with grafts,and off-loading *** in euglycaemic control,foot care and footwear,systemic antimicrobial therapy,and overall health care access and delivery,have resulted in an overall decrease in ***,the process of wound care after adequate debridement remains a major cost burden globally,especially in developing *** process revolves around two basic concerns regarding control/eradication of local infection and promotion of faster healing in a chronic DFU without *** modulation with various dressings and techniques are often a costly *** aspects of the topical therapy with modern/Western medicines are frequently not *** of and compliance to these therapies are important as both the wounds and their treatment are“chronic.”Naturally occurring agents/medications from traditional medicine systems have been used frequently in different cultures and nations,though without adequate clinical base/*** Chinese medicine involves restoring yin-yang balance,regulating the‘chi’,and promoting local blood *** medicines from India have been emphasizing on‘naturally’available products to control wound infection and promote all the aspects of wound *** is one more group of chemicals which are not pharmaceutical agents but can create acidic milieu in the wound to satisfy the above-mentioned basic *** natural and plant derived products(e.g

关键词： Diabetic foot infections Diabetic foot ulcers Management traditional medicines Topical agents Wound healing

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Carry forward advantages of traditional medicines in prevention and control of outbreak of COVID-19 pandemic

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Chinese Herbal medicines 2020年第3期12卷 207-213页

作者： Jia-gang Deng Xiao-tao Hou Tie-jun Zhang Gang Bai Er-wei Hao Justin Jang Hann Chu Jintanaporn Wattanathorn Panee Sirisa-ard Ch'ng Soo Ee John Low Chang-xiao Liu China-ASEAN Joint Laboratory for International Cooperation in traditional Medicine Research Guangxi University of Chinese MedicineNanning 530200China Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica Guangxi University of Chinese MedicineNanning 530200China State Key Laboratory of Drug Delivery and Pharmacokinetics Tianjin Institute of Pharmceutical ResearchTianjin 300462China State Key Laboratory of Medicinal Chemical Biology College of PharmacyNankai UniversityTianjin 300353China Laboratory of Molecular RNA Virology and Antiviral Strategies Department of Microbiology and ImmunologyNational University of SingaporeKent Ridge 117597Singapore Research Institute for Human High Performance and Health Promotion Khon Kaen UniversityKhon Kaen 40002Thailand Department of Pharmacognosy and Pharmaceutical Technology Faculty of Pharmacy.University of Chiang MaiChiang Mai 50200Thailand GAIQ Test Innovation(Malaysia)Service Center Selangor 40150Malaysia Bioalpha international Sdn.Bhd. Selangor 43000Malaysia

Members of the China-ASEAN Joint Laboratory for International Cooperation in traditional Medicine Research used the video conference platform to exchange and discuss the advantages of traditional medicine through the form of score exchange and report,and research and develop the amount and issues of the therapeutic COVID-19 products of *** paper mainly reviews the achievements of the implementation of the epidemic prevention and control plan,advances of scientific basic studies on SARS-CoV-2,analysis and screening of potential targets and pathways of antiviral compounds based on network pharmacology and development of antiviral food dual-use *** authors believe that the declaration of the(10+3)special meeting of national leaders on epidemic prevention and control should raise the medical and pharmaceutical issues of common *** is the responsibility of our joint laboratory members to accelerate the development of traditional medicine research and *** the authors believe that this exchange will certainly promote the development of the cause of cooperation.

关键词： COVID-19 pandemic international cooperation prevention and control research and development traditional medicines

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An updated study of traditional medicines to the era of 1,3,4 oxadiazole derivatives for malaria treatment

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traditional Medicine Research 2023年第1期8卷 36-42页

作者： Davinder Kumar Harsh Kumar Aakash Deep Rakesh Kumar Marwaha Department of Pharmaceutical Sciences Maharishi Dayanand UniversityRohtak 124001HaryanaIndia Department of Pharmaceutical Sciences Chaudhary Bansi Lal UniversityBhiwani 127021HaryanaIndia.

Discovering potent drug candidates requires new antimalarial *** this reason,antimalarial drug researchers focus on developing new drug candidates on promising *** the identification of these targets,a basic understanding of the metabolism and biochemical processes of malaria parasites such as Plasmodium falciparum can prove ***,malarial resistant parasites are becoming more and more significant issues as antimalarial medications *** drugs are becoming increasingly resistant,thus the search for new molecules is very important *** based combination therapies are becoming more popular for treating *** will ultimately lead to the selection of resistance due to their extensive and indiscriminate *** artemisinin-based combination therapies are therefore *** is an interest in finding suitable antimalarial compounds based on their potential effectiveness against *** potential activity of 1,3,4 oxadiazole analogues against malarial infections is a major draw of the search for suitable antimalarial *** review identifies existing antimalarial drugs that have own therapeutic effects and evaluating their feasibility for developing novel synthetic antimalarial derivatives.

关键词： antimalarial Plasmodium falciparum 1,3,4 oxadiazoles traditional medicines

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Using complementary and alternative medicines to prevent and treat pressure ulcers: a systematic review

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traditional Medicine Research 2021年第5期6卷 69-81页

作者： Ali Safdari Abdollah Abolfathi Davood Hekmatpou Fatemeh Mehrabi Student Research Committee Arak University of Medical SciencesArak ***Iran BSc of Nursing Iranian Social Security OrganizationArak ***Iran Department of Nursing School of Nursing and MidwiferyArak University of Medical SciencesArak ***Iran

Background:Pressure ulcers are skin lesions generated by ischemic conditions caused by pressure on soft *** studies have investigated complementary and alternative medicine(CAM)as preventative and treatment measures for pressure ***,we systematically reviewed the CAM literature in preventing and treating pressure ***:All clinical trial studies which used CAM were *** searched different databases,including Scientific Information Database,Irandoc,Google Scholar,PubMed,Medline,Scopus,Cochrane Library,Embase,and Science *** following keywords were used:“complementary and alternative medicine-CAM”,“integrative medicine”,“traditional medicine”,“pressure ulcer”,“bedsore”,“pressure sore healing”,and“prevention”.A Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2015 checklist was used to perform ***:After screening,35 studies were *** investigations suggested that honey,medicinal plants,such as resin salve,Angelica dahurica,Aloe vera,fruits,herbal oils,a combination of several traditional medicine methods,sheepskin,maggot therapy,massage,charcoal,and acupuncture were the most common CAM ***:CAM strategies can prevent and treat pressure *** reduce wound size,exudate and necrotic tissue levels,inflammation,pain,bleeding,and infections.

关键词： complementary therapies traditional medicines prevention healing pressure ulcer systematic review

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Innovative development path of ethnomedicines： an overview of ethnomedicines in China

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Frontiers of Medicine 2016年第2期10卷 166-177页

作者： Zhaoyun Zhu Ting Wang Dehuan Fu Yali Gui Jingkun Wang Tao Cui Yunnan Institute of Materia Medica Innovation and R & D Center of Yunnan Baiyao Group Co. Ltd. and Yunnan Province Company KeyLaboratory for New Drug Research and Development of TCM and Ethnomedicines Kunming 650111 China

In the long history of disease prevention and treatment, ancestral populations worldwide have gained knowledge and experiences in traditional medicines. For instance, ethnomedicines of Chinese ethnic minorities constitute an important part of traditional medicines. In our study, we firstly clarified the concept of ethnomedicines and the connotations of ethnopharmacology. The particularity of ethnomedicine research were then summed up, and the development profiles of the ethnomedicines of Chinese ethnic minorities were discussed by investigating the current status and existing problems. On this basis, we abstracted the innovative development path of ethnomedicines for the first time, which was found to follows：resource study -, standardized development research -~ industrialization of the achievements and efforts for internationalization. We found that platform establishment and team training are keys to achieving innovative development. Hence, this study provided a basis for ethnomedicine development.

关键词： traditional medicines ethnomedicines Chinese ethnic minorities ethnopharmacology research mode innovative development path

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Chemical Constituents from Ethanoic Extracts of the Aerial Parts of Leea aequata L.,a traditional Folk Medicine of Myanmar

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Natural Products and Bioprospecting 2019年第3期9卷 243-249页

作者： Nay Lin Tun Dong-Bao Hu Meng-Yuan Xia Dong-Dong Zhang Jun Yang Thaung Naing Oo Yue-Hu Wang Xue-Fei Yang Southeast Asia Biodiversity Research Institute Chinese Academy of SciencesYezinNay Pyi Taw 05282Myanmar Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China College of Resources and Environment Yuxi Normal UniversityYuxi 653100People’s Republic of China Forest Research Institute YezinNay Pyi Taw 05282Myanmar

We aimed at reporting the chemical constituents and antimicrobial activities of Leea aequata L.,a traditional folk medicine used in Myanmar for the treatment of wounds and skin diseases.A new neolignan,(7S,8R)-9′-O-acetylcedrusin(1),a new lactam,(3S,4S)-4-chloro-3-hydroxypiperidin-2-one(2),along with 21 known compounds,including fve lignans(3-7),four favonoid glycosides(8-11),and others(12-23),were isolated from the ethanoic extract of the aerial parts of *** structures of the new compounds were determined by NMR,MS,and ECD *** all the antimicrobial tests of the 23 compounds,only 3,4,5-trihydroxybenzoic acid ethyl ester(17)showed weak inhibitory activities against Escherichia coli and Salmonella enterica ***.

关键词： Leea aequata Vitaceae traditional medicines Lignans Flavonoids

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Inhibition of rat prostate smooth muscle contractility by extracts of Costus speciosus(crepe ginger)

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traditional Medicine Research 2022年第4期7卷 27-36页

作者： Nguok Ngie Su Jamie S.Simpson Philip EThompson Sabatino Ventura Drug Discovery Biology Monash Institute of Pharmaceutical SciencesMonash UniversityVIC 3052Australia Medicinal Chemistry Monash Institute of Pharmaceutical SciencesMonash UniversityVIC 3052Australia Sarawak Biodiversity Centre KM20Jalan Borneo HeightsSemengohKuching 93250Malaysia

Background:This study examined the chemistry and biological effects of Costus speciosus(***)Sm.(***)which has been traditionally used by Sarawak natives to treat urological disorders for ***:This study assesses the efficacy of *** in treating urological disorders by investigating its effects on the contractility of isolated prostate glands since this is the most effective way to relieve lower urinary tract symptoms that accompany benign prostatic *** were collected and extracts of *** rhizome,root,leaf and stem were made using water at different ***:*** rhizome and root decoction(boiling,about 100℃)combination extract(2 mg/mL)inhibited electrical field stimulation-induced neurogenic contractions of isolated rat prostatic gland by 44±8%(p=0.01,n=4);whereas room temperature(about 20℃)rhizome and root combination extract inhibited electrical field stimulation contractions by 62±8%(p=0.003,n=4).*** rhizome(p=0.0004,n=6),root(p<0.0001,n=6)and stem(p=0.0057,n=6)room temperature extracts inhibited electrical field stimulation-induced contractions of rat prostatic smooth muscle but leaf extract did not(p=0.09,n=6).Contractions mediated by exogenous administration of noradrenaline,acetylcholine,adenosine 5’-triphosphate or tyramine were only weakly inhibited by rhizome *** of *** rhizome room temperature extract separated by preparative high-performance liquid chromatography and evaluated by isolated organ bath bioassay revealed that inhibitory activity of the extract was due to highly polar soluble components present in the ***:*** extracts exert a direct inhibitory effect on prostate tissue which is likely to be therapeutically beneficial in treating lower urinary tract symptoms associated with benign prostatic hyperplasia.

关键词： benign prostatic hyperplasia Costaceae lower urinary tract symptoms smooth muscle contractility traditional medicines

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The Core Mechanism of traditional Medicine Is the Rational and Effective Use of Potassium Ions

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Natural Science 2022年第11期14卷 483-491页

作者： Jiapei Dai Wuhan Institute for Neuroscience and Neuroengineering South-Central Minzu University Wuhan China

The use of traditional medicines including natural drugs, especially traditional Chinese medicine (TCM), plays an important role in the prevention and treatment of human diseases;however, so far, the mechanism of its prevention, health care and treatment of diseases is unclear. Here, I propose that the core mechanism of traditional medicines is to correct the relative deficiency of potassium ions in body and at the same time improve the utilization efficiency of potassium ions, so as to improve or restore cell functions in organs and tissues, and let the body return to a normal state. In order to achieve such a core goal, the therapeutic effect of natural drugs has an important relationship with the rational matching of prescriptions and the quality of drugs, with particular emphasis on the concentrations and quantum energy levels of potassium ions or their compounds in the formula. The understanding of the core effect of potassium in natural drugs has a specific and important guiding role for the artificial cultivation and rational use of natural drugs. Moreover, these ideas may also provide an important theoretical basis for the development of modern agriculture and medicine, and the rational and comprehensive utilization of potassium resources.

关键词： traditional medicines Potassium Resource Relative Deficiency of Potassium Ions Na+ K+-ATPase Quantum Biology

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Strategies for Revitalization of traditional Medicine

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Chinese Herbal medicines 2010年第1期2卷 1-15,83页

作者： MUKHERJEE Pulok K PITCHAIRAJAN Venkatesh MURUGAN Venkatesh SIVASANKARAN Ponnusankar KHAN Yaseen School of Natural Product Studies Department of Pharmaceutical TechnologyJadavpur University

traditional medicine (TM) plays an inevitable role in drug discovery and development. Most of the therapeutically useful molecules used in the present day are inspired from TM. Herbal drugs are the oldest forms of medicines used for the treatment of various ailments and the TM of every country has a long history of their usage. To develop more data on their quality, safety, and efficacy, so also to improve the consumer’s need of modern days several thrust areas of research are to be focused on the development of TM. Based on the above concept, a paradigm shift is required for the revitalization of TM. These facts along with the modern scientific approaches, molecular tools, and strategies make it necessary for TM to be revitalized. Confluencing several strategies with the technological and scientific developments including pharmacogenomics, nutrigenomics, system biology, and related approaches, the scientific potential of TM can be explored further with international coordination and collaborations.

关键词： alternative medicine Ayurveda Chinese medicine drug discovery herbal resurgence Indian medicine Omic technology system biology traditional medicines

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traditional Herbal Medicine and Its Clinical Relevance: A Need to Preserve the Past for the Future

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Journal of Biosciences and medicines 2022年第7期10卷 64-75页

作者： Ahmed Hamza Tahir Zahid Hussain Hamza Yousuf Faryal Fazal Muhammad Abdullah Tahir Muhammad Kashif Institute of Biochemistry and Biotechnology University of the Punjab Lahore Pakistan Beaconhouse School System Okara Pakistan Institute of Industrial Biotechnology Government College University Lahore Pakistan Nishtar Medical University Multan Pakistan Roots College International Lahore Pakistan

Herbal medicines have been gaining popularity worldwide. They are an integral component of alternative medical care and provide a rich source for innovative drug discovery. However, the rapid increase in the demand for herbal medicines and products has led to the rapid depletion of herbal plants. In addition, rapid population growth, industrialization, and global climate change have endangered these medicinal plants. Given the imminent threat associated with the loss of medicinal plant diversity, this review highlights the need to protect these threatened plant species and avoid the loss of their therapeutic value. The aim of the study was to conserve resources and link them with current research activities and projects to develop novel and more effective drugs in the future.

关键词： Herbal medicines traditional medicines Conservation Biodiversity Alternative Therapy

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