检索结果-南通市图书馆

tetrahydroxystilbene glucoside protects against sodium azide-induced mitochondrial dysfunction in human neuroblastoma cells

引用

Chinese Herbal Medicines 2021年第2期13卷 255-260页

作者： Ru-yi Zhang Xu Zhang Lan Zhang Yan-chuan Wu Xue-jing Sun Lin Li Department of Pharmacy Xuanwu Hospital of Capital Medical UniversityBeijing Engineering Research Centre for Nerve System DrugsBeijing Institute for Brain DisordersKey Laboratory for Neurodegenerative Diseases of Ministry of EducationBeijing 100053China Department of Central Laboratory Xuanwu Hospital of Capital Medical UniversityBeijing 100053China Department of Haematology Xuanwu Hospital of Capital Medical UniversityBeijing 100053China

Objective:Mitochondrial dysfunction is evident in the early stage of Alzheimer's disease(AD).Therefore development of drugs that protect mitochondrial function is a promising strategy for *** present work was to investigate the effects of 2,3,5,4'-tetrahydroxystilbene-2-O-β-d-glucosides(TSG) on a mitochondrial dysfunction cell model induced by sodium azide and elucidate the underlying ***:Mitochondrial membrane potential(MMP) was detected by a fluorescence *** adenosine triphosphate(ATP) level was measured using a firefly luciferase-based *** oxygen species(ROS) was detected using dichlorofluorescin diacetate(DCFH-DA).The expression levels of Bcl-2 and Bax were measured by Western blotting *** cytometry was utilized to measure ***:Pretreatment of TSG(25-200 μmol/L) for 24 h significantly elevated MMP and ATP content,reduced ROS level and Bax/Bcl-2 ratio,and inhibited apoptosis in SH-SY5 Y cells exposed to sodium ***:These results suggest that TSG protects SH-SY5 Y cells against sodium azide-induced mitochondrial dysfunction and *** findings are helpful to understand the protective effect of TSG on mitochondria,which are involved in the early stage of AD.

关键词： Alzheimer’s disease mitochondria tetrahydroxystilbene glucoside sodium azide

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：