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Chinese Science Bulletin 1995年第4期40卷 334-339页

作者：吴刚义王书荣 Laboratory for Visual Information Processing Institute of Biophysics Chinese Academy of SciencesBeijing 100101 China

It has been established that the nucleus isthmi (NI) in lower vertebrates and its mammalian analogue, the nucleus parabigeminalis, receive input from the ipsilateral tectum and project back ipsilaterally in teleosts and birds, or bilaterally in amphibians, reptiles and *** nucleus receives visual excitation from the ipsilateral tectum. while it mainly exerts inhibition on cells recorded from the ipsilateral tectum. A recent study by Wang and coworkers shows that the nucleus isthmi pars magnoceUularis (Imc) and

关键词： tectum nucleus isthmi commissure electrical stimulation postsynaptic potential toad.

RECIPROCALLY TOPOGRAPHIC PROJECTIONS BETWEEN THE OPTIC tectum AND NUCLEUS ISTHMI IN THE TOAD

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Chinese Science Bulletin 1983年第1期28卷 139-140页

作者：王荫亭颜坤王书荣 Institute of Biophysics Academia Sinica Beijing

Brain of the blind:transcriptomics of the golden-line cavefish brain

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Current Zoology 2018年第6期64卷 765-773页

作者： Fanwei MENG Yahui ZHAO Tom TITUS Chunguang ZHANG John H.POSTLETHWAIT State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute of Neuroscience University of OregonEugeneOR 97403USA

The genus Sinocyclocheilus (golden-line barbel) includes 25species of cave-dwelling blind fish (cavefish)and more than 30 surface-dwelling species with normal *** environments are dark and generally nutrient-poor with few *** of several genera evolved convergent morphological adaptations in visual,pigmentation,brain,olfactory,and digestive systems. We compared brain morphology and gene expression patterns in a cavefish Sinocyclocheilus anophthalmus with those of a closely related surface-dwelling species *** showed that cavefish have a longer olfactory tract and a much smaller optic tectum than surface *** by RNA-seq revealed that many genes upregulated in cavefish are related to lysosomes and the degradation and metabolism of proteins,amino acids,and *** down- regulated in cavefish tended to involve "activation of gene expression in cholesterol biosynthesis" and cholesterol degradation in the *** encoding Srebfs (sterol regulatory element- binding transcription factors)and Srebf targets,including enzymes in cholesterol synthesis,were downregulated in cavefish brains compared with surface fish *** gene encoding Cyp46a1, which eliminates cholesterol from the brain,was also downregulated in cavefish brains,while the total level of cholesterol in the brain remained *** brains misexpressed several genes encoding proteins in the hypothalamus-pituitary axis,including Trh,Sst,Crh,Pomc,and *** results suggest that the rate of lipid biosynthesis and breakdown may both be depressed in golden-line cavefish brains but that the lysosome recycling rate may be increased in cavefish;properties that might be related to differences in nutrient availability in caves.

关键词： cavefish cholesterol cyp46a optic tectum Sinocyclocheilus transcriptomics

Postsynaptic Potentials and Morphological Features of Tectal Cells in Homing Pigeons

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Science China Chemistry 1993年第3期36卷 297-304页

作者：吴冈义王书荣颜坤 Laboratory for Visual Information Processing Institute of Biophysics Academia Sinica Beijing 100101 PRC

In this study postsynaptic potentials responding to the electrical stimulation of the optic nerve and the nucleus isthmipars parvocellularis (Ipc) were intracellularly recorded from 86 tectal cells in pigeons, 13 of which were marked with Lucifer yellow (LY). According to types of postsynaptic potentials and their succesion, the postsynaptic responses could be classified into four types: excitatory postsynaptic potential (EPSP)-inhibitory postsynaptic potential (IPSP) sequence (EI type), E, I and IE *** them, E or EI responses were mainly produced to the optic nerve stimulation, while the electrical stimulation of the lpc elicited I responses in more than half the recorded ***-marked tectal cells included five ganglionic cells, four pyramidal cells, two bipolar cells and two stellate *** ganglionic cells were mainly located in tectal layers Ⅲ and Ⅳ, whereas the others were in layer Ⅱ.It appears from both intracellular recordings and fluorescent markings that there is some correlation betwe n the morphological features and the postsynaptic response types of tectal cells.

关键词： homing pigeon nucleus isthmi tectum postsynaptie potentials electrical stimulation fluorescent marking.

Intracellular recording and morphology of tectal neurons activated by contralateral nucleus isthmi in toads

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Chinese Science Bulletin 1997年第19期42卷 1647-1651页

作者： Wang, SR Wu, GY Laboratory for Visual Information Processing Institute of Biophysics Chinese Academy of Sciences Beijing China

THE nucleus isthmi (NI) in lower vertebrates and its mammalian analogue, the nucleus para-bigeminalis, are all visual centres. They receive their tectal input ipsilaterally and project backipsilaterally in teleosts and birds, or bilaterally in amphibians and reptiles, as well as in mam-mals. It is well known that NI receives its visual excitation through the ipsilateral optic tec-tum (OT). NI mainly exerts inhibition on the ipsilateral OT in frogs.A recent study

关键词： nucleus isthmi tectum intracellular recording morphology toad

Notch signaling regulates neurogenesis in the cerebellar primodium

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Notch signaling regulates neurogenesis in the cerebellar pri...

Optic tecta I superficial inter neurons detect motion in larval zebrafish

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Min-Hua ZHENG~2,Ming SHI~1,Ying HUANG~1,Hua HAN~2,Yu-Qiang DING~1 1 Institute of Neuroscience and Key Laboratory of Neurobiology,Shanghai Institute for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031 2 Department of Medical Genetics and Developmental Biology,The Fourth Military Medical University,Xi''an 710032

＜正＞During the development of mouse cerebellum,the major types of neurons are temporally generated from progenitor cells located in the rhombic lip or ventricular zone of cerebellar *** of the balance between cerebellar progenitors differentiation and their maintenance for subsequent neurogenesis remains largely *** using Cre/loxP-triggered gene inactivation,we found that loss of Notch function resulted in defective tectum and cerebellum *** these mutant mice,the tectum and cerebellum were significantly reduced in size and the numbers of Purkinje cell and granular cell precursors were severely decreased at E16.5,compared with the wild-type littermates. Additionally,the lateral ventricle of mutant mice seemed gradually enlarged in the late embryonic stages,which might be a consequence of the abnormal development of midbrain and *** results suggest that Notch signaling maintains progenitor pools of cerebellar primordium,and may regulate their responsiveness to inductive signals involved in neurogenesis and gliogenesis.

关键词： notch neurogenesis tectum cerebellum

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Protein & Cell 2019年第4期10卷 238-248页

作者： Chen Yin Xiaoquan Li Jiulin Du Institute of Neuroscience State Key Laboratory of NeuroscieneeCenter for Excellenee in Brain Science and Intelligenee TechnologyChinese Academy of SciencesShanghai 200031China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China School of Life Science and Technology ShanghaiTech UniversityShanghai 200031China

Detection of moving objects is an essential skill for animals to hunt prey,recognize conspecifics and avoid *** zebrafish,as a vertebrate model,primarily uses its elaborate visual system to distinguish moving objects against background *** optic tectum(OT)receives and integrates inputs from various types of retinal ganglion cells(RGCs),including direction-selective(DS)RGCs and size-selective RGCs,and is required for both prey capture and predator ***,it remains largely unknown how motion information is processed within the *** we performed in vivo whole-cell recording and calcium imaging to investigate the role of superficial interneurons(SINs),a specific type of optic tecta I neurons,in motion detection of larval *** mainly receive excitatory synaptic inputs,exhibit transient ON-or OFF-type of responses evoked by light flashes,and possess a large receptive field(RF).One fifth of SINs are DS and classified into two subsets with separate preferred ***,SINs show size-dependent responses to moving *** are efficiently activated by moving objects but not static ones,capable of showing sustained responses to moving objects and having less visual adaptation than periventricular neurons(PVNs),the principal tecta I ***,ablation of SINs impairs prey capture,which requires local motion detection,but not global looming-evoked ***,starvation enhances the gain of SINs'motion responses while maintaining their size tuning and *** results indicate that SINs serve as a motion detector for sensing and localizing sized moving objects in the visual field.

关键词： optic tectum motion detection direction selectivity visual adaptation zebrafish