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Effect of particle size of calcium phosphate based bioceramic drug delivery carrier on the release kinetics of ciprofloxacin hydrochloride： an in vitro study

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Frontiers of Materials Science 2013年第3期7卷 261-268页

作者： Swamiappan SASIKUMAR Materials Chemistry Division Centre for Excellence in Nanomaterials School of Advanced Sciences VIT University Vellore-632 014 Tamilnadu India

Hydroxyapatite （HAP） is the constituent of calcium phosphate based bone cement and it is extensively used as a bone substitute and drug delivery vehicle in various biomedical applications. In the present study we investigated the release kinetics of ciprofloxacin loaded HAP and analyzed its ability to function as a targeted and sustained release drug carrier, Synthesis of HAP was carried out by combustion method using tartaric acid as a fuel and nitric acid as an oxidizer. Powder XRD and FTIR techniques were employed to characterize the phase purity of the drug carrier and to verify the chemical interaction between the drug and carrier, The synthesized powders were sieve separated to make two different drug carriers with different particle sizes and the surface topography of the pellets of the drug carrier was imaged by AFM. Surface area and porosity of the drug carrier was carried out using surface area analyzer. The in-vitro drug release kinetics was performed in simulated body fuid, at 37.3℃. The amount of ciprofloxacin released is measured using UV-visible spectroscopy following the characteristic Amax of 278 nm. The release saturates around 450 h which indicates that it can be used as a targeted and sustained release carrier for bone infections.

关键词： ceramic drug delivery system antibiotic hydroxyapatite (HAP) porosity targeted release

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A DNA Nanotube-Peptide biocomplex for mRNA Detection and Its Application in Cancer Diagnosis and targeted Therapy

A DNA Nanotube-Peptide biocomplex for mRNA Detection and Its...

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中国化学会第十三届全国分析化学年会

作者： Xiaoting Ji Haoyuan Lv Jiayi Guo Caifeng Ding Key Laboratory of Sensor Analysis of Tumor Marker Ministry of Education College of Chemistry and Molecular Engineering Qingdao University of Science and Technology

A biocomplex of DNA nanotube-peptide,consisting of six concatenated DNA strands,three lock DNA strands and a cell-penetrating peptide was developed *** MUC-1 aptamer which is part of DNA nanotube can specially recognize MUC-1 on the surface of MCF-7 *** c RGD facilitates recruitment and uptake of targeting drugs by binding to integrin receptors (αvβ3) of cytomembrane ***-cancer drug doxorubicin(DOX) and paclitaxel (PTX) were loaded into the capsulated DNA nanotube-peptide (CDNP),which was used as co-drug cargo *** as-prepared biocomplex can be utilized not only to deliver drug but also to achieve the anticancer effect in *** system that was composed by DNA strands and peptide has good biocompatibility and ***,the system can readily achieve detection of target mRNA of MCF-7 cell in *** detection limits of mRNA are 9.7×10 M and 1.8×10 M by using CDNP/DOX and CDNP/PTX-FITC as a probe,respectively.

关键词： DNA nanotube cRGD mRNA nanocarrier targeted release

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