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Dissecting Emerging Aspects of Regulatory Circuitry in Man and Mice: Regulatory T Cell Biology

Advances in Bioscience and Biotechnology 2018年第9期9卷 443-468页

作者： Tania Rahman Md. Ferdous Seraj Annelise Casellato Department of Biochemistry and Molecular Biology Bio21 Molecular Science and Biotechnology Institute University of Melbourne Melbourne Australia Department of Microbiology and Immunology University of Melbourne at the Peter Doherty Institute for Infection and Immunity Melbourne Australia School of Civil Environmental and Chemical Engineering RMIT University Melbourne Australia Departamento de Química Inorganica Instituto de Química Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil

Regulatory T cells (Treg), a component of adaptive immunity, are well known for their immunosuppressive roles and their ability to maintain the balance between the immunological and pathological reactions. Treg have been shown to provide protective responses and their depletion has resulted severe pathology in some pathogen infections. The work presented here has unravelled the potential of regulatory cells in the immune system including different repertoir of Treg cell subsets, markers to distinguish them, Treg suppression mechanisms in the pathogenesis of various infections and summarize different mouse models depleting Tregs. These findings would help set up future avenues of research to elucidate a key mechanism of action of these cells and provide new therapeutic insights for pathogenesis and also for broader antibacterial/antiviral/antiproliferative immunity.

关键词： Regulatory T Cells Foxp3 ttreg pTreg IL-10 TGF-β Helios Neuropilin-1

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Carcinogens-induced proliferation of thymus-derived Treg cells is triggered by migratory CD11b+ dermal dendritic cells

Carcinogens-induced proliferation of thymus-derived Treg cel...

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第十三届全国免疫学学术大会

作者： Li Kang Jiming Gao Yi Cheng Meixiang Wang Liwen Yue Wengang Song Hua Tang Taishan Medical University

Polyaromatic hydrocarbons(PAHs) are prevalent and potent carcinogens. However, whether these carcinogens contact could break out the immune system balance before carcinogens inducing tumor formation, if it was, how the changing was mediated are unclear. In this study, 9,10-dimethyl-1,2-benzanthracene(DMBA), a model PAH widely used to study tumorigenesis, induced functional thymus-derived Treg(ttreg) proliferation in mice draining lymph node after DMBA treatment. The behavior of carcinogens in inducing ttreg proliferation was DMBA treatment area size dependent, and it could be blocked by anti-MHC-II antibody, indicating the process of DMBA induced ttreg proliferation was conducted by antigen presenting cells. Removing the DMBA contacted skin could inhibit the proliferation of ttreg, which suggesting that migratory dendritic cells(DCs) might play a crucial role in the antigen presentation. To investigate which migratory DCs subset triggered DMBA induced ttreg proliferation, bone marrow chimera from ZBTB46-DTR hematopoietic progenitors mice were constructed. ttreg proliferation decreased when conditional and efficient depletion cDCs, however, Langerin+ DCs depletion had no effect on ttreg proliferation in Langerin-DTR mice. Taken together, DMBA induced ttreg proliferation is MHC-II dependent CD11 b+ dermal DCs triggering manner.

关键词： carcinogens ttreg dendritic cells

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