Carcinogens-induced proliferation of thymus-derived Treg cells is triggered by migratory CD11b+ dermal dendritic cells
作者单位：Taishan Medical University
会议名称：《第十三届全国免疫学学术大会》
会议日期：2018年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：carcinogens tTreg dendritic cells
摘 要：Polyaromatic hydrocarbons(PAHs) are prevalent and potent carcinogens. However, whether these carcinogens contact could break out the immune system balance before carcinogens inducing tumor formation, if it was, how the changing was mediated are unclear. In this study, 9,10-dimethyl-1,2-benzanthracene(DMBA), a model PAH widely used to study tumorigenesis, induced functional thymus-derived Treg(tTreg) proliferation in mice draining lymph node after DMBA treatment. The behavior of carcinogens in inducing tTreg proliferation was DMBA treatment area size dependent, and it could be blocked by anti-MHC-II antibody, indicating the process of DMBA induced tTreg proliferation was conducted by antigen presenting cells. Removing the DMBA contacted skin could inhibit the proliferation of tTreg, which suggesting that migratory dendritic cells(DCs) might play a crucial role in the antigen presentation. To investigate which migratory DCs subset triggered DMBA induced tTreg proliferation, bone marrow chimera from ZBTB46-DTR hematopoietic progenitors mice were constructed. tTreg proliferation decreased when conditional and efficient depletion cDCs, however, Langerin+ DCs depletion had no effect on tTreg proliferation in Langerin-DTR mice. Taken together, DMBA induced tTreg proliferation is MHC-II dependent CD11 b+ dermal DCs triggering manner.