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The future of artificial hibernation medicine:protection of nerves and organs after spinal cord injury

Neural Regeneration Research 2024年第1期19卷 22-28页

作者： Caiyun Liu Haixin Yu Zhengchao Li Shulian Chen Xiaoyin Li Xuyi Chen Bo Chen School of Acupuncture&Moxibustion and Tuina Tianjin University of Traditional Chinese MedicineTianjinChina Research Center of Experimental Acupucture Science Tianjin University of Traditional Chinese MedicineTianjinChina Characteristic Medical Center of Chinese People’s Armed Police Force TianjinChina Binhai New Area Hospital of TCM TianjinChina Fourth Teaching Hospital of Tianjin University of TCM TianjinChina

Spinal cord injury is a serious disease of the central nervous system involving irreversible nerve injury and various organ system *** present,no effective clinical treatment *** one of the artificial hibernation techniques,mild hypothermia has preliminarily confirmed its clinical effect on spinal cord ***,its technical defects and barriers,along with serious clinical side effects,restrict its clinical application for spinal cord *** hibernation is a futureoriented disruptive technology for human life *** involves endogenous hibernation inducers and hibernation-related central neuromodulation that activate particular neurons,reduce the central constant temperature setting point,disrupt the normal constant body temperature,make the body adapt"to the external cold environment,and reduce the physiological resistance to cold ***,studying the artificial hibernation mechanism may help develop new treatment strategies more suitable for clinical use than the cooling method of mild hypothermia *** review introduces artificial hibernation technologies,including mild hypothermia technology,hibernation inducers,and hibernation-related central neuromodulation *** summarizes the relevant research on hypothermia and hibernation for organ and nerve *** studies show that artificial hibernation technologies have therapeutic significance on nerve injury after spinal co rd injury through inflammatory inhibition,immunosuppression,oxidative defense,and possible central *** also promotes the repair and protection of res pirato ry and digestive,cardiovascular,locomoto r,urinary,and endocrine *** review provides new insights for the clinical treatment of nerve and multiple organ protection after spinal cord injury thanks to artificial *** present,artificial hibernation technology is not mature,and research fa ces various *** rtheless,the effort is wo rthwhi

关键词： artificial hibernation central thermostatic-resista nt regulation hypothermia multi-system protection neuroprotection organ protection spinal cord injury synthetic torpor

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On the immunological limitations of hibernation and synthetic torpor as a supporting technique for astronauts’ radioprotection in deep space missions

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World Journal of Immunology 2019年第1期9卷 1-4页

作者： Joseph J Bevelacqua James Welsh Seyed Mohammad Javad Mortazavi Bevelacqua Resources RichlandWA 99352United States Department of Radiation Oncology Loyola Stritch School of MedicineHines VA Hospital ChicagoChicagoIL 60153United States Shiraz University of Medical Sciences Shiraz ***Iran

Although human hibernation has been introduced as an effective technique in space exploration,there are concerns regarding the intrinsic risks of the approach(i.e.,synthetic torpor)and other factors involved in this *** concerns about the brain changes and the state of consciousness during hibernation,an"Achilles heel"of the hibernation is the negative impact of torpor on factors such as the number of circulating leukocytes,complement levels,response to lipopolysaccharides,phagocytotic capacity,cytokine production,lymphocyte proliferation,and antibody ***,increased virulence of bacteria in deep space can significantly increase the risk of *** increased infection risk during long-term space missions with the combined effects of radiation and microgravity affect the astronauts’immune *** these additional immune system stressors,torpor-induced extraimmunosuppression can be potentially life threatening for astronauts.

关键词： Space radiation Hibernation Radioprotection synthetic torpor Immunology

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