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Neuro-and immuno-modulation mediated by the cardiac sympathetic nerve:a novel insight into the anti-ischemic efficacy of acupuncture

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Journal of Traditional Chinese Medicine 2024年第5期44卷 1058-1066页

作者： XI Hanqing LI Xia ZHANG Ziyi CUI Xiang JING Xianghong ZHU Bing GAO Xinyan Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing 100700China

Communication between sympathetic nerves and the immune system is a crucial and active process during myocardial ischemia(MI),as myocardial damage and inflammatory stimuli concurrently *** nerves undergo structural and functional changes after MI,leading to adverse left ventricular(LV)remodeling and heart failure(HF).The complex inflammatory response to MI,including local myocardial anti-inflammatory repair and systemic immune reactions,plays a key role in adverse LV ***,we review the progressive structural and electrophysiological remodeling of the LV and the involvement of sympathetic tone in complex and dynamic processes that are susceptible to MI pathological *** has been reported to effectively improve cardiac function,eliminate arrhythmia,and mitigate adverse LV remodeling via somatosensory regulation after ***,acupuncture has an anti-inflammatory effect on the pathological process of myocardial *** this Review,we aim to summarize the involvement of sympathetic nerve activation in the neuro-immune modulation of structural and functional cardiac changes after *** a noninvasive method for sympathetic regulation,acupuncture is an ideal option because of its anti-ischemic efficacy.A better understanding of the neural circuitry that regulates cardiac function and immune responses following MI could reveal novel targets for acupuncture treatment.

关键词： neuroinflammatory diseases sympathetic nerves myocardial ischemia acupuncture review

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A Novel Apprehension of the Primary Lung Meridian, Sinew Channel, Divergent Channel, Luo-Connecting Channel Acting as a Single Unit System to Serve Respiration Function Based on Modern Neurophysiology and Kinesiology

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Chinese Medicine 2020年第2期11卷 31-95页

作者： Peter Chin Wan Fung Regina Kit Chee Kong Division of Medical Physics Department of Medicine University of Hong Kong Hong Kong China School of Chinese Medicine Southern Medical University Guangzhou China

The TCM philosophy of a meridian and associated channels pertains to the specific function of one or more organs. We define the Lung Primary Meridian (LUM) together with the Lung Sinew (LUSC), Divergent (LUDC), Luo-connecting (LULCC) Channels as a system of routes plus some parts of the body (such as muscles) to fulfil respiration, as a main function under different situations. There is very limited information about the Lung associated channels in classical literature of TCM. With a clear focus on the function of respiration, we have carried out a detailed analysis of the biomedical consequence of stimulating the LUM, analysed the roles played by LUSC, LUDC, and LULCC. The updated LUM and LUDC include acupoints of other meridians, serving the same purpose of performing satisfactory respiration starting from checking the quality of the inflow through the nose. The LUSC includes the respiratory muscles (plus the associated connective tissues) extending to various parts of the body. The muscles of the limb (as part of the LUSC) embrace the nerves that provide routes for somatosensory reflexes and play the role of locomotion, providing voluntary respiration via the pectoralis muscles. The muscles of LUSC are bounded by stiff connective tissue layers, forming compartments, and are part of the pulley system for various body locomotions. Within a compartment, the interstitial fluid, blood, lymph flows must be potent to protect the associated nerves related to LUM;the healthy state of the LUSC also provides freedom of various types of locomotion. The LULCC exists because the vagus nerve has a part of it passing through the spinal cords all the way down to the sacrum domain, with exiting nerve innervating two-third of the large intestine. The crucial steps of our deductions are supported by experimental evidence based on modern neurophysiology and kinesiolo

关键词： Lung Meridian Sinew Divergent Luo-Connecting Channels Mechanical Advantage of Muscles sympathetic nerves Parasympathetic nerves Muscles of the Tongue Pharynx Larynx Intercostal Muscles Inspiration and Expiration Muscles Swallowing Somatosensory and Segmental Reflexes Acupoints of the Lung Urinary Bladder Kidney Governing (DU) Conception (REN) Me-ridians Pulmonary Diseases Lung → Large-Intestine Connection Acupuncture Bian Stone Therapy

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