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Cross-linked self-assembling peptide scaffolds

Nano Research 2018年第1期11卷 586-602页

作者： Raffaele Pugliese Amanda Marchini Gloria Anna Ada Saracino1 Ronald N. Zuckermann3, Fabrizio Gelain IRCCS Casa Sollievo della Sofferenza Opera di San Pio da Pietralcina Viale Capuccini I San Giovanni Rotondo Foggia 71013 Italy Center for Nanomedicine and Tissue Engineering (CNTE) A. O. Ospedale Niguarda Cd Granda Piazza dell' Ospedale Maggiore 3 Milan 20162 Italy The Molecular Foundry Lawrence Berkeley National Laboratory 1 Cyclotron Road Berkeley California 94720 USA

Self-assembling peptides （SAPs） are synthetic bioinspired biomaterials that can be feasibly multi-functionalized for cell transplantation and/or drug delivery therapies. Despite their superior biocompatibility and ease of scaling-up for production, they are unfortunately hampered by weak mechanical properties due to transient non-covalent interactions among and within the self-assembled peptide chains, thus limiting their potential applications as fillers, hemostat solutions, and fragile scaffolds for soft tissues. Here, we have developed and characterized a cross-linking strategy that increases both the stiffness and the tailorability of SAP hydrogels, enabling the preparation of transparent flexible threads, discs, channels, and hemispherical constructs. Empirical and computational results, in close agreement with each other, confirmed that the cross-linking reaction does not affect the previously self-assembled secondary structures. In vitro tests also provided a first hint of satisfactory biocompatibility by favoring viability and differentiation of human neural stem cells. This work could bring self-assembling peptide technology to many applications that have been precluded so far, especially in regenerative medicine.

关键词： self-assembling peptide co-assembling peptide cross-linking sulfo-SMCC supramolecularself-assembly

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