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Ultraviolet irradiation induced oxidative stress and response of antioxidant system in an intertidal macroalgae Corallina officinalis L.

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Journal of Environmental Sciences 2010年第5期22卷 716-722页

作者： Lixia Li Jiqiang Zhao Xuexi Tang College of Marine Life Science Ocean University of China Qingdao 266003 China Chemistry and Biology College Yan Tai University Yantai 264005 China

The response of the antioxidant defense system of an intertidal macroalgae Corallina officinalis *** different dosages of UV-B irradiation was *** showed that superoxide dimutase （SOD） and peroxidase （POX） increased and then maintained at a relatively stable level when subjected to UV-B *** （CAT） activity under medium dosage of UV-B irradiation （Muv） and high dosage of UV-B irradiation （Huv） treatments were significantly *** peroxidase （APX） activity first remained unaltered and then increased in Huv *** addition,the assay on isozymes was carried out using non-denaturing polyacrylamide gel electrophoresis （PAGE）.The activities of some SOD isoforms were altered by *** new bands （POX V and POX VII） appeared upon exposure to all three UV-B *** III activity was increased by low dosage of UV-B irradiation （Luv）,whereas CAT III and CAT IV disappeared when the alga was exposed to Muv and *** bands of APX （APX VI and APX VII） were increased and a new band （APX X） was observed under Huv exposure.H 2 O 2 and thiobarbituric acid reacting substance （TBARS） increased under Muv and Huv ***,UV-B protection mechanisms are partly inducible and to a certain extent sufficient to prevent the accumulation of damage in ***.

关键词： UV-B irradiation Corallina officinalis L. superoxide dimutase catalase ascorbate peroxidase peroxidase

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Effect of SP-A/B in lipoic acid on acute paraquat poisoning

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World Journal of Emergency Medicine 2014年第1期5卷 57-62页

作者： Shou-peng Li Ji-yuan Han Peng Sun Guo-yan Wu Xiang-yan Bai Department of Emergency Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology

BACKGROUND: This study was undertaken to observe the concentration of SP-A/B and the pulmonary surfactant in the lung tissue of rats with acute lung injury/acute respiratory distress syndrome caused by paraquat poisoning after the treatment of metabolic antioxidant-lipoic acid and whether its influence was related to TNF-α.METHODS: Sixty-six male Sprage-Dawley rats were randomly divided into three groups: normal control group(NS group), 6 rats; paraquat poisoning group(PQ group), 30 rats; and paraquat+lipoic acid treatment group(LA group), 30 rats. The rats in the PQ and LA groups were subdivided into 3-, 6-, 12-, 24-, 48-hour subgroups, with 6 rats in each group. After the rats were sacrificed, lung tissue from the same part was taken from the rats. After HE staining, histological changes were observed in the tissue under a light microscope. Lung tissue was also taken to test the levels of superoxide dismutase(SOD) and malondialdehyde(MDA). Whole blood(0.8 mL) without anticoagulant was drawn from the tail vein of rats for the determination of the TNF-α level. The total RNA of the lung tissue was collected, and the Rt-PCR method was used to measure the levels of SP-A and SP-B ***: HE staining showed that histopathological changes were milder in the LA group than in the PQ group. There were significant differences in MDA and SOD levels between different intervals both in intergroups and intragroups except the 3-hour subgroup(P<0.01). Likewise, the significant differences in the levels of TNF-α were also present between the three groups and between different intervals(P<0.01). The significant differences in SP-A mRNA and SP-B mRNA amplification ratio were seen between the three groups at the same intervals(P<0.01), but the differences between different intervals in the PQ group were statistically significant(P<0.05). The differences between different intervals in the LA group were statistically significant(P<0.01).CONCLUSION: Lipoic acid in acute paraquat poi

关键词： Lipoic acid Paraquat Acute lung injury Surfactant protein Tumor necrosis factor-α Oxygen free radical superoxide dimutase Malonaldehyde

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