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Micronization of curcumin with biodegradable polymer by supercritical anti-solvent using micro swirl mixer

Frontiers of Chemical Science and Engineering 2018年第1期12卷 184-193页

作者： Kimthet Chhouk Wahyudiono Hideki Kanda Shin-Ichro Kawasaki Motonobu Goto Department of Chemical Engineering Nagoya University Nagoya 464-8603 Japan Department of Chemical Engineering and Food Technology Institute of Technology of Cambodia Phnom Penh Cambodia Department of Materials Process Engineering Nagoya University Nagoya 464-8603 Japan Research Institute for Chemical Engineering Process Technology National Institute of Advanced Industrial Science and Technology Sendai 983-8551 Japan

Curcumin is a hydrophobic polyphenol compound exhibiting a wide range of biological activities such as anti-inflammatory, anti-bacterial, anti-fungal, anti-carcinogenic, anti-human immunodeficiency virus, and antimicrobial activity. In this employed to produce the work, a swirl mixer was micronized curcumin with polyvinylpyrrolidone （PVP） by the supercritical antisolvent process to improve the bioavailability of curcumin. The effects of operating parameters such as curcumin/PVP ratio, feed concentration, temperature, pressure, and CO2 flow rate were investigated. The characterization and solubility of particles were determined by using scanning electron microscopy, Fourier Transform Infrared spectroscopy, and ultra-violet-visible spectroscopy. The result shows that the optimal condition for the production of curcumin/PVP particles is at curcumin/PVP ratio of 1：30, feed concentration of 5 mg·mL^-1, temperature of 40 ℃, pressure of 15 MPa, and CO2 flow rate of 15 mL·min^-1. Moreover, the dissolution of curcumin/PVP particles is faster than that of raw curcumin.

关键词： micronization curcumin polyvinylpyrrolidone supercritical anti-solvent swirl mixer

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supercritical antisolvent-based Technology for Preparation of Vitamin D3 Proliposome and Its Characteristics

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Chinese Journal of Chemical Engineering 2011年第6期19卷 1039-1046页

作者：夏菲金鹤阳赵亚平郭新秋 College of chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 China Instrumental Analysis Center Shanghai Jiao Tong University Shanghai 200240 China

Vitamin D3 （VD3） proliposomes （VDP）, consisted of hydrogenated phosphatidycholine （HPC） and VD3, were prepared using supercritical anti-solvent technology （SAS）. The effects of operation conditions （temperature, pressure and components） on the VD3 loading in VDP were studied. At the optimum conditions of pressure of 8.0 MPa, temperature of 45 ℃, and the mass ratio of 15.0% between VD3 and HPC, the VD3 loading reached 12.89%. VD3 liposomes （VDL） were obtained by hydrating VDP and the entrapment efficiency of VD3 in VDL reached 98.5%. The morphology and structure of VDP and VDL were characterized by SEM （scanning electron micro-scope）, TEM （transmission electron microscope） and XRD （X-ray diffractometer）. The structure of VD3 nanoparti-cles in HPC matrix was formed. The size of VDL with an average diameter of about 1μm was determined by dynamic light scattering instrument （DLS）. The results indicated that VDP can be made by SAS and VDL with high entrapment efficiency can be formed easily via the hydration of VDP.

关键词： hydrogenated phosphatidych'oline liposome encapsulation supercritical anti-solvent

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