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Protective Actions of Blumea Flavanones on Primary Cultured Hepatocytes and Liver subcellular organelle against Lipid Peroxidation

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Journal of Chinese Pharmaceutical Sciences 1998年第3期7卷 40-44页

作者：赵金华许实波王正濂林永成陈荣礼中山大学药学系香港理工大学应用生物化学技术系

To search for the protective actions of blumea flavanones (BFs) on hepatocytes and hepatic subcellular organelle against lipid peroxidation, monkey′s hepatocytes were isolated and cultured with or without blumea flavanones, then damaged by FeSO 4 cysteine or CCl 4. The lipid peroxidation (malondialdehyde production) and alteration in hepatocyte membrane (leakage of GPT) were estimated. Hepatic subcellular organelles were also isolated and incubated with or without blumea flavanones, then injured by FeSO 4 ascorbate. The generation of malondialdehyde(MDA) was measured. It was found that BFs 10 and 100 μmol·L 1 inhibited the MDA generation and GPT (glutamic pyruvic transaminase) leakage out of hepatocytes that were induced by CCl 4 or FeSO 4 cysteine. BFs could prevent lipid peroxidation initiated by FeSO 4 ascorbate in subcellular organelle suspension. Among BFs, BF 2 possessed the strongest activity. Conclusion: Blumea flavanones possess antioxidation activities that protect monkey′s hepatocytes and hepatic subcellular organelle against injuries induced by FeSO4 or CCl 4.

关键词： Blumea flavanones Antioxidants Macaca mulatta Hepatocyte subcellular organelle

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MicroRNAs in cardiovascular diseases

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Medical Review 2022年第2期2卷 140-168页

作者： Huaping Li Jiabing Zhan Chen Chen Daowen Wang Division of Cardiology Department of Internal MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders WuhanChina.

Cardiovascular diseases(CVDs)are the leadingcauses of death and disability worldwide,despite thewide diversity of molecular targets identified and thedevelopment of therapeutic ***(miRNAs)are a class of small(about 22 nucleotides)non-codingRNAs(ncRNAs)that negatively regulate gene expressionat the post-transcriptional level in the cytoplasm and playcomplicated roles in different *** miRNA overexpression in one type of cell protects against heartdisease,it promotes cardiac dysfunction in another typeof cardiac ***,recent studies have shown that,apart from cytosolic miRNAs,subcellular miRNAs suchas mitochondria-and nucleus-localized miRNAs aredysregulated in ***,the functional propertiesof cellular-and subcellular-localized miRNAs have notbeen well *** this review article,by carefullyrevisiting animal-based miRNA studies in CVDs,we willaddress the regulation and functional properties ofmiRNAs in various ***,the cell–cellcrosstalk and subcellular perspective of miRNAs *** will provide the background for attractivemolecular targets that might be useful in preventing theprogression of CVDs and heart failure(HF)as well asinsights for future studies.

关键词： apoptosis cardiovascular diseases fibrosis heart failure hypertrophy miRNAs subcellular organelle

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