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Medical Review 2023年第1期3卷 4-30页

作者： Yuanzhen Su Guanyu Jin Huicong Zhou Zhaofan Yang Lanqing Wang Zi Mei Qionghua Jin Shixian Lv Xuesi Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchunChina School of Materials Science and Engineering Peking UniversityBeijingChina School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Chemistry Capital Normal UniversityBeijingChina School of Materials Science and Engineering Peking UniversityNo.5 Yiheyuan RoadBeijing 100871China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences5625 Renmin StreetChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026Anhui ProvinceChina

The complexity of the tumor microenvironment(TME)severely hinders the therapeutic effects of various cancer treatment *** TME differs from normal tissues owing to the presence of hypoxia,lowpH,and immunesuppressive *** of the TME to reverse tumor growth equilibrium is considered an effective way to treat ***,polymeric nanomedicines have been widely used in cancer therapy,because their synthesis can be controlled and they are highly modifiable,and have demonstrated great potential to remodel the *** this review,we outline the application of various stimuli responsive polymeric nanomedicines to modulate the TME,aiming to provide insights for the design of the next generation of polymeric nanomedicines and promote the development of polymeric nanomedicines for cancer therapy.

关键词： cancer therapy polymeric nanomedicines stimuli responsive tumor microenvironment

stimuli-responsive nanocarriers for bacterial biofilm treatment

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Rare Metals 2022年第2期41卷 482-498页

作者： Meng Ding Wei Zhao Ling-Jie Song Shi-Fang Luan State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese of AcademyChangchun 130022China College of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China School of Chemistry and Chemical Engineering Yantai UniversityYantai 264005China National Engineering Laboratory of Medical Implantable Devices Key Laboratory for Medical Implantable Devices of Shandong ProvinceWEGO Holding Company LimitedWeihai 264210China

Bacterial biofilm infections have been threatening the human’s life and health globally for a long time because they typically cause chronic and persistent *** antibiotic therapies can hardly eradicate biofilms in many cases,as biofilms always form a robust fortress for pathogens inside,inhibiting the penetration of *** address the issues,many novel drug carriers emerged as promising strategies for biofilm *** them,stimuli-responsive nanocarriers have attracted much attentions for their intriguing physicochemical properties,such as tunable size,shape and surface chemistry,especially smart drug release *** on the microenvironmental difference between biofilm infection sites and normal tissue,many stimuli,such as bacterial products accumulating in biofilms(enzymes,glutathione,etc.),lower pH and higher H_(2)O_(2)levels,have been employed and proved in favor of“on-demand”drug release for biofilm ***,external stimuli including light,heat,microwave and magnetic fields are also able to control the drug releasing behavior *** this review,we summarized recent advances in stimuli-responsive nanocarriers for combating biofilm infections,and mainly,focusing on the different stimuli that trigger the drug release.

关键词： Nanocarriers stimuli responsive Bactericidal Biofilm eradication Drug release

Thermo-and pH-dual responsive inorganic-organic hybrid hydrogels with tunable luminescence

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Science China Chemistry 2018年第3期61卷 328-335页

作者： Jinlong Zhang Haibing Wei Junyan Tan Weihong Qiao Yan Guan Jie Zhang State Key Laboratory of Fine Chemicals School of Chemical Engineering Dalian University of Technology Beijing National Laboratory for Molecular Sciences Key Laboratory of Polymer Chemistry and Physics of Ministry of Education College of Chemistry and Molecular Engineering Peking University School of Chemistry and Chemical Engineering Provincial Key Laboratory of Advanced Functional Materials and Devices Hefei University of Technology

A thermo-and pH-dual responsive luminescent hydrogel was successfully constructed by coupling dysprosium-containing polyoxometalates Na_9 DyW_(10) O_(36)(DyW_(10)) with the ABA triblock copolymer, where the B block is PEO and the A block is the thermosensitive poly(methoxydi(ethylene glycol) methacrylate-co-N,N-dimethylaminoethyl methacrylate). The complex hybrid underwent a sol-gel phase transition above the lower critical solution temperature(LCST) of the A block. DyW_(10) was electrostatically encapsulated into the hydrophobic domain of the A block with enhanced photoluminescence. When temperature cooled down, the luminescence could be restored. By addition of acids to protonate the A block, and emission of DyW_(10) was simultaneously enhanced. Sensitivity of poly(N,N-dimethy laminoethyl methacrylate)(PDMAEMA) to pH also enabled the emission of DyW_(10)/copolymer hydrogel to be reversibly switched by alternating acid/base treatments.

关键词： stimuli responsive block copolymer polyoxometalate hydrogel luminescence

Thermo-induced physically crosslinked polypeptide-based block copolymer hydrogels for biomedical applications

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Regenerative Biomaterials 2023年第1期10卷 933-956页

作者： Dan Zhao Yan Rong Dong Li Chaoliang He Xuesi Chen CAS Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China College of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China

stimuli-responsive synthetic polypeptide-containing block copolymers have received considerable attention in recent ***,unique thermo-induced sol-gel phase transitions were observed for elaborately-designed amphiphilic diblock copolypeptides and a range of poly(ethylene glycol)(PEG)-polypeptide block *** thermo-induced gelation mechanisms involve the evolution of secondary conformation,enhanced intramolecular interactions,as well as reduced hydration and increased chain entanglement of PEG *** physical parameters,including polymer concentrations,sol-gel transition temperatures and storage moduli,were *** polypeptide hydrogels exhibited good biocompatibility in vitro and in vivo,and displayed biodegradation periods ranging from 1 to 5 *** unique thermo-induced sol-gel phase transitions offer the feasibility of minimal-invasive injection of the precursor aqueous solutions into body,followed by in situ hydrogel formation driven by physiological *** advantages make polypeptide hydrogels interesting candidates for diverse biomedical applications,especially as injectable scaffolds for 3D cell culture and tissue regeneration as well as depots for local drug *** review focuses on recent advances in the design and preparation of injectable,thermo-induced physically crosslinked polypeptide *** influence of composition,secondary structure and chirality of polypeptide segments on the physical properties and biodegradation of the hydrogels are ***,the studies on biomedical applications of the hydrogels are intensively ***,the major challenges in the further development of polypeptide hydrogels for practical applications are proposed.

关键词： injectable hydrogels polypeptides stimuli responsive secondary conformation tissue engineering immunotherapy

Thermal and pH Dual responsive Copolymer and Silver Nanoparticle Composite for Catalytic Application

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Chinese Journal of Chemistry 2015年第4期33卷 467-472页

作者： Luqman Ali Shah Wulian Chen Mohammad Siddiq Jianhua Hu Angang Dong Dong Yang State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200433China Department of Chemistry Quaid-i-Azam UniversityIslamabad 45320Pakistan Department of Chemistry Fudan UniversityShanghai 200433China

N-Isopropylacrylamide and vinyl imidazole copolymer,P(NIPAM-co-VI),was synthesized by free radical emulsion ***,the copolymer and silver nanoparticle composite,P(NIPAM-co-VI)-Ag,was pre-pared by in situ reduction of AgNO3 with *** to the coexistence of thermal-responsive PNIPAM and pH-responsive PVI,P(NIPAM-co-VI)and P(NIPAM-co-VI)-Ag exhibited both thermal and pH responsibility,their size would change while altering the temperature or pH of the *** thermal and pH dual responsive properties were studied by dynamic light scattering(DLS).P(NIPAM-co-VI)-Ag could be stably dispersed in water at a pH range from 3.0 to 9.3,which is favorable to use P(NIPAM-co-VI)-Ag as a catalyst in the reduction reaction of *** reaction rate constant(kapp)increased with the decrease of pH or the increase of VI content in the copolymer.

关键词： copolymer catalyst silver nanoparticle stimuli responsive emulsion polymerization

An acid-base responsive linear-cyclic polymer rotaxane molecular shuttle with fluorescence signal output

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Chinese Chemical Letters 2022年第3期33卷 1533-1536页

作者： Zhanqi Cao Dongpu Wu Mengzhen Li Fan Yang Zhikai Li Wankai An Song Jiang Xin Zheng Caoyuan Niu Dahui Qu College of Science Henan Agricultural UniversityZhengzhou 450002China Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research CenterFrontiers Science Center for Materiobiology and Dynamic ChemistryInstitute of Fine ChemicalsSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China

The preparation of intelligent-responsive materials with controllable topology structure has long been a significant objective for chemists in the field of materials science. In this paper, we designed and prepared a linear-cyclic reversible topological structure polymer based on the bistable [1]rotaxane molecular shuttle. A ferrocene-functionalized [1]rotaxane and naphthalimide fluorophore group are introduced into the both ends of the polymer, which exhibit distance-induced photo-electron transfer effect. The structural transformation between linear and cyclic state of polymer is demonstrated by simple acid-base stimuli, accompanying visual fluorescence changes. The transformation process was characterized by 1H NMR spectra and fluorescence spectra. This work provides a novel strategy to construct functionalized polymers with topological structure.

关键词： Supramolecular polymer Rotaxane molecular shuttle stimuli responsive Fluorescence signal Topological structure

Fluorescent Linear Supramolecular Polymer Based on Host-Guest Interactions

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Chinese Journal of Chemistry 2017年第11期35卷 1669-1672页

作者： Chenxiao Xiong Ruyi Sun School of Chemistry and Molecular Engineering East China Normal University Shanghai 200241 China

Construction of supramolecular polymers, in which functional monomer components are held together by non- covalent interactions, is considered as a promising design principle for functional materials. Linear fluorescent su- pramolecular polymer assembled on account of electrostatic attractions based host-guest interaction is synthesized and illustrated here. 1H NMR was involved to ensure the structure of guest and polymer, UV-vis and fluorescent spectra were recorded to be a readout signal to investigate the assemble process of polymer. TEM and AFM meas- urements were carried out to confirm the homogeneous nanometer-sized molecular assembly. It shows the way to be used as remote readout fluorescent functional material in the future.

关键词： supramolecular polymer stimuli responsive molecular machines functional material

Tumor microenvironment responsive drug delivery systems

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Asian Journal of Pharmaceutical Sciences 2020年第4期15卷 416-448页

作者： Qunye He Jun Chen Jianhua Yan Shundong Cai Hongjie Xiong Yanfei Liu Dongming Peng Miao Mo Zhenbao Liu Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Department of Urology Xiangya HospitalCentral South UniversityChangsha 410008China School of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China School of Pharmacy Hunan University of Chinese MedicineChangsha 410208China

Conventional tumor-targeted drug delivery systems(DDSs)face challenges,such as unsatisfied systemic circulation,low targeting efficiency,poor tumoral penetration,and uncontrolled drug ***,tumor cellular molecules-triggered DDSs have aroused great interests in addressing such *** the introduction of several additional functionalities,the properties of these smart DDSs including size,surface charge and ligand exposure can response to different tumor microenvironments for a more efficient tumor targeting,and eventually achieve desired drug release for an optimized therapeutic *** review highlights the recent research progresses on smart tumor environment responsive drug delivery systems for targeted drug *** targeting strategies and functional moieties sensitive to a variety of tumor cellular stimuli,including pH,glutathione,adenosine-triphosphate,reactive oxygen species,enzyme and inflammatory factors are *** emphasis of this review is placed on their responsive mechanisms,drug loading models,drawbacks and *** typical multi-stimuli responsive DDSs are *** the main challenges and potential future development are discussed.

关键词： Cancer therapy stimuli responsive Dynamic targeting Drug delivery system Controlled release

Smart bistable coordination complexes

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Smart Molecules

Smart Molecules 2024年第2期2卷 15-62页

作者： Xiong Xiao Zong-Ju Chen Russell J.Varley Cheng-Hui Li State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical EngineeringCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjingChina Carbon Nexus at the Institute for Frontier Materials Deakin UniversityWaurn PondsVictoriaAustralia

Smart molecules have attracted increasing attention due to their transformative role in creating the next generation of smart structures and *** bistable coordination complexes are a class of functional complexes which have two stable states that can be reversibly switched in response to external *** bistable molecules play a vital role in various applications,such as sensors,data storage,spintronics,smart windows,optical switches,information encryption and decryption,displays,actuators,***,the recent research studies into the development of these smart bistable metal coordination complexes are *** to the different external stimuli,these smart bistable coordination systems have been classified and summarized,including light-responsive systems,thermally-responsive systems,electrically-responsive systems,mechanicallyresponsive systems,and some other *** systems are further subdivided according to the changes in signals(e.g.,color,fluorescence,spin state,crystalline phase)under external *** design principles of each type of smart bistable metal complexes as well as their broad and innovative applications are comprehensively ***,the challenges and opportunities in this field are briefly analyzed and discussed.

关键词： bistable coordination chemistry dynamic bonds smart molecules stimuli responsive