Stimuli-responsive nanocarriers for bacterial biofilm treatment

作     者：Meng Ding Wei Zhao Ling-Jie Song Shi-Fang Luan 

作者机构：State Key Laboratory of Polymer Physics and ChemistryChangchun Institute of Applied ChemistryChinese of AcademyChangchun 130022China College of Applied Chemistry and EngineeringUniversity of Science and Technology of ChinaHefei 230026China School of Chemistry and Chemical EngineeringYantai UniversityYantai 264005China National Engineering Laboratory of Medical Implantable DevicesKey Laboratory for Medical Implantable Devices of Shandong ProvinceWEGO Holding Company LimitedWeihai 264210China 

出 版 物：《Rare Metals》 (稀有金属（英文版）)

年 卷 期：2022年第41卷第2期

页      面：482-498页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 10[医学] 0702[理学-物理学] 

基　　金：This work was financially supported by the National Natural Science Foundation of China(Nos.51873212 and 51803212) the Youth Innovation Promotion Association of Chinese Academy Science(No.2017269) the Natural Science Foundation of Shandong Province(No.ZR2019MEM008) Chinese Academy of Sciences-Wego Group Hightech Research&Development Program 

主　　题：Nanocarriers Stimuli responsive Bactericidal Biofilm eradication Drug release 

摘      要：Bacterial biofilm infections have been threatening the human’s life and health globally for a long time because they typically cause chronic and persistent *** antibiotic therapies can hardly eradicate biofilms in many cases,as biofilms always form a robust fortress for pathogens inside,inhibiting the penetration of *** address the issues,many novel drug carriers emerged as promising strategies for biofilm *** them,stimuli-responsive nanocarriers have attracted much attentions for their intriguing physicochemical properties,such as tunable size,shape and surface chemistry,especially smart drug release *** on the microenvironmental difference between biofilm infection sites and normal tissue,many stimuli,such as bacterial products accumulating in biofilms(enzymes,glutathione,etc.),lower pH and higher H_(2)O_(2)levels,have been employed and proved in favor of“on-demanddrug release for biofilm ***,external stimuli including light,heat,microwave and magnetic fields are also able to control the drug releasing behavior *** this review,we summarized recent advances in stimuli-responsive nanocarriers for combating biofilm infections,and mainly,focusing on the different stimuli that trigger the drug release.