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Vibration-reduced anxiety-like behavior relies on ameliorating abnormalities of the somatosensory cortex and medial prefrontal cortex

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Neural Regeneration Research 2024年第6期19卷 1351-1359页

作者： Afzal Misrani Sidra Tabassum Tintin Wang Huixian Huang Jinxiang Jiang Hongjun Diao Yanping Zhao Zhen Huang Shaohua Tan Cheng Long Li Yang South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research Panyu Central Hospital School of Life Sciences Guangzhou University School of Life Sciences South China Normal University Guangzhou Hongai Cultural Development Inc. 5. Yinguo Health Management Team College of Biophotonics South China Normal University

Tibetan singing bowls emit low-frequency sounds and produce perceptible harmonic tones and vibrations through manual tapping. The sounds the singing bowls produce have been shown to enhance relaxation and reduce anxiety. However, the underlying mechanism remains unclear. In this study, we used chronic restraint stress or sleep deprivation to establish mouse models of anxiety that exhibit anxiety-like behaviors. We then supplied treatment with singing bowls in a bottomless cage placed on the top of a cushion. We found that unlike in humans, the combination of harmonic tones and vibrations did not improve anxietylike behaviors in mice, while individual vibration components did. Additionally, the vibration of singing bowls increased the level of N-methyl-D-aspartate receptor 1 in the somatosensory cortex and prefrontal cortex of the mice, decreased the level of γ-aminobutyric acid A(GABA) receptor α 1 subtype, reduced the level of CaMKII in the prefrontal cortex, and increased the number of GABAergic interneurons. At the same time, electrophysiological tests showed that the vibration of singing bowls significantly reduced the abnormal low-frequency gamma oscillation peak frequency in the medial prefrontal cortex caused by stress restraint pressure and sleep deprivation. Results from this study indicate that the vibration of singing bowls can alleviate anxiety-like behaviors by reducing abnormal molecular and electrophysiological events in somatosensory and medial prefrontal cortex.

关键词： anxiety medial prefrontal cortex parvalbumin interneuron pressure somatosensory cortex Tibetan singing bowl vibration

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In vivo neuronal and astrocytic activation in somatosensory cortex by acupuncture stimuli

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Neural Regeneration Research 2022年第11期17卷 2526-2529页

作者： Xiao-Yue Chang Kai Chen Tong Cheng Pui To Lai Li Zhang Kwok-Fai So Edward S.Yang Key Laboratory of CNS Regeneration(Minstry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Electrical and Electronic Engineering The University of Hong KongHong Kong Special Administrative RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Guangzhou Regenerative Medicine and Health Guangdong Laboratory GuangzhouGuangdong ProvinceChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina

Acupuncture is a medical treatment that has been widely pra cticed in China for over 3000 years,yet the neural mechanisms of acupuncture are not fully understood.We hypothesized that neurons and astrocytes act independently and synergistically under acupuncture stimulation.To investigate this,we used two-photon in vivo calcium reco rding to observe the effects of acupuncture stimulation at ST36(Zusanli)in mice.Acupuncture stimulation in peripheral acupoints potentiated calcium signals of pyramidal neurons and astrocytes in the somatosensory cortex and resulted in late-onset calcium transients in astrocytes.Chemogenetic inhibition of neurons augmented the astrocytic activity.These findings suggest that acupuncture activates neuronal and astrocytic activity in the somatosensory co rtex and provide evidence for the involvement of both neurons and astrocytes in acupuncture treatment.

关键词： acupuncture astrocyte chemogenetic neuron N-methyl-D-aspartate receptor somatosensory cortex transient receptor potential A1 two-photon in vivo imaging

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Blood flow activation in rat somatosensory cortex under sciatic nerve stimulation revealed by laser speckle imaging

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Progress in Natural Science:Materials International 2003年第7期 44-49页

作者： WANG Zheng, LUO Qingming, CHENG Haiying, LUO Weihua, GONG Hui and LU Qiang(The Key Laboratory of Biomedical Photonics of Ministry of Education of China, Huazhong University of Science and Technology, Wuhan 430074, China)

In many functional neuroimaging research the change of local cerebral blood flow (CBF) induced by sensory stimulation is regarded as an indicator of the change in cortical neuronal activity although a precise and full spatio-temporal description of local CBF response coupled to neural activity has still not been laid out. Using the laser speckle imaging technique a relatively large exposed area in so-matosensory cortex of rat was imaged for the observation of the variations of CBF during sciatic nerve stimulation. The results showed that cerebral blood flow activation was spatially localized and discretely distributed in the targeted microvasculature. Individual arteries, veins and capillaries in different diameters were activated with the time going. The response pattern of CBF related to the function of brain activity and energy metabolism is delineated exactly.

关键词： blood flow activation somatosensory cortex sciatic nerve stimulation laser speckle imaging.

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Activity-dependent development of callosal projections in the somatosensory cortex

Activity-dependent development of callosal projections in th...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Chun-Lei WANG,Lei ZHANG,Yang ZHOU,Jing ZHOU,Xiu-Juan YANG,Shu-min DUAN,Zhi-Qi XIONG,Yu-Qiang DING Institute of Neuroscience,Chinese Academy of Sciences,Shanghai 200031,China

＜正＞Callosal connections between cerebral hemispheres represent the largest commissural system in the brain,but the mechanisms underlying its development are not well understood.We here report that neuronal activity is essential for the development and maintenance of callosal projections in the somatosensory cortex.We found that suppression of neuronal excitation by over-expressing an inward rectifying potassium channel Kir2.1 in a subpopulation of layerⅡ/Ⅲcortical neurons resulted in aberrant targeting of their axons in the contralateral cortex,including an overshoot of projections for layersⅡ/Ⅲto layerⅠand decreased projections to the border between the primary and secondary somatosensory cortices.Blocking synaptic transmission by expressing tetanus toxin light chain in these axons caused an even more striking reduction of the projections at the border,and a poor ramification and eventual disappearance of these projections over the entire cortex.Thus,both electrical activity and synaptic transmission are critical for the development of callosal connections.

关键词： Corpus callosum Development Neuronal activity somatosensory cortex Barrel cortex

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Changes in brain activation in stroke patients after mental practice and physical exercise: a functional MRI study

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Neural Regeneration Research 2014年第15期9卷 1474-1484页

作者： Hua Liu Luping Song Tong Zhang Capital Medical University School of Rehabilitation Medicine China Rehabilitation Research Center

Mental practice is a new rehabilitation method that reters to the mental rehearsal ot motor imagery content with the goal of improving motor performance. However, the relationship between activated regions and motor recovery after mental practice training is not well understood. In this study, 15 patients who suffered a firstever subcortical stroke with neurological deficits affecting the right hand, but no significant cognitive impairment were recruited. 10 patients underwent mental practice combined with physical practice training, and 5 patients only underwent physical practice training. We observed brain activation regions after 4 weeks of training, and explored the correlation of activation changes with functional recovery of the affected hands. The results showed that, after 4 weeks of mental practice combined with physical training, the Fugl-Meyer assessment score for the affected right hand was significantly increased than that after 4 weeks of practice training alone. Functional MRI showed enhanced activation in the left primary somatosensory cortex, attenuated activation intensity in the right primary motor cortex, and enhanced right cerebellar activation observed during the motor imagery task using the affected right hand after mental practice training. The changes in brain cortical activity were related to functional recovery of the hand. Experimental findings indicate that cortical and cerebellar functional reorganization following mental practice contributed to the improvement of hand function.

关键词： nerve regeneration brain activation cortical activation somatosensory cortex corticalreorganization stroke mental practice functional recovery motor imagery neural regeneration

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Effects of visual information regarding tactile stimulation on the somatosensory cortical activation：a functional MRI study

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Neural Regeneration Research 2017年第7期12卷 1119-1123页

作者： Hyeok Gyu Kwon Sung Ho Jang Mi Young Lee Department of Physical Therapy College of Health Sciences Catholic University of Pusan Pusan Republic of Korea Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University Daegu Republic of Korea Department of Physical Therapy College of Health and Therapy Daegu Haany University Gyeongsansi Republic of Korea

Many studies have investigated the evidence for tactile and visual interactive responses to activation of various brain regions.However,few studies have reported on the effects of visuo-tactile multisensory integration on the amount of brain activation on the somatosensory cortical regions.The aim of this study was to examine whether coincidental information obtained by tactile stimulation can affect the somatosensory cortical activation using functional MRI.Ten right-handed healthy subjects were recruited for this study.Two tasks（tactile stimulation and visuotactile stimulation）were performed using a block paradigm during f MRI scanning.In the tactile stimulation task,in subjects with eyes closed,tactile stimulation was applied on the dorsum of the right hand,corresponding to the proximal to distal directions,using a rubber brush.In the visuotactile stimulation task,tactile stimulation was applied to observe the attached mirror in the MRI chamber reflecting their hands being touched with the brush.In the result of SPM group analysis,we found brain activation on the somatosensory cortical area.Tactile stimulation task induced brain activations in the left primary sensory-motor cortex（SM1）and secondary somatosensory cortex（S2）.In the visuo-tactile stimulation task,brain activations were observed in the both SM1,both S2,and right posterior parietal cortex.In all tasks,the peak activation was detected in the contralateral SM1.We examined the effects of visuo-tactile multisensory integration on the SM1 and found that visual information during tactile stimulation could enhance activations on SM1 compared to the tactile unisensory stimulation.

关键词： nerve regeneration functional MRI somatosensory cortex somatosensory cortical activation visuotactile stimulation neural regeneration

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Spike timing-dependent plasticity of neocortical excitatory synapses on inhibitory interneurons depends on target cell type

Spike timing-dependent plasticity of neocortical excitatory ...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Jiang-Teng LU~1,Cheng-Yu LI~1,Jian-Ping ZHAO~1,Mu-Ming POO~(1,2*),Xiao-Hui ZHANG~(1*) 1 Institute of Neuroscience and Key Laboratory of Neurobiology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China 2 Division of Neurobiology,Department of Molecular and Cell Biology,Helen Wills Neuroscience Institute,University of California,Berkeley,CA 94720,USA

＜正＞Repetitive correlated spiking can induce long-term potentiation（LTP） and long-term depression（LTD） of many excitatory synapses on glutamatergic neurons,in a manner that depends on the timing of pre- and postsynaptic spiking. However,it is largely unknown whether and how such spike timing-dependent plasticity（STDP） operates at neocortical excitatory synapses on inhibitory interneurons,which have diverse physiological and morphological characteristics.In this study we found that these synapses exhibit target cell-dependent STDP.In layer 2/3 of the somatosensory cortex,the pyramical cell（PC） forms divergent synapses on fast spiking（FS） and low-threshold spiking（LTS） interneurons that exhibit short-term synaptic depression and facilitation in response to high-frequency stimulation,respectively.At PC-LTS synapses,repetitive correlated spiking induced LTP or LTD,depending on the timing of pre- and postsynaptic spiking. However,regardless of the timing and frequency of spiking,correlated activity induced only LTD at PC-FS synapses.This target cell-specific STDP was not caused by the difference in the short-term plasticity between these two types of synapses.Activation of postsynaptic N-methyl-D-aspartate subtype of glutamate receptors（NMDARs） was required for LTP induction at PC-LTS synapses,whereas activation of metabotropic glutamate receptors（mGluRs） was required for LTD induction at both PC-LTS and PC-FS synapses.The absence of LTP at PC-FS synapses may be attributed in part to a much lower level of NMDARs relative to non-NMDARs,as compared to that at PC-LTS synapses.Such dependence of STDP on postsynaptic interneuron types may contribute to differential processing and storage of information in cortical local circuits.

关键词： synaptic plasticity spike timing-dependent plasticity（STDP） excitatory synapse inhibitory interneuron target-cell specificity somatosensory cortex

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Balanced bilateral sensory input is essential for target selection of callosal axons

Balanced bilateral sensory input is essential for target sel...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Ying HUANG~(**),Ning-Ning SONG~(**),Lei ZHANG,Ze-Lan HU,Jia-Yin CHEN,Yu-Qiang DING~* Department of Anatomy and Neurobiology,Tongji University School of Medicine,Shanghai 20092,China

＜正＞Prior to initial contact formation,intrinsic developmental programs and external guidance cues are responsible for guiding growing axons into their target field.Sensory input is generally thought to be necessary for refining and consolidating neuronal connections in developing neuronal networks.We here report that cortical callosal axons in the somatosensory cortex absolutely require sensory input for their target selection in the contralateral cortex. Eliminating sensory input to either hemisphere by unilateral transection of the infraorbital nerve（ION） prevents target selection of callosal axons in the contralateral cortex.Strikingly,blocking sensory input bilaterally,by simultaneously transecting both IONs,callosal projections are largely restored.In contrast,non-simultaneous bilateral ION transection has the same effect as unilateral transection,regardless of which side is lesioned first.Our data demonstrate the critical role of somatosensory input in guiding callosal axons into their target cortical territory.

关键词： activity barrel cortex somatosensory cortex infraorbital nerve（ION） callosal axon

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