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In situ phase transitional polymeric vaccines for improved immunotherapy

National Science Review 2022年第2期9卷 99-108页

作者： Jie Wang Yi Wang Shenglin Qiao Muhetaerjiang Mamuti Hongwei An Hao Wang CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology (NCNST) Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Cancer vaccines have exhibited immense potential in cancer treatment.Through activating the host’s immune system,vaccines stimulate extensive functional T cells to eliminate cancer.However,the therapeutic efficacy of cancer vaccines is limited by their inferior lymph node delivery and inadequate uptake of dendritic cells.Herein,we propose an in situ phase transitional strategy on vaccine manufacturing to maximally enhance lymph node drainage while ensuring adequate dendritic cell uptake.The phase transitional vaccines,with dynamic size modulation property,retain a small size(24.4±3.1 nm) during lymph node draining then transform into larger particles(483.0±41.6 nm) on-site by external signal input.Results show that this strategy induced rapid and robust immune response in a mouse melanoma tumor model.Furthermore,a stronger humoral immune response was observed in mice when immunized with MHC-Ⅱ restricted antigen,which demonstrated that lymph node-targeted cancer vaccine delivery could be effe ctively manipulated through dynamic size modulation.

关键词： nanomedicine lymph node delivery cancer vaccine size modulation dendritic cell

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High-throughput synthesis of size-controlled Pt-based catalysts

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Particuology 2023年第12期83卷 232-240页

作者： Zhuoran Deng Liqiang Zhao Daojian Cheng State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing100029China College of Information Science and Technology Beijing University of Chemical TechnologyBeijing100029China

Pt catalysts are commonly used for chemical reaction processes due to its high catalytic activity and selectivity.Notably,the size of metal particles often has a significant impact on the performance of the metal-loaded catalysts.Therefore,developing highly efficiently synthesis method for the size control of Pt catalysts has great development prospects and research value.In this study,high-throughput size tuning of Pt-based catalysts was achieved by carbonizing the carriers.The experimental and characterization results showed that the size of the loaded Pt nanoparticles varied with different concentrations of glucose solution during carriers carbonization process.The reduction of 4-nitrophenol as a template reaction indicated that the reaction rate constant of the catalyst is approximately linear with the size of Pt particles.Importantly,a laboratory-built high-throughput synthesis system was applied for the catalyst synthesis,which enhances the automation of the laboratory exploratory experiments and makes it possible to synthesize catalysts with controllable size in batches.

关键词： High-throughput synthesis size modulation Pt-based catalysts 4-Nitrophenol reduction

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