In situ phase transitional polymeric vaccines for improved immunotherapy
In situ phase transitional polymeric vaccines for improved immunotherapy作者机构：CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology (NCNST) Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences
出 版 物：《National Science Review》 (国家科学评论(英文版))
年 卷 期：2022年第9卷第2期
页 面：99-108页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the National Key R&D Program of China (2018YFE0205400) the National Natural Science Foundation of China (51725302, 11621505 and 51890894) the Strategic Priority Research Program of Chinese Academy of Sciences (XDB36000000)
主 题：nanomedicine lymph node delivery cancer vaccine size modulation dendritic cell
摘 要：Cancer vaccines have exhibited immense potential in cancer treatment.Through activating the host’s immune system,vaccines stimulate extensive functional T cells to eliminate cancer.However,the therapeutic efficacy of cancer vaccines is limited by their inferior lymph node delivery and inadequate uptake of dendritic cells.Herein,we propose an in situ phase transitional strategy on vaccine manufacturing to maximally enhance lymph node drainage while ensuring adequate dendritic cell uptake.The phase transitional vaccines,with dynamic size modulation property,retain a small size(24.4±3.1 nm) during lymph node draining then transform into larger particles(483.0±41.6 nm) on-site by external signal input.Results show that this strategy induced rapid and robust immune response in a mouse melanoma tumor model.Furthermore,a stronger humoral immune response was observed in mice when immunized with MHC-Ⅱ restricted antigen,which demonstrated that lymph node-targeted cancer vaccine delivery could be effe ctively manipulated through dynamic size modulation.
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