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Comparison of the effects of first and second generation silicone hydrogel contact lens wear on tear film osmolarity

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International Journal of Ophthalmology(English edition) 2013年第5期6卷 666-670页

作者： Guzin Iskeleli Yunus Karakoc Ahmet Ozkok Ceyhun Arici Omer Ozcan Osman Ipcioglu Department of Ophthalmology Cerrahpasa School of MedicineIstanbul University Department of Biophysics Inonu University Department of Biochemistry Gata Haydarpasa Training Hospital

AIM:To compare the effects of first and second generation silicone hydrogel(SiH) contact lens wear on tear film ***:The healthy subjects who have never used contact lenses before were enrolled in the *** film osmolarity values of 16 eyes(group 1) who wore first generation SiH contact lenses were compared with those of 18 eyes(group 2) who wore second generation SiH contact lenses after three months ***:Beforecontactlenswear,tearfilmosmolarity of groups 1 and 2 were 305.02±49.08 milliosmole(mOsm) and 284.66±30.18mOsm,*** three months of contact lens wear,osmolarity values were found 317.74±60.23mOsm in group 1 and 298.40±37.77mOsm in group *** osmolarity values for both groups of SiH contact lens wear after three months periods were slightly higher than before the contact lens wear,the difference was not statistically significant. CONCLUSION:contact lens wear may cause evaporation from the tear film and can increase tear film osmolarity leading to symptoms of dry eye *** the current study,there is a tendency to increase tear film osmolarity for both groups of SiH contact lens wear,but the difference is not statistically significant.

关键词： dry eye silicone hydrogel contact lens contact lens related dry eye tear film osmolarity

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Comparation of effectiveness of silicone hydrogel contact lens and hydrogel contact lens in patients after LASEK

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International Journal of Ophthalmology(English edition) 2015年第6期8卷 1131-1135页

作者： Wen-Juan Xie Jin Zeng Ying Cui Juan Li Zhong-Ming Li Wei-Xiong Liao Xiao-Hong Yang Department of Ophthalmology Guangdong General HospitalGuangdong Eye Institute Guangdong Academy of Medical Science

AIMTo conduct a comparative study of effectiveness of silicone hydrogel contact lens and hydrogel contact lens, which are used in patients after laser-assisted subepithelial keratomileusis (LASEK).METHODSSixty-three patients (121 eyes) with a spherical equivalent ≤-5.0 D were chosen after undergoing LASEK in 2012 at Guangdong General Hospital. They were randomly divided into 2 groups. The silicone hydrogel group included 32 cases (61 eyes) that wore silicone hydrogel contact lenses for 4-6d after the operation, while the hydrogel group included 31 cases (60 eyes) who wore hydrogel contact lenses for 4-6d after the operation. Patients' self-reported postoperative symptoms (including pain, photophobia, tears, and foreign body sensation) were evaluated. The healing time of the corneal epithelium, the visual acuity of patients without contact lens after epithelial healing, and the incidence of delayed corneal epithelial shedding were also assessed. The follow-up time was *** symptoms were milder in the silicone hydrogel group than in the hydrogel group. There were significant differences in pain, foreign body sensation, and photophobia between the 2 groups (P0.05). The healing time of the corneal epithelium in the silicone hydrogel lens group was markedly shorter than that in the hydrogel group (4.07±0.25 vs 4.33±0.82d, t=2.43, P=0.02). Visual acuity without contact lenses after healing of the corneal epithelium was better in the silicone hydrogel group compared with the hydrogel group (χ2=7.76, P=0.02). There was no significant difference in the occurrence of delayed corneal epithelial shedding between the 2 groups (P>0.05).CONCLUSIONPatients with LASEK using silicon hydrogel contact lenses had less discomfort and shorter corneal epithelial healing time compared with those using hydrogel contact lenses,

关键词： laser-assisted subepithelial keratomileusis silicone hydrogel contact lens hydrogel contact lens epithelial healing

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Clinic study on silicone hydrogel contact lenses used as bandage contact lenses after LASEK surgery

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International Journal of Ophthalmology(English edition) 2011年第3期4卷 314-318页

作者： Xiao-Mei Qu Jin-Hui Dai Zhen-Ying Jiang and Yi-Feng Qian Department of Ophthalmology Eye and ENT Hospital Affiliated to Fudan University Shanghai 200031 China

AIM: To compare the clinical performance of two types of silicon hydrogel contact lenses used as bandage lenses after LASEK surgery. METHODS: A prospective, double-masked study was conducted on 42 eyes of 21 patients who received binocular LASEK surgeries. The interocular difference in spherical equivalent power was less than -1.50D. Patients were randomly assigned to wear Galyfilcon A (lens A) bandage contact lens in one eye and Balafilcon A (lens B) in the fellow eye after the surgery. The responses to a subjective questionnaire on comfort of wearing, corneal epithelial status, conjunctival hyperemia, limbal neovascularization, lens fitting and contact lens debris were assessed 1 and 5 days postoperatively. Corneal endothelium was assessed before and 5 days after the surgery upon bandage lens removal. RESULTS: There was no difference between the two groups in terms of conjunctival hyperemia, limbal neovascularization, contact lens fitting, corneal epithelial status, corneal endothelium cell density (CD) and endothelium cell size (CS) at any postoperative visit. Complaints of discomfort, including foreign body sensation, pain and intolerance were statistically more among lens B wearers at any postoperative visit (P lens B appeared to attract much more debris than lens A at the 5-day post-operative follow-up visit (P hydrogel lenses investigated in this study demonstrated similar clinical performance in terms of corneal responses and lens fitting. However, lens A showed a better performance in terms of comfort of wearing and deposit resistance.

关键词： therapeutic contact lens bandage contact lens silicone hydrogel contact lens LASEK

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