检索结果-南通市图书馆

Trends and frontiers in signal amplification for aptamer-based tumor detection:A bibliometric analysis

World Journal of Clinical Cases 2024年第21期12卷 4726-4741页

作者： Dan Cai Gui-Lin Chen Ting Wang Kun-He Zhang Department of Gastroenterology The First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Jiangxi Institute of Gastroenterology and Hepatology Nanchang 330006Jiangxi ProvinceChina Department of Anorectal Surgery The 908th Hospital of the Chinese People's Liberation Army Joint Logistics Support ForceNanchang 330000Jiangxi ProvinceChina

BACKGROUND Malignant tumors are one of the leading causes of death worldwide,imposing a substantial economic and social *** detection is the key to improving cure rates and reducing mortality rates,which requires the development of sensitive early detection *** amplification techniques play a crucial role in aptamer-based early detection of tumors and are increasingly garnering attention from *** To investigate the current research status,developmental trajectories,and hotspots in signal amplification for aptamer-based tumor detection through bibliometric *** English publications pertaining to signal amplification in aptamer-based tumor detection were retrieved from the Web of Science Core Collection *** and CiteSpace software were employed to analyze various information within this field,including countries,institutions,authors,co-cited authors,journals,co-cited journals,cited references,and *** A total of 757 publications were included in this *** accounted for 85.47%of all publications,with Nanjing University(China)emerging as the institution with the highest publication *** most influential authors and journals were Hasanzadeh *** Iran and"Biosensors and Bioelectronics",*** and carcinoembryonic antigen(CEA)stood out as the most researched tumor-related ***,the predominant signal amplification technique,nanomaterial,and signal transduction method were identified as hybridization chain reactions,gold nanoparticles,and electrochemical methods,*** the past 3 years,exosomes,CEA,electrochemical biosensors,and nanosheets have emerged as research hotspots,exhibiting a robust burst of *** This study is the first bibliometric analysis of literature on signal amplification in aptamer-based tumor detection and elucidates the current status,hotspots,and prospective research directions within this ***,i

关键词： Aptamer signal amplification Tumor Bibliometrics Electrochemistry Nanosheet

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

signal amplification for Highly Sensitive Immunosensing

引用

Journal of Analysis and Testing 2017年第1期1卷 53-70页

作者： Huangxian Ju State Key Laboratory of Analytical Chemistry for Life Science Department of ChemistryNanjing UniversityNanjing 210023China

To dissolve the bottleneck problem of life and biomedical science in detection of biomolecules with low abundance and acquisition of ultraweak biological signals,highly sensitive analytical methods coupling with the specificity of biological recognition events have been quickly developed by the exploring of signal amplification *** strategies have extensively been introduced into the development of highly sensitive immunosensing methods by combining with highly specific immunological *** can be divided into two *** group of strategies attempts to transfer the immunological recognition event into large number of reporter probes or signal probes for signal readout by employing nano/micro-materials as vehicles for multi-labeling and/or molecular biological amplification for increasing the abundance of the signal *** other uses nanomaterials or enzyme mimics as catalytic tools/tags to obtain enhanced detection *** review focuses on the significant advances in design of signal amplification strategies for highly sensitive immunosensing.

关键词： signal amplification Immunosensing Immunological recognition Reporter probes Nanoparticles Enzyme mimics Polymerase chain reaction Rolling circle amplification Hybridization chain reaction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current trends in nanomaterials-mediated biosensing platforms and signal amplification strategies for antibiotics detection in dairy products

引用

Food and Health 2024年第1期6卷 28-42页

作者： Cui-Yun Zhou Feng Jiang Chen-Xi Huang Hubei Provincial Institute for Food Supervision and Test Wuhan 430070China College of Food Science and Technology Huazhong Agricultural UniversityWuhan 430070China Key Laboratory of Detection Technology of Focus Chemical Hazards in Animal-derived Food for State Market Regulation Wuhan 430070 China Hubei Provincial Engineering and Technology Research Center for Food Quality and Safety Test Wuhan 430070China State Key Laboratory of Biocatalysis and Enzyme Engineering Hubei Key Laboratory of Industrial BiotechnologySchool of Life SciencesHubei UniversityWuhan 430062China

Dairy products have become one of the most prevalent daily foods worldwide,but safety concerns are *** dairy farming,unscrupulous traders misuse antibiotics to treat some diseases such as mastitis in cows,leading to antibiotic residues in dairy ***,sensitive,and simple detection methods for antibiotic residues are particularly important for food safety in dairy *** detection technology can effectively detect antibiotics,but there are defects such as complicated pre-treatment and high *** are widely used in food safety due to fast detection speed,low detection cost,strong anti-interference ability,and suitability for the field ***,these sensors often fail to trigger the signal conversion output due to low target *** cope with this issue,some high-efficiency signal amplification systems can be introduced to improve the detection sensitivity and linear range of *** this review,we focused on:(i)Sources and toxicity of major antibiotics in animal-derived foods.(ii)Nanomaterial-mediated biosensors for real-time detection of target antibiotics in animal-derived foods.(iii)signal amplification techniques to increase the sensitivity of ***,future prospects and challenges in this research field are discussed.

关键词： Nanosensors signal amplification Antibiotics detection Animal-derived foods.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cascaded DNA circuits-programmed self-assembly of spherical nucleic acids for high signal amplification

引用

Science China Chemistry 2020年第1期63卷 92-98页

作者： Xiang Li Dongbao Yao Junxiang Zhou Xiang Zhou Xianbao Sun Bing Wei Chengxu Li Bin Zheng Haojun Liang Key Laboratory of Soft Matter Chemistry Chinese Academy of SciencesCollaborative Innovation Center of Chemistry for Energy MaterialsDepartment of Polymer Science and EngineeringHefei National Laboratory for Physical Sciences at the MicroscaleUniversity of Science and Technology of China School of Chemistry and Chemical Engineering Hefei Normal University

signal amplification is an important issue in DNA nanotechnology and molecular *** this work,we report a strategy for the catalytic self-assembly of spherical nucleic acids(SNAs)programmed by two-layer cascaded DNA circuits through integrating an entropy-driven catalytic network,a catalytic hairpin assembly circuit,and a facile SNA assembly-based reporter *** integrated system could implement^100,000-fold signal amplification in the presence of 1 pM of input *** powerful amplification ability of nucleic acid signal,our strategy should be of great potential in fabricating more robust dynamic networks to be applied for signal transduction,DNA computing,and nucleic acid-based diagnostics.

关键词： catalytic self-assembly DNA circuit signal amplification spherical nucleic acids

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Current signal amplification strategies in aptamer-based electrochemical biosensor:A review

引用

Chinese Chemical Letters 2021年第5期32卷 1593-1602页

作者： Lei He Rongrong Huang Pengfeng Xiao Yuan Liu Lian Jin Hongna Liu Song Li Yan Deng Zhu Chen Zhiyang Li Nongyue He State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringNational Demonstration Center for Experimental Biomedical Engineering Education(Southeast University)Southeast UniversityNanjing 210096China Department of Clinical Laboratory the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Economical Forest Cultivation and Utilization of 2011 Collaborative Innovation Center in Hunan Province Hunan Key Laboratory of Biomedical Nanomaterials and DevicesHunan University of TechnologyZhuzhou 412007China

Due to their high specificity and affinity towards various targets,along with other unique advantages such as stability and low cost,aptamers are widely applied in analytical techniques.A typical aptamerbased electrochemical biosensor is composed of a aptamer as the biological recognition element and transducer converting the biologic interaction into electrical signals for the quantitative measurement of *** of the sensitivity of a biosensor is significantly important in order to achieve the detection of biomolecules with low abundance,and different amplification strategies have been *** strategies either employ nanomaterials such as gold nanoparticles to con struct electrodes which can transfer the biological reactions more efficiently,or attempt to obtain enhanced signal through multi-labeled carriers or utilize enzyme mimics to catalyze redox *** review discusses recent advances in signal amplification methods and their *** assessment of each method is also considered.

关键词： Electrochemical Aptasensor signal amplification Nanomaterials DNA nanotechnology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Personal glucose meters coupled with signal amplification technologies for quantitative detection of non-glucose targets:Recent progress and challenges in food safety hazards analysis

引用

Journal of Pharmaceutical Analysis 2023年第3期13卷 223-238页

作者： Feng He Haijie Wang Pengfei Du Tengfei Li Weiting Wang Tianyu Tan Yaobo Liu Yanli Ma Yuanshang Wang A.M.Abd El-Aty Institute of Food&Nutrition Science and Technology Shandong Academy of Agricultural SciencesShandong Provincial Key Laboratory of Agro-Products Processing TechnologyKey Laboratory of Novel Food Resources ProcessingMinistry of AgricultureJinan250100China School of Life Sciences and Food Engineering Hebei University of EngineeringHandanHebei056038China College of Life Sciences Yantai UniversityYantaiShandong264005China College of Food Science and Technology Huazhong Agricultural UniversityWuhan430070China Department of Pharmacology Faculty of Veterinary MedicineCairo University12211GizaEgypt Department of Medical Pharmacology Medical FacultyAtaturk University25240ErzurumTurkey

Ensuring food safety is paramount *** effective detection methods to ensure food safety can be challenging owing to trace hazards,long detection time,and resource-poor sites,in addition to the matrix effects of *** glucose meter(PGM),a classic point-of-care testing device,possesses unique application advantages,demonstrating promise in food ***,many studies have used PGM-based biosensors and signal amplification technologies to achieve sensitive and specific detection of food *** amplification technologies have the potential to greatly improve the analytical performance and integration of PGMs with biosensors,which is crucial for solving the challenges associated with the use of PGMs for food safety *** review introduces the basic detection principle of a PGM-based sensing strategy,which consists of three key factors:target recognition,signal transduction,and signal *** studies of existing PGM-based sensing strategies combined with various signal amplification technologies(nanomaterial-loaded multienzyme labeling,nucleic acid reaction,DNAzyme catalysis,responsive nanomaterial encapsulation,and others)in the field of food safety detection are *** perspectives and potential opportunities and challenges associated with PGMs in the field of food safety are *** the need for complex sample preparation and the lack of standardization in the field,using PGMs in combination with signal amplification technology shows promise as a rapid and cost-effective method for food safety hazard analysis.

关键词： Food safety Personal glucose meter signal amplification Point-of-care testing Detection principle

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Enrichment and analysis of circulating tumor cells by integrating multivalent membrane nano-interface and endogenous enzyme-signal amplification

引用

Chinese Chemical Letters 2023年第1期34卷 574-577页

作者： Mengjiao Wang Dayong Li Chengjie Duan Jin Jiao Youjing Gong Xiaoping Wang Zhongyun Wang Yang Xiang State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing 210023China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100191China Department of Neurology Tongren HospitalShanghai JiaoTong University School of MedicineShanghai 200336China Department of Anesthesiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

For circulating tumor cells(CTCs)-based cancer diagnosis and monitoring,effective enrichment and specific analysis of CTCs present significant *** biomembrane interfaces can enhance the highaffinity interactions between various receptors and ligands in life activities by mediating the rearrangement and positioning of membrane-bound components through its *** by this,we have constructed a multivalent membrane nano-interface using aptamer-linked liposomes for the efficient capture of ***,the subsequent introduction of rolling circle amplification(RCA)reaction has increased the number of aptamers and extended them to the surrounding space to improve the affinity of the membrane nano-interface for *** CTCs are enriched,alkaline phosphatase overexpressed on the surface of tumor cells is used as endogenous enzyme-mediated signal amplification by catalyzing 4-nitrophenyl phosphate(p NPP)with color change,achieving the analysis of ***,the enrichment and visual analysis of human hepatocellular carcinoma(HepG2)with a detection limit of 10 cells/m L can be obtained by integrating the multivalent membrane nano-interface and endogenous enzyme signal *** detection of the target in the serum proved this method has the potential for further clinical application and provides a potential method for studying the correlation between alkaline phosphatase dimer and cancer progression.

关键词： CTCs Nano-interface Alkaline phosphatase dimer signal amplification Liposomes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sensitive detection of thyroid stimulating hormone by inkjet printed microchip with a double signal amplification strategy

引用

Chinese Chemical Letters 2018年第12期29卷 1879-1882页

作者： Beibei Yang Dongmei Liu Lina Zhu Yun Liu Xiaoning Wang Liang Qiao Weijia Zhang Baohong Liu Department of Chemistry Shanghai Stomatological HospitalCollaborative Innovation Center of Chemistry for Energy MaterialsFudan UniversityShanghai 200433China Department of Pharmacy Qingdao Municipal HospitalQingdao 266001China

An electrochemical immunosensor for sensitive detection of thyroid stimulating hormone(TSH) has been developed by using an inkjet printed microchip and based on a double signal amplification strategy using magnetic beads(MBs), alkaline phosphatase(ALP) and p-aminophenyl phosphate(pAPP) *** pulse voltammetry(DPV), cyclic voltammogram(CV) and amperometric i-t curve(i-t) were employed to characterize the immunosensor. High sensitivity and good selectivity were observed. The detection linear range was from 0.01 μIU/mL to 10 μIU/mL, in which the peak currents increased along with the concentration. The detection limit was 0.005 μIU/mL at S/N = 3. The immunosensor was also applied for TSH detection in human serum with recoveries from 98.0% to 101.8% and relative standard deviations from 1.3% to 3.1%, demonstrating potential value in clinical diagnosis.

关键词： Electrochemical immunosensor Inkjet printed microchip signal amplification Thyroid stimulating hormone Alkaline phosphatase

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

signal amplification in a Dynamic Bistable System with Directed Topology

Signal Amplification in a Dynamic Bistable System with Direc...

引用

第三十届中国控制会议

作者： ZHOU Yinzuo~1,ZHOU Jie~2,WANG Xiaofan~1 1.Department of Automation,Shanghai Jiao Tong University,Shanghai 200240,P.R.China 2.Temasek Laboratories,National University of Singapore,Singapore 117508,Singapore

＜正＞We proposed a method to amplify the signal in a double well system by dynamically adjusting the weight of the connections between the objective and its *** method is to increase the weights of the connections linking the objective unit with its neighbors in the different well while to decrease the weights of the connections linking the objective unit with its neighbors in the same *** method is proved to be quite effective and efficient as only local information of a system is needed,and it can be utilized to arbitrary node as long as it has neighbors in both *** theoretical analysis provides an explanation of the mechanism of this ***,we found that when extending this method by applying the dynamic adjusting strategy to all of the nodes,this method is also effective in enhancing the signal.

关键词： signal amplification Weight Adaption

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Influence of coupling asymmetry on signal amplification in a three-node motif

引用

Chinese Physics B 2023年第1期32卷 239-243页

作者：梁晓明方超张希昀吕华平 School of Physics and Electronic Engineering Jiangsu Normal UniversityXuzhou 221116China Department of Physics Jinan UniversityGuangzhou 510632China

The three-node feedforward motif has been revealed to function as a weak signal amplifier. In this motif, two nodes(input nodes) receive a weak input signal and send it unidirectionally to the third node(output node). Here, we change the motif's unidirectional couplings(feedforward) to bidirectional couplings(feedforward and feedback working together).We find that a small asymmetric coupling, in which the feedforward effect is stronger than the feedback effect, may enable the three-node motif to go through two distinct dynamic transitions, giving rise to a double resonant signal response. We present an analytical description of the double resonance, which agrees with the numerical findings.

关键词： network motif synchronization coupling asymmetry signal amplification

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：