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A thermodynamic model showing that information recording can drive active ion transport

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2058-2060页

作者： Xiang Zou Kun Song Minbiao Ji Lingzhao Min Liangfu Zhou Ying Mao Liang Chen Department of Neurosurgery Neurosurgical Institute of Fudan UniversityNational Center for Neurological DisordersHuashan HospitalFudan UniversityShanghai200040China Department of Physics Fudan UniversityShanghai200433China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science School of Basic Medical Sciences and Institutes of Brain ScienceFudan UniversityShanghai200040China

Dear Editor,Ion gradients are characteristic features of a living cell that do not represent thermodynamic equilibrium.These unequilibrium status are maintained by various ion pumps such as Na-K-ATPase,which are known as the P-type ATPases.Working mechanism of Na-K-ATPase is described as Post-Albers cycle1(Fig.1a).However,the reaction scheme is non-Michaelis-Menten kinetics assembled from transient-state results,which can hardly be used to rebuild the real reaction cycle.

关键词： recording maintained showing

Thyroid carcinoma showing thymus-like differentiation: Case presentation of a young man

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World Journal of Clinical Oncology 2014年第5期5卷 1117-1120页

作者： Chiara Abeni Chiara Ogliosi Luigina Rota Paola Bertocchi Alessandra Huscher Giordano Savelli Mariano Lombardi Alberto Zaniboni Department of Medical Oncology Fondazione Poliambulanza 25124 Brescia Italy Department of Radiotherapy Fondazione Poliambulanza 25124 Brescia Italy Department of Nuclear Medicine Fondazione Poliambulanza 25124 Brescia Italy Department of Pathology Fondazione Poliambulanza 25124 Brescia Italy

Ectopic thymic tissue can be present in the thyroid gland and a carcinoma showing thymus-like differentiation(CASTLE) may arise from such tissue. We are reported the case of a 26-year-old man with CASTLE, with cervical subcutaneous nodules relapse, who showed a good response to treatment with surgery, chemotherapy and radiotherapy. The problematic aspect of this case was the diagnosis; only on review were we able to make a final diagnosis. CASTLE is a very rare neoplasm. It is important to differentiate this cancer from others tumors such as primary or metastatic squamous cell carcinoma of the head and neck or squamous cell thyroid carcinoma, because the therapy and prognosis are different.Diagnosis is complicated and requires careful histological analysis(CD5- and P63-positive with presence of Hassall's corpuscles); unfortunately there is no gold standard treatment so, in this case, we administered a sandwich of chemotherapy and radiotherapy.

关键词： Carcinoma showing thymus-like differentiation thymic CD5 Hassall’s corpuscles Thyroidectomy Chemotherapy Radiotherapy

Imported Wine Market showing Signs of Recovery 后疫情时代，进口酒市缓慢复苏 B13

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Opinions and attitudes toward targeted temperature management in the emergency department and intensive care unit in a developing country: a survey study

华夏酒报

作者：徐菲远

New figures show that bottled wine imports dropped sharply during China’s coronavirus lockdown period,but some trade professionals have said there are signs of a recovery on the market.今年1～4月,我国瓶装葡萄酒的进... 详细信息

关键词：葡萄酒 Imported Market Recovery showing Signs

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World Journal of Emergency Medicine 2023年第2期14卷 138-142页

作者： Abdullah Bakhsh Hadeel Alotaibi Sara Alothman Abdulrahman Alothman Rahaf Alothman Abdulrahman Alsulami Malak Alamoudi Ali Alothman Ali Al-Shareef Department of Emergency Medicine the King Abdulaziz UniversityJeddah 21589Saudi Arabia Faculty of Medicine the King Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Anesthesia Intensive Care Unitthe King Abdulaziz UniversityJeddah 21589Saudi Arabia College of Medicine King Saud Bin Abdulaziz University for Health SciencesCollege of MedicineJeddah 21589Saudi Arabia King Abdulaziz Medical City Jeddah 21589Saudi Arabia King Abdullah International Medical Research Center Jeddah 21589Saudi Arabia

INTRODUCTION The past two decades have witnessed one of the most contentious scientific debates in the field of temperature management after cardiac arrest in adults.It started in 2002,following the publication of two groundbreaking trials showing lower mortality rates and improved neurologic recovery with the use of active cooling.[1,2]International recommendations advocate active cooling in the range of 32–34℃for comatose survivors of out-of-hospital cardiac arrest (OHCA).[3,4]The year2013 marked the tipping point with the release of the TTM 1 trial.

关键词： breaking release showing

Iron,the endolysosomal system and neuroinflammation:a matter of balance

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Neural Regeneration Research 2022年第5期17卷 1003-1004页

作者： Daniel A.Bórquez Pamela J.Urrutia Marco T.Núñez Center for Biomedical Research Faculty of MedicineUniversidad Diego PortalesSantiagoChile Department of Biology Faculty of SciencesUniversidad de ChileSantiagoChile

Iron accumulation and neuroinflammation are cardinal features of many neurodegenerative diseases(Urrutia et al.,2021).However,the hierarchy in the pathogenic mechanisms and the molecular connections between these proc... 详细信息

关键词： Iron system showing

Exercise and quality of life in cancer

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Journal of Sport and Health Science 2023年第4期12卷 489-490页

作者： Carmen Fiuza-Luces Pedro L.Valenzuela Alejandro Santos-Lozano Ana Ruiz-Casado Alejandro Lucia Physical Activity and Health Research Group(PaHerg) Research Institute of Hospital 12 de Octubre(‘i+12’)Madrid 28041Spain Department of Systems Biology University of AlcalaMadrid 28871Spain i+HeALTH Research Group Department of Health SciencesEuropean University Miguel de CervantesValladolid 47012Spain Department of Medical Oncology Hospital Universitario Puerta de Hierro MajadahondaInstituto de Investigacion Sanitaria Puerta de Hierro-Segovia de Arana(IDIPHISA)Madrid 28220Spain Faculty of Sport Sciences Universidad Europea de MadridMadrid 28670Spain

Historically,patients with cancer were told to avoid physical exertion.This dogma has changed over the last 2 decades,with an exponential growth in the number of studies showing not only the safety,but also the benefits of regular physical activity/exercise in the cancer continuum,notably for attenuating treatment-related toxicities and side effects.

关键词： cancer patients showing

Auricular embryonal rhabdomyosarcoma

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World Journal of Pediatrics 2022年第5期18卷 358-360页

作者： Javier Arredondo Montero Monica Bronte Anaut Sara Hernandez-Martin Juan Carlos Lopez-Gutierrez Pediatric Surgery Department Complejo Hospitalario de NavarraCalle Irunlarrea 331008 PamplonaNavarraSpain Pathology Department Complejo Hospitalario de NavarraPamplonaSpain Pediatric Surgery Department Hospital Universitario La PazMadridSpain

A 13-month-old girl presented with a red-violaceous tumor of 13 mm in diameter on the inner side of the root of the right helix,with increased temperature and cystic consistency(Fig.1).No pulse was palpable in the lesion.An ultrasonography was performed,showing a 1.6 cm rounded lesion with well-defined margins,hypoechogenic and homogeneous,compatible with hemangioma.Empirical treatment with oral propranolol was started without improve-ment.

关键词： sarcoma ultrasonography showing

The equality, diversity and inclusion in energy and AI: Call for actions

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能源与人工智能(英文)

能源与人工智能(英文) 2022年第2期8卷 1-4页

作者： Jin Xuan Raffaella Ocone Department of Chemical Engineering Loughborough UniversityLoughboroughUnited Kingdom Institute for GeoEnergy Engineering Heriot-Watt UniversityEdinburghUnited Kingdom

Introduction“Energy and AI”is a cutting-edge,interdisciplinary research area at the interface of two very relevant scientific topics.AI is a fast-growing technology already showing profound impact to the global economy and society.Energy is a sector where drastic changes are urgently needed for the net zero transition and AI will play the enabling role[1]in such transition.

关键词： transition. equality showing

Gene body demethylation increases expression and is associated with self-pruning during grape genome duplication

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Horticulture Research 2020年第1期7卷 1572-1583页

作者： Luming Zou Wenwen Liu Zhan Zhang Everard J.Edwards Elias Kirabi Gathunga Peige Fan Wei Duan Shaohua Li Zhenchang Liang Beijing Key Laboratory of Grape Science and Enology and CAS Key Laboratory of Plant Resources Institute of BotanyChinese Academy of SciencesBeijing 100093PR China University of the Chinese Academy of Sciences Beijing 100049PR China College of Life Science Shanxi Normal UniversityShanxi 041004PR China CSIRO Agriculture&Food Locked Bag 2Glen OsmondSA 5064Australia Sino-Africa Joint Research Center Chinese Academy of SciencesWuhan 430074PR China

A colchicine-induced autotetraploid grapevine exhibiting potentially valuable agronomic traits for grape production and breeding,including self-pruning,was identified.This study investigated DNA methylation variation and its role in gene expression during self-pruning in the autotetraploid grapevine.We used RNA-Seq to estimate differentially expressed genes between diploid and autotetraploid grapevine shoot tips.The genes showing increases in the autotetraploid were mainly related to stress response pathways,whereas those showing decreases in the autotetraploid were related to biological metabolism and biosynthesis.Whole-genome bisulfite sequencing was performed to produce single-base methylomes for the diploid and autotetraploid grapevines.Comparison between the methylomes revealed that they were conserved in CG and CHG contexts.In the autotetraploid grapevine,hypodifferentially methylated regions(DMRs)and hyper-DMRs in the gene body increased or decreased gene expression,respectively.Our results indicated that a hypo-DMR in the ACO1 gene body increased its expression and might promote self-pruning.This study reports that hypo-DMRs in the gene body increase gene expression in plants and reveals the mechanism underlying the changes in the modifications affecting gene expression during genome duplication.Overall,our results provide valuable information for understanding the relationships between DNA methylation,gene expression,and autotetraploid breeding in grape.

关键词： metabolism breeding showing