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Preoperative serum albumin Levels and Postoperative Acute Kidney Injury in Off-Pump Coronary Artery Bypass Surgery: A Single-Center Study in Bangladesh

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World Journal of Cardiovascular Surgery 2024年第8期14卷 131-144页

作者： Ahmad Pear Salahuddin Md. Abir Tazim Chowdhury Munama Magdum Dewan Iftakher Reza Chowdhury Nittya Nanda Pal Md. Nahedul Morshed Md. Zafar-Al-Nimari Latifa Nasrin Farooque Ahmed Department of Cardiac Surgery National Heart Foundation Hospital and Research Institute (NHFH&RI) Dhaka Bangladesh Department of Cardiothoracic and Vascular Surgery Evercare Hospital Dhaka Dhaka Bangladesh National Institute of Preventive and Social Medicine Dhaka Bangladesh Mother and Child Welfare Center Cumilla Bangladesh

Background: serum albumin, a vital plasma protein, helps maintain intravascular colloidal osmotic pressure, cardiac output, and renal function. Low preoperative serum albumin is linked to poor outcomes, including acute kidney injury (AKI), after off-pump coronary artery bypass (OPCAB) surgery. This study aimed to assess the relationship between preoperative serum albumin levels and early postoperative renal injury. Methods: This prospective comparative cross-sectional study was conducted from August 2019 to February 2021 at the National Heart Foundation Hospital & Research Institute, Bangladesh. It included 160 adult patients with normal preoperative renal function undergoing OPCAB. Patients were divided into two groups: Group A (serum albumin ≥ 4.0 gm/dl) and Group B (serum albumin Results: Preoperative serum albumin was significantly different between groups (Group A: 4.21 ± 0.05 gm/dl, Group B: 3.69 ± 0.04 gm/dl, p = 0.028). Group B had a higher incidence of hypertension (71.25% vs. 51.25%, p st and 3rd postoperative days were higher in Group B (p th day. Postoperative AKI occurred in 18.75% of Group A and 36.25% of Group B. Multivariate regression indicated that low preoperative serum albumin is an independent risk factor for postoperative AKI (p = 0.012, OR = 1.815, CI: 0.675 - 1.162). Conclusion: Preoperative serum albumin level is a valuable predictor of postoperative renal function. Ensuring high normal serum albumin levels before surgery can help minimize the risk of postoperative AKI.

关键词： serum albumin Acute Kidney Injury (AKI) Off-Pump Coronary Artery Bypass Surgery Bangladesh

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serum albumin complexed with ellagic acid from pomegranate peel and its metabolite urolithin B

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Food Bioscience 2022年第2期46卷 1029-1039页

作者： Peiyu Xue Guangjie Zhang Hongmei Zhao Wencheng Wang Jie Zhang Li Ren School of Biology and Food Engineering Anyang Institute of TechnologyAnyang455000China School of Life Sciences Jilin UniversityChangchun130012China College of Food Science and Engineering Jilin UniversityChangchun130062China

As one of fruit waste by-products,the pomegranate peel is rich in bioactive compounds such as ellagic *** acid and its main gut microbial metabolite urolithin B have been reported to exhibit numerous biological activities and widely used as dietary supplements in the past *** of these two compounds to serum albumin(SA)might affect their metabolism,efficacy,and body *** interaction of ellagic acid and urolithin B with SA was investigated and BSA interference on the anti-cancer activity of these two compounds was also *** of spectra experiments showed that ellagic acid and urolithin B could form complexes with bovine serum albumin(BSA)and urolithin B has a higher binding force and number of binding sites than ellagic acid when forming a complex with *** results of molecular docking and molecular dynamics simulations suggested that ellagic acid and urolithin B tended to bind in site I rather than site *** MTT assay results indicated that the IC_(50) value of ellagic acid decreased from 123.58μM to 55.91μM,while the IC_(50) value of urolithin B decreased from 83.67μM to 47.40μ*** acid and urolithin B can form complexes with serum albumin and the anti-cancer activity of ellagic acid and urolithin B was enhanced when combined with BSA.

关键词： Ellagic acid Urolithin B serum albumin Anti-cancer activity

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Studies on Interactions of Antibiotics with serum albumin by Surface Plasmon Resonance Biosensor

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Chemical Research in Chinese Universities 2006年第3期22卷 324-327页

作者： SUN Ying LIU Shi-chun LIU Xia SONG Da-qian BI Shu-yun ZHANG Han-qi College of Chemistry Jilin University Changchun 130012 P. R. China State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan Umversity Changsha 410082 P. R. China

Characterizing how chemical compounds binding to serum albumin is essential in evaluating drug candidates and is the focus of this study. A surface plasmon resonance biosenser developed in this laboratory was used to determine the binding constants of antibiotics with serum albumin. The binding constants of five antibiotics（asithromycin, spectinomycin, gentamycin, metacycline and kanamycin） with serum albumins were obtained.

关键词： serum albumin Surface plasmon resonance Antibiotic Human serum albumin (HSA) Bovine serum albumin (BSA)

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Association between serum albumin levels and disease severity in adult patients with dengue: A 7-year retrospective cohort study in China's Mainland

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Asian Pacific Journal of Tropical Medicine 2023年第5期16卷 204-212,I0001页

作者： Changtai Wang Huiqin Yang Jielan Xu Jian Wang Lingzhai Zhao Wenxin Hong Fuchun Zhang Department of Infectious Disease Guangzhou Eighth People's HospitalGuangzhou Medical UniversityGuangzhouChina Department of Clinical Laboratory Guangzhou Eighth People's HospitalGuangzhou Medical UniversityGuangzhouChina Department of Infectious Disease Guangzhou Red Cross HospitalJinan UniversityGuangzhouChina

Objective:To identify the association between serum albumin levels and disease severity among adult patients with dengue in China's ***:This retrospective cohort study analyzed the data of adult patients(aged≥18 years)hospitalized with laboratory-confirmed dengue in a tertiary center for infectious diseases from 2013 to 2019 in China's *** albumin levels were estimated and compared between patients with severe dengue and non-severe ***,the association between serum albumin levels and severe dengue was evaluated using a generalized linear model[relative risks(RR)].Multivariate logistic regression analysis was performed to identify the potential predictors of severe ***:Overall,1568 patients were included in this *** these patients,34(2.17%)developed severe *** median serum albumin levels were significantly lower in patients with severe dengue than that in those with non-severe dengue(33 g/L vs.37 g/L,Palbuminemia(RR 4.877,95%CI 2.193-11.461,Palbumin levels(OR 1.303,95%CI 1.161-1.462,Pserum albumin levels to distinguish severe dengue was ***:Lower serum albumin levels were significantly associated with disease severity in adult patients with *** on admission resulted in at least a four-fold increased risk of severe dengue.

关键词： Dengue Severe dengue serum albumin Hypoalbuminemia Prediction

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Postoperative decrease of serum albumin predicts shortterm complications in patients undergoing gastric cancer resection

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World Journal of Gastroenterology 2017年第27期23卷 4978-4985页

作者： Zhi-Jian Liu Xiao-Long Ge Shi-Chao Ai Hong-Kan Wang Feng Sun Li Chen Wen-Xian Guan Department of Gastrointestinal Surgery Nanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical School Sir Run Run Shaw Hospital Zhejiang University School of Medicine First Affiliated Hospital of Zhejiang University School of Medicine

AIM To find an accurate and simple predictor for postoperative short-term complications after gastrectomy. METHODS Two hundred and twenty-three patients undergoing gastric cancer resection between October 1,2015 and September 30,2016 were enrolled in this study. Univariate and multivariate analyses were used toidentify risk factors for complications after gastrectomy. The cutoff values and diagnostic accuracy were examined by receiver operating characteristic *** Sixty-two(27.8%) patients had short-term complications after gastric cancer resection. The postoperative decrease in serum albumin(?ALB) was an independent risk factor for complications(OR = 17.957,95%CI: 6.073-53.095,P < 0.001). The cutoff value was 14.0% and the area under the curve was higher than that of C-reactive protein on postoperative day 3(area under the curve: 0.806 vs 0.709). Patients with ?ALB ≥ 14.0% were more likely to have short-term complications after gastrectomy(46.7% vs 5.0%,P < 0.001),prolonged hospital stay(17.2 ± 10.8 d vs 14.1 ± 4.2 d,P = 0.007) and higher comprehensive complication index(P < 0.001) than those with ?ALB < 14.0%.CONCLUSION Postoperative ?ALB with a cutoff of 14.0% can be used to recognize patients who have high risk of short-term complications following gastric cancer resection.

关键词： Gastric cancer Postoperative complications Gastrectomy serum albumin Predictor

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Correlation of serum albumin level on postoperative day 2 with hospital length of stay in patients undergoing emergency surgery for perforated peptic ulcer

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World Journal of Gastrointestinal Surgery 2023年第7期15卷 1434-1441页

作者： Dan Xie Ping-Lan Lu Wen Xu Jing-Ya You Xiao-Gang Bi Ying Xian Department of General Intensive Care Unit Lingnan HospitalThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510530Guangdong ProvinceChina Department of Surgical Intensive Care Unit The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Perforated peptic ulcer(PPU)is a common emergency surgical condition and a significant cause of morbidity and mortality *** advances in surgical techniques have improved outcomes for patients with PPU,many factors still affect postoperative hospital stay and overall *** potential factor is the serum albumin(SA)level,a widely utilized marker of nutritional status that has been associated with length of stay and complications in various surgical *** To clarify the correlation of SA level on postoperative day 2 with hospital length of stay(HLOS)in patients undergoing emergency surgery for perforated peptic ulcer(PPU).METHODS We retrospectively collected and analyzed clinical baseline data,including blood routine and SA levels,of patients who underwent emergency PPU surgery and postoperative treatment at the Lingnan Hospital,the Third Affiliated Hospital of Sun Yat-sen University between December 2012 and September *** were grouped according to HLOS with 7 d as the cut-off value,and relevant indicators were analyzed using SPSS *** Of the 37 patients undergoing emergency surgery for PPU referred to our department,33 had gastric and 4 had duodenal ulcer *** median HLOS was 10 *** were 8 patients in the≤7-d group(median HLOS:7 d)and 29 patients in the>7-d group(median HLOS:10 d).The≤7-d group had markedly higher SA on postoperative day 2 than the>7-d group(37.7 g/L vs 32.6g/L;P7 d(Odds ratio=0.629,P=0.015).The cut-off of SA on postoperative day 2 was 30.6g/L,with an area under the curve of 0.86 and a negative predictive value of 100%for the prediction of HLOS≤7 *** The SA level on postoperative day 2 was associated with the HLOS in patients undergoing emergency surgery for *** pre-and post-operative albumin levels should be monitored,and infusion of human SA should be considered in a timely man

关键词： Perforated peptic ulcer Emergency surgery serum albumin Hospital length of stay

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serum albumin as a prognostic predictor reflecting host immunity in patients with non-small cell lung cancer

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Journal of Nutritional Oncology 2023年第3期8卷 136-142页

作者： Ling-Yu Li Hai-Shuang Sun Xiao Chen Dong-Sheng Xu Nai-Fei Chen Han-Fei Guo Wei Han Xu Yan Fei-Fei Guo Jia-Xuan Li Tan-Lun Zeng Wen-Qian Li Jiu-Wei Cui Cancer Center The First Hospital of Jilin UniversityChangchun 130021JilinChina Department of Respiratory Medicine The First Hospital of Jilin UniversityChangchun 130021JilinChina

Objective:serum albumin(ALB)can transport nutrients to circulating and local immune cells by passing through blood vessels and has attracted attention as a prognostic predictor of non-small cell lung cancer(NSCLC)because it reflects the host immunity from peripheral blood(PBL)to the tumor microenvironment. Methods:Clinical data regarding the PBL and tumor tissues were obtained at The First Hospital of Jilin University between February 2009 and March *** detected indices of glucose and lipid metabolism,classified and counted PBL lymphocytes using flow cy-tometry,determined the tumor-infiltrating lymphocytes by quantitative immunofluorescence,and analyzed the T-cell receptor(TCR)rep-ertoire by high-throughput sequencing of the TCR β-*** correlations between ALB and metabolic immune indices were analyzed by t tests and Pearson chi-square test. Results:A total of 211 enrolled NSCLC patients were divided into a relatively high-ALB group(>41.75 g/L,n = 56)and a low-ALB group(≤41.75 g/L,n = 155);patients with high ALB had lower Treg cells(Palbumin could affect the host immunity,and

关键词： serum albumin Tumor-infitrating lymphocytes TCR diversity Non-small cell ung cancer Prognosis

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Postoperative Reduction in serum albumin Predicts Complications after Rectal Cancer Surgery

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Journal of Nutritional Oncology 2021年第4期6卷 169-175页

作者： Yi Fan Cheng Yan Yu Chen Yong Lu Chang Bao Liu Department of Gastrointestinal Surgery Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityTaizhou 317000ZhejiangChina Department of Coloproctology The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027ZhejiangChina

Background The serum albumin(Alb)level often decreases early in the postoperative ***,it is unclear whether a decline in the serum albumin level(ΔAlb)is a predictor of postoperative *** aimed to determine the relationship between theΔAlb and complications following surgery for rectal cancer(RC).Methods We retrospectively collected the records of patients aged≥18 years who underwent RC surgery between January 2015 and August *** determined the cut-off value of theΔAlb using subject working characteristic curve analysis and analyzed complications above grade II according to the Clavien-Dindo *** and multifactor analyses of the risk factors for postoperative complications were *** A total of 430 RC patients were included in this *** area under theΔAlb curve was 0.786,with a critical value of 22%.We selected 20%as the critical point for grouping *** total postoperative complication rate was significantly higher in patients who had a≥20%serum Alb decline than those had aserum Alb decline(200 ml)(OR=1.684,95%CI=1.043-2.716 P=0.033)were independent risk factors for postoperative complications follow RC *** TheΔAlb predicted the incidence of postoperative complications in patients after RC *** could help identify patients at risk of complications early during the perioperative period,thereby helping to more effectively manage high-risk patients.

关键词： serum albumin Postoperative reduction Complications Rectal cancer Postoperative complications

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Effect of Largehead Atractylodes Rhizome on serum albumin Level and Intestinal Mucosa Morphology in Rats with Cerebral Hemorrhage

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医学信息 2010年第6期23卷 1824-1826页

作者： WANG Jian-lin1,ZHANG Su-ming1,YANG Zhi-xiu2,ZHANG Xiao-min2,FAN Yun-hu2,WANG Jing-mei2(1.Neurology Department,Tongji Hospital of Tongji Medical College of Huazhong University of Science & Technology Wuhan 430030 2.Neurology Department of The Second People's Hospital of Yunnan Province Kunming Yunnan 650021,China) Neurology Department Tongji Hospital of Tongji Medical College of Huazhong Unversity of Science & Technology Wuhan430030 Neurology Department of The Second People's Hospital of Yunnan Province Kunming Yunnan 650021 China

Objective To evaluate the effect and mechanism of largehead atractylodes rhizome on the serum albumin level and jejunal mucosa morphology in rats with cerebral *** The cerebral hemorrhage rat model was established by using a simple grouping experimental design method to detect the serum albumin level and the morphological parameter of the jejunal mucosa in the treatment and control groups on Day 1,7 and 14 after cerebral *** Compared with the control group,the serum albumin was increased in the treatment group on Day 1 and 7 after the operation(Pserum albumin level of rats,and can aggravate the injury of the small intestinal mucosa in the early stage,but relieve in the late stage.

关键词： largehead atractylodes rhizome cerebral hemorrhage rat serum albumin intestinal mucosa

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Insight into the binding mechanisms of BODIPY-based photosensitizers to human serum albumin

Insight into the binding mechanisms of BODIPY-based photosen...

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中国化学会第四届卟啉与酞菁学术研讨会

作者：陈亚玉刘见永黄明东李金宇 College of Chemistry Fuzhou University

＜正＞Photodynamic therapy（PDT）is a promising and clinically approved technique for treating various ***（PS）is a critical and necessary component of PDT（1）.Very recently,boron-dipyrromethene（BODIPY）-based deri... 详细信息

关键词： Photosensitizer BODIPY interaction molecular simulations serum albumin

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