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serum amyloid p component:a new biomarker for low sperm concentration?

Asian Journal of Andrology 2021年第5期23卷 450-455页

作者： Annika Sonesson Johan Malm Lars Rylander Aleksander Giwercman Andreas Hillarp Department of Translational Medicine Lund UniversityMalmo 20502Sweden University and Regional Laboratories Region Skane Department of Clinical Chemistry and PharmacologyMalmo 20502Sweden Department of Laboratory Medicine Division of Occupational and Environmental MedicineLund UniversityLund 22381Sweden

serum amyloid p component(SAp)is present in seminal plasma,on spermatozoa,and in different tissues of the male reproductive tract,but its function is not *** aims of this study were to determine if the concentration of SAp in seminal plasma is associated with commonly assessed semen parameters and to investigate if SAp could be a new,indirect biomarker for these *** a cross-sectional study of 203 young volunteers,the concentration of SAp in seminal plasma was measured with a in-house developed enzyme-linked immunosorbent *** plots,pearson’s correlation coefficients(r),and linear regression models were produced,and SAp showed a statistically significant correlation with sperm concentration(r=0.75),sperm number(r=0.68),semen volume(r=-0.19),progressive sperm motility(r=0.24),and sperm immotility(r=-0.20).When the study group was dichotomized,SAp could be used to discriminate samples with a sperm concentrationperating characteristic curves,the corresponding areas under the curves were 0.97,0.93,and 0.82,respectively,with pp in seminal plasma showed a strong,positive correlation with the concentration of spermatozoa in *** may be used as a new indirect potential biomarker for sperm concentration in fresh and in frozen,stored *** addition,it is envisaged that the assay could be developed into a home fertility test to differentiate between a low and a normal sperm concentration.

关键词： fertility reproduction seminal plasma serum amyloid p component sperm

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