Serum amyloid P component:a new biomarker for low sperm concentration?
作者机构：Department of Translational MedicineLund UniversityMalmo 20502Sweden University and Regional Laboratories Region SkaneDepartment of Clinical Chemistry and PharmacologyMalmo 20502Sweden Department of Laboratory MedicineDivision of Occupational and Environmental MedicineLund UniversityLund 22381Sweden
出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)
年 卷 期：2021年第23卷第5期
页 面：450-455页
核心收录：
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
基 金：Financial support was received from Southern Health Care Region Skane County Council's Research and Development Foundation-PhD Study Grant. Grants were also received from ReproUnion (InterregV EU Regional Fund)
主 题：fertility reproduction seminal plasma serum amyloid P component sperm
摘 要：Serum amyloid P component(SAP)is present in seminal plasma,on spermatozoa,and in different tissues of the male reproductive tract,but its function is not *** aims of this study were to determine if the concentration of SAP in seminal plasma is associated with commonly assessed semen parameters and to investigate if SAP could be a new,indirect biomarker for these *** a cross-sectional study of 203 young volunteers,the concentration of SAP in seminal plasma was measured with a in-house developed enzyme-linked immunosorbent *** plots,Pearson’s correlation coefficients(r),and linear regression models were produced,and SAP showed a statistically significant correlation with sperm concentration(r=0.75),sperm number(r=0.68),semen volume(r=-0.19),progressive sperm motility(r=0.24),and sperm immotility(r=-0.20).When the study group was dichotomized,SAP could be used to discriminate samples with a sperm concentrationor≥5×10^(6)ml^(-1),15×10^(6)ml^(-1),or 40×10^(6)ml^(-1),and in receiver operating characteristic curves,the corresponding areas under the curves were 0.97,0.93,and 0.82,respectively,with P0.001 for all three cutoff values *** concentration of SAP in seminal plasma showed a strong,positive correlation with the concentration of spermatozoa in *** may be used as a new indirect potential biomarker for sperm concentration in fresh and in frozen,stored *** addition,it is envisaged that the assay could be developed into a home fertility test to differentiate between a low and a normal sperm concentration.
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