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Asian Pacific Journal of Tropical Medicine 2014年第12期7卷 985-990页

作者： Bao-Qin Liu Xin Gong Zhe Jin Beijing University of Chinese Medicine Department of Gynecology Oriental Hospital of Beijing University of Chinese Medicine

Objective:To investigate the efteets of traditional Chinese *** decoction,on the expression angiogenesis factors in human endometrial cells during the sequelae of pelvic inflammatoty disease(SPID) and explore the role of Danzhi decction in improving the blood stasis microenvironment of ***:A three-dimensional(3D) co—culture system including human vascular endothelial cells(VECs),endometrial stromal cells and glandular epithelial cells was established in vitro and treated with Danzhi decoction,sterilized water and aspirin respectively.A Milliplex multifunctional liquid chip technique was used to measure the expression levels of vascular endothelial growth factor(VEGF)—A/C/D,fibroblast growth factor-1/*** growth factor(EGF) HB-EGF,bone morphogenetic *** colony stimulating factor,hepatocyte growth factor,interleukin-8,*** growth factor and *** location of angiogenesis factors was monitored by immunofluorescence labeling and confocal laser scanning microscope3 D ***:Endometrial stromal cells and glandular epithelial cells were isolated and primary cultured for establishing a 3D co-culture *** levels of VEGF—A/C/D in Danzhi decoction group and aspirin group were significantly lower than those in mock group(P0.05).Furthermore,the alterative location of VEGF—A/C/D was observed in the cytoplasm of endometrial glandular epithelial ***:Danzhi decoction mav inhibit the expression of VEGF in the blood stasis microenvironment of SPID by targeting the cytoplasm of endometrial glandular epithelial cell.

关键词： Danzhi decoction sequelae of pelvic inflammatory disease Endometrial cells Angiogenesis factor Microenvironment

Acute and delayed psychiatric sequelae among patients hospitalised with COVID-19:a cohort study using LIFE study data

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General Psychiatry 2022年第3期35卷 173-182页

作者： Fumiko Murata Megumi Maeda Chieko Ishiguro Haruhisa Fukuda Department of Health Care Administration and Management Kyushu University Graduate School of Medical SciencesFukuokaJapan National Center for Global Health and Medicine ShinjukukuTokyoJapan

Background Characterising the psychiatric sequelae of coronavirus disease 2019(COVID-19)can inform the development of long-term treatment ***,few studies have examined these sequelae at different time points after COVID-19 *** The study aimed to investigate the incidences and risks of acute and delayed psychiatric sequelae in patients hospitalised with COVID-19 in *** This retrospective cohort study was conducted using a database comprising healthcare claims data from public health insurance enrollees residing in a Japanese *** analysed a primary cohort comprising patients hospitalised with COVID-19 between March 2020 and July 2021 and two control cohorts comprising patients hospitalised with influenza or other respiratory tract infections(RTI)during the same *** calculated the incidences of acute(1–3 months after infection)and delayed(4–6 months after infection)psychiatric *** sequelae were identified using diagnosis codes and categorised as mood/anxiety/psychotic disorder,mood disorder,anxiety disorder,psychotic disorder or *** logistic regression models were used to estimate the odds ratios(ORs)of psychiatric sequelae occurrence after COVID-19 infection compared with influenza and other *** The study population with acute psychiatric sequela consisted of 662 patients with COVID-19,644 patients with influenza,and 7369 patients with RTI who could be followed for 3 months;the study population with delayed psychiatric sequelae consisted of 371 patients with COVID-19,546 patients with influenza,and 5397 patients with RTI who could be followed for 6 *** the analysis of acute psychiatric sequelae,COVID-19 had significantly higher odds of mood/anxiety/psychotic disorder(OR:1.39,p=0.026),psychotic disorder(OR:2.13,p<0.001),and insomnia(OR:2.59,p<0.001)than influenza,and significantly higher odds of insomnia(OR:1.44,p=0.002)and significantly lower odds of anxiety disorder(OR:0.56,p<0.

关键词： patients psychiatric sequelae

Effective strategies against COVID-19 and the importance of infection sequelae

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Global Health Research and Policy 2022年第1期7卷 37-43页

作者： Jade Khalife Social Medicine and Global Health Faculty of MedicineLund UniversityJan Waldenströms Gata 3521428 MalmöSweden

COVID-19 is a serious threat to human health and *** acute burden of the pandemic includes more than 18.2 million deaths worldwide,and is unprecedented in modern *** represents only a fraction of the total burden,as it excludes infection *** effective global strategic paradigm has been missing throughout the ***‘flattening the curve’approach neglected the importance of infection sequelae,and being centered on healthcare capacity was conceptually contrary to a people-centered health *** March 2022,the World Health Organization revised its pandemic approach,importantly shifting emphasis away from managing transmission and towards *** limitations,this now recognizes the role of infection sequelae,whose impact is becoming clearer in both variety and *** on the foundational concepts of Sun Tzu and Carl von Clausewitz,most country approaches do not qualify as strategies,but rather as operational *** are also largely ineffective,neglecting infection sequelae,viral evolution dangers and other *** purpose of this article is to summarize the evidence on COVID-19 infection sequelae,and alongside other contextual parameters use this to motivate that infection should be *** is then used to answer the question:What is an effective strategy against COVID-19?

关键词： COVID-19 Strategy sequelae Long COVID Chronic disease

Long-term observation of outer retinopathy-like sequelae in intrapapillary hemorrhage with adjacent peripapillary subretinal hemorrhage using multimodal imaging

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Advances in Ophthalmology Practice and Research 2021年第1期1卷 55-59页

作者： Renpan Zeng Lixia Du Li Chen Department of Ophthalmology Sichuan Provincial Corps HospitalChinese People's Armed Police ForcesLeshan614000China

*** Intrapapillary hemorrhage with adjacent peripapillary subretinal hemorrhage(IHAPSH)is a rare disorder of fundus oculi,which presents most often in young myopic adults with a tilted,crowded disc that may predispose patients to bleeding from the optic *** often extends into the peripapillary subretinal space and vitreous1 and usually causes sudden blurry vision and floater *** clinical and experimental studies have shown that subretinal hemorrhage can cause photoreceptor cell apoptosis and presents as outer retinopathy-like lesions.2–4 The damage mechanism is thought to be due to iron toxicity and blockage of the diffusion of nutrient substances vital to the outer retina from the choroidal circulation by subretinal hemorrhage.5,6 However,interestingly,Patrick Sibony et *** 10 white women with *** hemorrhage resolved without sequelae over 3–6 months in all patients.7 Most recently,Ming Zou et *** thirty-eight eyes of 37 consecutive IHAPSH patients,and all patients were followed for 2 *** a mean follow-up of 2.85 months,the hemorrhage resolved spontaneously without sequelae.8 The two studies indicated that IHAPSH was a benign syndrome,and the photoreceptor cells were not affected by subretinal hemorrhage secondary to ***,we present a young male who suffered from IHAPSH with sequelae of outer retinopathy-like lesions in long-term observation using multimodal *** our knowledge,this is the first IHAPSH case that presents sequelae of outer retinopathy-like lesions,and we demonstrated the long-term evolution of sequelae using multimodal imaging.

关键词： hemorrhage sequelae papillary

Treatment　of　sequelae　of　Wind　Stroke　by　Acupuncture　in　Combination　with　Massage

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中国针灸 1995年第S2期15卷 261-262页

作者： Yang Pengwen(Yi County Hopital of TCM,HeBei province)

ＴｒｅａｔｍｅｎｔｏｆＳｅｑｕｅｌａｅｏｆＷｉｎｄＳｔｒｏｋｅｂｙＡｃｕｐｕｎｃｔｕｒｅｉｎＣｏｍｂｉｎａｔｉｏｎｗｉｔｈＭａｓｓａｇｅ￥ＹａｎｇＰｅｎｇｗｅｎ（ＹｉＣｏｕｎｔｙＨｏｐｉｔａｌｏｆＴＣＭ，ＨｅＢｅｉｐ... 详细信息

ＴｒｅａｔｍｅｎｔｏｆＳｅｑｕｅｌａｅｏｆＷｉｎｄＳｔｒｏｋｅｂｙＡｃｕｐｕｎｃｔｕｒｅｉｎＣｏｍｂｉｎａｔｉｏｎｗｉｔｈＭａｓｓａｇｅ￥ＹａｎｇＰｅｎｇｗｅｎ（ＹｉＣｏｕｎｔｙＨｏｐｉｔａｌｏｆＴＣＭ，ＨｅＢｅｉｐｒｏｖｉｎｃｅ）３０ｃａｓｅｓｏｆ...

关键词： Acupuncture Combination Massage sequelae Stroke Treatment Wind by of with

Clinical　Observation　on　Treatment　of　sequelae　of　Apoplexy　With　Eye　and　Body　Acupuncture

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中国针灸 1995年第S2期15卷 259-260页

作者： Huang Xiaojie Wang jianmin Wang yuzhen zhao yajing Li Fengshan(PLA Hospital 465,Jinn 132011 )

ＣｌｉｎｉｃａｌＯｂｓｅｒｖａｔｉｏｎｏｎＴｒｅａｔｍｅｎｔｏｆＳｅｑｕｅｌａｅｏｆＡｐｏｐｌｅｘｙＷｉｔｈＥｙｅａｎｄＢｏｄｙＡｃｕｐｕｎｃｔｕｒｅ￥ＨｕａｎｇＸｉａｏｊｉｅ；Ｗａｎｇｊｉａｎｍｉｎ；Ｗａｎｇｙｕｚ... 详细信息

ＣｌｉｎｉｃａｌＯｂｓｅｒｖａｔｉｏｎｏｎＴｒｅａｔｍｅｎｔｏｆＳｅｑｕｅｌａｅｏｆＡｐｏｐｌｅｘｙＷｉｔｈＥｙｅａｎｄＢｏｄｙＡｃｕｐｕｎｃｔｕｒｅ￥ＨｕａｎｇＸｉａｏｊｉｅ；Ｗａｎｇｊｉａｎｍｉｎ；Ｗａｎｇｙｕｚｈｅｎ；ｚｈａｏｙａｊｉｎｇ；Ｌｉ...

关键词： Observation Acupuncture Body Clinical Eye Apoplexy sequelae Treatment With and

Risk factors causing structural sequelae after anastomotic leakage in mid to low rectal cancer

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World Journal of Gastroenterology 2015年第19期21卷 5910-5917页

作者： Woong Bae Ji Jung Myun Kwak Jin Kim Jun Won Um Seon Hahn Kim Department of Surgery Korea University College of Medicine

AIM: To investigate the risk factors causing structural sequelae after anastomotic leakage in patients with mid to low rectal ***: Prospectively collected data of consecutive subjects who had anastomotic leakage after surgical resection for rectal cancer from March 2006 to May 2013 at Korea University Anam Hospital were retrospectively analyzed. Two subgroup analyses were performed. The patients were initially divided into the sequelae(stricture, fistula, or sinus) and no sequelae groups and then divided into the permanent stoma(PS)and no PS groups. Univariate and multivariate analyses were performed to identify the risk factors of structural sequelae after anastomotic ***: Structural sequelae after anastomotic leakage were identified in 29 patients(39.7%).Multivariate analysis revealed that diversion ileostomy at the first operation increases the risk of structural sequelae [odds ratio(OR) = 6.741; P = 0.017].Fourteen patients(17.7%) had permanent stoma during the follow-up period(median, 37 mo). Multivariate analysis showed that the tumor level from the dentate line was associated with the risk of permanent stoma(OR = 0.751; P = 0.045).CONCLUSION: Diversion ileostomy at the first operation increased the risk of structural sequelae of the anastomosis, while lower tumor location was associated with the risk of permanent stoma in the management of anastomotic leakage.

关键词： Anastomotic leakage Permanent stoma Leakage sequelae rectal cancer Anastomotic leakagefate

Effect of Different Factors on the Quality of Life and sequelae of COVID-19 Patients After Discharge

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Infectious Diseases & Immunity 2023年第2期3卷 60-66页

作者： Nan Guo Ya-Ping Yao Le Song Guan-Zhen Wang Jun-Li He Ning Zheng Qiong Mo Wen-Xu Ni Bo Zhang Fu-Sheng Wang Lei Huang Chinese PLA Medical School Beijing 100853China Department of Infectious Diseases the Fifth Medical CenterChinese PLA General HospitalBeijing 100039China National Clinical Research Center for Infectious Diseases Beijing 100039China Southern Medical University Guangzhou 510515Guangdong ProvinceChina Department of Infectious Diseases Chinese PLA General Hospital of Central Theater CommandWuhan 430070Hubei ProvinceChina Capital Medical University Beijing 100053China Xuanwu Hospital Capital Medical UniversityBeijing 100053China Department of Transfusion Chinese PLA General Hospital of Central Theater CommandWuhan 430070Hubei ProvinceChina.

Background The continued spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)remains an international public health emergency,resulting in a significant global disease *** long-term effects of SARS-CoV-2 infection in humans and the long-term prognosis of patients with coronavirus disease 2019(COVID-19)after discharge remain *** aimed to assess the quality of life(QoL)and sequelae in patients with COVID-19 after discharge from the hospital by conducting multiple follow-up visits to understand the long-term effects of SARS-CoV-2 on patients'health and its possible influencing *** COVID-19 patients discharged from Huoshenshan Hospital(Wuhan,China)between February 15 and April 5,2020,were followed up at 6,9,and 12 months after *** completed questionnaires on postdischarge QoL and sequelae under the guidance of medical staff with professional *** demographic and clinical characteristics of the COVID-19 patients were analyzed using descriptive statistics.A generalized estimating equation model was used to analyze the QoL-related ***χ2 test(or Fisher exact test)and multivariate logistic regression analysis were used to analyze the sequelae and influencing *** A total of 175 patients participated in at least 1 follow-up visit,and 120 completed all 3 follow-up *** diagnosed with severe and critically ill COVID-19 had worse mental conditions(χ2=7.653,P=0.022)than those with the nonsevere type(not severe or critical)and were more likely to feel fatigued(χ2=4.836,P=0.028).Female patients had a higher risk of sleep disturbance(χ2=10.026,P=0.002)and dyspnea(χ2=5.672,P=0.017)and had more difficulty returning to their original work and life(χ2=8.922,P=0.003)than male *** with diabetes had a worse appetite(χ2=4.669,P=0.031)and were more prone to sleep disturbance(χ2=4.417,P=0.036)after *** proportion of patients with at least 1 sequela increased from 29.76%(50/168)a

关键词： COVID-19 Quality of life sequelae Follow-up

Neurological sequelae in Cranioencephalic Trauma Patients at the National Hospital in Zinder (Niger)

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Open Journal of Modern Neurosurgery 2022年第2期12卷 104-115页

作者： Mahaman Sani Rabiou Abd-el Kader Moumouni Abiba Tamou Tabe Essosinam Kpelao Stackys Hounkpatin Moussa Taofik Abdoulaye Adamou Babana Dede Regine Diane Ajavon Aminata Kelani Soumaila Sanoussi Depetement of Neurosurgery Zinder Hospital Zinder Niger Department of Neurosurgery Kara University Hospital Center KaraTogo Depeartment of Radiology Kara Regional Hospital Center Kara Togo Department of Neurosurgery Syvanus Olympio University Hospital Center Lome Togo Depetement of Traumatology Zinder Hospital Zinder Niger Department of Neurosurgery Maradi Niger Reference Hospital Maradi Niger Faculty of Health Sciences University of Kara Kara Togo Depetement of Neurosurgery CHU Niamey Niamey Niger

Introduction: Cranioencephalic trauma is a frequent reason for admission to emergency departments and is a source of mild to severe neuropsychological defects that will persist over time. Their management remains difficult. Objectives: To evaluate the sequelae presented by patients suffering from cranioencephalic trauma. Methods: This was a retrospective, descriptive, cross-sectional study conducted at the National Hospital of Zinder. It will include all patients admitted and hospitalised in the emergency, intensive care and neurosurgery departments of Zinder National Hospital for head injury over a period of 28 months from 1 January 2016 to 30 April 2018. Brain scan, X-ray were the imaging tests used. Results: Out of a total of 974 admissions, 367 were retained, i.e. 37.6%, with a male predominance (82.6%). The average age was 26.5 years. MVAs were represented in 89.7% of cases. Moderate CTE accounted for 64% of cases. Altered consciousness was reported in 295 patients (80.38% of cases). Brain scans were used in 76.7% of cases and skull X-rays in 4.2% of cases. Medical management was performed in all patients. Treatment was operative in 78 patients (21.25%). Recovery without immediate sequelae was found in 187 patients (50.9%). Persistent headache represented 47.7% of the late sequelae observed in the patients, epileptic seizures represented 16.8% of the late sequelae, neurological deficit represented 14.7%. Conclusion: Cranioencephalic trauma represents a major public health issue. Although their in-hospital management remains a challenge, post-hospital management related to the appearance of sequelae remains another.

关键词： Cranioencephalic Trauma CT Scan X-Ray sequelae Niger

Neuroprotective effect of Sanqi Tongshuan Tablets on sequelae post-stroke in rats

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Chinese Herbal Medicines 2019年第1期11卷 45-51页

作者： Wei-ting Wang Chun-hua Hao Shao-xiang Zhang Xiang-hua Zhang Feng Guo Shuang-yong Sun Rui Zhang Zhuan-you Zhao Li-da Tang State Key Laboratory of Pharmacokinetics and Pharmacodynamics Tianjin Institute of Pharmaceutical Research Kunming Hospital of Traditional Chinese Medicine Kunming Institute of Nephrology

Objective: To identify the therapeutic effect and possible mechanisms of Chinese medicine Sanqi Tongshuan Tablets(SQTS) on sequelae post-stroke in ***: The rat cerebral ischemia sequelae post-stroke models were successfully induced by blocking the middle cerebral artery with electric coagulator after the seventh week and balance beam test ≤ 4. The rats were then received with SQTS(0.5, 1, and 2 g/kg) and Naodesheng(NDS, 1.24 g/kg), Vinpocetine(VP,1.55 mg/kg) for 30 d. The beam-walking test and shuttle test were performed before and after 10, 20, and 30 d of administration. In addition, histopathology changes and GAP-43, GFAP were measured by H&E staining and ***: The model displayed signs of brain damage on motor function, learning and memory function and histopathology. After 30 d of treatment, SQTS at different doses(0.5, 1.0, and 2.0 g/kg) restored the beam-walking scores by 21.7%(P > 0.05), 30.4%(P > 0.05), and 39.1%(P 0.05), 50.0%(P > 0.05), and 75.0%(P sequelae post-stroke in rats, which might be through the pathway of regeneration or neuroplasticity.

关键词： learning and memory motor function rats Sanqi Tongshuan Tablets sequelae post-strokes