Neuroprotective effect of Sanqi Tongshuan Tablets on sequelae post-stroke in rats

作     者：Wei-ting Wang Chun-hua Hao Shao-xiang Zhang Xiang-hua Zhang Feng Guo Shuang-yong Sun Rui Zhang Zhuan-you Zhao Li-da Tang 

作者机构：State Key Laboratory of Pharmacokinetics and Pharmacodynamics Tianjin Institute of Pharmaceutical Research Kunming Hospital of Traditional Chinese Medicine Kunming Institute of Nephrology 

出 版 物：《Chinese Herbal Medicines》 (中草药（英文版）)

年 卷 期：2019年第11卷第1期

页      面：45-51页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by Tianjin 131 Innovative Talent Training Project(2016) 

主　　题：learning and memory motor function rats Sanqi Tongshuan Tablets Sequelae post-strokes 

摘      要：Objective: To identify the therapeutic effect and possible mechanisms of Chinese medicine Sanqi Tongshuan Tablets(SQTS) on sequelae post-stroke in ***: The rat cerebral ischemia sequelae post-stroke models were successfully induced by blocking the middle cerebral artery with electric coagulator after the seventh week and balance beam test ≤ 4. The rats were then received with SQTS(0.5, 1, and 2 g/kg) and Naodesheng(NDS, 1.24 g/kg), Vinpocetine(VP,1.55 mg/kg) for 30 d. The beam-walking test and shuttle test were performed before and after 10, 20, and 30 d of administration. In addition, histopathology changes and GAP-43, GFAP were measured by H&E staining and ***: The model displayed signs of brain damage on motor function, learning and memory function and histopathology. After 30 d of treatment, SQTS at different doses(0.5, 1.0, and 2.0 g/kg) restored the beam-walking scores by 21.7%(P 0.05), 30.4%(P 0.05), and 39.1%(P 0.05), 50.0%(P 0.05), and 75.0%(P 0.05), respectively. On the other hand, the histological changes were less severe and the GAP-43 expression increased in hippocampal CA1 and cortical ***: SQTS showed therapeutic benefits on sequelae post-stroke in rats, which might be through the pathway of regeneration or neuroplasticity.